WO PCT/CN2024/112677 2024-08-16 IEC240314PCT CN 202311037231.5 2023-08-16 AKESO BIOPHARMA CO., LTD. COMPOUND AND ANTIBODY-DRUG CONJUGATE COMPRISING SAME 16 8 AA PAT source 1..8 mol_type protein note HCDR1 organism synthetic construct GGSFSGYY 7 AA PAT source 1..7 mol_type protein note HCDR2 organism synthetic construct INHSGST 11 AA PAT source 1..11 mol_type protein note HCDR3 organism synthetic construct ARDKWTWYFDL 12 AA PAT source 1..12 mol_type protein note LCDR1 organism synthetic construct QSVLYSSSNRNY 000 9 AA PAT source 1..9 mol_type protein note LCDR3 organism synthetic construct QQYYSTPRT 117 AA PAT source 1..117 mol_type protein note Patritumab VH organism synthetic construct QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVETSKNQFSLKLSSVTAADTAVYYCARDKWTWYFDLWGRGTLVTVSS 351 DNA PAT source 1..351 mol_type other DNA note nucleic acid encoding Patritumab VH organism synthetic construct caggtgcagctgcagcagtggggcgccggactgctgaagccatccgagaccctgtctctgacatgtgccgtgtacggcggctccttttctggctactattggagctggatcaggcagccccctggcaagggactggagtggatcggcgagatcaaccacagcggctccaccaactataatccctctctgaagagccgggtgaccatcagcgtggagacatccaagaatcagttctccctgaagctgagctccgtgaccgcagcagacacagccgtgtactattgcgcccgggacaagtggacctggtactttgatctgtggggcagaggcaccctggtgacagtgtctagc 113 AA PAT source 1..113 mol_type protein note Patritumab VL organism synthetic construct DIEMTQSPDSLAVSLGERATINCRSSQSVLYSSSNRNYLAWYQQNPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPRTFGQGTKVEIK 339 DNA PAT source 1..339 mol_type other DNA note nucleic acid encoding Patritumab VL organism synthetic construct gacatcgagatgacccagtcccctgattctctggccgtgagcctgggagagagggcaacaatcaactgtagaagctcccagtccgtgctgtactctagctccaaccggaattacctggcctggtatcagcagaatccaggccagccccctaagctgctgatctattgggccagcaccagggagtccggagtgccagaccgcttctccggctctggcagcggcacagacttcaccctgacaatctctagcctgcaggccgaggacgtggccgtgtactattgccagcagtactatagcacccccaggacatttggccagggcaccaaggtggagatcaag 330 AA PAT source 1..330 mol_type protein note Patritumab CH organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 990 DNA PAT source 1..990 mol_type other DNA note nucleic acid encoding Patritumab CH organism synthetic construct gcctctacaaaggggcccagcgtgtttcctctggcccctagcagcaagtctacaagcggaggaacagcagctctgggctgcctggtgaaggactacttcccagagcccgtgaccgtgtcttggaactcaggagccctgaccagcggagtgcacacatttccagccgtgctgcagagcagcggactgtatagcctgagcagcgtggtgaccgtgccttcttctagcctgggcacccagacctacatctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagagggtggagcccaagtcttgcgacaagacccacacttgtcctccttgtccagccccagagctgctgggaggaccaagcgtgttcctgttccctcccaagcccaaggacaccctgatgatcagcaggaccccagaagtgacttgcgtggtggtggacgtgtctcacgaggaccccgaagtgaagttcaattggtacgtggacggcgtggaggtgcacaacgctaagaccaagcccagggaggagcagtacaacagcacctaccgggtggtgtccgtgctgacagtgctgcaccaggattggctgaacggcaaggagtacaagtgcaaggtgtccaataaggccctgccagcccctatcgagaagaccatcagcaaggccaagggccagcctagagagcctcaggtgtacaccctgcctccttctcgggaggagatgaccaagaaccaggtgtccctgacttgcctcgtgaagggcttctaccccagcgatattgccgtcgagtgggagtctaacggccagcccgagaacaactacaagaccacacctccagtgctggatagcgacggcagcttcttcctgtacagcaagctgaccgtggacaaaagccgctggcagcagggcaacgtgttttcttgcagcgtgatgcacgaagccctgcacaaccactacacccagaagagcctgagcctgtctccaggcaag 107 AA PAT source 1..107 mol_type protein note Patritumab CL organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 321 DNA PAT source 1..321 mol_type other DNA note nucleic acid encoding Patritumab CL organism synthetic construct cgtacggtggcagccccatctgtcttcatttttccccctagtgacgagcagctgaaatccggaacagcctctgtggtctgtctgctgaacaatttctaccctcgcgaagccaaggtgcagtggaaagtcgataacgctctgcagagtggcaattcacaggagagcgtgactgaacaggactccaaggattctacctatagtctgagctccactctgaccctgtccaaagcagattacgaaaagcacaaagtgtatgcctgtgaggtcacccaccaggggctgagttctccagtcaccaaatccttcaacagaggcgaatgt 5 AA PAT source 1..5 mol_type protein note repeat unit of a linker organism synthetic construct GGGGS 20 AA PAT source 1..20 mol_type protein note a linker organism synthetic construct GGGGSGGGGSGGGGSGGGGS