LC22210020P-EN CN 202111544686.7 2021-12-16 MABWELL (SHANGHAI) BIOSCIENCE CO., LTD. CAMPTOTHECIN COMPOUND AND CONJUGATE THEREOF 10 5 AA PAT REGION 1..5 note CDR-H1 source 1..5 mol_type protein organism synthetic construct SYWMH 17 AA PAT REGION 1..17 note CDR-H2 source 1..17 mol_type protein organism synthetic construct EITPSDNYGSYNQKFKG 10 AA PAT REGION 1..10 note CDR-H3 source 1..10 mol_type protein organism synthetic construct GHGNYVSFDY 11 AA PAT REGION 1..11 note CDR-L1 source 1..11 mol_type protein organism synthetic construct RASQDISNYLN 7 AA PAT REGION 1..7 note CDR-L2 source 1..7 mol_type protein organism synthetic construct YTSRLES 10 AA PAT REGION 1..10 note CDR-L3 source 1..10 mol_type protein organism synthetic construct QQGYTLPPYT 119 AA PAT REGION 1..119 note VH source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWMHWVRQAPGQGLEWMGEITPSDNYGSYNQKFKGRVTITRDTSTSTAYMELSSLRSEDTAVYYCARGHGNYVSFDYWGQGTLVTVSS 108 AA PAT source 1..108 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCQQGYTLPPYTFGQGTKLEIK 330 AA PAT REGION 1..330 note heavy chain, constant region source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note light chain, constant region source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC