CN 240529 1PCWO CN 202410115964.4 2024-01-26 Shanghai Allink Biotherapeutics Co., Ltd. Anti-FGFR2b Antibody and Antibody-Drug Conjugate 66 5 AA PAT source 1..5 mol_type protein organism synthetic construct SYNIH 17 AA PAT source 1..17 mol_type protein organism synthetic construct YIYPDNGDTNYNQKFKG 4 AA PAT source 1..4 mol_type protein organism synthetic construct DWTY 113 AA PAT source 1..113 mol_type protein organism synthetic construct QAYLQQSGAELVRSGASVKMSCKASGYTFTSYNIHWVKQTPGQGLEWIGYIYPDNGDTNYNQKFKGKAALTADTSSSTAYMQISSLTSEDSAVYFCARDWTYWGQGTLVTVSA 10 AA PAT source 1..10 mol_type protein organism synthetic construct SATSIVNHMY 7 AA PAT source 1..7 mol_type protein organism synthetic construct FTSNLAS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQWSSTPFT 106 AA PAT source 1..106 mol_type protein organism synthetic construct QIVLTQSPALMSASPGEKVTMTCSATSIVNHMYWYQQKPGSSPKPWIYFTSNLASGVPARFSGSGSGTSYSLTISSMEVEDAATYYCQQWSSTPFTFGSGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYYIH 17 AA PAT source 1..17 mol_type protein organism synthetic construct WIYHENGDTEFAPKFQG 4 AA PAT source 1..4 mol_type protein organism synthetic construct KITY 113 AA PAT source 1..113 mol_type protein organism synthetic construct EVQLQQSGAELVRSGASVKLSCTASGFNIKDYYIHWMKQRPEQGLEWIGWIYHENGDTEFAPKFQGKATMTADTSSNTAYLQLNSLTSEDSGVYYCNAKITYWGQGTLVTVSA 11 AA PAT source 1..11 mol_type protein organism synthetic construct KASQNVGTNVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct SASYRFS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQYYSSPYT 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIMMTQSQKFMSTSVGDRVSVTCKASQNVGTNVAWYQQIPGQSPKALIYSASYRFSGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCQQYYSSPYTFGGGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct SYNMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct YIYPENGDTNYNQRFKG 000 112 AA PAT source 1..112 mol_type protein organism synthetic construct QAYLQQSGAELVRSGASVKMSCKASGYTFTSYNMHWIKQTPGQGLEWIGYIYPENGDTNYNQRFKGKATLTADTSSRTAYMQISSLTSEDSAVYFCATADYWGQGTSVTVSS 10 AA PAT source 1..10 mol_type protein organism synthetic construct SASSSVNHMY 7 AA PAT source 1..7 mol_type protein organism synthetic construct LTSNLAS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQWSSNPFT 106 AA PAT source 1..106 mol_type protein organism synthetic construct EIVLTQSPALMSASPGERVTMTCSASSSVNHMYWYQQKPRSSPKPWIYLTSNLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPFTFGSGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYNMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct YIYPNNGDTSYNQKFKG 4 AA PAT source 1..4 mol_type protein organism synthetic construct GLLD 113 AA PAT source 1..113 mol_type protein organism synthetic construct EVQLQQSGPELVKPGASVKMSCKASGYTFTDYNMHWVKQSHGKSLEWIGYIYPNNGDTSYNQKFKGKATLTVNKSSSTAYMELRSLTSEDSAVYYCARGLLDWGQGTLVTVSA 11 AA PAT source 1..11 mol_type protein organism synthetic construct GASENIYGALN 7 AA PAT source 1..7 mol_type protein organism synthetic construct GATNLAD 9 AA PAT source 1..9 mol_type protein organism synthetic construct QNVLSTPYT 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPASLSASVGETVTITCGASENIYGALNWYQRKQGKSPQLLIYGATNLADGMSSRFSGSGSGRQYSLKISSLHPDDVATYYCQNVLSTPYTFGGGTKLEIK 17 AA PAT source 1..17 mol_type protein organism synthetic construct YIYPENGDTNYAQKFQG 112 AA PAT source 1..112 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGYIYPENGDTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCATADYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGYIYPENGDTNYNQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCATADYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGYIYPENGDTNYNQKFQGRVTMTRDTSIRTAYMELSRLRSDDTAVYYCATADYWGQGTLVTVSS 10 AA PAT source 1..10 mol_type protein organism synthetic construct RASSSVNHLA 10 AA PAT source 1..10 mol_type protein organism synthetic construct RASSSVNHMA 7 AA PAT source 1..7 mol_type protein organism synthetic construct LTSNRAT 106 AA PAT source 1..106 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASSSVNHLAWYQQKPGQAPRLLIYLTSNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQWSSNPFTFGQGTKLEIK 106 AA PAT source 1..106 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASSSVNHMAWYQQKPGQAPRPLIYLTSNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQWSSNPFTFGQGTKLEIK 106 AA PAT source 1..106 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASSSVNHMYWYQQKPGQSPRPLIYLTSNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQWSSNPFTFGQGTKLEIK 17 AA PAT source 1..17 mol_type protein organism synthetic construct IIYPNNGDTSYAQKFQG 17 AA PAT source 1..17 mol_type protein organism synthetic construct YIYPNNGDTSYNQKFQG 17 AA PAT source 1..17 mol_type protein organism synthetic construct YIYPNNGDTSYAQKFQG 113 AA PAT source 1..113 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGIIYPNNGDTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGLLDWGQGTLVTVSS 113 AA PAT source 1..113 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGYIYPNNGDTSYNQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGLLDWGQGTLVTVSS 113 AA PAT source 1..113 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGYIYPNNGDTSYNQKFQGRVTMTVDKSTSTVYMELSSLRSEDTAVYYCARGLLDWGQGTLVTVSS 113 AA PAT source 1..113 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGYIYPNNGDTSYAQKFQGRVTMTVDKSTSTVYMELSSLRSEDTAVYYCARGLLDWGQGTLVTVSS 113 AA PAT source 1..113 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGIIYPNNGDTSYAQKFQGRVTMTVDKSTSTVYMELSSLRSEDTAVYYCARGLLDWGQGTLVTVSS 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASENIYGALN 7 AA PAT source 1..7 mol_type protein organism synthetic construct GATSLQS 7 AA PAT source 1..7 mol_type protein organism synthetic construct GATSLAS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQQKPGKAPKLLIYGATSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQQKPGKSPKLLIYGATSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQQKPGKAPKLLIYGATSLQSGVPSRFSGSGSGRDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQRKPGKAPKLLIYGATSLQSGVPSRFSGSGSGRDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQRKPGKAPKLLIYGATSLASGVPSRFSGSGSGRDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQRKPGKSPKLLIYGATSLASGVPSRFSGSGSGRDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQRKPGKSPKLLIYGATSLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQQKPGKSPKLLIYGATSLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQQKPGKAPKLLIYGATSLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIK 443 AA PAT source 1..443 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGYIYPNNGDTSYAQKFQGRVTMTVDKSTSTVYMELSSLRSEDTAVYYCARGLLDWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQRKPGKAPKLLIYGATSLASGVPSRFSGSGSGRDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQQKPGKSPKLLIYGATSLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASENIYGALNWYQQKPGKAPKLLIYGATSLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLSTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC