23-154PCT JP 2023-140983 2023-08-31 ペプチドリーム株式会社 PeptiDream Inc. 鈴木芳典 SUZUKI Yoshinori ＶＥＧＦＲ－２アゴニスト活性を有するペプチド複合体 51 000 14 AA PAT

source 1..14 mol_type protein organism synthetic construct

WWVDVQDDLYFVDC 15 AA PAT

source 1..15 mol_type protein organism synthetic construct

WWVDVQDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 6 note X represents (S)-2-Aminoheptanoic acid(Ahp)

WWVDVXDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct

WWVDVWDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 6 note F represents (S)-2-Amino-4-phenylbutanoic acid(Hph)

WWVDVFDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 6 note A represents (S)-2-Amino-3-cyclohexylpropanoic acid(Cha)

WWVDVADDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 6 note F represents 4-Carboxy-L-phenylalanine(F4COO)

WWVDVFDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct

WWVDVQGDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 11 note A represents (S)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid(Bph)

WWVDVQDDLYAVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 12 note F represents (S)-2-Amino-4-phenylbutanoic acid(Hph)

WWVDVQDDLYFFDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct

WWVDVQDDLYFVACG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct

WWVDVQDDLYFVSCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct

WWVDVKDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 5 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg)

WWVDLKDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 11 note Y represents (S)-2-Amino-3-(4-phenoxyphenyl)propanoic acid(Yph)

WWVDVKDDLYYVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 11 note F represents (S)-2-Amino-3-(4-guanidinophenyl)propanoic acid(F4G)

WWVDVKDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWVDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 11 note Y represents (S)-2-Amino-3-(4-phenoxyphenyl)propanoic acid(Yph)

WWLDVKDDLYYVDCG 15 AA PAT

WWLDVKDDLYYYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 1 note K represents N6-carbamoyl-L-lysine(Hcit) MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

KWLDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 1 note A represents (S)-2-Amino-3-(2-aminopyridin-4-yl)propanoic acid(4Py2NH2) MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

AWLDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 1 note A represents (S)-2-Amino-3-(6-aminopyridin-3-yl) propanoic acid(3Py6NH2) MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

AWLDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 1 note F represents (S)-2-Amino-3-(4-(carboxymethoxy) phenyl) propanoic acid(F4aao) MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

FWLDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note G represents (S)-2-Amino-2-cyclohexylacetic acid(Chg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWGDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLQVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 5 note T represents allo-threonine(alT) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDTKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 5 note G represents (S)-2-Amino-2-cyclohexylacetic acid(Chg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDGKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVKDDNYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 11 note F represents (S)-2-Amino-3-(4-chlorophenyl)propanoic acid(F4C) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note G represents (S)-2-Amino-2-cyclohexylacetic acid(Chg)

WWLDVKDDLYFGDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note X represents (S)-2-Amino-4-(pyridin-4-yl)butanoic acid(H4Py)

WWLDVKDDLYFXDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVKDDLYFYSCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVKDDLYFYFCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty) MOD_RES 13 note F represents (S)-2-Amino-3-(4-(carboxymethoxy) phenyl) propanoic acid(F4aao)

WWLDVKDDLYFYFCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 6 note X represents (S)-2-Aminoheptanoic acid(Ahp) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVXDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWVDVKGVNYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 4 note M represents (S)-2-Amino-4-(methylsulfonyl)butanoic acid(MetO2) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWVMVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 11 note Y represents (S)-2-Amino-3-(4-phenoxyphenyl)propanoic acid(Yph) MOD_RES 13 note K represents N6-carbamimidoyl-L-lysine(Har)

WWVDVKDDLYYVKCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note Y represents homo-L-tyrosine(Hty) MOD_RES 11 note F represents (S)-2-Amino-3-(4-guanidinophenyl)propanoic acid(F4G)

WWYDVKDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 11 note F represents (S)-2-Amino-3-(4-guanidinophenyl)propanoic acid(F4G) MOD_RES 12 note Y represents homo-L-tyrosine(Hty) MOD_RES 13 note P represents hydroxyproline(Hyp)

WWVDVKDDLYFYPCG 15 AA PAT

WWLDVKDDLYFVDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 11 note F represents (S)-2-Amino-3-(4-guanidinophenyl)propanoic acid(F4G) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 1 note W represents (S)-2-Amino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid(W7N) MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVKDDLYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVKNDLYFYDCG 15 AA PAT

WWLDVKDDAYFYDCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note L represents (S)-2-Amino-3,3-dimethylbutanoic acid(Tbg) MOD_RES 9 note A represents (S)-2-Amino-4,4-dimethylpentanoic acid(Atb) MOD_RES 11 note F represents (S)-2-Amino-3-(4-guanidinophenyl)propanoic acid(F4G) MOD_RES 12 note Y represents homo-L-tyrosine(Hty)

WWLDVKDDAYFYDCG 15 AA PAT

WWLDVKDDAYFYPCG 15 AA PAT

source 1..15 mol_type protein organism synthetic construct MOD_RES 3 note Y represents homo-L-tyrosine(Hty) MOD_RES 9 note A represents (S)-2-Amino-4,4-dimethylpentanoic acid(Atb) MOD_RES 11 note F represents (S)-2-Amino-3-(4-guanidinophenyl)propanoic acid(F4G)

WWYDVKDDAYFVDCG 15 AA PAT

WWYDVKDDAYFYDCG