JP FP2217 JP 2022-041864 2022-03-16 DAIICHI SANKYO COMPANY, LIMITED. トランスフェリン受容体２の発現を抑制するｓｉＲＮＡ siRNA suppressing expression of Transferrin receptor 2 47 2886 RNA PAT source 1..2886 mol_type mRNA organism Homo sapiens atcgctgggggacagcctgcaggcttcaggaggggacacaagcatggagcggctttggggtctattccagagagcgcaacaactgtccccaagatcctctcagaccgtctaccagcgtgtggaaggcccccggaaagggcacctggaggaggaagaggaagacggggaggagggggcggagacattggcccacttctgccccatggagctgaggggccctgagcccctgggctctagacccaggcagccaaacctcattccctgggcggcagcaggacggagggctgccccctacctggtcctgacggccctgctgatcttcactggggccttcctactgggctacgtcgccttccgagggtcctgccaggcgtgcggagactctgtgttggtggtcagtgaggatgtcaactatgagcctgacctggatttccaccagggcagactctactggagcgacctccaggccatgttcctgcagttcctgggggaggggcgcctggaggacaccatcaggcaaaccagccttcgggaacgggtggcaggctcggccgggatggccgctctgactcaggacattcgcgcggcgctctcccgccagaagctggaccacgtgtggaccgacacgcactacgtggggctgcaattcccggatccggctcaccccaacaccctgcactgggtcgatgaggccgggaaggtcggagagcagctgccgctggaggaccctgacgtctactgcccctacagcgccatcggcaacgtcacgggagagctggtgtacgcccactacgggcggcccgaagacctgcaggacctgcgggccaggggcgtggatccagtgggccgcctgctgctggtgcgcgtgggggtgatcagcttcgcccagaaggtgaccaatgctcaggacttcggggctcaaggagtgctcatatacccagagccagcggacttctcccaggacccacccaagccaagcctgtccagccagcaggcagtgtatggacatgtgcacctgggaactggagacccctacacacctggcttcccttccttcaatcaaacccagttccctccagttgcatcatcaggccttcccagcatcccagcccagcccatcagtgcagacattgcctcccgcctgctgaggaagctcaaaggccctgtggccccccaagaatggcaggggagcctcctaggctccccttatcacctgggccccgggccacgactgcggctagtggtcaacaatcacaggacctccacccccatcaacaacatcttcggctgcatcgaaggccgctcagagccagatcactacgttgtcatcggggcccagagggatgcatggggcccaggagcagctaaatccgctgtggggacggctatactcctggagctggtgcggaccttttcctccatggtgagcaacggcttccggccccgcagaagtctcctcttcatcagctgggacggtggtgactttggaagcgtgggctccacggagtggctagagggctacctcagcgtgctgcacctcaaagccgtagtgtacgtgagcctggacaacgcagtgctgggggatgacaagtttcatgccaagaccagcccccttctgacaagtctcattgagagtgtcctgaagcaggtggattctcccaaccacagtgggcagactctctatgaacaggtggtgttcaccaatcccagctgggatgctgaggtgatccggcccctacccatggacagcagtgcctattccttcacggcctttgtgggagtccctgccgtcgagttctcctttatggaggacgaccaggcctacccattcctgcacacaaaggaggacacttatgagaacctgcataaggtgctgcaaggccgcctgcccgccgtggcccaggccgtggcccagctcgcagggcagctcctcatccggctcagccacgatcgcctgctgcccctcgacttcggccgctacggggacgtcgtcctcaggcacatcgggaacctcaacgagttctctggggacctcaaggcccgcgggctgaccctgcagtgggtgtactcggcgcggggggactacatccgggcggcggaaaagctgcggcaggagatctacagctcggaggagagagacgagcgactgacacgcatgtacaacgtgcgcataatgcgggtggagttctacttcctttcccagtacgtgtcgccagccgactccccgttccgccacatcttcatgggccgtggagaccacacgctgggcgccctgctggaccacctgcggctgctgcgctccaacagctccgggacccccggggccacctcctccactggcttccaggagagccgtttccggcgtcagctagccctgctcacctggacgctgcaaggggcagccaatgcgcttagcggggatgtctggaacattgataacaacttctgaggccctggggatcctcacatccccgtcccccagtcaagagctcctctgctcctcgcttgaatgattcagggtcagggaggtggctcagagtccacctctcattgctgatcaatttctcattacccctacacatctctccacggagcccagaccccagcacagatatccacacaccccagccctgcagtgtagctgaccctaatgtgacggtcatactgtcggttaatcagagagtagcatcccttcaatcacagccccttcccctttctggggtcctccatacctagagaccactctgggaggtttgctaggccctgggacctggccagctctgttagtgggagagatcgctggcaccatagccttatggccaacaggtggtctgtggtgaaaggggcgtggagtttcaatatcaataaaccacctgatatcaataa 40 DNA PAT misc_feature 1..40 note TfR2-003.5 source 1..40 mol_type other DNA organism synthetic construct modified_base order(2,8,10,15,17,20,23,26,27,32,35,39,40) mod_base OTHER note uracil gtgaggatgtcaactatgatcatagttgacatcctcactt 40 DNA PAT misc_feature 1..40 note TfR2-005.5 source 1..40 mol_type other DNA organism synthetic construct modified_base order(3,6,10,11,15,18,19,22,25,26,39,40) mod_base OTHER note uracil gctcctcgcttgaatgattaatcattcaagcgaggagctt 40 DNA PAT misc_feature 1..40 note TfR2-006.5, TfR2-006.6 source 1..40 mol_type other DNA organism synthetic construct modified_base order(1,10,12,14,16,20,21,24,31,33,39,40) mod_base OTHER note uracil tgggcagactctctatgaattcatagagagtctgcccatt 40 DNA PAT misc_feature 1..40 note TfR2-022.5 source 1..40 mol_type other DNA organism synthetic construct modified_base order(8,10,12,14,20,22,23,26,33,35,39,40) mod_base OTHER note uracil ggcagactctctatgaacatgttcatagagagtctgcctt 40 DNA PAT misc_feature 1..40 note TfR2-039.5, TfR2-039.6, TfR2-039.8, TfR2-039.9, TfR2-039.19, TfR2-039.21, TfR2-039.22, TfR2-039.23, TfR2-039.24, TfR2-039.25, TfR2-039.26, TfR2-039.5G source 1..40 mol_type other DNA organism synthetic construct modified_base order(4,13,16,18,20,25,31,32,33,38,39,40) mod_base OTHER note uracil acctcaaagccgtagtgtatacactacggctttgaggttt 40 DNA PAT misc_feature 1..40 note TfR2-046.5 source 1..40 mol_type other DNA organism synthetic construct modified_base order(6,15,17,21,25,29,31,35,39,40) mod_base OTHER note uracil gcgactgacacgcatgtacgtacatgcgtgtcagtcgctt 40 DNA PAT misc_feature 1..40 note TfR2-065.5 source 1..40 mol_type other DNA organism synthetic construct modified_base order(6,10,12,13,16,17,20,28,35,38,39,40) mod_base OTHER note uracil agcagtgcctattccttcatgaaggaataggcactgcttt 40 DNA PAT misc_feature 1..40 note TfR2-007.5, TfR2-007.6 source 1..40 mol_type other DNA organism synthetic construct modified_base order(4,6,9,10,13,16,20,21,24,31,38,39,40) mod_base OTHER note uracil acctctcattgctgatcaattgatcagcaatgagaggttt 40 DNA PAT misc_feature 1..40 note TfR2-013.5, TfR2-013.6 source 1..40 mol_type other DNA organism synthetic construct modified_base order(4,7,10,17,20,23,24,26,27,34,39,40) mod_base OTHER note uracil ggctagtggtcaacaatcatgattgttgaccactagcctt 40 DNA PAT misc_feature 1..40 note TfR2-019.5, TfR2-019.6, TfR2-019.8, TfR2-019.9, TfR2-019.6G, TfR2-019.22, TfR2-019.22s source 1..40 mol_type other DNA organism synthetic construct modified_base order(3,8,9,10,14,16,20,21,24,26,27,33,39,40) mod_base OTHER note uracil cgtggagtttcaatatcaattgatattgaaactccacgtt 40 DNA PAT misc_feature 1..40 note TfR2-037.5 source 1..40 mol_type other DNA organism synthetic construct modified_base order(5,8,10,16,19,21,27,32,33,38,39,40) mod_base OTHER note uracil accctaatgtgacggtcatatgaccgtcacattagggttt 40 DNA PAT misc_feature 1..40 note TfR2-076.5, TfR2-076.3, TfR2-076.6 source 1..40 mol_type other DNA organism synthetic construct modified_base order(3,6,10,11,12,14,17,18,20,23,30,31,34,39,40) mod_base OTHER note uracil gctgatcaatttctcattataatgagaaattgatcagctt 40 DNA PAT misc_feature 1..40 note TfR2-077.5 source 1..40 mol_type other DNA organism synthetic construct modified_base order(1,6,10,11,15,20,22,25,26,34,37,39,40) mod_base OTHER note uracil tagcatcccttcaatcacatgtgattgaagggatgctatt 40 DNA PAT misc_feature 1..40 note TfR2-081.5 source 1..40 mol_type other DNA organism synthetic construct modified_base order(2,10,13,17,18,19,24,33,39,40) mod_base OTHER note uracil ctgggacggtggtgactttaaagtcaccaccgtcccagtt 40 DNA PAT misc_feature 1..40 note TfR2-061.5 source 1..40 mol_type other DNA organism synthetic construct modified_base order(15,18,19,22,27,28,29,33,37,39,40) mod_base OTHER note uracil caggcagccaaacctcattaatgaggtttggctgcctgtt 40 DNA PAT misc_feature 1..40 note TfR2-006.3 source 1..40 mol_type other DNA organism synthetic construct modified_base order(1,10,12,14,16,20,24,31,39,40) mod_base OTHER note uracil tgggcagactctctatgaattcatagagagtctgcccatt 40 DNA PAT misc_feature 1..40 note TfR2-007.3 source 1..40 mol_type other DNA organism synthetic construct modified_base order(4,6,10,13,16,20,24,31,38,39,40) mod_base OTHER note uracil acctctcattgctgatcaattgatcagcaatgagaggttt 40 DNA PAT misc_feature 1..40 note TfR2-013.3 source 1..40 mol_type other DNA organism synthetic construct modified_base order(4,10,17,20,23,24,26,34,39,40) mod_base OTHER note uracil ggctagtggtcaacaatcatgattgttgaccactagcctt 40 DNA PAT misc_feature 1..40 note TfR2-019.3 source 1..40 mol_type other DNA organism synthetic construct modified_base order(3,10,14,16,20,24,26,39,40) mod_base OTHER note uracil cgtggagtttcaatatcaattgatattgaaactccacgtt 40 DNA PAT misc_feature 1..40 note TfR2-039.3 source 1..40 mol_type other DNA organism synthetic construct modified_base order(4,13,16,18,20,31,32,38,39,40) mod_base OTHER note uracil acctcaaagccgtagtgtatacactacggctttgaggttt 40 DNA PAT misc_feature 1..40 note TfR2-039.10, TfR2-039.11, TfR2-039.12, TfR2-039.20 source 1..40 mol_type other DNA organism synthetic construct modified_base order(4,13,16,18,25,31,32,33,38,39,40) mod_base OTHER note uracil acctcaaagccgtagtgtatacactacggctttgaggttt 40 DNA PAT misc_feature 1..40 note TfR2-019.15, TfR2-019.17 source 1..40 mol_type other DNA organism synthetic construct modified_base order(3,8,10,14,16,20,21,24,26,27,33,39,40) mod_base OTHER note uracil cgtggagtttcaatatcaattgatattgaaactccacgtt 40 DNA PAT misc_feature 1..40 note oligonucleotide portion of AD47882.5G, oligonucleotide portion of AD47882.23G, oligonucleotide portion of AD47882.23sG source 1..40 mol_type other DNA organism synthetic construct modified_base order(6,9,10,12,15,16,17,19,31,36,39,40) mod_base OTHER note uracil ccacgtgattctcctttctagaaaggagaatcacgtggtt 19 DNA PAT misc_feature 1..19 note TfR2-039.28S, TfR2-039.29S, TfR2-039.31S, TfR2-039.32S, TfR2-039.9S, oligonucleotide portion of TfR2-039.23SG source 1..19 mol_type other DNA organism synthetic construct modified_base order(4,13,16,18) mod_base OTHER note uracil acctcaaagccgtagtgta 19 DNA PAT misc_feature 1..19 note TfR2-019.29S, TfR2-019.34S source 1..19 mol_type other DNA organism synthetic construct modified_base order(8,9,10,14,16) mod_base OTHER note uracil cgtggagtttcaatatcaa 19 DNA PAT misc_feature 1..19 note TfR2-019.22S, TfR2-019.22sS, oligonucleotide portion of TfR2-019.22SG source 1..19 mol_type other DNA organism synthetic construct modified_base order(3,8,9,10,14,16) mod_base OTHER note uracil cgtggagtttcaatatcaa 19 DNA PAT misc_feature 1..19 note oligonucleotide portion of AD47882.23SG, oligonucleotide portion of AD47882.23sSG source 1..19 mol_type other DNA organism synthetic construct modified_base order(6,9,10,12,15,16,17,19) mod_base OTHER note uracil ccacgtgattctcctttct 21 DNA PAT misc_feature 1..21 note TfR2-039.9AS, TfR2-039.23AS, TfR2-039.35AS, TfR2-039.36AS, TfR2-039.37AS, TfR2-039.38AS, TfR2-039.39AS, TfR2-039.40AS, TfR2-039.43AS source 1..21 mol_type other DNA organism synthetic construct modified_base order(1,6,12,13,14,19,20,21) mod_base OTHER note uracil tacactacggctttgaggttt 21 DNA PAT misc_feature 1..21 note TfR2-019.22AS, TfR2-019.29AS, TfR2-019.34AS, TfR2-019.36AS, TfR2-019.38AS, TfR2-019.85AS, TfR2-019.86AS, TfR2-019.87AS, TfR2-019.80AS, TfR2-019.91AS, TfR2-019.92AS, TfR2-019.93AS, TfR2-019.94AS, TfR2-019.95AS source 1..21 mol_type other DNA organism synthetic construct modified_base order(1,2,5,7,8,14,20,21) mod_base OTHER note uracil ttgatattgaaactccacgtt 21 DNA PAT misc_feature 1..21 note TfR2-039.41AS, TfR2-039.42AS source 1..21 mol_type other DNA organism synthetic construct modified_base order(1,6,13,14,19,20,21) mod_base OTHER note uracil tacactacggctttgaggttt 21 DNA PAT misc_feature 1..21 note TfR2-039.45AS source 1..21 mol_type other DNA organism synthetic construct modified_base order(1,6,12,14,19,20,21) mod_base OTHER note uracil tacactacggctttgaggttt 21 DNA PAT misc_feature 1..21 note TfR2-019.71AS, TfR2-019.88AS, TfR2-019.89AS, TfR2-019.90AS source 1..21 mol_type other DNA organism synthetic construct modified_base order(1,2,5,7,8,20,21) mod_base OTHER note uracil ttgatattgaaactccacgtt 21 DNA PAT misc_feature 1..21 note AD47882.9AS, AD47882.91AS, AD47882.92AS, AD47882.93AS, AD47882.94AS source 1..21 mol_type other DNA organism synthetic construct modified_base order(12,17,20,21) mod_base OTHER note uracil agaaaggagaatcacgtggtt 21 DNA PAT misc_feature 1..21 note AD47882.41AS, AD47882.88AS, AD47882.89AS source 1..21 mol_type other DNA organism synthetic construct modified_base order(17,20,21) mod_base OTHER note uracil agaaaggagaatcacgtggtt 20 DNA PAT misc_feature 1..20 note oligonucleotide portion of TfR2-019.22SG.e1 source 1..20 mol_type other DNA organism synthetic construct modified_base order(4,9,10,11,15,17) mod_base OTHER note uracil gcgtggagtttcaatatcaa 21 DNA PAT misc_feature 1..21 note oligonucleotide portion of TfR2-019.22SG.e2 source 1..21 mol_type other DNA organism synthetic construct modified_base order(5,10,11,12,16,18) mod_base OTHER note uracil ggcgtggagtttcaatatcaa 20 DNA PAT misc_feature 1..20 note TfR2-019.94AS.s1 source 1..20 mol_type other DNA organism synthetic construct modified_base order(1,2,5,7,8,14,20) mod_base OTHER note uracil ttgatattgaaactccacgt 19 DNA PAT misc_feature 1..19 note TfR2-019.94AS.s2 source 1..19 mol_type other DNA organism synthetic construct modified_base order(1,2,5,7,8,14) mod_base OTHER note uracil ttgatattgaaactccacg 22 DNA PAT misc_feature 1..22 note TfR2-019.94AS.e1 source 1..22 mol_type other DNA organism synthetic construct modified_base order(1,2,5,7,8,14,21,22) mod_base OTHER note uracil ttgatattgaaactccacgctt 23 DNA PAT misc_feature 1..23 note TfR2-019.94AS.e2 source 1..23 mol_type other DNA organism synthetic construct modified_base order(1,2,5,7,8,14,22,23) mod_base OTHER note uracil ttgatattgaaactccacgcctt 21 DNA PAT misc_feature 1..21 note TfR2-019.94AS.e3 source 1..21 mol_type other DNA organism synthetic construct modified_base order(1,2,5,7,8,14,21) mod_base OTHER note uracil ttgatattgaaactccacggt 19 DNA PAT misc_feature 1..19 note complementary region of TfR2-019 sense chain region source 1..19 mol_type other DNA organism synthetic construct modified_base order(3,8,9,10,14,16) mod_base OTHER note uracil cgtggagtttcaatatcaa 19 DNA PAT misc_feature 1..19 note complementary region of TfR2-019 antisense chain region source 1..19 mol_type other DNA organism synthetic construct modified_base order(1,2,5,7,8,14) mod_base OTHER note uracil ttgatattgaaactccacg 19 DNA PAT misc_feature 1..19 note complementary region of TfR2-039 sense chain region source 1..19 mol_type other DNA organism synthetic construct modified_base order(4,13,16,18) mod_base OTHER note uracil acctcaaagccgtagtgta 19 DNA PAT misc_feature 1..19 note complementary region of TfR2-039 antisense chain region source 1..19 mol_type other DNA organism synthetic construct modified_base order(1,6,12,13,14,19) mod_base OTHER note uracil tacactacggctttgaggt 19 DNA PAT misc_feature 1..19 note TfR2-039.30S source 1..19 mol_type other DNA organism synthetic construct modified_base order(13,16,18) mod_base OTHER note uracil acctcaaagccgtagtgta