SG 2022-08-15 AJL/LEIH/HK00057.0002/s4a TW TW 110130070 2021-08-16 VITAE BIOMEDICAL CO., LTD. CHEN, SHUI-TEIN Anti-GM2AP ANTIBODY AND APPLICATIONS THEREOF 119 14 AA PAT REGION 1..14 note GM2AP and one of the amino acids from position 1 to 14 isglycosylated with (GlcNAc)2Fuc(Man)3 source 1..14 mol_type protein organism synthetic construct PIIVPGNVTLSVVG 193 AA PAT REGION 1..193 note GM2AP and one of the amino acids from position 57 to 70 isglycosylated with (GlcNAc)2Fuc(Man)3 source 1..193 mol_type protein organism synthetic construct MQSLMQAPLLIALGLLLAAPAQAHLKKPSQLSSFSWDNCDEGKDPAVIRSLTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAASLKGI 193 AA PAT REGION 1..193 note GM2AP and one of the amino acids from position 57 to 70 isglycosylated with (GlcNAc)2Fuc(Man)3 source 1..193 mol_type protein organism synthetic construct MQSLMQAPLLIALGLLLAAPAQAHLKKPSQLSSFSWDNCDEGKDPAVIRSLTLEPDPIIVPGNVTLSVVGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAASLKGI 202 AA PAT REGION 1..202 note GM2AP and one of the amino acids from position 57 to 70 isglycosylated with (GlcNAc)2Fuc(Man)3 source 1..202 mol_type protein organism synthetic construct MQSLMQAPLLIALGLLLAAPAQAHLKKPSQLSSFSWDNCDEGKDPAVIRSLTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAASLKGIRHHHHHHHH 113 AA PAT REGION 1..113 note 21-2B5-F7 light chain variable region source 1..113 mol_type protein organism synthetic construct DIVMTQTASSVYVTPGESVSISCRSTKSLLHSNGDTYLYWFLQRPGQSPQLLIYRMSNLAPGVPDRFSGGGSGTAFTLRISRVEAEDVGVYYLYATSTISFHVRCWDQAGAET 120 AA PAT REGION 1..120 note 21-2B5-F7 heavy chain variable region source 1..120 mol_type protein organism synthetic construct EIQLQQSGAELVRPGTSVKISCMASGYSFTGYNMNWVRQSHGRSLEWIGNINPYFGSPNYNQKFKGKATLTLDRSSNTAYMQLNRVTSEDSAVYYCASRQLGLGDTMDYWGQGTSVTVSS 107 AA PAT REGION 1..107 note 21-4E3-C8-A light chain variable region source 1..107 mol_type protein organism synthetic construct DIVMTQSHKFMSTSVGDRVTITCKASQDVSTAVGWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSRFGTDYTLTISSVQAEDLALYYCQQHYITPWTFGGGTKLEIK 119 AA PAT REGION 1..119 note 21-4E3-C8-A heavy chain variable region source 1..119 mol_type protein organism synthetic construct QVQLQQPGADFVKPGASVKLSCKASGYTFTSYWINWVKQRPGQGLEWIGNIYPGSGSTNYNEKFKNKATLTIDTSSSTAYMQLSSLTSDDSAVYYCSRSTLYSYDDGSWGQGTTLTVSS 107 AA PAT REGION 1..107 note 21-4E3-C8-A heavy chain variable region source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASLGERVSLTCRASQEISGDLSWLQQKPDGTIKRLIYAASTLASGVPKRFSGSRSGSDYSLTISGLESEDFADYYCLQYVSYPFTFGSGTKLEIK 117 AA PAT REGION 1..117 note 21-4E3-C8-B light chain variable region source 1..117 mol_type protein organism synthetic construct QIQLQQSGPELGKPGASVKISCKASDYTFTDFYISWVKQRPGQGLEWIGWIYPLDDHTKYNEKFKGKATLTVDISSNTVYMQLSSLTSEDSAVYFCARIYGYAMDYWGQGTSVTVSS 107 AA PAT REGION 1..107 note 21-2H9-G2 light chain variable region source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASLGERVSLTCRASQEISGDLSWLQQKPDGTIKRLIYAASTLASGVPKRFSGSRSGTDYSLTISGLESEDFADYYCLQYVSYPFTFGSGTKLEIK 119 AA PAT REGION 1..119 note 21-2H9-G2 heavy chain variable region source 1..119 mol_type protein organism synthetic construct QVQLQQPGADFVKPGASVKLSCKASGYTFTSYWINWVKQRPGQGLEWIGNIYPGSGSTNYNEKFKNKATLTIDTSSSTAYMQLSSLTSDDSAVYYCSRSTLYSYDDGSWGQGTTLTVSS 107 AA PAT REGION 1..107 note 21-4G4-B11 light chain variable region source 1..107 mol_type protein organism synthetic construct EIVMTQSHNHVHISGRQGHHHLQGQSGCEYCCRLVSTETRAISITTDFTGHPPGTLESLIAFTGSRSGTDYTLTISSVQAEDLALYYCQQHYITPWTFGGGTKLEIK 117 AA PAT REGION 1..117 note 21-4G4-B11 heavy chain variable region source 1..117 mol_type protein organism synthetic construct QIQLQQSGPELGKPGASVKISCKASDYTFTDFYISWVKQRPGQGLEWIGWIYPLDDHTKYNEKFKGKATLTVDISSNTVYMQLSSLTSEDSAVYFCARIYGYAMDYWGQGTSVTVSS 113 AA PAT REGION 1..113 note 21-4B10-E1 light chain variable region source 1..113 mol_type protein organism synthetic construct DIVMTSETHLCICHSWRVSLHLLQVYIESPAIIWRHLFVLVPTEARPVSSAPDISDVQPCPRSPTQVQWRWVRNCFHTENQISGGTGCGCLLLYATSTISFHVRCWDQAGAET 120 AA PAT REGION 1..120 note 21-4B10-E1 heavy chain variable region source 1..120 mol_type protein organism synthetic construct EIQLQQSGAELVRPGTSVKISCMASGYSFTGYNMNWVRQSHGRSLEWIGNINPYFGSPNYNQKFKGKATLTLDRSSNTAYMQLNRVTSEDSAVYYCASRQLGLGDTMDYWGQGTSVTVSS 107 AA PAT REGION 1..107 note 22-2E9-G12 light chain variable region source 1..107 mol_type protein organism synthetic construct DIVMTQSQKFMSTSIGDRVSVTCKASQNVNTNIAWYQQKPGQSPKALIYSASYRYSGVPDRFTGSGSGTDFTLTISSVQSEDLAEYFCQQYIGYPYTFGGGTKLEIK 120 AA PAT REGION 1..120 note 22-2E9-G12-A heavy chain variable region source 1..120 mol_type protein organism synthetic construct QVQLQQPGATLVRPGASVKLSCKASGYTFINYWINWVKWRPGQGLEWIGNINPNCGVTKYNEQIKSEATLTVDKSSSIAYMQLSSLTSEDSAVYYCPHLLLRWLLHVPFAMVYWGQGTSV 118 AA PAT REGION 1..118 note 22-2E9-G12-B heavy chain variable region source 1..118 mol_type protein organism synthetic construct EVQLVETGGGLVQPQGSLKLSCAASGFNFNTYAMNWVRQAPGKGLEWVARIRTKSNSYATYYADSVKDRFIISRDDSQSMLYLQMNNLKTEDTAIFYCVVTYWGFIYWGQGTLVTVSA 112 AA PAT REGION 1..112 note 22-3E6-B11 light chain variable region source 1..112 mol_type protein organism synthetic construct DVVMTQTPLTLSVTIGQPASISCKSSQSLLYSDRKTYLNWLFQRPGQSPKRLIYLVSKLDSGVPDRFTGSGSGTDFTLKISRVEAEDLGIYYCWQGTHFPQTFGGGTKLEIK 115 AA PAT REGION 1..115 note 22-3E6-B11 heavy chain variable region source 1..115 mol_type protein organism synthetic construct EVQLQQSGPELVKPGASVKMSCKASGYSFTAYYIHWMKQSPEKSLEWIGEINPSTDDTTYNQNFKSKATLTVDRSSRTAYMQLRSLTSEDSAVYFCARYGEGAYWGQGTLVTVSA 112 AA PAT REGION 1..112 note 22-4B11-B9 light chain variable region source 1..112 mol_type protein organism synthetic construct DVVMTQIPLTLSVIIGQPASISCKSSQSLLYSDGKTYLNWLLQRPGQSPKRLIYLVSKLDSGVSDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPQTYGGGTKLEIK 115 AA PAT REGION 1..115 note 22-4B11-B9 heavy chain variable region source 1..115 mol_type protein organism synthetic construct EVQLQQSGPELVKPGASVKISCKASGYSFTGFPHALGEAKSTKEPTVDWRDISIYWWYYLQSEVQGQGHIDCRQILQYSLYATQEPDITRLCSLLLCKIRRGGLLGPRDSGLCLC 106 AA PAT REGION 1..106 note 22-5B1-B2 light chain variable region source 1..106 mol_type protein organism synthetic construct IVMTQSPKSMSMSVGERVTLSCKASENVGTYVSWYQQKPEQSPKLLIYGASNRYTGVPDRFTGSGSATDFTLTISSVQAEDLADYHCGQSYSYPLTFGAGTKLELK 115 AA PAT REGION 1..115 note 22-5B1-B2 heavy chain variable region source 1..115 mol_type protein organism synthetic construct EVQMQQSGPELVKPGASVEISCKASGYSFTGYYIHWVKQSPEKNLEWIGEVNPISGGTTYNQRFKAKATLNVDTLSNTAYMQLKSLTSEDSAVYFCARYGATDYWGQGTSVTVSS 115 AA PAT REGION 1..115 note 22-5F2-E10 light chain variable region source 1..115 mol_type protein organism synthetic construct EVQLQQSGPELVKPGASVKISCKASGYSFTGYYIHWVRRSPEKSLAWIGEINPTTGGTSYNQKFRAKATLTVDTSSSTAYIQLKSLTSEDSAIYYCARYGEGAYWGQGTLVTVSA 113 AA PAT REGION 1..113 note 22-5F2-E10 heavy chain variable region source 1..113 mol_type protein organism synthetic construct DVVLTQTPLTLSVTFGQPASISCKSSQSLFIITWKDIFVFGCYRGQASLQSAISFWCLNWTLESLTGSVAVDQGQISHTRSTEWRLRIWEFIIAGKVHIFLRRTVEAPCWKSN 737 DNA PAT misc_feature 1..737 note 21-2B5-F7 light chain variable region source 1..737 mol_type other DNA organism synthetic construct gttagatctgtgagcgagctgcgtagaatgagttcctggcgctgcttgtgctctggatccctggagccattggggatattgtgatgactcagactgcatcctctgtatatgtcactcctggagagtcagtctccatctcctgcaggtctactaagagtctcctgcatagtaatggcgacacttatttgtattggttcctacagaggccaggccagtctcctcagctcctgatatatcggatgtccaaccttgccccaggagtccctgacaggttcagtggcggtgggtcaggaactgctttcacactgagaatcagtagagtggaggctgaggatgtgggtgtttattacctgtatgcaacatcttgaatatcctttcacgttcggtgctgggaccaagctggagctgaaacgggctgatgttgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggccactcacaagacatcaacttcaccccattgtcaagagcttcaacaggatgagtgtacgcg 730 DNA PAT misc_feature 1..730 note 21-2B5-F7 heavy chain variable region source 1..730 mol_type other DNA organism synthetic construct tacaaagtaaccactcaaaggataaaataatcgcgaatttgccccccccaagagacaacgacgaagattggggtcatcctcttccttctgtcagtaactgcaggtgtccactctgagatccagctgcaacagtctggagctgagctggtgaggcctgggacttcagtgaagatatcctgcatggcttctggttactcattcactggctacaatatgaactgggtgaggcaaagccatggaaggagccttgagtggatcggaaatattaatccttactttggtagtcctaactacaatcagaagttcaagggcaaggccacattgactttagacagatcctccaacacagcctacatgcagctcaacagagtgacatctgaggactctgcagtctactactgtgcatcaaggcagctcgggctgggagatactatggactactggggtcaaggaacctcagtcaccgtctcctcagccaaaacaacagccccatcggtctatccactggcccctgtgtgtggagatacaagtggctcctcggtgactctaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagccagtccatcacctgcaattgtcgct 651 DNA PAT misc_feature 1..651 note 21-4E3-C8-A light chain variable region source 1..651 mol_type other DNA organism synthetic construct gtgtttctccggttgtctggtgttgacggagacattgtgatgacccagtctcacaaattcatgtccacatcagtgggagacagggtcaccatcacctgcaaggccagtcaggatgtgagtactgctgtaggctggtatcaacagaaaccagggcaatctcctaaactactgatttactgggcatccacccggcacactggagtccctgatcgcttcacaggcagtagatttgggacagactatactctcaccatcagcagtgtgcaggctgaagacctggcactttattactgtcagcaacattatatcactccgtggacgttcggtggaggcaccaagctggaaatcaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggccactcacaagaccacaacttcacccattcaacgg 658 DNA PAT misc_feature 1..658 note 21-4E3-C8-A heavy chain variable region source 1..658 mol_type other DNA organism synthetic construct cgacagtctttttggttgcagcagctacaggtgtccactcccaggtccaactgcagcagcctggtgctgactttgtgaagcctggggcctcagtgaagctgtcctgcaaggcttctggctacactttcaccagctactggataaactgggtgaagcagaggcctggacaaggccttgagtggattggaaatatttatcctggtagcggtagtactaactacaatgagaagttcaagaacaaggccacactgactatagacacatcctccagcacagcctacatgcagctcagcagcctgacatctgacgactctgcggtctactactgttcaagatcaaccctctatagttacgacgacggctcttggggccaaggcaccactctcacagtctcctcagccaaaacgacacccccatctgtctatccactggcccctggatctgctgcccaaactaactccatggtgaccctgggatgcctggtcaagggctatttccctgagccagtgacagtgacctggaactctggatccctgtccagcggtgtgcacaccttcccagctgtcctgcagtctgacctctacactctgagcagctcagtgactgtcccctccagcacctggcccagcgagaccgtcacctgcaacgtgcccctccc 653 DNA PAT misc_feature 1..653 note 21-4E3-C8-B light chain variable region source 1..653 mol_type other DNA organism synthetic construct tgttgctctggtttccaggtatcagatgtgacatccagatgacgcagtctccatcctccttatctgcctctctgggagaaagagtcagtctcacttgtcgggcaagtcaggaaattagtggtgacttaagctggcttcagcagaaaccagatggaactattaaacgcctgatatacgccgcatccactttagcttctggtgtcccaaaaaggttcagtggcagtaggtctgggtcagattattctctcaccatcagcggccttgagtctgaagattttgcagactattactgtctacaatatgttagttatccattcacgttcggctcggggacaaagttggaaataaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggccacttcacatagacagcaaatctcacccattcaacag 653 DNA PAT misc_feature 1..653 note 21-4E3-C8-B heavy chain variable region source 1..653 mol_type other DNA organism synthetic construct ttgaacttgccattcctcctgtcaggaactgcaggtgtccattgccagatccagctgcagcagtctggacctgaactggggaagcctggggcttcagtgaagatatcctgcaaggcttctgactacaccttcactgacttctatataagttgggtgaaacagaggcctggacagggacttgagtggattggatggatttatcctttagacgatcatactaagtacaatgagaagttcaagggcaaggccacattgactgtagacatatcctccaacacagtctacatgcagctcagcagcctgacctctgaggactctgcggtctatttctgtgccagaatctatggatatgctatggactactggggtcaaggaacctcagtcaccgtctcctcagccaaaacaacagccccatcggtctatccactagcccctgtgtgtggagatacaactggctcctcggtgactttaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggattcctgtccagtggtgtgcacacctttccagctgtcctgcagtctgacctctacaccctcagcagctcagcgactgtaacctcgagcacctggcccagccataccatacctgcagacggtccccc 751 DNA PAT misc_feature 1..751 note 21-2H9-G2 light chain variable region source 1..751 mol_type other DNA organism synthetic construct gcggtcatctgcacgatcatgagggtacctcgctcacgtgctttaagattcttgtcagctctggtttccaggtatcagatgtgacatccagatgacccagtctccatcctccttatctgcctctctgggagaaagagtcagtctcacttgtcgggcaagtcaggaaattagtggtgacttaagctggcttcagcagaaaccagatggaactattaaacgcctgatctacgccgcatccactttagcttctggtgtcccaaaaaggttcagtggcagtaggtctgggtgagattattctctcaccatcagcggccttgagtctgaagattttgcagactattactgtctacaatatgttagttatccattcacgttcggctcggggacaaagttggaaataaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggccactcacaagacatcagttttcccccattatcagagggctttcaccaggaatgagtgtagcccgccaaaaaaaaaaaaaaac 660 DNA PAT misc_feature 1..660 note 21-2H9-G2 heavy chain variable region source 1..660 mol_type other DNA organism synthetic construct cgtctgtctttttggttgcagcagctacaggtgtccactcccaggtccaactgcagcagcctggtgctgactttgtgaagcctggggcctcagtgaagctgtcctgcaaggcttctggctacactttcaccagctactggataaactgggtgaagcagaggcctggacaaggccttgagtggattggaaatatttatcctggtagcggtagtactaactacaatgagaagttcaagaacaaggccacactgactatagacacatcctccagcacagcctacatgcagctcagcagcctgacatctgacgactctgcggtctactactgttcaagatcaaccctctatagttacgacgacggctcttggggccaaggcaccactctcacagtctcctcagccaaaacgacacccccatctgtctatccactggcccctggatctgctgccccaaaactaactccatggtgaccctgggatgcctggtcaagggctatttccctgagccagtgacagtgacctggaactctggatccctgtccagcggtgtgcacaccttcccagctgtcctgcagtctgacctctacactctgagcagctcagtgactgtcccctccagcacctggcccagcgagaccgtcacctgcaacgtgcccgtcca 795 DNA PAT misc_feature 1..795 note 21-4G4-B11 light chain variable region source 1..795 mol_type other DNA organism synthetic construct gactagagcacgtggtgtctggtgttgacggagaaattgtgatgacccagtctcacaatcatgtccacatcagtgggagacagggtcaccatcacctgcaaggccagtcaggatgtgagtactgctgtaggctggtatcaacagaaaccagggcaatctcctaaactactgattttactgggcatccacccggcacactggagtccctgatcgctttcacaggcagtagatctgggacagactatactctcaccatcagcagtgtgcaggctgaagacctggcactttattactgtcagcaacattatatcactccgtggacgttcggtggaggcaccaagctggaaatcaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaccttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggccactcacaagacatcaacttcacccattgtcaagagcttcaacaggaatgagtgtagggggggggaaaaaaaaaaaaaaaaaaaaaaggcggaggggacgcggataaaaataaccgttagcatgacttaagtgcgtaacatattcaatctttctttccgcgggggcgggaaagagg 666 DNA PAT misc_feature 1..666 note 21-4G4-B11 heavy chain variable region source 1..666 mol_type other DNA organism synthetic construct catgaatggagctgggtcattctcttcctcctgtcaggaactgcaggtgtccattgccagatccagctgcagcagtctggacctgaactggggaagcctggggcttcagtgaagatatcctgcaaggcttctgactacaccttcactgacttctatataagttgggtgaaacagaggcctggacagggacttgagtggattggatggatttatcctttagacgatcatactaagtacaatgagaagttcaagggcaaggccacattgactgtagacatatcctccaacacagtctacatgcagctcagcagcctgacctctgaggactctgcggtctatttctgtgccagaatctatggatatgctatggactactggggtcaaggaacctcagtcaccgtctcctcagccaaaacaacagccccatcggtctatccactggcccctgtgtgtggagatacaactggctcctcggtgactctaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagccagtccatcacctgcaatggcccgcag 720 DNA PAT misc_feature 1..720 note 21-4B10-E1 light chain variable region source 1..720 mol_type other DNA organism synthetic construct gccccccttttttatgggggggggaacttgcctcagctcagttccttgggctgcttgtgctctggatccctggagccattggggatattgtgatgacttcagaaactcacctctgtatatgtcactcctggagagtcagtctccatctcctgcaggtctactaagagtctcctgcatagtaatggcgacacttatttgtattggttcctacagaggccaggccagtctcctcagctcctgatatatcggatgtccaaccttgccccaggagtccctgacaggttcagtggcggtgggtcaggaactgctttcacactgagaatcagtagagtggaggctgaggatgtgggtgtttattactgtatgcaacatcttgaatatcctttcacgttcggtgctgggaccaagctggagctgaaacgggctgatgttgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctaacctgtgaggccactcacaagacatcaacttcacccattcaacggg 687 DNA PAT misc_feature 1..687 note 21-4B10-E1 heavy chain variable region source 1..687 mol_type other DNA organism synthetic construct agccttccccccccaaagggaggggtgaccttgctattccttctgtcagtaactgcaggtgtccactctgagatccagctgcaacagtctggagctgagctggtgaggcctgggacttcagtgaagatatcctgcatggcttctggttactcattcactggctacaatatgaactgggtgaggcaaagccatggaaggagccttgagtggatcggaaatattaatccttactttggtagtcctaactacaatcagaagttcaagggcaaggccacattgactttagacagatcctccaacacagcctacatgcagctcaacagagtgacatctgaggactctgcagtctactactgtgcatcaaggcagctcgggctgggagatactatggactactggggtcaaggaacctcagtcaccgtctcctcagccaaaacaacagccccatcggtctatccactagcccctgtgtgtggagatacaagtggctcctcggtgactttaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagctcagtccgtcgcactgcttgctgttca 680 DNA PAT misc_feature 1..680 note 22-2E9-G12 light chain variable region source 1..680 mol_type other DNA organism synthetic construct ggtcatactgctgtggtgtctggtgttgatggagacattgtgatgacccagtctcaaaaattcatgtccacatcaataggagacagggtcagcgtcacctgcaaggccagtcagaatgtgaatactaatatagcctggtatcaacagaaaccaggacagtctcctaaagcactgatttactcggcttcctaccgctatagtggagtccctgatcgcttcacaggcagtggatctgggacagatttcactctcaccatcagcagtgtgcagtctgaggacttggcagaatatttctgtcagcaatatatcggctatccgtacacgttcggaggggggaccaagctggaaataaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggccactcacaagacatcaacttcacccattgtcaagagcttcaacaggaatgagtgtaaccc 676 DNA PAT misc_feature 1..676 note 22-2E9-G12-A heavy chain variable region source 1..676 mol_type other DNA organism synthetic construct gggtcatctcttcttggtagcaactgctacaggtgtccactcccaggtccaactgcagcagcctggggcttgactggtgaggcctggggcttcagtgaagttgtcctgcaaggcttctggctacaccttcatcaactactggataaactgggtgaagtggaggcctggacaaggccttgagtggattggaaatattaatcctaattgtggtgttactaagtacaatgagcagatcaagagcgaggccacactgactgtagacaaatcctccagcatagcctacatgcaactcagcagcctgacatctgaggactctgcggtctattactgtcctcatttattactacgatggttgctacacgtcccctttgctatggtctactggggtcaaggaacctcagtcaccgtctcctcagccaaaacaacagccccatcggtctatccactggcccctgtgtgtggagatacaagtggctcctcggtgactctaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagccagtccatcacctgcaattggccctcccca 726 DNA PAT misc_feature 1..726 note 22-2E9-G12-B heavy chain variable region source 1..726 mol_type other DNA organism synthetic construct gtggggtcaatatacattgtcatgctgttagggctgaagtgggttttctttgttgttttttatcaaggtgtgcattgtgaggtgcagcttgttgagactggtggaggattggtgcagcctcaagggtcattgaaactctcatgtgcggcctctggattcaacttcaatacctatgccatgaactgggtccgccaggctccaggaaagggtttggaatgggttgctcgcataagaactaaaagtaattcttatgcaacatattatgccgattcagtgaaagacaggttcatcatctccagagatgattcccaaagcatgctctatctgcaaatgaacaacttgaaaactgaggacacagccatattttactgtgtggttacctactgggggtttatttactggggccaagggactctggtcactgtctctgcagccaaaacaacagccccatcggtctatccactggcccctgtgtgtggagatacaagtggctcctcggtgactctaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagccagtccatcacctgcaatgtggcccaacacggcaagcagcacccgtaaaaaaaaaaatttggt 788 DNA PAT misc_feature 1..788 note 22-3E6-B11 light chain variable region source 1..788 mol_type other DNA organism synthetic construct agctcaacaacaaaaaaaacaaaaaacaaaaaaagataaaatctacacgtgacgggagttggggggagaggcagtgctcttttttttaggggggggggacactagttgcctgttaggctgttggtgctctggattcgggaaaccaacggtgatgttgtgatgacccagactccactcactttgtcggttaccattggacaaccagcctccatatcttgcaagtcaagtcagagcctcttatatagtgatagaaagacatatttgaattggttgtttcagaggccaggccagtctccaaagcgcctaatctatctggtctctaaactggactctggagtccctgacaggttcactggcagtggatcagggacagatttcacactgaaaatcagcagagtggaggctgaggatttgggaatttattattgctggcaaggtacacattttcctcagacgttcggtggaggcaccaagttggaaatcaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaaagtcaaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggccactcacaaagagatcaaatttcacccattcaacg 657 DNA PAT misc_feature 1..657 note 22-3E6-B11 heavy chain variable region source 1..657 mol_type other DNA organism synthetic construct gtaggaagctgggtttcctcttaatcctgtcagtaactacaggtgtcccactctgaggtccagctgcagcagtctggacctgagctggtgaagcctggggcttcagtgaagatgtcctgcaaggcttctggttactcattcactgcctattacatacactggatgaagcaaagtcctgaaaagagccttgagtggattggagagattaatcctagcactgatgacacaacctacaaccagaacttcaagtccaaggccacattgactgtagacaggtcctccagaacagcctacatgcaactcaggagcctgacatctgaggactctgcagtctatttctgtgcaagatacggcgagggggcttactggggccaagggactctggtcactgtctctgcagccaaaacaacagccccatcggtctatccactggcccctgtgtgtggagatacaagtggctcctcggtgactctaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagccagaccatcacctgcaatgtgctcgct 889 DNA PAT misc_feature 1..889 note 22-4B11-B9 light chain variable region source 1..889 mol_type other DNA organism synthetic construct gcatcgccttaacacgctcgtccttatttgctacactgaaggtgcccgtacgctttcgggtatcgttgacatgaaatgcccagtcatgccgttggggtaagcgttgaccactgaagcttgacagttaagcctttgggtaatcgttgaacaataaaagatgccagtttagcctttggggcttttatttatagggcgggaaaacactagtgcctgttaggctgttggtgctctggattcgggaaaccaacggtgatgttgtgatgacccagattccactcactttgtcggttatcattggacaaccagcctccatctcttgcaagtcaagtcagagcctcttatatagtgatggaaagacatatttgaattggttgttacagaggccaggccagtctccaaagcgcctaatctatctggtgtctaaactggactctggagtctctgacaggttcactggcagtggatcagggacagatttcacactgaaaatcagcagagtggaggctgaggatttgggagtttattattgctggcaaggtacacattttccgcagacgtacggtggaggcaccaagctggaaatcaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctggaggcccgcgtcgacacatcagcgccacctcagtgccaaggg 757 DNA PAT misc_feature 1..757 note 22-4B11-B9 heavy chain variable region source 1..757 mol_type other DNA organism synthetic construct acggtaatgaaagaagggggtggacctgggttttttttttgccgttttttttccaccttttttaaaatttggggttaaaaccccccccctttttcaatgtagaacctgggctttattttaatcctgtcagtaactacaggtgtccactctgaggtccagctgcaacagtctggacctgagctggtgaagcctggggcgtcagtgaagatttcctgcaaggcttctggttactcattcactggttttcctcatgcactgggtgaagcaaagtcctgaaaagagccttgagtggattggagagattaatcctagtactggtggtactacctacaatcagaggttcaaggccaaggccacattgactgtagacaaatcctacagtacagcctatatgcaactcaggagcctgacatctgaagactctgcagtctattactgtgcaagatacggcgagggggcttactggggccaagggactctggtctctgtctctgcggccaaaacaacagccccatcggtctatccactggcccctgtgtgtggagatacaagtggctcctcggtgactctaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagccagtccatcacctgcatataatcttgcaag 1013 DNA PAT misc_feature 1..1013 note 22-5B1-B2 light chain variable region source 1..1013 mol_type other DNA organism synthetic construct ctgttcatgcctgcagacatgacagtcagaagatgagttacatcatcgagaatgaatagcttatgatattcgattgttcgataacaatgcatgacaaacaagctagtatgattgatcctacggtcactcagatggttactatgcaagacgaaagaagacagatgctacatatcaaactctcttggtgcaggtcatttacttccttttttgatgagtactttgcataaagttcctagagggcagaccagctgttccatgatttataaacctaggcccttctccacggagatctcaaaagcatcataacttcactgggggggcccccctcaaatgtgggggggggggaggacgccttatatccttgctgttctggttatatggtgctgatgggaacattgtaatgacccaatctcccaaatccatgtccatgtcagtaggagagagggtcaccttgagctgcaaggccagtgagaatgtgggtacttatgtatcctggtatcaacagaaaccagagcagtctcctaaactgctgatatacggggcatccaaccggtacactggggtccccgatcgcttcacaggcagtggatcagcaacagatttcactctgaccatcagcagtgtgcaggctgaagaccttgcagattatcactgtggacagagttacagctatccgctcacgttcggtgctgggaccaagctggagctgaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagaccatcaaagtcaaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggccactcacaagacatcaacttcacccattcaagg 1066 DNA PAT misc_feature 1..1066 note 22-5B1-B2 heavy chain variable region source 1..1066 mol_type other DNA organism synthetic construct gtattatgtgaggtgtcttttcctggtggcatcttcatcctattgtcttctgtcaacgtgattttcttttatacagcttctgtactcagtatttatatattagtatgcatttatttctttcttatctgttttcgtaattacgtggggttaatcggactgttagaaagctgtgttgagatttgctttttatgtttgctttaattaggatgctattgatctgagtttgatatgtaattatacagcatccatttcgaatggtaacagtaagctcttatggatttcgacaggattcatgtacaaaggttttagcaatggtgcttcctgggttctatgctggagtctcttgttgtaattggtggaagatttttaaacattcgctaaaaagcagcaaagaataataagaaaaaggtgttgaactgggtctttgttttaatcctgtcagtaactacaggtgtccactctgaggtccagatgcagcagtctggacctgagctggtgaagcctggggcttcagtggagatttcctgcaaggcttctggttactcattcactggctattacatacactgggtgaagcaaagtcctgaaaagaaccttgaatggattggagaggttaatcctattagtggtggtactacctacaaccagagattcaaggccaaggccacattgaatgtggacacattatccaacacagcctacatgcagctcaagagcctgacatctgaggactctgcagtctatttctgtgcacgatacggggctacggactattggggtcaaggaacctcagtcaccgtctcctcagccaaaacaacagccccatcggtctatccactggcccctgtgtgtggagatacaagtggctcctcggtgactctaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagccagtccatctaccgctatagaacgtgca 767 DNA PAT misc_feature 1..767 note 22-5F2-E10 heavy chain variable region source 1..767 mol_type other DNA organism synthetic construct ttacaaaataaacagataagcgtttccattaaacataaaaaatttatggtaacgctttttttttttggggggggggaaccaagttgcctgttaggctgttggtgctctggattcgggataccaacggtgatgttgtgctgacccagactccactcactttgtcggttacctttggacaaccagcctccatctcttgcaagtcaagtcagagcctctttatatagtgatggaaagacatatttgtatttggttgttacagaggccaggccagtctccaaagcgcctaatctttctggtgtctaaactggactctggagtccctgacaggttcagtggcagtggatcagggacagatttcacactgaagatcaacagagtggaggctgaggatttgggaatttattattgctggcaaggtacacattttcctcagacgtacggtggaggcaccatgctggaaatcaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggtcactcacaagactatcaacttcacccattcaagtg 737 DNA PAT misc_feature 1..737 note 22-5F2-E10 light chain variable region source 1..737 mol_type other DNA organism synthetic construct acatacaatcaatcgaacatacacaaaacattacccctcttataaaacatttcgttacacctccctactcccccccgatgagtcgccgggctttattttaaatcctgtcagtaactacaggtgtccactctgaggtccagctgcagcagtctggacctgaactggtgaagcctggggcttcagtgaagatatcttgcaaggcttctggttactcattcactggctactacatacactgggtgaggcgaagtcctgaaaagagccttgcgtggattggagagattaatcctaccactggtggtacttcctacaaccagaaattcagggccaaggccacattgactgtagacacgtcgtccagcacagcctatattcagctcaagagcctgacatctgaggactctgcaatctattactgtgcaagatacggcgagggggcttactggggccaagggactctggtcactgtctctgcagccaaaacaacagccccatcggtctatccactggcccctgtgtgtggagatacaagtgggctccctcggtgactctaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagccagtccatcacctcatacgacctgctaa 11 AA PAT REGION 1..11 note 21-2B5-F7 LCDR1 source 1..11 mol_type protein organism synthetic construct KSLLHSNGDTY 000 9 AA PAT REGION 1..9 note 21-2B5-F7 LCDR3 source 1..9 mol_type protein organism synthetic construct YATSTISFH 8 AA PAT REGION 1..8 note 21-2B5-F7 HCDR1 source 1..8 mol_type protein organism synthetic construct GYSFTGYN 8 AA PAT REGION 1..8 note 21-2B5-F7 HCDR2 source 1..8 mol_type protein organism synthetic construct INPYFGSP 13 AA PAT REGION 1..13 note 21-2B5-F7 HCDR3 source 1..13 mol_type protein organism synthetic construct ASRQLGLGDTMDY 6 AA PAT REGION 1..6 note 21-4E3-C8-A LCDR1 source 1..6 mol_type protein organism synthetic construct QDVSTA 000 10 AA PAT REGION 1..10 note 21-4E3-C8-A LCDR3 source 1..10 mol_type protein organism synthetic construct QQHYITPWTF 8 AA PAT REGION 1..8 note 21-4E3-C8-A HCDR1 source 1..8 mol_type protein organism synthetic construct GYTFTSYW 8 AA PAT REGION 1..8 note 21-4E3-C8-A HCDR2 source 1..8 mol_type protein organism synthetic construct IYPGSGST 12 AA PAT REGION 1..12 note 21-4E3-C8-A HCDR3 source 1..12 mol_type protein organism synthetic construct SRSTLYSYDDGS 6 AA PAT REGION 1..6 note 21-4E3-C8-B LCDR1 source 1..6 mol_type protein organism synthetic construct QEISGD 000 9 AA PAT REGION 1..9 note 21-4E3-C8-B LCDR3 source 1..9 mol_type protein organism synthetic construct LQYVSYPFT 8 AA PAT REGION 1..8 note 21-4E3-C8-B HCDR1 source 1..8 mol_type protein organism synthetic construct DYTFTDFY 8 AA PAT REGION 1..8 note 21-4E3-C8-B HCDR2 source 1..8 mol_type protein organism synthetic construct IYPLDDHT 10 AA PAT REGION 1..10 note 21-4E3-C8-B HCDR3 source 1..10 mol_type protein organism synthetic construct ARIYGYAMDY 6 AA PAT REGION 1..6 note 21-2H9-G2 LCDR1 source 1..6 mol_type protein organism synthetic construct QEISGD 000 9 AA PAT REGION 1..9 note 21-2H9-G2 LCDR3 source 1..9 mol_type protein organism synthetic construct LQYVSYPFT 9 AA PAT REGION 1..9 note 21-2H9-G2 HCDR1 source 1..9 mol_type protein organism synthetic construct GYTFTSYWI 8 AA PAT REGION 1..8 note 21-2H9-G2 HCDR2 source 1..8 mol_type protein organism synthetic construct IYPGSGST 12 AA PAT REGION 1..12 note 21-2H9-G2 HCDR3 source 1..12 mol_type protein organism synthetic construct SRSTLYSYDDGS 6 AA PAT REGION 1..6 note 21-4G4-B11 LCDR1 source 1..6 mol_type protein organism synthetic construct SGCEYC 000 9 AA PAT REGION 1..9 note 21-4G4-B11 LCDR3 source 1..9 mol_type protein organism synthetic construct QQHYITPWT 8 AA PAT REGION 1..8 note 21-4G4-B11 HCDR1 source 1..8 mol_type protein organism synthetic construct DYTFTDFY 8 AA PAT REGION 1..8 note 21-4G4-B11 HCDR2 source 1..8 mol_type protein organism synthetic construct IYPLDDHT 10 AA PAT REGION 1..10 note 21-4G4-B11 HCDR3 source 1..10 mol_type protein organism synthetic construct ARIYGYAMDY 11 AA PAT REGION 1..11 note 21-4B10-E1 LCDR1 source 1..11 mol_type protein organism synthetic construct IESPAIIWRHL 000 9 AA PAT REGION 1..9 note 21-4B10-E1 LCDR3 source 1..9 mol_type protein organism synthetic construct YATSTISFH 8 AA PAT REGION 1..8 note 21-4B10-E1 HCDR1 source 1..8 mol_type protein organism synthetic construct GYSFTGYN 8 AA PAT REGION 1..8 note 21-4B10-E1 HCDR2 source 1..8 mol_type protein organism synthetic construct INPYFGSP 13 AA PAT REGION 1..13 note 21-4B10-E1 HCDR3 source 1..13 mol_type protein organism synthetic construct ASRQLGLGDTMDY 6 AA PAT REGION 1..6 note 22-2E9-G12 LCDR1 source 1..6 mol_type protein organism synthetic construct QNVNTN 000 9 AA PAT REGION 1..9 note 22-2E9-G12 LCDR3 source 1..9 mol_type protein organism synthetic construct QQYIGYPYT 8 AA PAT REGION 1..8 note 22-2E9-G12-A HCDR1 source 1..8 mol_type protein organism synthetic construct GYTFINYW 7 AA PAT REGION 1..7 note 22-2E9-G12-A HCDR2 source 1..7 mol_type protein organism synthetic construct INPNCGV 17 AA PAT REGION 1..17 note 22-2E9-G12-A HCDR3 source 1..17 mol_type protein organism synthetic construct PHLLLRWLLHVPFAMVY 8 AA PAT REGION 1..8 note 22-2E9-G12-B HCDR1 source 1..8 mol_type protein organism synthetic construct GFNFNTYA 10 AA PAT REGION 1..10 note 22-2E9-G12-B HCDR2 source 1..10 mol_type protein organism synthetic construct IRTKSNSYAT 9 AA PAT REGION 1..9 note 22-2E9-G12-B HCDR3 source 1..9 mol_type protein organism synthetic construct VVTYWGFIY 11 AA PAT REGION 1..11 note 22-3E6-B11 LCDR1 source 1..11 mol_type protein organism synthetic construct QSLLYSDRKTY 000 9 AA PAT REGION 1..9 note 22-3E6-B11 LCDR3 source 1..9 mol_type protein organism synthetic construct WQGTHFPQT 8 AA PAT REGION 1..8 note 22-3E6-B11 HCDR1 source 1..8 mol_type protein organism synthetic construct GYSFTAYY 8 AA PAT REGION 1..8 note 22-3E6-B11 HCDR2 source 1..8 mol_type protein organism synthetic construct INPSTDDT 8 AA PAT REGION 1..8 note 22-3E6-B11 HCDR3 source 1..8 mol_type protein organism synthetic construct ARYGEGAY 11 AA PAT REGION 1..11 note 22-4B11-B9 LCDR1 source 1..11 mol_type protein organism synthetic construct QSLLYSDGKTY 000 9 AA PAT REGION 1..9 note 22-4B11-B9 LCDR3 source 1..9 mol_type protein organism synthetic construct WQGTHFPQT 8 AA PAT REGION 1..8 note 22-4B11-B9 HCDR1 source 1..8 mol_type protein organism synthetic construct GYSFTGFP 7 AA PAT REGION 1..7 note 22-4B11-B9 HCDR2 source 1..7 mol_type protein organism synthetic construct ISIYWWY 8 AA PAT REGION 1..8 note 22-4B11-B9 HCDR3 source 1..8 mol_type protein organism synthetic construct CKIRRGGL 6 AA PAT REGION 1..6 note 22-5B1-B2 LCDR1 source 1..6 mol_type protein organism synthetic construct ENVGTY 000 9 AA PAT REGION 1..9 note 22-5B1-B2 LCDR3 source 1..9 mol_type protein organism synthetic construct GQSYSYPLT 8 AA PAT REGION 1..8 note 22-5B1-B2 HCDR1 source 1..8 mol_type protein organism synthetic construct GYSFTGYY 8 AA PAT REGION 1..8 note 22-5B1-B2 HCDR2 source 1..8 mol_type protein organism synthetic construct VNPISGGT 8 AA PAT REGION 1..8 note 22-5B1-B2 HCDR3 source 1..8 mol_type protein organism synthetic construct ARYGATDY 8 AA PAT REGION 1..8 note 22-5F2-E10 LCDR1 source 1..8 mol_type protein organism synthetic construct GYSFTGYY 8 AA PAT REGION 1..8 note 22-5F2-E10 LCDR2 source 1..8 mol_type protein organism synthetic construct INPTTGGT 8 AA PAT REGION 1..8 note 22-5F2-E10 LCDR3 source 1..8 mol_type protein organism synthetic construct ARYGEGAY 11 AA PAT REGION 1..11 note 22-5F2-E10 HCDR1 source 1..11 mol_type protein organism synthetic construct QSLFIITWKDI 000 8 AA PAT REGION 1..8 note 22-5F2-E10 HCDR3 source 1..8 mol_type protein organism synthetic construct GKVHIFLR