CN X205AWO CN 202210838614.1 2022-07-14 苏州宜联生物医药有限公司 MediLink Therapeutics(SuZhou)Co.,Ltd. 抗体药物偶联物及其制备方法和用途 86 119 AA PAT source 1..119 mol_type protein organism synthetic construct QIQLVQSGAELVRPGASVKMSCKTSGYTFTTYNVHWVKQTPRQGLEWIGAISPGNGLTSYTQKFKAKATLTVDKSSSTAYMQLSSLTSEDSAVYFCARGGFRLGSMDYWGQGTSVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIVMTQSHKFMSTSVGDRVSVTCKASQNVGTSVAWYQQRPGQSPKELIYWASNRFTGVPDRFTGSGSGTDFTLTITNVQSEDLADYFCQQYSSPPLTFGAGTKLELK 5 AA PAT source 1..5 mol_type protein organism synthetic construct TYNVH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AISPGNGLTSYTQKFKA 17 AA PAT source 1..17 mol_type protein organism synthetic construct AISPGSGLTSYAQKFQG 10 AA PAT source 1..10 mol_type protein organism synthetic construct GGFRLGSMDY 11 AA PAT source 1..11 mol_type protein organism synthetic construct KASQNVGTSVA 11 AA PAT source 1..11 mol_type protein organism synthetic construct SASQNVGTSVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct WASNRFT 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQYSSPPLT 8 AA PAT source 1..8 mol_type protein organism synthetic construct GYTFTTYN 8 AA PAT source 1..8 mol_type protein organism synthetic construct ISPGNGLT 8 AA PAT source 1..8 mol_type protein organism synthetic construct ISPGSGLT 12 AA PAT source 1..12 mol_type protein organism synthetic construct ARGGFRLGSMDY 6 AA PAT source 1..6 mol_type protein organism synthetic construct QNVGTS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QHYSKLPLT 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVESGAEVKQPGESVKVSCKTSGYTFTTYNVHWVRQAPGQGLEWMGAISPGSGLTSYAQKFQGRVTLTVDKSTSTAYMELSSLRSEDTAVYYCARGGFRLGSMDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSFLSASVGDRVTITCSASQNVGTSVAWYQQKPGQSPKELIYWASNRFTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSSPPLTFGQGTKVEIK 120 AA PAT source 1..120 mol_type protein organism synthetic construct QAYLQQSGADLVRPGASVKMSSKASGSSFTTYIIHWIKQTPGQGLEWIGAIYPGNGYTSYNQKFKGKATLTVDKSYNTAYIQLSSLSSEDSAVYFCARGNYGNYEGFTYWGQGTLVTVSA 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQTTSSLSVSLGDRITISCSASQAIYKYLNWYQQKPDGTVKLLIYYTSTLHSGVPSRFSGSGSGTDYSLTISNLEPEDIASYYCQQYNKFPFTFGSGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct TYIIH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIYPGNGYTSYNQKFKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIYPGSGYTSYAQKFQG 11 AA PAT source 1..11 mol_type protein organism synthetic construct GNYGNYEGFTY 11 AA PAT source 1..11 mol_type protein organism synthetic construct SASQAIYKYLN 7 AA PAT source 1..7 mol_type protein organism synthetic construct YTSTLHS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQYNKFPFT 8 AA PAT source 1..8 mol_type protein organism synthetic construct GSSFTTYI 8 AA PAT source 1..8 mol_type protein organism synthetic construct IYPGNGYT 8 AA PAT source 1..8 mol_type protein organism synthetic construct IYPGSGYT 13 AA PAT source 1..13 mol_type protein organism synthetic construct ARGNYGNYEGFTY 6 AA PAT source 1..6 mol_type protein organism synthetic construct QAIYKY 116 AA PAT source 1..116 mol_type protein organism synthetic construct QVQLVESGPGLVQPSETLSLTCTVSGFSLTNYGVHWVRQPPGKGLEWIGVIWSGGRTNYNPSLQSRVTISKDNSTNQVSLKLSSVTAADTAVYYCAKRDGIYGDYWGQGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVESGAEVKQPGESVKVSCKASGSSFTTYIIHWIRQAPGQGLEWMGAIYPGSGYTSYAQKFQGRVTLTVDKSTSTAYMELSSLRSEDTAVYFCARGNYGNYEGFTYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSASQAIYKYLNWYQQKPGQAPKLLIYYTSTLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYNKFPFTFGQGTKVEIK 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVKMSCKASGYTFTSNNLHWVKLTPRQGLEWIGAVYPGNGDTSYTQKFKGKATLTVDKSSSIAYMQLSSPTSEDSAVYFCARGLPYLGAMDYWGQGTSVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIVMTQSQRFMSTTVGDRVSITCKASQNVGIFVTWYQQKPGQSPKLLIYSASSRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSRSPLSFGAGTKLELK 5 AA PAT source 1..5 mol_type protein organism synthetic construct SNNLH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AVYPGNGDTSYTQKFKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct AVYPGSGDTSYSQKFQG 10 AA PAT source 1..10 mol_type protein organism synthetic construct GLPYLGAMDY 11 AA PAT source 1..11 mol_type protein organism synthetic construct KASQNVGIFVT 11 AA PAT source 1..11 mol_type protein organism synthetic construct SASQNVGIFVT 7 AA PAT source 1..7 mol_type protein organism synthetic construct SASSRYT 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQYSRSPLS 8 AA PAT source 1..8 mol_type protein organism synthetic construct GYTFTSNN 8 AA PAT source 1..8 mol_type protein organism synthetic construct VYPGNGDT 8 AA PAT source 1..8 mol_type protein organism synthetic construct VYPGSGDT 12 AA PAT source 1..12 mol_type protein organism synthetic construct ARGLPYLGAMDY 6 AA PAT source 1..6 mol_type protein organism synthetic construct QNVGIF 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSASQDIGTYLNWYQQKPGQAPKLLIYHTSRLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHYSKLPLTFGQGTKVEIK 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVESGAEVKQPGESVKVSCKASGYTFTSNNLHWVRQAPGQGLEWMGAVYPGSGDTSYSQKFQGRVTLTVDKSASTAYMELSSLRSEDTAVYFCARGLPYLGAMDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSFLSASVGDRVTITCSASQNVGIFVTWYQQKPGQSPKLLIYSASSRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSRSPLSFGQGTKVEIK 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVKMSCKASGYTFASYNMHWVKKTPRQGLEWIGAIYPGNGNTSYNQKFKGKATLTVDKSSSTAYMQLSSLTSEDSAVYFCVRGGRGLGTMDYWGQGTSVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIVMTQSHKFMSTSVGDRVSITCKASQDVGSSVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCQHYRNIPLTFGAGTKLELK 5 AA PAT source 1..5 mol_type protein organism synthetic construct SYNMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIYPGNGNTSYNQKFKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIYPGSGNTSYSQKFQG 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIYPGSGNTGYSQKFQG 10 AA PAT source 1..10 mol_type protein organism synthetic construct GGRGLGTMDY 11 AA PAT source 1..11 mol_type protein organism synthetic construct KASQDVGSSVA 11 AA PAT source 1..11 mol_type protein organism synthetic construct SASQDVGSSVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct WASTRHT 9 AA PAT source 1..9 mol_type protein organism synthetic construct QHYRNIPLT 8 AA PAT source 1..8 mol_type protein organism synthetic construct GYTFASYN 8 AA PAT source 1..8 mol_type protein organism synthetic construct IYPGNGNT 8 AA PAT source 1..8 mol_type protein organism synthetic construct IYPGSGNT 12 AA PAT source 1..12 mol_type protein organism synthetic construct VRGGRGLGTMDY 6 AA PAT source 1..6 mol_type protein organism synthetic construct QDVGSS 330 AA PAT source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVESGAEVKQPGESVKVSCKASGYTFASYNMHWVRQAPGQGLEWMGAIYPGSGNTSYSQKFQGRVTLTVDKSASTAYMELSSLRSEDTAVYFCVRGGRGLGTMDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSFLSASVGDRVTITCSASQDVGSSVAWYQQKPGQSPKLLIYWASTRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHYRNIPLTFGQGTKVEIK 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVESGAEVKQPGESVKVSCKASGYTFASYNMHWVRQAPGQGLEWMGAIYPGSGNTGYSQKFQGRVTLTVDKSASTAYMELSSLRSEDTAVYFCVRGGRGLGTMDYWGQGTLVTVSS 116 AA PAT source 1..116 mol_type protein organism synthetic construct QVQLKESGPVLVAPSQSLSITCTVSGFSLTNYGVHWVRQPPGKGLEWLGVIWSGGRTNYNSALMSRLSISKDNSKSQVFLKMNSLQTDDTAMYYCAKRDGIYGDYWGQGTSVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQTTSSLSASLGDRVTISCRASQDIGTYLNWYQQKPDGTVTLLIYHTSRLHSGVPSRFSGSGSGTDFSLTISSLEPEDIATYYCQHYSKLPLTFGAGTKLELK 8 AA PAT source 1..8 mol_type protein organism synthetic construct GFSLTNYG 7 AA PAT source 1..7 mol_type protein organism synthetic construct IWSGGRT 10 AA PAT source 1..10 mol_type protein organism synthetic construct AKRDGIYGDY 6 AA PAT source 1..6 mol_type protein organism synthetic construct QDIGTY 107 AA PAT source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT source 1..449 mol_type protein organism synthetic construct QVQLVESGAEVKQPGESVKVSCKASGYTFASYNMHWVRQAPGQGLEWMGAIYPGSGNTGYSQKFQGRVTLTVDKSASTAYMELSSLRSEDTAVYFCVRGGRGLGTMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIQMTQSPSFLSASVGDRVTITCSASQDVGSSVAWYQQKPGQSPKLLIYWASTRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHYRNIPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT source 1..449 mol_type protein organism synthetic construct QVQLVESGAEVKQPGESVKVSCKTSGYTFTTYNVHWVRQAPGQGLEWMGAISPGSGLTSYAQKFQGRVTLTVDKSTSTAYMELSSLRSEDTAVYYCARGGFRLGSMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIQMTQSPSFLSASVGDRVTITCSASQNVGTSVAWYQQKPGQSPKELIYWASNRFTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSSPPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 231 AA PAT source 1..231 mol_type protein organism synthetic construct PKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 237 AA PAT source 1..237 mol_type protein organism synthetic construct GGGGSPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK