SG 11202204350U 2022-04-25 14866-020-055 EP 19205006.0 2019-10-24 NOVAGO THERAPEUTICS AG NOVEL ANTI-NOGO-A ANTIBODIES 27 360 DNA PAT source 1..360 mol_type other DNA note NG004 variable heavy chain (VH) sequence organism Homo sapiens CDS 1..360 protein_id 2 translation EVQLVESGGGVVQPGRSLRLSCAASGFTFRSHAMHWVRQAPGKGLEWVAVTSYDGTNKYYADSVKGRFTISKDNSKNTLYLQMDSLRVEDTAVYYCARGRAVAGTREDYWGQGTLVTVSS gaggtgcagctggtggagtctgggggaggcgtggtccagcctgggaggtccctgagactctcctgtgcagcctctggattcaccttcaggagccatgctatgcactgggtccgccaggctccaggcaaggggctggagtgggtggcagttacatcatatgatggaaccaataaatactacgcagactccgtgaagggccgattcaccatctccaaagacaattccaagaacacgctgtatctgcaaatggacagcctcagagttgaggacacggctgtgtattactgtgcgagaggccgagcagtggctggtacgagggaagattattggggccagggaaccctggtcaccgtctcctcg 120 AA PAT source 1..120 mol_type protein organism Homo sapiens EVQLVESGGGVVQPGRSLRLSCAASGFTFRSHAMHWVRQAPGKGLEWVAVTSYDGTNKYYADSVKGRFTISKDNSKNTLYLQMDSLRVEDTAVYYCARGRAVAGTREDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism Homo sapiens SHAMH 17 AA PAT source 1..17 mol_type protein organism Homo sapiens VTSYDGTNKYYADSVKG 11 AA PAT source 1..11 mol_type protein organism Homo sapiens GRAVAGTREDY 339 DNA PAT source 1..339 mol_type other DNA note NG004 variable kappa chain (VK) sequence organism Homo sapiens CDS 1..339 protein_id 7 translation DIQMTQSPDSLAVSLGERATINCKSSQSVLFSSNSKNYLAWYQQKPGQPPKVLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYTTRPTFGLGTKVDIK gacatccagatgacccagtctccagactccctggctgtgtctctgggcgagagggccaccatcaactgcaagtccagccagagtgttttattcagctccaacagtaagaactacttagcttggtaccagcagaaaccaggacagcctcctaaggtgctcatttactgggcatctacccgggaatccggggtccctgaccgattcagtggcagcgggtctgggacagatttcactctcaccatcagcagcctgcaggctgaagatgtggcagtttattactgtcagcaatattatactactcgccctacgttcggcctagggaccaaagtggatatcaaa 113 AA PAT source 1..113 mol_type protein organism Homo sapiens DIQMTQSPDSLAVSLGERATINCKSSQSVLFSSNSKNYLAWYQQKPGQPPKVLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYTTRPTFGLGTKVDIK 17 AA PAT source 1..17 mol_type protein organism Homo sapiens KSSQSVLFSSNSKNYLA 7 AA PAT source 1..7 mol_type protein organism Homo sapiens WASTRES 9 AA PAT source 1..9 mol_type protein organism Homo sapiens QQYYTTRPT 342 DNA PAT source 1..342 mol_type other DNA note NG034 variable heavy chain (VH) sequence organism Homo sapiens CDS 1..342 protein_id 12 translation EVQLVETGGGLVPPGGSLRLSCAASGFTFTNYSMHWVRLAPGKRLEYISAISSDGGDPFYASSVKGRVAISRDNSKKTLYLQMGRLRPEDTAVYYCVSDAFDVWGQGTMVTVSS gaggtgcagctggtggagactgggggaggcttggtcccaccgggggggtccctgagactctcctgtgcagcctctggattcaccttcaccaactattctatgcactgggtccgcctggctccagggaagagactggaatatatttcagctattagtagtgatggcggtgacccattttatgcaagctctgtgaagggcagagtcgccatctccagagacaattccaagaagacgttgtatcttcaaatgggcagactgagacctgaggacacggctgtatattattgtgtgagtgatgcttttgatgtctggggccaggggacaatggtcaccgtctcttcg 114 AA PAT source 1..114 mol_type protein organism Homo sapiens EVQLVETGGGLVPPGGSLRLSCAASGFTFTNYSMHWVRLAPGKRLEYISAISSDGGDPFYASSVKGRVAISRDNSKKTLYLQMGRLRPEDTAVYYCVSDAFDVWGQGTMVTVSS 5 AA PAT source 1..5 mol_type protein organism Homo sapiens NYSMH 17 AA PAT source 1..17 mol_type protein organism Homo sapiens AISSDGGDPFYASSVKG 5 AA PAT source 1..5 mol_type protein organism Homo sapiens DAFDV 336 DNA PAT source 1..336 mol_type other DNA note NG034 variable kappa chain (VK) sequence organism Homo sapiens CDS 1..336 protein_id 17 translation EIVLTQSPLSLSVTLGQPASISCRSSQSLLYSNGNTYLNWFQQRPGQSPRRLLYRVSNRDSGVPDRFSGSGSGTHFTLKISRVEAEDVGVYYCMQGTHWPRTFGQGTKVEIK gaaattgtgctgacccagtctccactctccctgtccgtcacccttggacagccggcctccatctcctgcaggtctagtcaaagcctcctatacagtaatggcaacacctacttgaattggtttcagcagaggccaggccaatctccaaggcgcctactttatagggtttctaaccgggactctggggtcccagacagattcagcggcagtgggtcaggcactcatttcacactgaaaattagtagggtggaggctgaggatgttggagtttattactgcatgcaaggtacacactggcctcgcacgttcggccaagggaccaaggtggagatcaaa 112 AA PAT source 1..112 mol_type protein organism Homo sapiens EIVLTQSPLSLSVTLGQPASISCRSSQSLLYSNGNTYLNWFQQRPGQSPRRLLYRVSNRDSGVPDRFSGSGSGTHFTLKISRVEAEDVGVYYCMQGTHWPRTFGQGTKVEIK 16 AA PAT source 1..16 mol_type protein organism Homo sapiens RSSQSLLYSNGNTYLN 7 AA PAT source 1..7 mol_type protein organism Homo sapiens RVSNRDS 9 AA PAT source 1..9 mol_type protein organism Homo sapiens MQGTHWPRT 7 AA PAT PEPTIDE 1..7 note minimal epitope recognized by antibody NG004 source 1..7 mol_type protein note minimal epitope recognized by NG004 organism synthetic construct INAALQE 15 AA PAT PEPTIDE 1..15 note Peptide 34: amino acods 133-147 of the Nogo-A d20plus region source 1..15 mol_type protein note Peptide 34 organism synthetic construct EEIKEPENINAALQE 15 AA PAT PEPTIDE 1..15 note Peptide 35: amino acids 137-151 of the Nogo-A d20plus region source 1..15 mol_type protein note Peptide 35 organism synthetic construct EPENINAALQETEAP 15 AA PAT PEPTIDE 1..15 note Peptide 36: amino acids 141-155 of the Nogo-A d20plus region source 1..15 mol_type protein note Peptide 36 organism synthetic construct INAALQETEAPYISI 15 AA PAT PEPTIDE 1..15 note Peptide 33: amino acids 129-143 of the Nogo-A d20plus region source 1..15 mol_type protein note Artificial Sequence organism synthetic construct SGIKEEIKEPENINA 15 AA PAT PEPTIDE 1..15 note Peptide 37: amino acids 145-159 of the Nogo-A d20plus region source 1..15 mol_type protein note Artificial Sequence organism synthetic construct LQETEAPYISIACDL 31 AA PAT PEPTIDE 1..31 note Consensus sequence of petides 33 to 37 PEPTIDE 13..19 note minimal epitope recognized by NG004 source 1..31 mol_type protein note Artificial Sequence organism synthetic construct SGIKEEIKEPENINAALQETEAPYISIACDL