CN PF 241161PCT CN 202311825615.3 2023-12-27 JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD. JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD. MULTISPECIFIC ANTIBODY TARGETING HER3 AND TROP2 AND CONJUGATE THEREOF 58 127 AA PAT source 1..127 mol_type protein organism synthetic construct QVQLQESGGGSVQSGGSLRLSCAASGYTTSSVCMAWFRQAPGNEREGVAHITRDGRTMYADSVRGRFTISQDNAKNTLFLQMNSLKPEDTGMYYCAARVCEWRSTVQAPRSEAYQLWGRGTQVTVSS 127 AA PAT source 1..127 mol_type protein organism synthetic construct QVQLVESGGGSVQSGGSLRLSCAASGYTTSSVCMAWFRQAPGNEREGVAHITRDGRTMYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAARVCEWRSTVQAPRSEAYQLWGQGTLVTVSS 127 AA PAT source 1..127 mol_type protein organism synthetic construct QVQLVESGGGSVQSGGSLRLSCAASGYTTSSVCMAWFRQAPGNGLEGVAHITRDGRTMYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAARVCEWRSTVQAPRSEAYQLWGQGTLVTVSS 127 AA PAT source 1..127 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGYTTSSVCMAWFRQAPGKGLEGVAHITRDGRTMYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAARVCEWRSTVQAPRSEAYQLWGQGTLVTVSS 127 AA PAT source 1..127 mol_type protein organism synthetic construct QVQLVESGGGSVQSGGSLRLSCAASGYTTSSVCMAWFRQAPGKGLEGVAHITRDGRTMYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAARVCEWRSTVQAPRSEAYQLWGQGTLVTVSS 127 AA PAT source 1..127 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGYTTSSVCMAWFRQAPGNGLEGVAHITRDGRTMYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAARVCEWRSTVQAPRSEAYQLWGQGTLVTVSS 127 AA PAT source 1..127 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGYTTSSVCMAWFRQAPGNEREGVAHITRDGRTMYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAARVCEWRSTVQAPRSEAYQLWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct SVCMA 16 AA PAT source 1..16 mol_type protein organism synthetic construct HITRDGRTMYADSVRG 19 AA PAT source 1..19 mol_type protein organism synthetic construct RVCEWRSTVQAPRSEAYQL 10 AA PAT source 1..10 mol_type protein organism synthetic construct GYTTSSVCMA 9 AA PAT source 1..9 mol_type protein organism synthetic construct HITRDGRTM 19 AA PAT source 1..19 mol_type protein organism synthetic construct RVCEWRSTVQAPRSEAYQL 7 AA PAT source 1..7 mol_type protein organism synthetic construct GYTTSSV 5 AA PAT source 1..5 mol_type protein organism synthetic construct TRDGR 19 AA PAT source 1..19 mol_type protein organism synthetic construct RVCEWRSTVQAPRSEAYQL 8 AA PAT source 1..8 mol_type protein organism synthetic construct GYTTSSVC 7 AA PAT source 1..7 mol_type protein organism synthetic construct ITRDGRT 21 AA PAT source 1..21 mol_type protein organism synthetic construct AARVCEWRSTVQAPRSEAYQL 232 AA PAT source 1..232 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 121 AA PAT source 1..121 mol_type protein organism synthetic construct QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGMNWVKQAPGQGLKWMGWINTYTGEPTYTDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCARGGFGSSYWYFDVWGQGSLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct NYGMN 17 AA PAT source 1..17 mol_type protein organism synthetic construct WINTYTGEPTYTDDFKG 12 AA PAT source 1..12 mol_type protein organism synthetic construct GGFGSSYWYFDV 10 AA PAT source 1..10 mol_type protein organism synthetic construct GYTFTNYGMN 10 AA PAT source 1..10 mol_type protein organism synthetic construct WINTYTGEPT 12 AA PAT source 1..12 mol_type protein organism synthetic construct GGFGSSYWYFDV 7 AA PAT source 1..7 mol_type protein organism synthetic construct GYTFTNY 6 AA PAT source 1..6 mol_type protein organism synthetic construct NTYTGE 12 AA PAT source 1..12 mol_type protein organism synthetic construct GGFGSSYWYFDV 8 AA PAT source 1..8 mol_type protein organism synthetic construct GYTFTNYG 8 AA PAT source 1..8 mol_type protein organism synthetic construct INTYTGEP 14 AA PAT source 1..14 mol_type protein organism synthetic construct ARGGFGSSYWYFDV 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQLTQSPSSLSASVGDRVSITCKASQDVSIAVAWYQQKPGKAPKLLIYSASYRYTGVPDRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGAGTKVEIK 11 AA PAT source 1..11 mol_type protein organism synthetic construct KASQDVSIAVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct SASYRYT 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQHYITPLT 11 AA PAT source 1..11 mol_type protein organism synthetic construct KASQDVSIAVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct SASYRYT 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQHYITPLT 11 AA PAT source 1..11 mol_type protein organism synthetic construct KASQDVSIAVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct SASYRYT 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQHYITPLT 000 6 AA PAT source 1..6 mol_type protein organism synthetic construct QDVSIA 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQHYITPLT 330 AA PAT source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 451 AA PAT source 1..451 mol_type protein organism synthetic construct QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGMNWVKQAPGQGLKWMGWINTYTGEPTYTDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCARGGFGSSYWYFDVWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIQLTQSPSSLSASVGDRVSITCKASQDVSIAVAWYQQKPGKAPKLLIYSASYRYTGVPDRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGAGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 587 AA PAT source 1..587 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGYTTSSVCMAWFRQAPGNEREGVAHITRDGRTMYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAARVCEWRSTVQAPRSEAYQLWGQGTLVTVSSGAPGGGGGSQVQLQQSGSELKKPGASVKVSCKASGYTFTNYGMNWVKQAPGQGLKWMGWINTYTGEPTYTDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCARGGFGSSYWYFDVWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 336 AA PAT source 1..336 mol_type protein organism synthetic construct GSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQLFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS 398 AA PAT source 1..398 mol_type protein organism synthetic construct MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQLFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS 402 AA PAT source 1..402 mol_type protein organism synthetic construct MKFREPLLGGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLRRLPQLVGVHPPLQGSSHGAAAIGQPSGELRLRGVAPPPPLQNSSKPRSRAPSNLDAYSHPGPGPGPGSNLTSAPVPSTTTRSLTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQLFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 468 AA PAT source 1..468 mol_type protein organism synthetic construct MGWSLILLFLVAVATRVLSQVQLVESGGGLVKPGGSLRLSCAASGFTFSDYAMSWIRQAPGKGLEWVSTISDGGTYTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREWGDYDGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 236 AA PAT source 1..236 mol_type protein organism synthetic construct MDFQVQIISFLLISASVIMSRGDIQMTQSPSSLSASVGDRVTITCRASQEISGYLSWYQQKPGKAPKRLIYAASTLDSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQYDSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 29 DNA PAT source 1..29 mol_type other DNA organism synthetic construct cccaccggtcaggtgcagctgcaggagtc 28 DNA PAT source 1..28 mol_type other DNA organism synthetic construct cccggatcctgaggagacggtgacctgg