38120-3564US (11002WO01) US 63/244,299 2021-09-15 Regeneron Pharmaceuticals, Inc. Reticulocalbin-3 (RCN3) Variants And Treatment Of Asthma With Interleukin-4 Receptor Alpha (IL4R) Antagonists 12 15631 DNA PAT source 1..15631 mol_type genomic DNA organism Homo sapiens acatttgcgggaacgcagagcggagcgtggagagcggagcgaagctggataacagggtaaagggagtgggtggggggcctctgtccagggagggcggctcgggtcgaggaccagggtccggactgggagcaatgacggggagcctgcctgacctctcgctggccacaactatgccctgcaccttgcgtgggatgtgcgccacgtctgtctctgtaattccccctggcaggtctgggacccccctgagactccgtcagaagattcggtcctccccataggtggctttacctctaagcatcccgccctcttttcccccatcgcccgccctttttgagcccgaaagcttgcagccaacttccaactccctgtcctgtcctaggtaacccctccaccccgccattctcctatcccgtgtctgtccccatccctgtgacccctgacccctggcctttgccactccccagggaccgatgatgtggcgaccatcagttctgctgcttctgttgctactgaggcacggggcccaggggaagccatccccagacgcaggccctcatggccaggggagggtgcaccaggcggcccccctgagcgacgctccccatgatgacgcccacgggaacttccagtacgaccatgaggctttcctgggacgggaagtggccaaggaattcgaccaactcaccccagaggaaagccaggcccgtctggggtaagagagacattcggttggggcgtgtccagaggtggggcttaggagagagacgcgggggtatcgacaggggtcagagaaatggcgtggactgaacttcatttctttgtgagaaatgaaattctaccttctatccttgggaaaaagaaattaagttaaaattgaggcctaaagaggacctttgagaccgggcgtggtggctcatgcctgtaatcccagcactttgggaggccaaggcaggccgatcacttgaggtcaggagttcgagaacagcctggccaacatggtgaaatcccgtctctactaaaaatacaaaattaggcaggcgtggtggtgggcacctgtaatcccagctactcgggaggctgaggcaggagaatcgcttgaacctgggaggtggaggttgcagtgagccaaaattgcaccactgccctccagtcagggcgacaaagtgagactccgtctaaaaaacaacaacaacaataaaaaagaggacctttgagggcagcaaaatctgggttagattctgccccctaagcgctccttattcttttgtcccagacatctcccctccccaagcctcagtttcctgctctgtaaatggcagggactggtgtggaaaatgaggtttggcctttaaggagcccggccagtgcaggagagtggcagagccctgagtttcagggtgagctgggtggaatggagccctgtccaccctctccgtccaggcctgagcgcaggggggcgcgatgggagcagccgccttcttctgtgcatcctcctgacactgattgagcctgcaaaggtttatcgagcacctgctatgtgccaggcactgctctaggtgctgaagtcacaacagctaacacatctgtcctcctgaagtttacactgtggtgagggaaacagcaagaagtcaataagtagaaagtggatcaaatagagataaatgcatccaagaaagataaagcaagagagtcagaaagtgtggaggggagaggttgttggtgggggggagttgcaatttttatttatttatttatttatttatttacttattgagatggagtctcgctctgtcacccaggctggagtgcagtggtgcgatctcggctcactgcaacctccacctcctgggctcaagcaattgtcctgtctcagcctcccaagtagctgggattacaggcgctagccaccacgcccagctaattttgtatttttattttttatttttatttttgttgttgttgtttttgagatggagtctcgctctgtcacccaggctggagtgcagtgacgtgatctcggctcagtggaacctccgcctcccgggttcaaccagttgttctgcctcgtactccctagtagctagagtcctagctacaagtgaacgctacaagtcctagctacaagtgaacgcctccacatccagcaaagttttttttctttccttttttttttttggagacagagtgagactctgtctcccgggctagagtgcagtggcgtgatctcagctcatgcaacctctgcctcccaggttcaagcaattctcctgcctcagccttccgagtagctgggactatgggtgcacgcccacacgcccagctaatttttttttttttttttgtattttagtagagatggggtttcactgtgttgcccaggctggtctcgagctcctgagctcaggcaatccgcccgccttggcctcccaaagtgctggaattaatgcgtgagccacagcacccagcccaggcccaggtaatttttcttttttttcttttttttttttttttgagacggagttttgctcttgttgcccaggctggagtgcagtggcgcaatctcggctcaccacaacctccgcctcctgggttcaagtgattctcctgcctcagccttccgagtagctgggattacaggcatgcaccaccatgcccggctaattttgtatttttagtagagatggggtttctccatgttggtcaggctggtatcgacctcctgacctcaggtgatctgcccacctcggcctcccgaagtgctgggattataggcatgagccaccgcacccggctggagctgcaattttaaacagggaacttggacaaggcctccatgagaaggtggtatgtggtatttgagccatgtgggtatcggagtgaatagcattccaggcagacagaacagttaagtgcaaaggccctgaggcaggagtgggcttggagtgtcagagcaacagttctgaggcccgtgtggctggaactcagtgagaaaggggagagagtgggaggtgagggcagagaaggagcaaaggggttcagcatggtggttcatgtgtgtgatcccagcactttgggaggccaaggctgggggatcacttgagcccaggagttcaagaccagcctgggcaacatagtgataccccgcctctacaaaacaaatacaaaaattagcccagcatggtggcgtgctcctgtagtcccagatactagggaggctgaggagggaggatcacttgggcctgggaggtcaaggctgcagtgagccaaaatcatgccgctgcactccagcctaagcaacagagcaagactttgtctcaaaaagagagagggccaggtgcagtggctcacgcctgcaatcccagcactttgggagtccaaagcgggcggattgcctgagaccatgcaaagggggtcagatcatgcaatgcaaagccttttaggccacgatgaagatttaggcttttctccaattgagagtagaactgagggagggcatgagctgacttaggttttgagagaatcctgctggctgcgaggtggggaacagactgtagggagcaagaagcagggagcccagtgaggaagcgactgcgatagtccaggtggaagacaagacaagatggtggtcagatcagggtggagacagtggcagtggtccccaggactgctggctgggagattgtgcttggatgggcatgcatgaaggagaaatggaggaagaagggcagtgacaggttagcacatttagcttagcactaatggcaatgccaggcattgtcctaagtgctttattattgttattattattattattttgagacgcagtctcgctctgtctcccagtctggagtgcagtggcgtgatctcggctcactgcaagctccacctcccgggttcatgccattctcctgcctcagcctcccgagtagctgggactacaggcgcccaccaccacgcccagctaatttttttgtatttttagtagagacggggtttcgccgtgttagccaggatggtctagatctgctgacctcgtgatccacccacctcggcctcccaaagcactgggattacaggcgtgagccatggcgcctggcctttttttttttttttttttttttgagacagagtctcactctgtcatccaggctggagtgcaacggcgcgatctcggctcactgcaagctgcgcctcccaggttcacgccattctcctgcctcagcctcccgagtagctgggactacaggcacctgccaccacgcccggctaattttttgtatttttagtagagacggggtttcaccatgttagccaggatggtctcgatctcctgaccttgtgatccgccctcctcggcctccaaagtgttttttgtttgtttgtttgtttttgagacaaggtcttactctgttgcccaggctggagtgcagtggcacgatctcggctcactgcaacctacgcctcctgggttcaagcaattctcctgcctcagcctcccgagtagtggatattacaggcatccaccactgtgcccggctactttttgtatttttagtagagacggtttcaccatgttggccaggctggtctggaactcctcacctcaggtgatctgcccacttcggcctcccaaagtgctgggattacaggcgtgagccaccgtgcccggcctattattgttattattatttgagacggagtctcgctctgttgcccaggctggagtgcagtggtactatctcggctcactgcaacctccacctcccagattcaaccaattctcccgcgtcagcctccagagtagctgggatttcaggtgcgtgccaccatgccctgctaatttttgtatttttagtagagacaaggtttcaccatgtggaccaggctggtctggaacgtctgatctcaagtgattcgcctgtcttggcttcccaaagtgctgggattacaggcgtgagccaccgcgcctgtcctgtcctaagtgctttacatggcctaactcatttattccccacaaccgcccttttggggtaggtaccgttttttcttcctccgttttacagaggggtaactgagacacagagaggttaagtcacttgcccacagtcacacagccagtaagaggaagtggctggatttggacctaaaatgtctggctgtggagcccaagcgcttaacaacaccaggaacctcagagaagggtgtgattccggggacagagtggggccctagacagactggagcagagaccgcctggtgcgggaggtggggcggtgactcaggcaggcctggagagggctctgctgtctcggattttcgactttagggagggggccgcgggggcctagggacggtgacagggaggagggctccaggtagtctctgttaattagagattgggagaggaccggcctggcaaggcgtcaccaagggagaggagaggggcccgagagctgataggcgtggcccaagagaaggggagagatggaacctaaagtggcttgacatgcgacagggaggggcacaggagcccggaggagcatggggaggggcagagggagactgagcccccggggttgcgggtgatggtcctcaggcagtgcctgattcagccgggagcaggcaggggaaagccacggggctcagcacagggcagggctggagggagaggagcctgaaattgacacgcgcagcctggtaagggggaggggcatggggcgggtcggggcctgagacagcgggggatcgggggtgtggccgtggctgtctgggttcagagtcaatcttgcaacagggcccccttggcaagggtcacagtgcgacgccgcgctccccttcaccaccccagctcggcccagcgagaggtgcagcacgtgcaggccgagggcggggccggcgcggagagggtggccctgcatcgtagtaggtccctcccccgcagtgctcccagcaggcccgctcgttctggagaagggcgtgactcgacctgggggtggaccctaggctgaggggtagggtcctccggtgggcttggtcccgaaattgacccgcgcccctccccagttagcccgcggaccgtggactgtattttcagccccggatccgaagtgtcccagggggcgtggcccgtgcgaggggcggggcctgggggcgggaccagagcctgacgtgtgcccgccccggcttctaggcggatcgtggaccgcatggaccgcgcgggggacggcgacggctgggtgtcgctggccgagcttcgcgcgtggatcgcgcacacgcagcagcggcacatacgggactcggtgagcgcggcctgggacacgtacgacacggaccgcgacgggcgtgtgggttgggaggagctgcgcaacgccacctatggccactacgcgcccggtacgcggcgagcccccgaccctgctccccatacaccgtgaccctgaccttctggaccgcctcattctgagaaccctgaacccatttacccggagtccctggcccctaaccaggctctacccacttttaggagcccataactgtgagatcttcagtttctcacctctggcttctcttttttgtttttcgtctgcttatttttctggtatttagctgcatgctaaaaacgatctttttttcaaacatgaagtcacaattaggtgctaaaagccactgaacgcacccaaacagggacttgaaacctgggccctcaaattaaaagtccaatgctctaccaactaagctacccaggttcccttcagggctttcattctgggactcaccacctctgtgacaatatgactagggtacttgagatccctggccaaggacacctactttccatgccttgtcatcctgacccctaacttctgtgacctctcatcctgagaaccccaaagccagttactcagcccctgactctcagatccctcctttctgtcccaagtcccagcctcagtgccccacaccctgccacacacacagccctcattctctccctcctctcctctctgtccctggccccagcctccccgtccagtctgtcctccacagggctccgggggcggggttcttcatgcccagcactgactctgcccctccctccccctcctgggcccccaggagacggtcccactccccagccgggacgtttcctcctgtggctttgtttttctgcattttctgcaccaaatggattttctgtggttttcctgaactcaccacactcttcaaacctctaccttctgcccatattgttccctccagttacaatgcccgtcccctcctctcagtcaagccatctcagtccctgtaagctaccccatcacagccttagtctggggccaaaaggcccactgtcaactcatagtgggccattcctgtctccacacgcttggatcagttatttcttctctctgagaatcaatttttgcattcagaaagtagaatacatggaaaaacccactgtatgtgcttttttgtgatgattaaatgcaatattgtgcataaagagcttagcatataatctctcacaagttagctaatttattgggtggatataatatgttacatagcctgggtgccatggctcacgcctgtaatcccagcactttgggaggccgaggtgggtggatcacgtgagatcagaagttagagaccagcctggccaatgtggcaaaaccccgtcttaccacaaaaaaatacttagctgggcgtgatggtgtgcacctgtgatcacagctactctggagggtgaggcaagagaatcacttgaacccaggaggcagaagttgcagtgagccgagatcacatcactgcactctggccttggcgacagagtgagactctgtctcaaaaaaaaaaaaatatatatatatatagatagatagatagatagatagatatagatatacacacacatactaataatatgttatataacatattatatacttaaatatatatacaaattatatataaagtatcaatatatgcttttttttttttgtgagggagttttgctcttgttgcccaggctggagtgcagtggcgtggtctcggctcactgcaacctccgcctcccgggttcaagcgattttcctgcctcagcctcccaagtagctgggattacaggcatgcgccaccacgcctggctaattttgtatttttagtagagatggggtttctccatgttggtcaggctggtctcgaactcccaacctcaggtgatctgcccacctcggcctcccaaagtgctgtgattacaggtttgagccaccgcacccggcctacttttttttttttttttttttttttgagatggaatggagtttcactcttgttggccaggctgcagtgcaatggcaaggtctcggcttactacaacctcatcctcctgggttcaagcaattctcctgcctcagcctcacgagtagctaggactacaggcgcccaccaccatgccaggcaaatttttgtatttttagtagagaaggagtttcaccatgttgaccaggctggtctcgaactcctgacctcaggcgatccacccacctcggcctcccaaagtgctgggattacaggtgtgagccactgtgccaggcttctaaaatttttttttttttttttttgagacatagcctccctctgtcgcccaggctggaaagcagtggtgcagtctcagctcacggcaacctccgcttcctgggttcaatcgactcttgtgcctcagactcccgagtagctgggattacaggcgtgccccaccatgcccggctaagtatttttttggtagagatggggtttcgccatgttggccaggctggtctcaaactcctgacctcaagtgatctgccagcttcagcctcccaaagtgctgctattacaggcgtgagccactgcatccagcctactgatatatacttattaactccacagaaatctttgtaccccagtaggatttactttgtctttgttttaacctgcttggcgtttcctccattaaagctcatctcactgagacctgtccttccccaggtgaagaatttcatgacgtggaggatgcagagacctacaaaaagatgctggctcgggacgagcggcgtttccgggtggccgaccaggatggggactcgatggccactcgagaggagctgacagccttcctgcaccccgaggagttccctcacatgcgggacatcgtgattgctgtgagtggcggctggggaaccctgtcccccacacccttccggggacccaggcttccggttcaggtcctgcttcccagcaccgacctgggggcaggcagtcacctggttctccagcatcttgccggggaagccaggccgcaaacacaggtcagaggacggtgacctttcccacctccactctcagtcccctggggtctgatctctcctcgtctggccttcccctccctgtgctcgcatttggggtccaggcccccagccttccctcagacagccactgtgccccaccttatacaatttcttttctttcttttttttttttgagacatagtctccctcggttgcccaggctggaaagcagtggtgcgatctcagctcactgcaacctccgcctcccgggttcaagcaattctcctgcctcagcgtcccgagtagctgggattacaggggcgcaccaccacacctggctaatttttagtagagacagggtttcttcatgttggttaggctggtctcaaacttttgacctcaggtgatccgcccgcctcagcctcccaaagtgctaggattataggcatgagccaccgtgcccggccaatttttaatttttttttctagtagagatgggatttcaccatgttggccaggctggtcttgaactccggacctcaggtgatctgcccaccttggcctcccaaagtgctgggattacaggcatgagccaccgtgcctggccccaaaatgtgctttgttctatagaagaaggctttttttttctttccttcctcttttttttttttagtttttgagacagggcctaactctgttacccagaccggagggcagtggctcaatctcagctcactgcaacctcaaactcttgggctcaagtaatcctcccacctccgccttctgagaagctgaggccaccaggcacaagccaccatgtctggctaatgtttttttttttttttttttcagacggagtctcgctctgtcgcccatgctggagtgcagtgatgcgatctcggctcactgcaagctctgcctcccgggttcactccattcttctgcctcagcctcccgagtggctgggactacaggcgcatgccgccatgcccggctaatttttttttttttttttttagtagagacggggtttcactgtgttagccaggatggtctcgatctcctgacctcgtgatccacccacctcggccttccaaagtgctgggattacagttgtgagccaccacgcccggccatgcctggctaatttttaaattttgtgtagagacagggtctcgccatgttgcccaggctagtctcaaaatcctgggctcaatcgatcctcccgcctcggcctcccaaagtgctgggattacaggtgtgagccaccgtgcccagcccacagtcttatagtgaatgagtttggatataaattggggaacaaaagtcgttttgctccagaagggcacaaaaacaaggagcggaggtgtccagtgtgtcagaagaagccccaaagtgcaccatgttcacacataaagcagaggtaggttctaggctctgctaaacataaaggagcttctccccttggagggtgtttgctggggcttgagcaagttattagggacccaggacagctccccttgtgagcaacaaacctgtgcactgctggacattagggcctctgggctctggccccgtaaatgcaggtggtgcctgtttgatgataacatcccagaaagcccgcaaatttcccacatgccacctgttgagactgctctactgcctgcctcccacagctgcccggagctaaatttccaagagaacctctcactcttaccccaggggtccagcctcccccaggagccagggtcatcggcccccagcctcaatgcccctttctcctccaggaaaccctggaggacctggacagaaacaaagatggctatgtccaggtggaggagtacatcggtgagtgggccccaatttcttcttgggatgcctgtcctctctcaggcatgggcagggttggtgggggtagccggaggtacatcacccatcatcagagaacagtggccctcagacatgggggcaggggcactcactgcttgagttcatttagccacccaacatttattgagcacctactctataccagacacaaaaagcatctattgagcacctgctgtgtgtcacgcccaggatacacttactgagcacctactgcatatgggtggttgcgcctacagcagacaataacacagacaaatcccttcttgggggtctggagtttctacaaaatcaaggctcaggggctatgtttagttgagaatgggggtcaggaagctggtcttgaacctgcgcctgcacagcaaacactgtttcctgttacatgggatgttgggggatcctcacaataccccctgagttctgagttctccctgggcccctgccactgtccctgcccctagcgggcaaaaaatttagtcaaggagaacgctaacaaggaattttttttttttttttttttttttgagacagtttttttctgttgctcaggctggagcgcggtggcgtggtatcggctctctgcaacctccgcctcccgggctcaagagattcttctgcctcagcctcctgagtagctgggattactggtgcctgccaccacgcctggctaatttttgtatttttagtggagatgggatttcaccatgttggccaggctggtctagaactcccaacctcaggtgatctgctcatcttggcctcccaaagtggtgggattacaggcgtgagcaaccacgcccggccaggaatttttttttaagtttgaaaacattgtttattcttttatttttttctgaccacatcctacatgagaaaacatttttctttctttccttctctcactttctttctttctgtcactctttctttctatctgtctgtctgtgtgtgtgtgtgtctctctctttattaaatagagatgggttctcactatattgtccaggctggtctagaactcctgggctcaagcaatcttcccaccttggcctcccaaagagctgagattacaggcatgaatcaccacacctggctgagagaacatttttatatttttttcttaagagatggggttgggccaggcgcagtggctcatacctgtaatcccagcactttgggaggctgagatggatggatcatgaagtcaggagttcgagaccagcctggccaagatggtgtactaaaaatacaaaaattagccgggcctgttggcaggagcctgtaatcccagttactctggggactgaggcaagagaatctctggaacccgggaggcaaaggttgcagtgagctgtaatcgcgccattgcacttcagtctgggcaacaagagcgaaactccatcttaaaaaaaaaaaaaaaagatggggtcttgccctgtcgcccaggctggagtgcagtggggtgatcttggctcactgcagccttgacctcctgggctcaagggatcctcccacctcagcctcccaagtagctgagactccaggcacagtgcggcctctggagatacttctggttgtcacttctagaggggtgaggatgctactgacgtctcctggatagagcccagagatgctccttagcattctccggtgcacaggacaggccctgacaacaaggaggtcacaggccccagatgccagcagctgtccccatctctttttttttttttttgagacagagtctcgctattgtcgcccaggctggagtgcagtggcatgatctcggctcactgcaacctccgcctcccaggttcaagcaattctcttgtttcagcctcctgagtaggtgggattatgggcgtgcactaccacgcctggctaattttgtatttttagtagagacggggtttcaccattttggtcaggctggtcttgaactcttgacctcaggttatccacctgcctcggcctcccaaagtgctgggattacaggcgcgaaccaccgcacccagcctatcttctcaattacttcatcccattaagacttcatcttccattcctcagctctaccaggcagacactgtcactatcctccattatatagatgacacctgaggcccaggggggttgaagggatctgctgaagacaatgggaagaggcagggctaggatttgaaccttggtgtttgggctctggcacctatttcttaactcctccccaaccagtaacatatcaaaatgtataaaattggggtgggtgccatggctcacgcctgtattcccagcactttaggaggccaaggtgggtggatcacttgaggtcaagagttcaagaccagcctggccaacatgatgaaaccctgtctctactaaaactagaaaaattagctgggcgtggtggcgggtacctgtaatcccagctacttgggaggctgaggcaggagaatcacttgaacccagaaggtgcaggttgcagtgagctgagattgtgtcactgcactccagcctgtaatcccagcactttgggagactgaggcaggtggatcatggggtcaggagtttgagagcagcctggccaagatggtgaaaccccgcctctactaaaaatataaaaattagctgggtgtggtggcacgcacctgtaatcccagctacttgggaggctgaggcaggagaatcgcttgaacctgggaggcagaggttgcagtgagctgagattgcgccattgcactacagcctgggcaacaagagcgaaactccatcttaaaaaaaaaaagggggtggggtcttgccctgttgcccaggctggagtgcagtggggtaatcacagcgagactccatctcaaaaaaaaaaaaaaaaatttgtagaaacagggtcttgctatgttgcccaggttggtcttgaatcttggcctcaaatgaccctcctgcctgggtctcccaaagtgttggattacagtcatcactgcacctggcatctctgtcacctgctaactggccagaaacatcctcgcacgttcctcctgcatagacattgcttactatgtgccaggcactgccttgcccattgcacacactacttcacgtgtgtgtcaatgaaatcaatcaatcatgcaatcaaccaatcaaatgaatttcacctgtaacacaaatgattgcttataagtcaggttttgttactaattccatcgaaacagaagaggacgctgaggcgagagagagggtagtgagttgctcaagggcctggttcaggaagtatcagagccaggatcagcccccagctccactagacccccagagctgcccctgaccttgtcccctctgtcccggcccccagcggatctgtactcagccgagcctggggaggaggagccggcgtgggtgcagacggagaggcagcagttccgggacttccgggatctgaacaaggatgggcacctggatgggagtgaggtgggccactgggtgctgccccctgcccaggaccagcccctggtggaagccaaccacctgctgcacgagagcgacacggacaaggtgcagtgacggggcctcggcaggagcgaggagcgggtgggcattgcgggccagactccagaaaggagcaagacctgggcctggagctcagggtcccttttaggtgggataaaaaaagagggacagagagagggaggaaaagagagggcacggagccccagaaagagagggggacagagacccagagacccaaagagagaaggacagggaccaagacggggacagattcagagagaaagggacagaggcccagagaacaagggtcccagagacttcgggacacgcttggatgcagggagggcttttgaaagcagggccgtgttgtcccctctgaaccctgaccctccctccaggatgggcggctgagcaaagcggaaatcctgggtaattggaacatgtttgtgggcagtcaggccaccaactatggcgaggacctgacccggcaccacgatgagctgtgagcaccgcgcacctgccacagcctcagaggcccgcacaatgaccggaggaggggccgctgtggtctggccccctccctgtccaggccccgcaggaggcagatgcagtcccaggcatcctcctgcccctgggctctcagggaccccctgggtcggcttctgtccctgtcacacccccaaccccagggaggggctgtcatagtcccagaggataagcaatacctatttctgactgagtctcccagcccagacccagggacccttggccccaagctcagctctaagaaccgccccaacccctccagctccaaatctgagcctccaccacatagactgaaactcccctggccccagccctctcctgcctggcctggcctgggacacctcctctctgccaggaggcaataaaagccagcgccggga 15631 DNA PAT misc_feature 13482 note n is a, c, g, or t source 1..15631 mol_type genomic DNA organism Homo sapiens acatttgcgggaacgcagagcggagcgtggagagcggagcgaagctggataacagggtaaagggagtgggtggggggcctctgtccagggagggcggctcgggtcgaggaccagggtccggactgggagcaatgacggggagcctgcctgacctctcgctggccacaactatgccctgcaccttgcgtgggatgtgcgccacgtctgtctctgtaattccccctggcaggtctgggacccccctgagactccgtcagaagattcggtcctccccataggtggctttacctctaagcatcccgccctcttttcccccatcgcccgccctttttgagcccgaaagcttgcagccaacttccaactccctgtcctgtcctaggtaacccctccaccccgccattctcctatcccgtgtctgtccccatccctgtgacccctgacccctggcctttgccactccccagggaccgatgatgtggcgaccatcagttctgctgcttctgttgctactgaggcacggggcccaggggaagccatccccagacgcaggccctcatggccaggggagggtgcaccaggcggcccccctgagcgacgctccccatgatgacgcccacgggaacttccagtacgaccatgaggctttcctgggacgggaagtggccaaggaattcgaccaactcaccccagaggaaagccaggcccgtctggggtaagagagacattcggttggggcgtgtccagaggtggggcttaggagagagacgcgggggtatcgacaggggtcagagaaatggcgtggactgaacttcatttctttgtgagaaatgaaattctaccttctatccttgggaaaaagaaattaagttaaaattgaggcctaaagaggacctttgagaccgggcgtggtggctcatgcctgtaatcccagcactttgggaggccaaggcaggccgatcacttgaggtcaggagttcgagaacagcctggccaacatggtgaaatcccgtctctactaaaaatacaaaattaggcaggcgtggtggtgggcacctgtaatcccagctactcgggaggctgaggcaggagaatcgcttgaacctgggaggtggaggttgcagtgagccaaaattgcaccactgccctccagtcagggcgacaaagtgagactccgtctaaaaaacaacaacaacaataaaaaagaggacctttgagggcagcaaaatctgggttagattctgccccctaagcgctccttattcttttgtcccagacatctcccctccccaagcctcagtttcctgctctgtaaatggcagggactggtgtggaaaatgaggtttggcctttaaggagcccggccagtgcaggagagtggcagagccctgagtttcagggtgagctgggtggaatggagccctgtccaccctctccgtccaggcctgagcgcaggggggcgcgatgggagcagccgccttcttctgtgcatcctcctgacactgattgagcctgcaaaggtttatcgagcacctgctatgtgccaggcactgctctaggtgctgaagtcacaacagctaacacatctgtcctcctgaagtttacactgtggtgagggaaacagcaagaagtcaataagtagaaagtggatcaaatagagataaatgcatccaagaaagataaagcaagagagtcagaaagtgtggaggggagaggttgttggtgggggggagttgcaatttttatttatttatttatttatttatttacttattgagatggagtctcgctctgtcacccaggctggagtgcagtggtgcgatctcggctcactgcaacctccacctcctgggctcaagcaattgtcctgtctcagcctcccaagtagctgggattacaggcgctagccaccacgcccagctaattttgtatttttattttttatttttatttttgttgttgttgtttttgagatggagtctcgctctgtcacccaggctggagtgcagtgacgtgatctcggctcagtggaacctccgcctcccgggttcaaccagttgttctgcctcgtactccctagtagctagagtcctagctacaagtgaacgctacaagtcctagctacaagtgaacgcctccacatccagcaaagttttttttctttccttttttttttttggagacagagtgagactctgtctcccgggctagagtgcagtggcgtgatctcagctcatgcaacctctgcctcccaggttcaagcaattctcctgcctcagccttccgagtagctgggactatgggtgcacgcccacacgcccagctaatttttttttttttttttgtattttagtagagatggggtttcactgtgttgcccaggctggtctcgagctcctgagctcaggcaatccgcccgccttggcctcccaaagtgctggaattaatgcgtgagccacagcacccagcccaggcccaggtaatttttcttttttttcttttttttttttttttgagacggagttttgctcttgttgcccaggctggagtgcagtggcgcaatctcggctcaccacaacctccgcctcctgggttcaagtgattctcctgcctcagccttccgagtagctgggattacaggcatgcaccaccatgcccggctaattttgtatttttagtagagatggggtttctccatgttggtcaggctggtatcgacctcctgacctcaggtgatctgcccacctcggcctcccgaagtgctgggattataggcatgagccaccgcacccggctggagctgcaattttaaacagggaacttggacaaggcctccatgagaaggtggtatgtggtatttgagccatgtgggtatcggagtgaatagcattccaggcagacagaacagttaagtgcaaaggccctgaggcaggagtgggcttggagtgtcagagcaacagttctgaggcccgtgtggctggaactcagtgagaaaggggagagagtgggaggtgagggcagagaaggagcaaaggggttcagcatggtggttcatgtgtgtgatcccagcactttgggaggccaaggctgggggatcacttgagcccaggagttcaagaccagcctgggcaacatagtgataccccgcctctacaaaacaaatacaaaaattagcccagcatggtggcgtgctcctgtagtcccagatactagggaggctgaggagggaggatcacttgggcctgggaggtcaaggctgcagtgagccaaaatcatgccgctgcactccagcctaagcaacagagcaagactttgtctcaaaaagagagagggccaggtgcagtggctcacgcctgcaatcccagcactttgggagtccaaagcgggcggattgcctgagaccatgcaaagggggtcagatcatgcaatgcaaagccttttaggccacgatgaagatttaggcttttctccaattgagagtagaactgagggagggcatgagctgacttaggttttgagagaatcctgctggctgcgaggtggggaacagactgtagggagcaagaagcagggagcccagtgaggaagcgactgcgatagtccaggtggaagacaagacaagatggtggtcagatcagggtggagacagtggcagtggtccccaggactgctggctgggagattgtgcttggatgggcatgcatgaaggagaaatggaggaagaagggcagtgacaggttagcacatttagcttagcactaatggcaatgccaggcattgtcctaagtgctttattattgttattattattattattttgagacgcagtctcgctctgtctcccagtctggagtgcagtggcgtgatctcggctcactgcaagctccacctcccgggttcatgccattctcctgcctcagcctcccgagtagctgggactacaggcgcccaccaccacgcccagctaatttttttgtatttttagtagagacggggtttcgccgtgttagccaggatggtctagatctgctgacctcgtgatccacccacctcggcctcccaaagcactgggattacaggcgtgagccatggcgcctggcctttttttttttttttttttttttgagacagagtctcactctgtcatccaggctggagtgcaacggcgcgatctcggctcactgcaagctgcgcctcccaggttcacgccattctcctgcctcagcctcccgagtagctgggactacaggcacctgccaccacgcccggctaattttttgtatttttagtagagacggggtttcaccatgttagccaggatggtctcgatctcctgaccttgtgatccgccctcctcggcctccaaagtgttttttgtttgtttgtttgtttttgagacaaggtcttactctgttgcccaggctggagtgcagtggcacgatctcggctcactgcaacctacgcctcctgggttcaagcaattctcctgcctcagcctcccgagtagtggatattacaggcatccaccactgtgcccggctactttttgtatttttagtagagacggtttcaccatgttggccaggctggtctggaactcctcacctcaggtgatctgcccacttcggcctcccaaagtgctgggattacaggcgtgagccaccgtgcccggcctattattgttattattatttgagacggagtctcgctctgttgcccaggctggagtgcagtggtactatctcggctcactgcaacctccacctcccagattcaaccaattctcccgcgtcagcctccagagtagctgggatttcaggtgcgtgccaccatgccctgctaatttttgtatttttagtagagacaaggtttcaccatgtggaccaggctggtctggaacgtctgatctcaagtgattcgcctgtcttggcttcccaaagtgctgggattacaggcgtgagccaccgcgcctgtcctgtcctaagtgctttacatggcctaactcatttattccccacaaccgcccttttggggtaggtaccgttttttcttcctccgttttacagaggggtaactgagacacagagaggttaagtcacttgcccacagtcacacagccagtaagaggaagtggctggatttggacctaaaatgtctggctgtggagcccaagcgcttaacaacaccaggaacctcagagaagggtgtgattccggggacagagtggggccctagacagactggagcagagaccgcctggtgcgggaggtggggcggtgactcaggcaggcctggagagggctctgctgtctcggattttcgactttagggagggggccgcgggggcctagggacggtgacagggaggagggctccaggtagtctctgttaattagagattgggagaggaccggcctggcaaggcgtcaccaagggagaggagaggggcccgagagctgataggcgtggcccaagagaaggggagagatggaacctaaagtggcttgacatgcgacagggaggggcacaggagcccggaggagcatggggaggggcagagggagactgagcccccggggttgcgggtgatggtcctcaggcagtgcctgattcagccgggagcaggcaggggaaagccacggggctcagcacagggcagggctggagggagaggagcctgaaattgacacgcgcagcctggtaagggggaggggcatggggcgggtcggggcctgagacagcgggggatcgggggtgtggccgtggctgtctgggttcagagtcaatcttgcaacagggcccccttggcaagggtcacagtgcgacgccgcgctccccttcaccaccccagctcggcccagcgagaggtgcagcacgtgcaggccgagggcggggccggcgcggagagggtggccctgcatcgtagtaggtccctcccccgcagtgctcccagcaggcccgctcgttctggagaagggcgtgactcgacctgggggtggaccctaggctgaggggtagggtcctccggtgggcttggtcccgaaattgacccgcgcccctccccagttagcccgcggaccgtggactgtattttcagccccggatccgaagtgtcccagggggcgtggcccgtgcgaggggcggggcctgggggcgggaccagagcctgacgtgtgcccgccccggcttctaggcggatcgtggaccgcatggaccgcgcgggggacggcgacggctgggtgtcgctggccgagcttcgcgcgtggatcgcgcacacgcagcagcggcacatacgggactcggtgagcgcggcctgggacacgtacgacacggaccgcgacgggcgtgtgggttgggaggagctgcgcaacgccacctatggccactacgcgcccggtacgcggcgagcccccgaccctgctccccatacaccgtgaccctgaccttctggaccgcctcattctgagaaccctgaacccatttacccggagtccctggcccctaaccaggctctacccacttttaggagcccataactgtgagatcttcagtttctcacctctggcttctcttttttgtttttcgtctgcttatttttctggtatttagctgcatgctaaaaacgatctttttttcaaacatgaagtcacaattaggtgctaaaagccactgaacgcacccaaacagggacttgaaacctgggccctcaaattaaaagtccaatgctctaccaactaagctacccaggttcccttcagggctttcattctgggactcaccacctctgtgacaatatgactagggtacttgagatccctggccaaggacacctactttccatgccttgtcatcctgacccctaacttctgtgacctctcatcctgagaaccccaaagccagttactcagcccctgactctcagatccctcctttctgtcccaagtcccagcctcagtgccccacaccctgccacacacacagccctcattctctccctcctctcctctctgtccctggccccagcctccccgtccagtctgtcctccacagggctccgggggcggggttcttcatgcccagcactgactctgcccctccctccccctcctgggcccccaggagacggtcccactccccagccgggacgtttcctcctgtggctttgtttttctgcattttctgcaccaaatggattttctgtggttttcctgaactcaccacactcttcaaacctctaccttctgcccatattgttccctccagttacaatgcccgtcccctcctctcagtcaagccatctcagtccctgtaagctaccccatcacagccttagtctggggccaaaaggcccactgtcaactcatagtgggccattcctgtctccacacgcttggatcagttatttcttctctctgagaatcaatttttgcattcagaaagtagaatacatggaaaaacccactgtatgtgcttttttgtgatgattaaatgcaatattgtgcataaagagcttagcatataatctctcacaagttagctaatttattgggtggatataatatgttacatagcctgggtgccatggctcacgcctgtaatcccagcactttgggaggccgaggtgggtggatcacgtgagatcagaagttagagaccagcctggccaatgtggcaaaaccccgtcttaccacaaaaaaatacttagctgggcgtgatggtgtgcacctgtgatcacagctactctggagggtgaggcaagagaatcacttgaacccaggaggcagaagttgcagtgagccgagatcacatcactgcactctggccttggcgacagagtgagactctgtctcaaaaaaaaaaaaatatatatatatatagatagatagatagatagatagatatagatatacacacacatactaataatatgttatataacatattatatacttaaatatatatacaaattatatataaagtatcaatatatgcttttttttttttgtgagggagttttgctcttgttgcccaggctggagtgcagtggcgtggtctcggctcactgcaacctccgcctcccgggttcaagcgattttcctgcctcagcctcccaagtagctgggattacaggcatgcgccaccacgcctggctaattttgtatttttagtagagatggggtttctccatgttggtcaggctggtctcgaactcccaacctcaggtgatctgcccacctcggcctcccaaagtgctgtgattacaggtttgagccaccgcacccggcctacttttttttttttttttttttttttgagatggaatggagtttcactcttgttggccaggctgcagtgcaatggcaaggtctcggcttactacaacctcatcctcctgggttcaagcaattctcctgcctcagcctcacgagtagctaggactacaggcgcccaccaccatgccaggcaaatttttgtatttttagtagagaaggagtttcaccatgttgaccaggctggtctcgaactcctgacctcaggcgatccacccacctcggcctcccaaagtgctgggattacaggtgtgagccactgtgccaggcttctaaaatttttttttttttttttttgagacatagcctccctctgtcgcccaggctggaaagcagtggtgcagtctcagctcacggcaacctccgcttcctgggttcaatcgactcttgtgcctcagactcccgagtagctgggattacaggcgtgccccaccatgcccggctaagtatttttttggtagagatggggtttcgccatgttggccaggctggtctcaaactcctgacctcaagtgatctgccagcttcagcctcccaaagtgctgctattacaggcgtgagccactgcatccagcctactgatatatacttattaactccacagaaatctttgtaccccagtaggatttactttgtctttgttttaacctgcttggcgtttcctccattaaagctcatctcactgagacctgtccttccccaggtgaagaatttcatgacgtggaggatgcagagacctacaaaaagatgctggctcgggacgagcggcgtttccgggtggccgaccaggatggggactcgatggccactcgagaggagctgacagccttcctgcaccccgaggagttccctcacatgcgggacatcgtgattgctgtgagtggcggctggggaaccctgtcccccacacccttccggggacccaggcttccggttcaggtcctgcttcccagcaccgacctgggggcaggcagtcacctggttctccagcatcttgccggggaagccaggccgcaaacacaggtcagaggacggtgacctttcccacctccactctcagtcccctggggtctgatctctcctcgtctggccttcccctccctgtgctcgcatttggggtccaggcccccagccttccctcagacagccactgtgccccaccttatacaatttcttttctttcttttttttttttgagacatagtctccctcggttgcccaggctggaaagcagtggtgcgatctcagctcactgcaacctccgcctcccgggttcaagcaattctcctgcctcagcgtcccgagtagctgggattacaggggcgcaccaccacacctggctaatttttagtagagacagggtttcttcatgttggttaggctggtctcaaacttttgacctcaggtgatccgcccgcctcagcctcccaaagtgctaggattataggcatgagccaccgtgcccggccaatttttaatttttttttctagtagagatgggatttcaccatgttggccaggctggtcttgaactccggacctcaggtgatctgcccaccttggcctcccaaagtgctgggattacaggcatgagccaccgtgcctggccccaaaatgtgctttgttctatagaagaaggctttttttttctttccttcctcttttttttttttagtttttgagacagggcctaactctgttacccagaccggagggcagtggctcaatctcagctcactgcaacctcaaactcttgggctcaagtaatcctcccacctccgccttctgagaagctgaggccaccaggcacaagccaccatgtctggctaatgtttttttttttttttttttcagacggagtctcgctctgtcgcccatgctggagtgcagtgatgcgatctcggctcactgcaagctctgcctcccgggttcactccattcttctgcctcagcctcccgagtggctgggactacaggcgcatgccgccatgcccggctaatttttttttttttttttttagtagagacggggtttcactgtgttagccaggatggtctcgatctcctgacctcgtgatccacccacctcggccttccaaagtgctgggattacagttgtgagccaccacgcccggccatgcctggctaatttttaaattttgtgtagagacagggtctcgccatgttgcccaggctagtctcaaaatcctgggctcaatcgatcctcccgcctcggcctcccaaagtgctgggattacaggtgtgagccaccgtgcccagcccacagtcttatagtgaatgagtttggatataaattggggaacaaaagtcgttttgctccagaagggcacaaaaacaaggagcggaggtgtccagtgtgtcagaagaagccccaaagtgcaccatgttcacacataaagcagaggtaggttctaggctctgctaaacataaaggagcttctccccttggagggtgtttgctggggcttgagcaagttattagggacccaggacagctccccttgtgagcaacaaacctgtgcactgctggacattagggcctctgggctctggccccgtaaatgcaggtggtgcctgtttgatgataacatcccagaaagcccgcaaatttcccacatgccacctgttgagactgctctactgcctgcctcccacagctgcccggagctaaatttccaagagaacctctcactcttaccccaggggtccagcctcccccaggagccagggtcatcggcccccagcctcaatgcccctttctcctccaggaaaccctggaggacctggacagaaacaaagatggctatgtccaggtggaggagtacatcggtgagtgggccccaatttcttcttgggatgcctgtcctctctcaggcatgggcagggttggtgggggtagccggaggtacatcacccatcatcagagaacagtggccctcagacatgggggcaggggcactcactgcttgagttcatttagccacccaacatttattgagcacctactctataccagacacaaaaagcatctattgagcacctgctgtgtgtcacgcccaggatacacttactgagcacctactgcatatgggtggttgcgcctacagcagacaataacacagacaaatcccttcttgggggtctggagtttctacaaaatcaaggctcaggggctatgtttagttgagaatgggggtcaggaagctggtcttgaacctgcgcctgcacagcaaacactgtttcctgttacatgggatgttgggggatcctcacaataccccctgagttctgagttctccctgggcccctgccactgtccctgcccctagcgggcaaaaaatttagtcaaggagaacgctaacaaggaattttttttttttttttttttttttgagacagtttttttctgttgctcaggctggagcgcggtggcgtggtatcggctctctgcaacctccgcctcccgggctcaagagattcttctgcctcagcctcctgagtagctgggattactggtgcctgccaccacgcctggctaatttttgtatttttagtggagatgggatttcaccatgttggccaggctggtctagaactcccaacctcaggtgatctgctcatcttggcctcccaaagtggtgggattacaggcgtgagcaaccacgcccggccaggaatttttttttaagtttgaaaacattgtttattcttttatttttttctgaccacatcctacatgagaaaacatttttctttctttccttctctcactttctttctttctgtcactctttctttctatctgtctgtctgtgtgtgtgtgtgtctctctctttattaaatagagatgggttctcactatattgtccaggctggtctagaactcctgggctcaagcaatcttcccaccttggcctcccaaagagctgagattacaggcatgaatcaccacacctggctgagagaacatttttatatttttttcttaagagatggggttgggccaggcgcagtggctcatacctgtaatcccagcactttgggaggctgagatggatggatcatgaagtcaggagttcgagaccagcctggccaagatggtgtactaaaaatacaaaaattagccgggcctgttggcaggagcctgtaatcccagttactctggggactgaggcaagagaatctctggaacccgggaggcaaaggttgcagtgagctgtaatcgcgccattgcacttcagtctgggcaacaagagcgaaactccatcttaaaaaaaaaaaaaaaagatggggtcttgccctgtcgcccaggctggagtgcagtggggtgatcttggctcactgcagccttgacctcctgggctcaagggatcctcccacctcagcctcccaagtagctgagactccaggcacagtgcggcctctggagatacttctggttgtcacttctagaggggtgaggatgctactgacgtctcctggatagagcccagagatgctccttagcattctccggtgcacaggacaggccctgacaacaaggaggtcacaggccccagatgccagcagctgtccccatctctttttttttttttttgagacagagtctcgctattgtcgcccaggctggagtgcagtggcatgatctcggctcactgcaacctccgcctcccaggttcaagcaattctcttgtttcagcctcctgagtaggtgggattatgggcgtgcactaccacgcctggctaattttgtatttttagtagagacggggtttcaccattttggtcaggctggtcttgaactcttgacctcaggttatccacctgcctcggcctcccaaagtgctgggattacaggcgcgaaccaccgcacccagcctatcttctcaattacttcatcccattaagacttcatcttccattcctcagctctaccaggcagacactgtcactatcctccattatatagatgacacctgaggcccaggggggttgaagggatctgctgaagacaatgggaagaggcagggctaggatttgaaccttggtgtttgggctctggcacctatttcttaactcctccccaaccagtaacatatcaaaatgtataaaattggggtgggtgccatggctnacgcctgtattcccagcactttaggaggccaaggtgggtggatcacttgaggtcaagagttcaagaccagcctggccaacatgatgaaaccctgtctctactaaaactagaaaaattagctgggcgtggtggcgggtacctgtaatcccagctacttgggaggctgaggcaggagaatcacttgaacccagaaggtgcaggttgcagtgagctgagattgtgtcactgcactccagcctgtaatcccagcactttgggagactgaggcaggtggatcatggggtcaggagtttgagagcagcctggccaagatggtgaaaccccgcctctactaaaaatataaaaattagctgggtgtggtggcacgcacctgtaatcccagctacttgggaggctgaggcaggagaatcgcttgaacctgggaggcagaggttgcagtgagctgagattgcgccattgcactacagcctgggcaacaagagcgaaactccatcttaaaaaaaaaaagggggtggggtcttgccctgttgcccaggctggagtgcagtggggtaatcacagcgagactccatctcaaaaaaaaaaaaaaaaatttgtagaaacagggtcttgctatgttgcccaggttggtcttgaatcttggcctcaaatgaccctcctgcctgggtctcccaaagtgttggattacagtcatcactgcacctggcatctctgtcacctgctaactggccagaaacatcctcgcacgttcctcctgcatagacattgcttactatgtgccaggcactgccttgcccattgcacacactacttcacgtgtgtgtcaatgaaatcaatcaatcatgcaatcaaccaatcaaatgaatttcacctgtaacacaaatgattgcttataagtcaggttttgttactaattccatcgaaacagaagaggacgctgaggcgagagagagggtagtgagttgctcaagggcctggttcaggaagtatcagagccaggatcagcccccagctccactagacccccagagctgcccctgaccttgtcccctctgtcccggcccccagcggatctgtactcagccgagcctggggaggaggagccggcgtgggtgcagacggagaggcagcagttccgggacttccgggatctgaacaaggatgggcacctggatgggagtgaggtgggccactgggtgctgccccctgcccaggaccagcccctggtggaagccaaccacctgctgcacgagagcgacacggacaaggtgcagtgacggggcctcggcaggagcgaggagcgggtgggcattgcgggccagactccagaaaggagcaagacctgggcctggagctcagggtcccttttaggtgggataaaaaaagagggacagagagagggaggaaaagagagggcacggagccccagaaagagagggggacagagacccagagacccaaagagagaaggacagggaccaagacggggacagattcagagagaaagggacagaggcccagagaacaagggtcccagagacttcgggacacgcttggatgcagggagggcttttgaaagcagggccgtgttgtcccctctgaaccctgaccctccctccaggatgggcggctgagcaaagcggaaatcctgggtaattggaacatgtttgtgggcagtcaggccaccaactatggcgaggacctgacccggcaccacgatgagctgtgagcaccgcgcacctgccacagcctcagaggcccgcacaatgaccggaggaggggccgctgtggtctggccccctccctgtccaggccccgcaggaggcagatgcagtcccaggcatcctcctgcccctgggctctcagggaccccctgggtcggcttctgtccctgtcacacccccaaccccagggaggggctgtcatagtcccagaggataagcaatacctatttctgactgagtctcccagcccagacccagggacccttggccccaagctcagctctaagaaccgccccaacccctccagctccaaatctgagcctccaccacatagactgaaactcccctggccccagccctctcctgcctggcctggcctgggacacctcctctctgccaggaggcaataaaagccagcgccggga 124 AA PAT REGION 1..124 note Synthetic sequence; Dupilumab HCVR source 1..124 mol_type protein organism synthetic construct EVQLVESGGGLEQPGGSLRLSCAGSGFTFRDYAMTWVRQAPGKGLEWVSSISGSGGNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRLSITIRPRYYGLDVWGQGTTVTVS 112 AA PAT REGION 1..112 note Synthetic sequence; Dupilumab LCVR source 1..112 mol_type protein organism synthetic construct DIVMTQSPLSLPVTPGEPASISCRSSQSLLYSIGYNYLDWYLQKSGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGFYYCMQALQTPYTFGQGTKLEIK 8 AA PAT REGION 1..8 note Synthetic sequence; Dupilumab HCDR1 source 1..8 mol_type protein organism synthetic construct GFTFRDYA 8 AA PAT REGION 1..8 note Synthetic sequence; Dupilumab HCDR2 source 1..8 mol_type protein organism synthetic construct ISGSGGNT 18 AA PAT REGION 1..18 note Synthetic sequence; Dupilumab HCDR3 source 1..18 mol_type protein organism synthetic construct AKDRLSITIRPRYYGLDV 11 AA PAT REGION 1..11 note Synthetic sequence; Dupilumab LCDR1 source 1..11 mol_type protein organism synthetic construct QSLLYSIGYNY 000 9 AA PAT REGION 1..9 note Synthetic sequence; Dupilumab LCDR3 source 1..9 mol_type protein organism synthetic construct MQALQTPYT 451 AA PAT REGION 1..451 note Synthetic sequence; Dupilumab heavy chain source 1..451 mol_type protein organism synthetic construct EVQLVESGGGLEQPGGSLRLSCAGSGFTFRDYAMTWVRQAPGKGLEWVSSISGSGGNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRLSITIRPRYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 219 AA PAT REGION 1..219 note Synthetic sequence; Dupilumab light chain source 1..219 mol_type protein organism synthetic construct DIVMTQSPLSLPVTPGEPASISCRSSQSLLYSIGYNYLDWYLQKSGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGFYYCMQALQTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC