W535921 JP 2022019051 2022-02-09 国立研究開発法人医薬基盤・健康・栄養研究所 National Institutes of Biomedical Innovation, Health and Nutrition Antibodies or antibody fragments thereof binding to FCRL1 ＦＣＲＬ１に結合する抗体又は該抗体断片 80 3069 DNA PAT source 1..3069 mol_type genomic DNA organism Homo sapiens gatgagctgctgctgctcgactctgaggtgcattctttttttgatgagaggcatctctaggtaccatccctgacctggtcctcatgctgccgaggctgttgctgttgatctgtgctccactctgtgaacctgccgagctgtttttgatagccagcccctcccatcccacagaggggagcccagtgaccctgacgtgtaagatgccctttctacagagttcagatgcccagttccagttctgctttttcagagacacccgggccttgggcccaggctggagcagctcccccaagctccagatcgctgccatgtggaaagaagacacagggtcatactggtgcgaggcacagacaatggcgtccaaagtcttgaggagcaggagatcccagataaatgtgcacagggtccctgtcgctgatgtgagcttggagactcagcccccaggaggacaggtgatggagggagacaggctggtcctcatctgctcagttgctatgggcacaggagacatcaccttcctttggtacaaaggggctgtaggtttaaaccttcagtcaaagacccagcgttcactgacagcagagtatgagattccttcagtgagggagagtgatgctgagcaatattactgtgtagctgaaaatggctatggtcccagccccagtgggctggtgagcatcactgtcagaatcccggtgtctcgcccaatcctcatgctcagggctcccagggcccaggctgcagtggaggatgtgctggagcttcactgtgaggccctgagaggctctcctccgatcctgtactggttttatcacgaggatatcaccctggggagcaggtcggccccctctggaggaggagcctccttcaacctttccctgactgaagaacattctggaaactactcctgtgaggccaacaatggcctgggggcccagcgcagtgaggcggtgacactcaacttcacagtgcctactggggccagaagcaatcatcttacctcaggagtcattgaggggctgctcagcacccttggtccagccaccgtggccttattattttgctacggcctcaaaagaaaaataggaagacgttcagccagggatccactcaggagccttcccagccctctaccccaagagttcacctacctcaactcacctaccccagggcagctacagcctatatatgaaaatgtgaatgttgtaagtggggatgaggtttattcactggcgtactataaccagccggagcaggaatcagtagcagcagaaaccctggggacacatatggaggacaaggtttccttagacatctattccaggctgaggaaagcaaacattacagatgtggactatgaagatgctatgtaaggttatggaagattctgctctttgaaaaccatccatgaccccaagcctcaggcctgatatgttcttcagagatcctggggcattagctttccagtatacctcttctggatgccattctccatggcactattccttcatctactgtgaagtgaagttggcgcagccctgaagaaactacctaggagaactaatagacacaggagtgacagggactttgttatcagaaccagattcctgccggctcctttgaaaacaggtcatattgtgctcttctgtttacaagaggaaacaagatggaataaaagaaattgggatcttgggttggagggacagtgaagcttagagcacatgaactcaaggttagtgactctgcaggacttcacagagagagctgtgcccatcattcagtccaagtgctttctctgcccagacagcacagaactccagccccgctacttacatggatcatcgagtttccacctaaaatatgattctatttattttgagtcactgttaccaaattagaactaaaacaaagttacataaaaagttattgtgactccacttaattttagtgacgtatttttgtatatataggccaacctataccacatccaaaattatgtatctattacagcccctagaagctttataaatacagtgtgtcttcttttattcacaaaatttttgaaatcgtggtaatatggtttgaaacctgtatcttaattattttttttttaaattgagacagggtctcactctgtcactcaatctggaatgcagtggcacaatcttgcctcactgcaacgcctgcctctcaggctcaagcaaacctctcacctcagcctgctgagtagctgggactacaggcacatgccaccaaacttggccattttttgtcttacgtagagacaagatttcaccgttttgcccaggctggtctcaaactcctgggctcaagcaatgtattgaattttaaaataaccaggcactcactcttatgaattaataaacatttggaggtatataaagtaaaaagttaaagtctttcctgtaagttaacacaaatgttaactattgttaaaaactttacaggtagctctctagatatttttctatttttgtatgtatacttatgcatacatgtaagtatataaacatttagaagtgtacctatctaacaaactattatgaaatactttcaaatctgtaaatagatctattatactattttaaaagtctctatagtagtgtgttatatagataaatcataacttttttctttttttattgtagtaaatatgcacaacataaaattgatcattttaaccatttttaagtgtacaattcagtggcattaagtactatcataatatattttaatccttctcatcactggtggacattaaggagactctcaaaaaattcatattataaaaacaaagttcaaacaaatgtctttgtactagcatattatggcactcctgctggattatctgaaggataaatttgtaaatctagtattgctagattatgcatattaaatattcttgttaaatagtcttcaatgtctctcaggtaaggctgtatcaatttatatcttcaccaacaacgtctgggaaatcagtttgtggggtgtattacttagttttcacattgctaataaagacatatccaagactgggtaatttataaa 5385 DNA PAT source 1..5385 mol_type genomic DNA organism Macaca fascicularis ctgcaactggtggaattgaatcaaactgtatttaaaaaggagcatctttaattttctcagccttcatagaagaggaaatggagactggtcattggagggctcttcttccttctacttccgctgaagggtaacttctgatctcaacttcctcaaacctctgatgagctgctgctgctcgactctgaggtgcattgtttttttgatgagaggcatctctaggtaccatccctgacctggtcctcatgctgccgaggctgttgctgttgatctgtgctccactctgtgaacccgccgggctgttgttgatagtcagcccctcccatcccacagaggggagcccagtgaacctgacctgtaagatgccctctctacagagttcagatgcccagttccagttctgcttcttcagagatgaccaggccttgggcccgggctggagcagctctcccaagctccagatcgccaacatgtggaaagaagactcagggtcctactggtgcgaggcacagacaatggcatccaaagtcttgaggagctggagatcccagataaatgtgcacagggtccctgttgctgatgtgagcttggagactcagcccccaggaggacaggtgatggagggagacagactggtcctcatctgctcagttgctatggggacaggagacatcaccttcctttggtacaaaggggctataggtttaaaccttcagacaaagacccagcgttcactgacagcagagtatgagattcctacagcgagggagagtgatgctgagcaatactactgtgtagctgaaaatggctatggtcccagacccagtgggctggtgagcatcactgtcagaatcccagtgtctcgtcccatcctcatggtcagggctcccagggcccaggctgtggtgggggatgtgctgaagcttcactgtgaggccctgagaggctctcatccgatcctgtactggttttatcacgaggatgtcatcttggggagcagctcagccccctctggaggaggagcctctttcaacctttccctgactgcagaacattctggaaactactcctgtgaggccaacaatggcctgggggcccagcgcagtgaggaggtgacactcaacttcacagtgcctactggggccagaagcaatcatcttacctccggagtcattgaggggctcctcggcacccttggtcctgccactgtggccttattattttgctacggcctcaaaagaaaaataggaagacgttcaaccagggatccactcaggagccttcccagccctgtaccccaagagttcccctacctcaactcacctaccccaggacagctacagcctacatatgaaaatgtgaatgttgtaagtgggcgtgatgtttattcgttggtgtactataaccagccggagcaggaatcagcagcagaaaccctggggacacatatggaggaccaggtttccttagacatctattccaggctgaggaaagcaaacattacggatgtggactatgaagacgctatgtaaggttatggaggattctgccctttgaaaaccatccatgaccccaagcctcagacctgatatgttcttcagagatcctggggcattagctttccagtatacctcttctggatgctattctccgtggcactattccttcatctactgatctactgtgaagtgaagttggcgcagccctgaagaaactacctaggagaaccaatagacacaggagtgacgggaactttgttatcagaaccagattcctgctggctcttttgagaaaggtcaacttgtgctcttctatttacaagagaaaacaggatggaataaaataaattaggatcttggggtggagggacagtgaagcttagagcacatgaactcaaggtcagtgattctgcaggacttcacagagagagctgtgaccatcatcattcagtccaagtgctttctctgcccagacagcacagaactccagcactgccacttacatgggtcatcgagtttccacctaaaatatgattctatttattttgagtcactgttaccaaattagaattaaaacaaagttacataaaaagttattgtgattacacttaattttagtcacatattctgtatatataggccaacctataccacatccaaaattatgtatctactacagcccctagaagctttatgaatacagtgtgtctttttttattcacaaaatttttgaaatcttggtaatatggtttgaagtctgtatcttattttttcttttttaaatttgagacagggtctcactctgtcacccagtttggaatgcagtggcacaatctcacctcactgcaacctctgcctctcaggctcaagcaaacctctgacctcagcctcctaagtggctgggactacaggcacatgccaccaaacctggctgattttcgtcttatgtacagaccagatgtcaccattttgcccagactggtctcaaactcctgggctcaagcaatgtattttaattttaaaacaacgagacgctcattcttatgaatgaataaacatttggaggtatataaagtaaaaagttaaagtctttcctgtaagttaacacaaatgtttactattgctaaaacctttacaggtagctctctagataattttcgatttttgtgtacatacttatacatacatgtaagtatataaacatttagaagtatacctatctaacaaaccatcatgaaatattttcaaatagatctattatactattttaaaagtctcaatagtagtgtgttatatagataaatcataacttttttcttttttattgtagcaaagatacataacataaaattgatcattttaaccatgtttaagtgtacagttcagtggcattaagtactatcataatatattttaatccttctcaccactggtggacattaaggaggttccaaaaaaattcatattataaaaacaaagttcaaacaaatgtctttgtacaagcatattatgcactcctcctggactatctgaaggataaatttgtaaatctagtattgctagattatgcatattaaatattcttgttaaatagtcttcaatgtttctaaggtaaggctgtatcaatttatacctccacccataacatctgggaaatcagtttgtggggtgtgtccgttagttctcacattgctaacaaagacatacccaagactgggcaatttataaaggaaagaggtttaattgacacacagttccaaatggctagagaggcctccggacacttataatcatggcagaagaggaagcaaacatgtccttcttcacatggcagcaggagagagaaagagtcctgtgttcagcctttgcccattttctatgtcatttgtgtttttcttacagtttttataggaactatttattaagacataatttataacagtgaaatacacagattttatgtgcatagttccatcagtttgacaaatgtatgcattcaagtaatccaaacccttatcatgatttaaagtattttcatcactctagaaagttccctcatactcatgtccagtctatttatgccactctgaaaacaactactgaacattatgcttttgaccatttctccattgtatgtgatgccaatatttttgtacaatctttcacttcactttttgtttacagtgaattttaaaatatggaaggttagtttttgcacagctgaactcaattttttaaaatcttgacttctaagtttcctatatttctgtcattttctatcagaccatgttgccatgttataaaacattctaatattttcttacaatgcctccatagttttattatatattcactcaatacattatgtgtatatgtggtatgaggtaggaatctaacttttactgtttttatctttatgtattttttttaatttaaaatgaggggtagggatttaactttttttcaaacacatataaattgttcactactgtttatttaaatagtctgttcttttcccttttattattattctattttatctcacttaaattcaacctaagcctgttttggactacaactaatactacagatcttcctaccacacttccccttgcataattcacttcaaacacattagtctcaggtttcctcaggcacatcaaatttagtcccagctcagaactctgtactttctatttccatgctttcatgttctttctcttgatatccttgctttcttattttcttcatttacattttctgttttgattttctgtttctggtccatggaaattttcattttctttttataaaactaacacagcttttttacattttatattttgcctgccagtgccatgtgcctggagctcatggagggcctcaaaggatgaaattggagtatcatgtgatcaggagtttgaacttgtttgtattgtatgatcatcccttctttaccttaatactcacattaaacattatctatggcttcttacattccacttcttcttaatcaatttctttctttaagaacttaaactttcccatcatttctgatagggtctgtgagtttatttgtccaaaaagtccaaaagcagaatttaagatcaatagcatagctttctgcacaacagttgtcatattttattctatggtcttctagcttctactactttctttgagaaatctatttaattgttgtttctttataattaatctatcttttctctccagttgcctttaagacttttatatttgatattatgcaatttcactatgatttgtctaaatgtggatttattttgctagagattcataactcaagtcgaaggtatcatgccttttttcaagtttagaaaatatccggttattatctctttattattatgctgctgcagcattatttgaattctttccctcagaaatttatgttagaagtttcctagacttcattctattctcatgactcttaattagtcttgccaaattttcatttcattatctcattgcattttaggtaatttcttaatctctatcttccagtttgctagttctttcttcaactgtttatctattttattgtttaacctatttattttctatttcaatgattacattttttgagattttattagcaaaatggttaaaaggatggtttcggaggattgtctggatttacattttgcctccattatttactagctctccagttttggttaaattaattaaccttttgtgcttcttgatgtgtaaaattgaaataacaattgtatataaataaatatagtgttgttttggtaattcagtaaaattatttgtgtaaaatgcttaagacagtgcctgaaatgacattgagtcctcaaaaaataaattattattagcattatta 429 AA PAT source 1..429 mol_type protein organism Homo sapiens MLPRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVPTGARSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLPQEFTYLNSPTPGQLQPIYENVNVVSGDEVYSLAYYNQPEQESVAAETLGTHMEDKVSLDIYSRLRKANITDVDYEDAM 437 AA PAT source 1..437 mol_type protein organism Macaca fascicularis MLPRLLLLICAPLCEPAGLLLIVSPSHPTEGSPVNLTCKMPSLQSSDAQFQFCFFRDDQALGPGWSSSPKLQIANMWKEDSGSYWCEAQTMASKVLRSWRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLWYKGAIGLNLQTKTQRSLTAEYEIPTARESDAEQYYCVAENGYGPRPSGLVSITVRIPVSRPILMVRAPRAQAVVGDVLKLHCEALRGSHPILYWFYHEDVILGSSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQRSEEVTLNFTVPTGARSNHLTSGVIEGLLGTLGPATVALLFCYGLKRKIGRRSTRDPLRSLPSPVPQEFPYLNSPTPGQLQPTYENVNVVSGRDVYSLVYYNQPEQESAAAETLGTHMEDQFAAYQDHLCSLPVGYRHSENAGLGPRFFKRP 116 AA PAT source 1..116 mol_type protein organism Mus musculus EVQLQESGPSLVKPSQTLSLTCSVTGDSITSGYWTWIRKFPGNKLEYMGYISYSGSTYYNPSLKSRISITRDTSKNQYYLQLNSVTTEDTATYYCARSYYYGMDSWGQGTSVTVSS 111 AA PAT source 1..111 mol_type protein organism Mus musculus DIVLTQSPASLAVSLGQRATISCRASESVDSYGNSFMHWYQQKPGQPPRLLIFRASNLESGIPARFSGSGSRTDFTLTINPVEADDVATYYCQQSNEDPYTFGGGTKLEIK 118 AA PAT source 1..118 mol_type protein organism Mus musculus EVKLEESGGGLVQPGGSMKLSCAASGFTFGDAWMDWVRQSPEKGLEWVAEIRSKANNHATYYAESVKGRFTISRDDSKSSVYLQMNSLRVEDTGIYYCTGGNYWFVYWGQGTLVTVSA 107 AA PAT source 1..107 mol_type protein organism Mus musculus DIVMTQSHKFMSTSVGDRVSITCKASQDVGSTVAWYQQNPGQSPKLLIYWASTRHTGVPDRFTGSGSGTDFILTISNVQSEDLADYFCQQYSSYPFTFGSGTKLEIK 119 AA PAT REGION 1..119 note Description of the artificial sequence: 1F9 VH amino acid source 1..119 mol_type protein organism synthetic construct QLQLQESGPGLVKASETLSLTCTVSGDSISSNTFYWGWIRQPPGKGLEWIGSIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARHEYGDFFDYWGQGTLVTVSS 108 AA PAT REGION 1..108 note Description of the artificial sequence: 1F9 VL amino acid source 1..108 mol_type protein organism synthetic construct EIVLTQSPGTLSLSPGERATLSCRASQSVSSNYLAWFQQRPGQAPRLFIYGVSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGGSLITFGQGTRLEIK 119 AA PAT REGION 1..119 note Description of the artificial sequence: 2A10 VH amino acid source 1..119 mol_type protein organism synthetic construct QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGGYHWSWIRQHPGKGLEWIGYIYNSGSTYYNPSLKSRVTISEDTSKNQFSLKLSSVTAADSAVYYCARLVGVTYFDCWGQGTLVTVSS 107 AA PAT REGION 1..107 note Description of the artificial sequence: 2A10 VL amino acid source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSVSTSVGDRVTITCRASQGIRSWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPPTFGQGTKVEIK 116 AA PAT REGION 1..116 note Description of the artificial sequence: 7G8 VH amino acid source 1..116 mol_type protein organism synthetic construct DVHLVQSGGGLVHPGGSLRLSCAGSGFTFSTYTMHWIRQAPGKDLEWVSAIGTGGGTDYADSVKGRFTISRDNAKNSLYLQMNSLRAEDMAVYYCAREVYWYFDLWGRGTLVTVSS 107 AA PAT REGION 1..107 note Description of the artificial sequence: 7G8 VL amino acid source 1..107 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPTFGQGTKVEIK 117 AA PAT REGION 1..117 note Description of the artificial sequence: 2G5 VH amino acid source 1..117 mol_type protein organism synthetic construct QVQLVESGGGVVQPGRSLRLSCAASGFTFSDYGMHWVRQAPGKGLEWVAVIWYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDWGRAFDIWGQGTMVTVSS 108 AA PAT REGION 1..108 note Description of the artificial sequence: 2G5 VL amino acid source 1..108 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFALYYCQQLNNWPPYTFGQGTKLEIK 116 AA PAT REGION 1..116 note Description of the artificial sequence: 5A2 VH amino acid source 1..116 mol_type protein organism synthetic construct QVQVVESGGGVVQPGRSLRLSCAASGFTFSNYGMHWVRQAPGKGLEWVAGIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARESPNFDYWGQGTLVTVSS 108 AA PAT REGION 1..108 note Description of the artificial sequence: 5A2 VL amino acid source 1..108 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRNNWPPWTFGQGTKVEIK 120 AA PAT source 1..120 mol_type protein organism Mus musculus DVLLQESGPGLVKPSQSLSLTCSVAGYSITSDYAWNWLRRFPGNRLEWMGYITYSGSTAYHPSLKGRISFTRDTSQNQVFLQLHSVTTEDSATYYCAQGGTLITTWFLRWGQGTLVTVSA 6 AA PAT REGION 1..6 note Description of the artificial sequence: DK610 HCDR1 amino acid source 1..6 mol_type protein organism synthetic construct SDYAWN 16 AA PAT REGION 1..16 note Description of the artificial sequence: DK610 HCDR2 amino acid source 1..16 mol_type protein organism synthetic construct YITYSGSTAYHPSLKG 11 AA PAT REGION 1..11 note Description of the artificial sequence: DK610 HCDR3 amino acid source 1..11 mol_type protein organism synthetic construct GGTLITTWFLR 111 AA PAT source 1..111 mol_type protein organism Mus musculus DIVLTQSPASLAVSLGQRATISCRASKSVSTSDYNYMHWYRQKPGQPPKLFIYLASNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSRELPSTFGGGTKLEIK 15 AA PAT REGION 1..15 note Description of the artificial sequence: DK610 LCDR1 amino acid source 1..15 mol_type protein organism synthetic construct RASKSVSTSDYNYMH 7 AA PAT REGION 1..7 note Description of the artificial sequence: DK610 LCDR2 amino acid source 1..7 mol_type protein organism synthetic construct LASNLES 9 AA PAT REGION 1..9 note Description of the artificial sequence: DK610 LCDR3 amino acid source 1..9 mol_type protein organism synthetic construct QQSRELPST 117 AA PAT source 1..117 mol_type protein organism Mus musculus QVQLQQPGAELVKPGTSVKLSCKASGYTFTRYWMHWVKQRPGQGLEWIGRIDPNSGGSKYNEKFKSKATLTVDKTSSSAYMQLNSLTSEDSAVYYCTRVNSGAMDYWGQGTSVTVSS 5 AA PAT REGION 1..5 note Description of the artificial sequence: DK681 HCDR1 amino acid source 1..5 mol_type protein organism synthetic construct RYWMH 17 AA PAT REGION 1..17 note Description of the artificial sequence: DK681 HCDR2 amino acid source 1..17 mol_type protein organism synthetic construct RIDPNSGGSKYNEKFKS 8 AA PAT REGION 1..8 note Description of the artificial sequence: DK681 HCDR3 amino acid source 1..8 mol_type protein organism synthetic construct VNSGAMDY 112 AA PAT source 1..112 mol_type protein organism Mus musculus DIVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSSNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVKAEDLAIYYCQQYSNYPTFGSGTKLEIK 17 AA PAT REGION 1..17 note Description of the artificial sequence: DK681 LCDR1 amino acid source 1..17 mol_type protein organism synthetic construct KSSQSLLYSSNQKNYLA 7 AA PAT REGION 1..7 note Description of the artificial sequence: DK681 LCDR2 amino acid source 1..7 mol_type protein organism synthetic construct WASTRES 8 AA PAT REGION 1..8 note Description of the artificial sequence: DK681 LCDR3 amino acid source 1..8 mol_type protein organism synthetic construct QQYSNYPT 119 AA PAT source 1..119 mol_type protein organism Mus musculus QVQLQQSGPELVKPGASVRISCKASGYTFTSYNIHWVKQRPGQGLEWIGWIYPGDGNPKYNEKFKGKTTLTADKSSSTAYMQLSSLTSEDSAVYFCARRIHYYDYFDYWGQGTTLTVSS 5 AA PAT REGION 1..5 note Description of the artificial sequence: DK1142 HCDR1 amino acid source 1..5 mol_type protein organism synthetic construct SYNIH 17 AA PAT REGION 1..17 note Description of the artificial sequence: DK1142 HCDR2 amino acid source 1..17 mol_type protein organism synthetic construct WIYPGDGNPKYNEKFKG 10 AA PAT REGION 1..10 note Description of the artificial sequence: DK1142 HCDR3 amino acid source 1..10 mol_type protein organism synthetic construct RIHYYDYFDY 112 AA PAT source 1..112 mol_type protein organism Mus musculus DVLMTQTPLSLPVSLGDQASISCRSSQSIVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEADDLGVYYCFQGSHVPWTFGGGTKLEIK 16 AA PAT REGION 1..16 note Description of the artificial sequence: DK1142 LCDR1 amino acid source 1..16 mol_type protein organism synthetic construct RSSQSIVHSNGNTYLE 7 AA PAT REGION 1..7 note Description of the artificial sequence: DK1142 LCDR2 amino acid source 1..7 mol_type protein organism synthetic construct KVSNRFS 9 AA PAT REGION 1..9 note Description of the artificial sequence: DK1142 LCDR3 amino acid source 1..9 mol_type protein organism synthetic construct FQGSHVPWT 119 AA PAT source 1..119 mol_type protein organism Mus musculus EVRLVESGGRLVQPKGSLRLSCAVSGFTFNTYAMYWIRQAPGKGLEWVARIRSKTNNFATYYADSVKDRFTISRDDSQSMLYLQMNNLKTEDTAMYYCVRDNSGSFDYWGQGTTLTVSS 5 AA PAT REGION 1..5 note Description of the artificial sequence: DK1141 HCDR1 amino acid source 1..5 mol_type protein organism synthetic construct TYAMY 19 AA PAT REGION 1..19 note Description of the artificial sequence: DK1141 HCDR2 amino acid source 1..19 mol_type protein organism synthetic construct RIRSKTNNFATYYADSVKD 8 AA PAT source 1..8 mol_type protein organism synthetic construct REGION 1..8 note Description of the artificial sequence: DK1141 HCDR3 amino acid DNSGSFDY 112 AA PAT source 1..112 mol_type protein organism Mus musculus DIVMAQSPSSLAVSVGEKVTMSCKSSQSLLHSSNQKNYLAWYQQKPGQSPNLLIYWASSRESGVPDRFTGSGSGTDFTLTISSVQAEDLATYYCQQYYSYPTFGAGTKLDLK 17 AA PAT REGION 1..17 note Description of the artificial sequence: DK1141 LCDR1 amino acid source 1..17 mol_type protein organism synthetic construct KSSQSLLHSSNQKNYLA 7 AA PAT REGION 1..7 note Description of the artificial sequence: DK1141 LCDR2 amino acid source 1..7 mol_type protein organism synthetic construct WASSRES 8 AA PAT REGION 1..8 note Description of the artificial sequence: DK1141 LCDR3 amino acid source 1..8 mol_type protein organism synthetic construct QQYYSYPT 119 AA PAT source 1..119 mol_type protein organism Mus musculus QVQLQQSGPELVKPGASVRISCKASGYTFTSYNIHWVKQRPGQGLEWIGWIYPGDGNTKYNEKFKGKTTLTADKSSSTAYMQLSSLTSEDSAVYFCARRIHYFDYFDYWGQGTTLTLSS 5 AA PAT REGION 1..5 note Description of the artificial sequence: DK1166 HCDR1 amino acid source 1..5 mol_type protein organism synthetic construct SYNIH 17 AA PAT REGION 1..17 note Description of the artificial sequence: DK1166 HCDR2 amino acid source 1..17 mol_type protein organism synthetic construct WIYPGDGNTKYNEKFKG 10 AA PAT REGION 1..10 note Description of the artificial sequence: DK1166 HCDR3 amino acid source 1..10 mol_type protein organism synthetic construct RIHYFDYFDY 112 AA PAT source 1..112 mol_type protein organism Mus musculus DVLMTQTPLSLPVSLGDQVSISCRSGQTIVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLRISRVEAEDLGVYYCFQGSHVPWTFGGGTKLEIK 16 AA PAT REGION 1..16 note Description of the artificial sequence: DK1166 LCDR1 amino acid source 1..16 mol_type protein organism synthetic construct RSGQTIVHSNGNTYLE 7 AA PAT REGION 1..7 note Description of the artificial sequence: DK1166 LCDR2 amino acid source 1..7 mol_type protein organism synthetic construct KVSNRFS 9 AA PAT REGION 1..9 note Description of the artificial sequence: DK1166 LCDR3 amino acid source 1..9 mol_type protein organism synthetic construct FQGSHVPWT 117 AA PAT source 1..117 mol_type protein organism Mus musculus QVQLQQSGTELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPGSGGTDYNKKFKGKAMLTADKSSNTAYMQLSSLTSDDSAVYFCARSNSYAMDYWGQGTSVTVSS 5 AA PAT REGION 1..5 note Description of the artificial sequence: DK1164 HCDR1 amino acid source 1..5 mol_type protein organism synthetic construct NYLIE 17 AA PAT REGION 1..17 note Description of the artificial sequence: DK1164 HCDR2 amino acid source 1..17 mol_type protein organism synthetic construct VINPGSGGTDYNKKFKG 8 AA PAT REGION 1..8 note Description of the artificial sequence: DK1164 HCDR3 amino acid source 1..8 mol_type protein organism synthetic construct SNSYAMDY 113 AA PAT source 1..113 mol_type protein organism Mus musculus DIVMSQSPSSLAVSVGEKVTVSCKSSQSLLYSGNQKNNLAWYKQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTMSSVKAEDLAVYYCQQYYSYPWTFGGGTKLEIK 17 AA PAT REGION 1..17 note Description of the artificial sequence: DK1164 LCDR1 amino acid source 1..17 mol_type protein organism synthetic construct KSSQSLLYSGNQKNNLA 7 AA PAT REGION 1..7 note Description of the artificial sequence: DK1164 LCDR2 amino acid source 1..7 mol_type protein organism synthetic construct WASTRES 9 AA PAT REGION 1..9 note Description of the artificial sequence: DK1164 LCDR3 amino acid source 1..9 mol_type protein organism synthetic construct QQYYSYPWT 117 AA PAT source 1..117 mol_type protein organism synthetic construct REGION 1..117 note Description of the artificial sequence: hzDK681 HV0 amino acid QVQLVQSGAEVKKPGASVKVSCKASGYTFTRYWMHWVRQAPGQGLEWMGRIDPNSGGSKYNEKFKSRVTITADTSTSTAYMELSSLRSEDTAVYYCARVNSGAMDYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct REGION 1..112 note Description of the artificial sequence: hzDK681 LV0, DK681 F11 VL and DK681 F14 VL amino acid DIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYSNYPTFGQGTKVEIK 119 AA PAT source 1..119 mol_type protein organism synthetic construct REGION 1..119 note Description of the artificial sequence: hzDK1142 HV0 amino acid QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNIHWVRQAPGQGLEWMGWIYPGDGNPKYNEKFKGRVTITADTSTSTAYMELSSLRSEDTAVYYCARRIHYYDYFDYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct REGION 1..112 note Description of the artificial sequence: hzDK1142 LV0 amino acid DIVMTQSPLSLPVTPGEPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPWTFGQGTKVEIK 7 AA PAT source 1..7 mol_type protein organism synthetic construct REGION 1..7 note Description of the artificial sequence: DK1142 F24 LCDR2 amino acid KISNRFS 117 AA PAT source 1..117 mol_type protein organism synthetic construct REGION 1..117 note Description of the artificial sequence: DK681 F11 and DK681 F13 VH amino acid QVQLVQSGAELVKPGASVKVSCKASGYTFTRYWMHWVKQAPGQGLEWIGRIDPNSGGSKYNEKFKSKATLTVDKSTSTAYMELSSLRSEDTAVYYCTRVNSGAMDYWGQGTLVTVSS 117 AA PAT source 1..117 mol_type protein organism synthetic construct REGION 1..117 note Description of the artificial sequence: DK681 F12 and DK681 F14 VH amino acid QVQLVQSGAEVKKPGASVKVSCKASGYTFTRYWMHWVKQAPGQGLEWIGRIDPNSGGSKYNEKFKSKATITVDKSTSTAYMELSSLRSEDTAVYYCTRVNSGAMDYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct REGION 1..112 note Description of the artificial sequence: DK681 F12 and DK681 F13 VL amino acid DIVMTQSPDSLAVSLGERATMNCKSSQSLLYSSNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAIYYCQQYSNYPTFGQGTKVEIK 119 AA PAT source 1..119 mol_type protein organism synthetic construct REGION 1..119 note Description of the artificial sequence: DK1142 F21 VH amino acid QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNIHWVRQAPGQGLEWMGWIYPGDGNPKYNEKFKGKTTLTADKSTSTAYMELSSLRSEDTAVYFCARRIHYYDYFDYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct REGION 1..112 note Description of the artificial sequence: DK1142 F21 and DK1142 F22 VL amino acid DIVMTQSPLSLPVTLGEPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPWTFGQGTKVEIK 119 AA PAT source 1..119 mol_type protein organism synthetic construct REGION 1..119 note Description of the artificial sequence: DK1142 F22 and DK1142 F24 VH amino acid QVQLVQSGAELVKPGASVKVSCKASGYTFTSYNIHWVKQAPGQGLEWIGWIYPGDGNPKYNEKFKGKTTLTADKSTSTAYMELSSLRSEDTAVYFCARRIHYYDYFDYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct REGION 1..112 note Description of the artificial sequence: DK1142 F24 VL amino acid DVVMTQSPLSLPVTLGEPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPKLLIYKISNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPWTFGQGTKVEIK 330 AA PAT source 1..330 mol_type protein organism Human ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein organism synthetic construct REGION 1..330 note Description of the artificial sequence: IgG1 (S239C) amino acid ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK