US UPN-22-9863.PCT US US 63/256,827 2021-10-18 The Trustees of The University of Pennsylvania COMPOSITIONS USEFUL IN TREATMENT OF CDKL5 DEFICIENCY DISORDER (CDD) 61 4634 DNA PAT misc_feature 1..4634 note vector genome repeat_region 1..130 note 5'ITR misc_feature 130..168 note AAV 2 seq upstream of 3'ITR regulatory 213..678 note promoter - hSynapsin regulatory_class promoter misc_feature 3596..4183 note WRPE regulatory 4201..4439 note polyA_signal - SV40 polyA regulatory_class polyA_signal_sequence misc_feature 4467..4505 note AAV2 seq upstream of 3'ITR repeat_region 4505..4634 note 3'ITR source 1..4634 mol_type other DNA organism synthetic construct CDS 699..3581 note hCDKL5_1 protein_id 2 translation MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttccttgtagttaatgattaacccgccatgctacttatctacgtagccatgctctaggaagatcctctagaactatagctagcatgcctgcagagggccctgcgtatgagtgcaagtgggttttaggaccaggatgaggcggggtgggggtgcctacctgacgaccgaccccgacccactggacaagcacccaacccccattccccaaattgcgcatcccctatcagagagggggaggggaaacaggatgcggcgaggcgcgtgcgcactgccagcttcagcaccgcggacagtgccttcgcccccgcctggcggcgcgcgccaccgccgcctcagcactgaaggcgcgctgacgtcactcgccggtcccccgcaaactccccttcccggccaccttggtcgcgtccgcgccgccgccggcccagccggaccgcaccacgcgaggcgcgagataggggggcacgggcgcgaccatctgcgctgcggcgccggcgactcagcgctgcctcagtctgcggtgggcagcggaggagtcgtgtcgtgcctgagagcgcagtcgaattcgccgccaccatgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctgagagcttatcgataatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaaatcatcgtcctttccttggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgcatcgataccgtcgatcgaggccgcttcgagcagacatgataagatacattgatgagtttggacaaaccacaactagaatgcagtgaaaaaaatgctttatttgtgaaatttgtgatgctattgctttatttgtaaccattataagctgcaataaacaagttaacaacaacaattgcattcattttatgtttcaggttcagggggagatgtgggaggttttttaaagcaagtaaaacctctacaaatgtggtaaaatcgataaggatcttcctagagcatggctacgtagataagtagcatggcgggttaatcattaactacaaggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 960 AA PAT REGION 1..960 note Synthetic Construct source 1..960 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL 4750 DNA PAT misc_feature 1..4750 note Vector Genome repeat_region 1..130 note 5'ITR misc_feature 130..168 note AAV2 seq usptream of 3'ITR regulatory 213..678 note promoter - hSynapsin regulatory_class promoter misc_feature 3590..3705 note miR183 misc_feature 3712..4299 note WRPE regulatory 4317..4555 note polyA_signal - SV40 polyA regulatory_class polyA_signal_sequence misc_feature 4583..4621 note AAV2 seq upstream of 3'ITR repeat_region 4621..4750 note 3'ITR source 1..4750 mol_type other DNA organism synthetic construct CDS 699..3581 note hCDKL5-1 protein_id 4 translation MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttccttgtagttaatgattaacccgccatgctacttatctacgtagccatgctctaggaagatcctctagaactatagctagcatgcctgcagagggccctgcgtatgagtgcaagtgggttttaggaccaggatgaggcggggtgggggtgcctacctgacgaccgaccccgacccactggacaagcacccaacccccattccccaaattgcgcatcccctatcagagagggggaggggaaacaggatgcggcgaggcgcgtgcgcactgccagcttcagcaccgcggacagtgccttcgcccccgcctggcggcgcgcgccaccgccgcctcagcactgaaggcgcgctgacgtcactcgccggtcccccgcaaactccccttcccggccaccttggtcgcgtccgcgccgccgccggcccagccggaccgcaccacgcgaggcgcgagataggggggcacgggcgcgaccatctgcgctgcggcgccggcgactcagcgctgcctcagtctgcggtgggcagcggaggagtcgtgtcgtgcctgagagcgcagtcgaattcgccgccaccatgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctgagagcttataccggtagtgaattctaccagtgccataggatagtgaattctaccagtgccatacacgtgagtgaattctaccagtgccatagcatgcagtgaattctaccagtgccataggtacccgataatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaaatcatcgtcctttccttggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgcatcgataccgtcgatcgaggccgcttcgagcagacatgataagatacattgatgagtttggacaaaccacaactagaatgcagtgaaaaaaatgctttatttgtgaaatttgtgatgctattgctttatttgtaaccattataagctgcaataaacaagttaacaacaacaattgcattcattttatgtttcaggttcagggggagatgtgggaggttttttaaagcaagtaaaacctctacaaatgtggtaaaatcgataaggatcttcctagagcatggctacgtagataagtagcatggcgggttaatcattaactacaaggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 960 AA PAT REGION 1..960 note Synthetic Construct source 1..960 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL 4757 DNA PAT misc_feature 1..4757 note Vector Genome repeat_region 1..130 note 5'ITR misc_feature 130..168 note AAV2 seq usptream of 3'ITR regulatory 213..678 note promoter - hSynapsin regulatory_class promoter misc_feature 690..695 note Kozak misc_feature 3719..4306 note WRPE regulatory 4324..4562 note polyA_signal - SV40 polyA regulatory_class polyA_signal_sequence misc_feature 4590..4628 note AAV2 seq usptream of 3'ITR repeat_region 4628..4757 note 3'ITR source 1..4757 mol_type other DNA organism synthetic construct misc_feature 696..3704 note nucleic acid sequence encoding hCDKL5-2GS ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttccttgtagttaatgattaacccgccatgctacttatctacgtagccatgctctaggaagatcctctagaactatagctagcatgcctgcagagggccctgcgtatgagtgcaagtgggttttaggaccaggatgaggcggggtgggggtgcctacctgacgaccgaccccgacccactggacaagcacccaacccccattccccaaattgcgcatcccctatcagagagggggaggggaaacaggatgcggcgaggcgcgtgcgcactgccagcttcagcaccgcggacagtgccttcgcccccgcctggcggcgcgcgccaccgccgcctcagcactgaaggcgcgctgacgtcactcgccggtcccccgcaaactccccttcccggccaccttggtcgcgtccgcgccgccgccggcccagccggaccgcaccacgcgaggcgcgagataggggggcacgggcgcgaccatctgcgctgcggcgccggcgactcagcgctgcctcagtctgcggtgggcagcggaggagtcgtgtcgtgcctgagagcgcagtcgaattcgccaccatgaagatccccaatatcggcaacgtgatgaataagttcgagatcctgggagtggtgggagagggagcatacggcgtggtgctgaagtgcagacacaaggagacacacgagatcgtggccatcaagaagtttaaggatagcgaggagaatgaggaggtgaaggagacaaccctgcgcgagctgaagatgctgcggacactgaagcaggagaacatcgtggagctgaaggaggccttccggagaaggggcaagctgtacctggtgtttgagtacgtggagaagaacatgctggagctgctggaggagatgcctaatggcgtgccccctgagaaggtgaagagctacatctatcagctgatcaaggccatccactggtgccacaagaacgacatcgtgcaccgcgatatcaagccagagaacctgctgatcagccacaatgacgtgctgaagctgtgcgatttcggctttgcccggaacctgtccgagggcaacaacgccaattacacagagtacgtggcaaccaggtggtaccggtcccctgagctgctgctgggagcaccatacggcaagtctgtggacatgtggagcgtgggctgcatcctgggagagctgtccgacggacagccactgttccctggcgagtctgagatcgatcagctgtttaccatccagaaggtgctgggccccctgccttccgagcagatgaagctgttctactctaacccaaggttccacggcctgaggtttccagccgtgaatcacccccagtctctggagcgccggtatctgggcatcctgaacagcgtgctgctggatctgatgaagaatctgctgaagctggaccctgccgatcgctacctgaccgagcagtgtctgaatcacccaacatttcagacccagagactgctggacaggagcccctcccgctctgccaagaggaagccttatcacgtggagagctccaccctgagcaatcgcaaccaggccggcaagtccacagccctgcagtctcaccaccggagcaactccaaggacatccagaatctgagcgtgggcctgccaagggcagacgagggcctgcctgccaacgagtccttcctgaatggaaacctggcaggagcctctctgagcccactgcacacaaagacctaccaggcctctagccagcctggctccacatctaaggacctgaccaacaataacatccctcacctgctgagcccaaaggaggccaagtccaagaccgagttcgactttaatatcgatccaaagcccagcgagggcccaggcacaaagtatctgaagagcaactccagatctcagcagaataggcactctttcatggagtcctctcagagcaaggccggcaccctgcagcccaacgagaagcagagcaggcactcctacatcgataccatcccacagagctcccgcagcccctcctatcggacaaaggccaagagccacggcgccctgtctgacagcaagtccgtgtctaatctgtccgaggcaagagcacagatcgcagagccaagcacctccaggtactttccctcttcctgtctggacctgaactctccaacaagccctacaccaaccagacacagcgatacaaggaccctgctgtctcccagcggcagaaataacaggaacgagggcaccctggatagcagaaggaccacaaccagacactccaagacaatggaggagctgaagctgcccgagcacatggactcctctcactcccactctctgagcgcccctcacgagtccttctcttacggcctgggctataccagcccttttagctcccagcagcgcccacacaggcactccatgtacgtgacaagagacaaggtgagggccaagggcctggacggcagcctgtccatcggacagggaatggcagcaagggcaaatagcctgcagctgctgtccccacagcctggagagcagctgccaccagagatgaccgtggccagatctagcgtgaaggagacaagcagggagggcacctcctctttccacacaagacagaagagcgagggcggcgtgtatcacgacccacactccgacgacggaaccgcacccaaggagaacaggcacctgtacaacgatccagtgccccgccgggtgggctctttctatcgggtgcctagcccacggcccgacaactcctttcacgagaataacgtgtctaccagagtgagctccctgcctagcgagtctagctccggcacaaaccactccaagaggcagccagcctttgatccctggaagtctcctgagaatatctctcacagcgagcagctgaaggagaaggagaagcagggcttctttcgcagcatgaagaagaagaagaagaagagccagacaaccgacagcaccaacggcgagaatcctagcatcaagaagtccctgttcccactgtttaactccaagaatcacctgaagcactctagctccctgaagaagctgcccgtggtgacacctccaatggtgcccaattccgactctcctgatctgctgaccctgcagaagagcatccacagcgcctccacaccatctagcagacccaaggagtggaggccagagaagatctccgatctgcagacccagtcccagcccctgaagtctctgcggaagctgctgcacctgtcctctgccagcaaccaccctgcaagctccgaccctaggttccagccactgacagcccagcagaccaagaactcttttagcgagatcagaatccacccactgtcccaggcctctggaggctctagcaacatccgccaggagcctgccccaaagggccggccagccctgcagctgccaggacagatggaccccggctggcacgtgtcctctgtgacaagatccgccaccgagggaccatcctactctgagcagctgggagcaaagtctggaccaaacggacacccttataacaggaccaatagatccaggatgcctaatctgaacgacctgaaggagacagccctgtgatagaagcttatcgataatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaaatcatcgtcctttccttggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgcatcgataccgtcgatcgaggccgcttcgagcagacatgataagatacattgatgagtttggacaaaccacaactagaatgcagtgaaaaaaatgctttatttgtgaaatttgtgatgctattgctttatttgtaaccattataagctgcaataaacaagttaacaacaacaattgcattcattttatgtttcaggttcagggggagatgtgggaggttttttaaagcaagtaaaacctctacaaatgtggtaaaatcgataaggatcttcctagagcatggctacgtagataagtagcatggcgggttaatcattaactacaaggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 1001 AA PAT REGION 1..1001 note Synthetic Construct note hCDKL5-2GS source 1..1001 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTTDSTNGENPSIKKSLFPLFNSKNHLKHSSSLKKLPVVTPPMVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL 4583 DNA PAT misc_feature 1..4583 note Vector Genome repeat_region 1..130 note 5'ITR misc_feature 130..168 note AAV2 seq upstream of 3'ITR regulatory 213..678 note promoter - hSynapsin regulatory_class promoter misc_feature 690..695 note Kozak misc_feature 3545..4132 note WRPE regulatory 4150..4388 note polyA_signal - SV40 polyA regulatory_class polyA_signal_sequence misc_feature 4416..4454 note AAV2 seq upstream of 3'ITR repeat_region 4454..4583 note 3'ITR source 1..4583 mol_type other DNA organism synthetic construct misc_feature 696..3530 note nucleic acid sequence encoding hCDKL5-3GS ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttccttgtagttaatgattaacccgccatgctacttatctacgtagccatgctctaggaagatcctctagaactatagctagcatgcctgcagagggccctgcgtatgagtgcaagtgggttttaggaccaggatgaggcggggtgggggtgcctacctgacgaccgaccccgacccactggacaagcacccaacccccattccccaaattgcgcatcccctatcagagagggggaggggaaacaggatgcggcgaggcgcgtgcgcactgccagcttcagcaccgcggacagtgccttcgcccccgcctggcggcgcgcgccaccgccgcctcagcactgaaggcgcgctgacgtcactcgccggtcccccgcaaactccccttcccggccaccttggtcgcgtccgcgccgccgccggcccagccggaccgcaccacgcgaggcgcgagataggggggcacgggcgcgaccatctgcgctgcggcgccggcgactcagcgctgcctcagtctgcggtgggcagcggaggagtcgtgtcgtgcctgagagcgcagtcgaattcgccaccatgaagatccccaatatcggcaacgtgatgaataagttcgagatcctgggagtggtgggagagggagcatacggagtggtgctgaagtgccggcacaaggagacacacgagatcgtggccatcaagaagtttaaggatagcgaggagaatgaggaggtgaaggagacaaccctgagggagctgaagatgctgcgcacactgaagcaggagaacatcgtggagctgaaggaggccttccggagaaggggcaagctgtacctggtgtttgagtacgtggagaagaacatgctggagctgctggaggagatgcctaatggcgtgccccctgagaaggtgaagagctacatctatcagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagggatatcaagccagagaacctgctgatcagccacaatgacgtgctgaagctgtgcgatttcggctttgcccgcaacctgtccgagggcaacaacgccaattacacagagtacgtggcaaccaggtggtaccggtccccagagctgctgctgggagcaccatacggcaagagcgtggacatgtggtccgtgggctgcatcctgggcgagctgtctgacggccagcctctgttcccaggcgagagcgagatcgatcagctgtttaccatccagaaggtgctgggccctctgccaagcgagcagatgaagctgttctactccaaccctaggttccacggcctgcgctttcccgccgtgaatcaccctcagagcctggagcgccggtatctgggcatcctgaactccgtgctgctggatctgatgaagaatctgctgaagctggaccccgccgataggtacctgaccgagcagtgtctgaaccaccccacattccagacccagagactgctggacaggtccccttctcgcaatcaggccggcaagtctacagccctgcagagccaccacaggagcaactccaaggacatccagaatctgagcgtgggcctgcctagggcagacgagggcctgccagcaaacgagtcctttctgaatggaaacctggcaggagcctctctgagcccactgcacacaaagacctaccaggccagctcccagccaggctccacatctaaggatctgaccaacaataacatcccacacctgctgtctcccaaggaggccaagagcaagaccgagttcgactttaatatcgatcccaagcctagcgagggcccaggcacaaagtatctgaagagcaactcccggagccagcagaatagacactccttcatggagtctagccagtctaaggccggcaccctgcagcccaacgagaagcagagccgccactcctacatcgataccatcccccagtcctctaggagcccttcctatcgcacaaaggccaagagccacggcgccctgtctgacagcaagtccgtgtctaatctgtccgaggcaagggcacagatcgcagagcccagcacctccagatactttcctagctcctgtctggacctgaactctccaacaagcccaacacccacccggcacagcgatacaagaaccctgctgtctcccagcggcagaaataacaggaacgagggcaccctggattctagaaggaccacaacccggcacagcaagacaatggaggagctgaagctgcccgagcacatggactctagccactcccactctctgagcgcccctcacgagtccttctcttacggcctgggctatacctccccattttcctctcaacagcgcccccaccggcactctatgtacgtgacacgggacaaggtgagagccaagggcctggacggcagcctgtccatcggacagggaatggcagcaagagcaaactccctgcagctgctgtctcctcagccaggagagcagctgccaccagagatgaccgtggcacggagctccgtgaaggagacaagcagagagggcacctctagcttccacacacggcagaagtccgagggcggcgtgtatcacgaccctcactctgacgacggcaccgccccaaaggagaacagacacctgtacaacgatccagtgcctaggagggtgggctccttctatcgggtgccatctccccgccctgacaatagctttcacgagaataacgtgtccacccgggtgtcctctctgccctctgagagctcctctggcacaaaccactctaagagacagcccgcctttgacccttggaagagcccagagaatatctctcacagcgagcagctgaaggagaaggagaagcagggcttctttaggagcatgaagaagaagaagaagaagagccagaccgtgcctaactccgactctcccgatctgctgaccctgcagaagagcatccacagcgcctccacaccaagctcccggcctaaggagtggcggcccgagaagatctccgatctgcagacccagagccagccactgaagtccctgcgcaagctgctgcacctgtctagcgccagcaaccaccctgcctcctctgacccaaggttccagcccctgacagcccagcagaccaagaactcttttagcgagatccgcatccacccactgtcccaagcctctggaggcagctccaacatcaggcaggagccagcaccaaagggccgccccgccctgcagctgcctggacagatggaccccggatggcacgtgtctagcgtgacacggtccgccaccgagggaccatcctactctgagcagctgggagcaaagagcggacctaacggacacccatataacagaaccaatagatccaggatgcctaatctgaacgacctgaaggagacagccctgtgatagaagcttatcgataatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaaatcatcgtcctttccttggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgcatcgataccgtcgatcgaggccgcttcgagcagacatgataagatacattgatgagtttggacaaaccacaactagaatgcagtgaaaaaaatgctttatttgtgaaatttgtgatgctattgctttatttgtaaccattataagctgcaataaacaagttaacaacaacaattgcattcattttatgtttcaggttcagggggagatgtgggaggttttttaaagcaagtaaaacctctacaaatgtggtaaaatcgataaggatcttcctagagcatggctacgtagataagtagcatggcgggttaatcattaactacaaggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 943 AA PAT REGION 1..943 note Synthetic Construct note hCDKL5-3GS source 1..943 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL 4706 DNA PAT misc_feature 1..4706 note Vector Genome repeat_region 1..130 note 5'ITR misc_feature 130..168 note AAV2 seq upstream of 3'ITR regulatory 213..678 note promoter - hSynapsin regulatory_class promoter misc_feature 690..695 note Kozak misc_feature 3668..4255 note WRPE regulatory 4273..4511 note polyA_signal - SV40 PolyA regulatory_class polyA_signal_sequence misc_feature 4539..4577 note AAV2 seq upstream of 3'ITR repeat_region 4577..4706 note 3'ITR source 1..4706 mol_type other DNA organism synthetic construct misc_feature 696..3653 note nucleic acid sequence encoding hCDKL5-4GS ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttccttgtagttaatgattaacccgccatgctacttatctacgtagccatgctctaggaagatcctctagaactatagctagcatgcctgcagagggccctgcgtatgagtgcaagtgggttttaggaccaggatgaggcggggtgggggtgcctacctgacgaccgaccccgacccactggacaagcacccaacccccattccccaaattgcgcatcccctatcagagagggggaggggaaacaggatgcggcgaggcgcgtgcgcactgccagcttcagcaccgcggacagtgccttcgcccccgcctggcggcgcgcgccaccgccgcctcagcactgaaggcgcgctgacgtcactcgccggtcccccgcaaactccccttcccggccaccttggtcgcgtccgcgccgccgccggcccagccggaccgcaccacgcgaggcgcgagataggggggcacgggcgcgaccatctgcgctgcggcgccggcgactcagcgctgcctcagtctgcggtgggcagcggaggagtcgtgtcgtgcctgagagcgcagtcgaattcgccaccatgaagatccccaatatcggcaacgtgatgaataagttcgagatcctgggagtggtgggagagggagcatacggagtggtgctgaagtgccggcacaaggagacacacgagatcgtggccatcaagaagtttaaggatagcgaggagaatgaggaggtgaaggagacaaccctgagggagctgaagatgctgcgcacactgaagcaggagaacatcgtggagctgaaggaggccttccggagaaggggcaagctgtacctggtgtttgagtacgtggagaagaacatgctggagctgctggaggagatgccaaatggcgtgccccctgagaaggtgaagtcctacatctatcagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagggatatcaagcccgagaacctgctgatctcccacaatgacgtgctgaagctgtgcgatttcggctttgcccgcaacctgagcgagggcaacaacgccaattacacagagtacgtggcaaccaggtggtaccggagccctgagctgctgctgggagcaccatacggcaagtctgtggacatgtggagcgtgggctgcatcctgggagagctgtccgacggacagccactgttccctggcgagtctgagatcgatcagctgtttaccatccagaaggtgctgggccccctgccttccgagcagatgaagctgttctactctaaccctaggttccacggcctgcgctttccagccgtgaatcacccccagtctctggagcgccggtatctgggcatcctgaacagcgtgctgctggatctgatgaagaatctgctgaagctggaccccgccgataggtacctgaccgagcagtgtctgaaccaccctacattccagacccagagactgctggacaggtccccatctcgcaatcaggccggcaagtccacagccctgcagtctcaccacaggagcaactccaaggacatccagaatctgtccgtgggcctgccaagggcagacgagggcctgcctgccaacgagagctttctgaatggaaacctggcaggagcctctctgagcccactgcacacaaagacctaccaggccagctcccagcctggctccacatctaaggacctgaccaacaataacatccctcacctgctgagcccaaaggaggccaagtccaagaccgagttcgactttaatatcgatccaaagccatccgagggaccaggaacaaagtatctgaagagcaactcccggagccagcagaatagacactctttcatggagtctagccagagcaaggccggcaccctgcagcctaacgagaagcagagccgccactcctacatcgataccatcccacagtcctctaggagcccctcctatcgcacaaaggccaagtcccacggcgccctgtctgacagcaagtccgtgtctaatctgagcgaggcaagggcacagatcgcagagccaagcacctccagatactttcccagctcctgtctggacctgaactctcccacaagccctacaccaacccggcacagcgatacaagaaccctgctgtctcctagcggcagaaataacaggaacgagggcaccctggatagcagaaggaccacaaccaggcactccaagacaatggaggagctgaagctgcctgagcacatggactctagccactcccactctctgagcgccccacacgagtccttctcttacggcctgggctataccagccctttttcctctcaacaacgcccacaccggcactccatgtacgtgacacgggacaaggtgagagccaagggcctggacggcagcctgtccatcggacagggaatggcagcaagggcaaatagcctgcagctgctgtccccacagcctggagagcagctgccaccagagatgaccgtggcacggagctccgtgaaggagacaagcagagagggcacctctagcttccacacacggcagaagagcgagggcggcgtgtatcacgacccacactccgacgacggaaccgcacctaaggagaacagacacctgtacaacgatccagtgccccgccgggtgggctctttctatcgggtgcctagcccacgccccgacaactcctttcacgagaataacgtgtctacccgggtgtcctctctgcccagcgagagctcctctggcacaaaccactccaagagacagccagcctttgatccctggaagtctcctgagaatatctctcacagcgagcagctgaaggagaaggagaagcagggcttctttcggtccatgaagaagaagaagaagaagagccagacaaccgacagcaccaacggcgagaatccaagcatcaagaagtccctgttccccctgtttaacagcaagaatcacctgaagcacagctcctctctgaagaagctgcccgtggtgacacctccaatggtgcccaattccgactctcctgatctgctgaccctgcagaagtccatccacagcgcctccacaccaagctcccggcccaaggagtggcggcccgagaagatcagcgatctgcagacccagtcccagcccctgaagtctctgagaaagctgctgcacctgtctagcgcctccaaccacccagcctcctctgaccctcggttccagccactgacagcccagcagaccaagaactcttttagcgagatccgcatccacccactgtcccaagcctctggaggcagctccaacatcaggcaggagcctgccccaaagggccgcccagccctgcagctgccaggacagatggaccccggctggcacgtgtctagcgtgacacggagcgccaccgagggaccttcctactctgagcagctgggagcaaagtctggaccaaacggacacccttataacagaaccaatagaagcaggatgccaaatctgaacgacctgaaggagacagccctgtgatagaagcttatcgataatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaaatcatcgtcctttccttggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgcatcgataccgtcgatcgaggccgcttcgagcagacatgataagatacattgatgagtttggacaaaccacaactagaatgcagtgaaaaaaatgctttatttgtgaaatttgtgatgctattgctttatttgtaaccattataagctgcaataaacaagttaacaacaacaattgcattcattttatgtttcaggttcagggggagatgtgggaggttttttaaagcaagtaaaacctctacaaatgtggtaaaatcgataaggatcttcctagagcatggctacgtagataagtagcatggcgggttaatcattaactacaaggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 984 AA PAT REGION 1..984 note Synthetic Construct note hCDKL5-4GS source 1..984 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTTDSTNGENPSIKKSLFPLFNSKNHLKHSSSLKKLPVVTPPMVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL 22 DNA PAT misc_feature 1..22 note targeting site source 1..22 mol_type other DNA organism synthetic construct agtgaattctaccagtgccata 23 DNA PAT misc_feature 1..23 note targeting site source 1..23 mol_type other DNA organism synthetic construct agcaaaaatgtgctagtgccaaa 24 DNA PAT misc_feature 1..24 note targeting sequence source 1..24 mol_type other DNA organism synthetic construct agtgtgagttctaccattgccaaa 23 DNA PAT misc_feature 1..23 note targeting sequence source 1..23 mol_type other DNA organism synthetic construct agggattcctgggaaaactggac 16 DNA PAT misc_feature 1..16 note spacer source 1..16 mol_type other DNA organism synthetic construct atgacttaaaccaggt 3430 DNA PAT misc_feature 1..3430 note transcript variant source 1..3430 mol_type other DNA organism synthetic construct gggggagttggaggaggaagaccctacaggaagttgagctgtactctccaacaggcgagcacatggtcgtctcctctctcccttcagggagtcatttaatacttcatgattagaacaaatatgtgaaagttcccaccaaccagtgagaatttcttccttcagacggttttggatcttactgcacagctttctgagaagttcttttggtgccatgttttgtggcttgcatcaaaagaggagtttgtcttcatgaagattcctaacattggtaatgtgatgaataaatttgagatccttggggttgtaggtgaaggagcctatggagttgtacttaaatgcagacacaaggaaacacatgaaattgtggcgatcaagaaattcaaggacagtgaagaaaatgaagaagtcaaagaaacgactttacgagagcttaaaatgcttcggactctcaagcaggaaaacattgtggagttgaaggaagcatttcgtcggaggggaaagttgtacttggtgtttgagtatgttgaaaaaaatatgctcgaattgctggaagaaatgccaaatggagttccacctgagaaagtaaaaagctacatctatcagctaatcaaggctattcactggtgccataagaatgatattgtccatcgagatataaaaccagaaaatctcttaatcagccacaatgatgtcctaaaactgtgtgactttggttttgctcgtaatctgtcagaaggcaataatgctaattacacagagtacgttgccaccagatggtatcggtccccagaactcttacttggcgctccctatggaaagtccgtggacatgtggtcggtgggctgtattcttggggagcttagcgatggacagcctttatttcctggagaaagtgaaattgaccaactttttactattcagaaggtgctaggaccacttccatctgagcagatgaagcttttctacagtaatcctcgcttccatgggctccggtttccagctgttaaccatcctcagtccttggaaagaagataccttggaattttgaatagtgttctacttgacctaatgaagaatttactgaagttggacccagctgacagatacttgacagaacagtgtttgaatcaccctacatttcaaacccagagacttctggatcgttctccttcaaggtcagcaaaaagaaaaccttaccatgtggaaagcagcacattgtctaatagaaaccaagccggcaaaagtactgctttgcagtctcaccacagatctaacagcaaggacatccagaacctgagtgtaggcctgccccgggctgacgaaggtctccctgccaatgaaagcttcctaaatggaaaccttgctggagctagtcttagtccactgcacaccaaaacctaccaagcaagcagccagcctgggtctaccagcaaagatctcaccaacaacaacataccacaccttcttagcccaaaagaagccaagtcaaaaacagagtttgattttaatattgacccaaagccttcagaaggcccagggacaaagtacctcaagtcaaacagcagatctcagcagaaccgccactcattcatggaaagctctcaaagcaaagctgggacactgcagcccaatgaaaagcagagtcggcatagctatattgacacaattccccagtcctctaggagtccctcctacaggaccaaggccaaaagccatggggcactgagtgactccaagtctgtgagcaacctttctgaagccagggcccaaattgcggagcccagtaccagtaggtacttcccatctagctgcttagacttgaattctcccaccagcccaacccccaccagacacagtgacacgagaactttgctcagcccttctggaagaaataaccgaaatgagggaacgctggactcacgtcgaaccacaaccagacattctaagacgatggaggaattgaagctgccggagcacatggacagtagccattcccattcactgtctgcacctcacgaatctttttcttatggactgggctacaccagccccttttcttcccagcaacgtcctcataggcattctatgtatgtgacccgtgacaaagtgagagccaagggcttggatggaagcttgagcatagggcaagggatggcagctagagccaacagcctgcaactcttgtcaccccagcctggagaacagctccctccagagatgactgtggcaagatcttcggtcaaagagacctccagagaaggcacctcttccttccatacacgccagaagtctgagggtggagtgtatcatgacccacactctgatgatggcacagcccccaaagaaaatagacacctatacaatgatcctgtgccaaggagagttggtagcttttacagagtgccatctccacgtccagacaattctttccatgaaaataatgtgtcaactagagtttcttctctaccatcagagagcagttctggaaccaaccactcaaaaagacaaccagcattcgatccatggaaaagtcctgaaaatattagtcattcagagcaactcaaggaaaaagagaagcaaggatttttcaggtcaatgaaaaagaaaaagaagaaatctcaaacagtacccaattccgacagccctgatcttctgacgttgcagaaatccattcattctgctagcactccaagcagcagaccaaaggagtggcgccccgagaagatctcagatctgcagacccaaagccagccattaaaatcactgcgcaagttgttacatctctcttcggcctcaaatcacccggcttcctcagatccccgcttccagcccttaacagctcaacaaaccaaaaattccttctcagaaattcggattcaccccctgagccaggcctctggcgggagcagcaacatccggcaggaacccgcaccgaagggcaggccagccctccagctgccagacggtggatgtgatggcagaagacagagacaccattctggaccccaagatagacgcttcatgttaaggacgacagaacaacaaggagaatacttctgctgtggtgacccaaagaagcctcacactccgtgcgtcccaaaccgagcccttcatcgtccaatctccagtcctgctccctatccagtactccaggtccgaggcacttccatgtgcccgacactccaggtccgaggcactgatgctttcagctgcccaacccagcaatccgggttctctttcttcgtgagacacgttatgagggaagccctgattcacagggcccaggtaaaccaagctgcgctcctgacataccatgagaatgcggcactgacgggcaagtgacttctgcaagcctgcggctggtcccaatgccctgaatcacctctctcatggaagaaccaattaacaccaatgaatcaaccattaaaaa 14572 DNA PAT misc_feature 1..14572 note transcript variant source 1..14572 mol_type other DNA organism synthetic construct agttgtctctgccgctggggaaggtaaagcggcgacggcgtcctcaggagctgtggggtcccctgctagaagtgggggactcggcgggggagtcatttaatacttcatgattagaacaaatatgtgaaagttcccaccaaccagtgagaatttcttccttcagacggttttggatcttactgcacagctttctgagaagttcttttggtgccatgttttgtggcttgcatcaaaagaggagtttgtcttcatgaagattcctaacattggtaatgtgatgaataaatttgagatccttggggttgtaggtgaaggagcctatggagttgtacttaaatgcagacacaaggaaacacatgaaattgtggcgatcaagaaattcaaggacagtgaagaaaatgaagaagtcaaagaaacgactttacgagagcttaaaatgcttcggactctcaagcaggaaaacattgtggagttgaaggaagcatttcgtcggaggggaaagttgtacttggtgtttgagtatgttgaaaaaaatatgctcgaattgctggaagaaatgccaaatggagttccacctgagaaagtaaaaagctacatctatcagctaatcaaggctattcactggtgccataagaatgatattgtccatcgagatataaaaccagaaaatctcttaatcagccacaatgatgtcctaaaactgtgtgactttggttttgctcgtaatctgtcagaaggcaataatgctaattacacagagtacgttgccaccagatggtatcggtccccagaactcttacttggcgctccctatggaaagtccgtggacatgtggtcggtgggctgtattcttggggagcttagcgatggacagcctttatttcctggagaaagtgaaattgaccaactttttactattcagaaggtgctaggaccacttccatctgagcagatgaagcttttctacagtaatcctcgcttccatgggctccggtttccagctgttaaccatcctcagtccttggaaagaagataccttggaattttgaatagtgttctacttgacctaatgaagaatttactgaagttggacccagctgacagatacttgacagaacagtgtttgaatcaccctacatttcaaacccagagacttctggatcgttctccttcaaggtcagcaaaaagaaaaccttaccatgtggaaagcagcacattgtctaatagaaaccaagccggcaaaagtactgctttgcagtctcaccacagatctaacagcaaggacatccagaacctgagtgtaggcctgccccgggctgacgaaggtctccctgccaatgaaagcttcctaaatggaaaccttgctggagctagtcttagtccactgcacaccaaaacctaccaagcaagcagccagcctgggtctaccagcaaagatctcaccaacaacaacataccacaccttcttagcccaaaagaagccaagtcaaaaacagagtttgattttaatattgacccaaagccttcagaaggcccagggacaaagtacctcaagtcaaacagcagatctcagcagaaccgccactcattcatggaaagctctcaaagcaaagctgggacactgcagcccaatgaaaagcagagtcggcatagctatattgacacaattccccagtcctctaggagtccctcctacaggaccaaggccaaaagccatggggcactgagtgactccaagtctgtgagcaacctttctgaagccagggcccaaattgcggagcccagtaccagtaggtacttcccatctagctgcttagacttgaattctcccaccagcccaacccccaccagacacagtgacacgagaactttgctcagcccttctggaagaaataaccgaaatgagggaacgctggactcacgtcgaaccacaaccagacattctaagacgatggaggaattgaagctgccggagcacatggacagtagccattcccattcactgtctgcacctcacgaatctttttcttatggactgggctacaccagccccttttcttcccagcaacgtcctcataggcattctatgtatgtgacccgtgacaaagtgagagccaagggcttggatggaagcttgagcatagggcaagggatggcagctagagccaacagcctgcaactcttgtcaccccagcctggagaacagctccctccagagatgactgtggcaagatcttcggtcaaagagacctccagagaaggcacctcttccttccatacacgccagaagtctgagggtggagtgtatcatgacccacactctgatgatggcacagcccccaaagaaaatagacacctatacaatgatcctgtgccaaggagagttggtagcttttacagagtgccatctccacgtccagacaattctttccatgaaaataatgtgtcaactagagtttcttctctaccatcagagagcagttctggaaccaaccactcaaaaagacaaccagcattcgatccatggaaaagtcctgaaaatattagtcattcagagcaactcaaggaaaaagagaagcaaggatttttcaggtcaatgaaaaagaaaaagaagaaatctcaaacagtacccaattccgacagccctgatcttctgacgttgcagaaatccattcattctgctagcactccaagcagcagaccaaaggagtggcgccccgagaagatctcagatctgcagacccaaagccagccattaaaatcactgcgcaagttgttacatctctcttcggcctcaaatcacccggcttcctcagatccccgcttccagcccttaacagctcaacaaaccaaaaattccttctcagaaattcggattcaccccctgagccaggcctctggcgggagcagcaacatccggcaggaacccgcaccgaagggcaggccagccctccagctgccaggtcagatggatcctggttggcatgtgtcctctgtgaccaggagtgccacagagggcccttcctactctgaacagctgggtgccaaaagtgggccaaatgggcacccctataacagaacaaatcgctcacgaatgccaaatctgaatgatttaaaagagacagccttgtaatttgtgctggtaggggggaggggtggacagacaagccagtggggaggggtgggaaagggtgggctgggcttggggcatgggccgggccaagtggtgagccaatattttcagctttatgaaggtgtgtgcaatattgcatgtgttggggccgttgagctcctcgcggccacaaatgctagtcagggatcttagagccacaggagttccttagggatcgccactccccacaggtcttgtgtgagaatagatagagtgtgccattgaggaagaagaaattcttgccagtttctcccctttacattccagctttagtgcaatctctgttgaacttgggaatgccaggatgtgtcctggcactgcaagggataggaaagtcgtgttgaccgatgcccttactacatatttttttctgcctagagtaaatgtggggtttattgtaatccaagagtatccctttgaagggttagcagatgaactgtatgtcttaaattgttttctaaacttccatatttgataggatttgtaacatttatttataattaatattgtactgttaaaatcatatcttttatgttataatgtaaagttattttgagctgtttgaaacattgtgaagcagtgggacagctacagtagtttctataaaaactaaacagtaacatttatatattgcatcaggagtattttattctatatataatatatatatatggtaaatatctgttttataaatatattcatttaaagaaagtatcgttatgacactatctgccatatttttatacatttgtgatatgaagtgagtattatacttctactaaagggagttgaattgtggctacacgtgactgtaacagtatgaaccttgctcaactttgaggccccagcagtagcctctagacatgatccttggtagcagacgagatgcagcatctctttccaaacctgcaggggaagaaagtcagataggccagtgagaattccagcaggcctggtttccgtcctcacacacttggctcctgtttgtgtccagggacgttacttgcacacaggggagaatagattgaggcgttactcgtgggtctttgtagagagaatgtgctcttccacttagcattagtgtagagcgtagaccaaagatttgccagtgaacattccttgttgtgagatcataagaggtacctgtctgcagatcttgcaaaccatctctatgctcctgaatattgtccactgtcccggagactcttggctgatggggtgtgagatatatgtgtggcatttctatttctgaatgccttttttgctattgctctctccaataccatatttaaaaggctcctggagcaattccagatagataaaaaattactctatccatttttttcttcctggggctgtccacttatgacaagattttcatgcacacctgttacgcacacaacccccatcagaacaggacctatcttcccctcatctgatctctttcagctcccaagttactcccaagtatcatcaaaccctttggccatcaagtgttatcctcccatgcctctgggtcatccttgagggaagtcacctcagcaccatcatctatcagtagtagtagatttttggaattagtctctgagcaataatacttttaaaggtccctcccacccctcaaagagataacttctcagtatttattacttgtcctcaaattctgagtgtcagcccctgcatcaagtcagctatgatcaaaatgtgctgttactgttaaccctcccccgagattttgagaatcatagctctgatgattatgaagattataaagactaaggtcctagtttccctgaagcttaaattgtgcacatattgcatttttatataaatactataatgtgtattgattatatagataggtcattttaaggtgctttttatttaattttaatgagtgtaataggcactaaaatgaaactcgactgggtactattactgaaaaaatttgactcaaaccaatagttttgcatgctctttagttctttttctgtcttacttctttcaccagttcagtactgtttgggtagctctgaattctggcttttccaggcagctgcttgatgatacaaatgaggtggaccatcagcagttttgcctggacactaatgactctaaaagggtgtgtatttaactcttctttttcatactagatctctaccttgtattccccccttgcaaaccagaaactacactttttttctctggaaagacttctcactgtgctatgcgcttaggaactgcacggtcccgttgccatgctgtggcattcgaggctcgtcacctaggggctggtttcccatgttgtcatccttgctaacactgggatctcagatgtttgcagaacatttctattcatgacggttcttcaaagaagggctagaatatttgccttctacctagagcaaagtaaacctaattgttgaagagtcaatacgtactttttgtactttcccagatttgagccagaaaatacctacagatatctacaaatgttttcaaccagtgttttcgaggtagctctttaatcctcttctcagcttttgtctgttctgacttttcatccaataagctgtaagtgaactacaatctgcatttccagcatgcaattctcttcctgctcacggagggggatgcaaaagttttctctcacacctaatgggccctctcttagcttttaactgttgttttcccctgttgatgaaaaattactgacatcacaaagattgccatccatggtagaaaggacttgatttaaagtcagaaaaatttgccttttctttaggaaggggaattcatgacatccatgtcctattatcggccgtaacttcctaaagaagaaaaagggtgaatgaaagcttatgttacttttatgaaagtatcactgatctcctttggaaaagaaactctgcttcactgtttttctacctttatttctctgccatcctcgtttttcctctctgaagttctaaataccctttaactgaaccttgttggtcttgctctaaaatttagcctctttctagagcccaagaccaaaagggagtgcttcatgctgaggggctcaagtgagctgactctacaactgtggttctcaactaggggcagatttacccccaagggtacatttggcaatgtctggggacatttggttgtcatagctgggggggaggtgatggtatgctactggcatcaagtggttagaggccacagatgctactaaacaccctgccatgcacaggacagccccccaaacaaacagtggtccagccccaagcactactagtgctgaggttgagaaaccctgccctacaccatcccaagcccaccagtctgcagagcttggctctggccttgttctgtccaggctacagtactgcaggtgtgatttcttcaacatcacattctcttaagagtcttcaaccactatgcctgaatccttggaatcctattgttcgtttccattgtcttgggcctgctaaaaggtgcatactttggaaggagaccagagttactttataggtgttggagaacttaaattctaggttagcatccttagaaaatctttcatagagccatgaggcttatatttagaagcaagcaacagcctggcagattggcatgatttttaccaactgctcaaaggcatccgtggctttcagctgtgtctcccgaaagaaaatgtctttgttttttattcaagtcatttaatagctctttacaaatattagcatatggcagaccaattagaagcaaaaaagtccgtattggtggttgtgatgtggctgttatagaagtatttgtgctgtatgctttggttaaatctgttttaaaacatgctttaagattcaccttacgcagttgtactttaattctaagctcagagctatgctgtcagtctctagtcacgccatgtattataaagtatgttgtggttgtagagttagccagtttagcatgttcctaatctgagaattagtggactatactaggaaatgctatcccattttccctttccagcccctcttagttaagatcatagtatcctcacttcttaaactagtctttagagtaaataaggaaaaaagccatttattttcttctagccatgtattattgagaatgactcatagtacaactttttttcaaaggccagaggattactttgcaagtgtgtagaaagatctgtctatttctgttcacctgggacctggtggtgactgaactctttcagcaagggcaatggctcaatgtgattcggtgctggagctcagctgggactcagtaaatctgcacgttctctgctggtcagaacatgtttcctggagagcattgcttttctatctagaagttcgttacctcctgcatgatagtgggatattgagatgtgggttctaagatccacagactcatacttttgtgaactttggaatgtggtagggtacactgaaccaagtcagaaaatagtgaaatatttccttgcctccttcagttcatcactaagaaagtgtgtaggcagagaaaacttacttatggtttgaagaaccacaattgtttttgaaaggggacatagaaaagacagtacaaaggttgtaagtgtcctgtcgctaattcccagggccagaatctcacaagaagatcctctcaaagacttaaaagcctggcttacaaaaataaccagaaaccaaacttgtaagcagttacaatttcttccttttgcttcttgaccagctgagatacagaatatcttgaggtctggttcagctgatgaaaaattctgtctcagaaacgatgagtaagaaaccatacaagaaaaagaagtccctcatctatctgcatacacgcaatgtgggagaagtggggtggctaggaaactctgggcctgctgcccccttcgattctttttttttttctttgtgaattgaatgtacgatacaaatggtaggccttcatgtgagccagttactacatgaatcttcatttcccacagtggtttgttcattcatcagcgttaggcttggtcctggctccacctttctcctctccgggcactgaccccacctttccgtgtatttactgtaggctattaaatatgatcatgacccgccttgcattttcattcatcacctgtttatgcccaaatttaaaggaagtttgtctcattttgccagaaaaaaattgtaatagtcggcacgctggatttgtagggccagcaaaattgcggcagtgaaactagtttcacttctaaagcccttcatttcccacaaggttaagctctcgaaaccccatttgatccttggttcctatttcgatcctcctttggaatctgaaaatcggtctccatgttgtatgcagattagaagttgccttgtttgttactcttccaacacagggtatcagggagaaagaggccttatctgttcctccatcccccctgttttgacagactgctaagaattcctcaggacttcctttggttggggattttactttcccaaaagtctgatctgatttctttcaggggtagacaagcttgtcctagtgctctgcttcaggtcttatcagaagaaacccaggaatagaaaaggtagatgccttgacttttgtccctgttgtggggactaaagtgttttttgccagaattgtcaaaagctccggttcaaactctgtagagtttcatggaaaaacaaaacaaaacaaaaaagatgcttatcgtcccggagaatgtgtaagtaagttctccagcacggcttaggttttccaaaatggaaagcaaagcttgcagacaacctgttttctctagagacacacaatgattctggccctcagtctgtttccctccccttgtttactctttggtcaccgatcgagtcaggctagaggggtaatacggtgattaaaagaagtaaattctcactgtaaacttggattgattaacagaaacaattaaaccaaacaaaatcattgccccaaatttctatctccaagaattgctttgtgccattttgaattcaggtagttattctgtatatacttagctaactattcagagcttcttcaatctctagtaagcttgaaggtggtgtctgggaagacacagggcagggtgacatttagactctgttcattcttaaaaatagggataagccagaatgatgtgacatctagtatgtggtagatgaagaatcagtggaaattcttaattgcacagactttataatccattatataaagtgtaattccatactttttactgtggcaagggtgtgatgtgattgttaatctttttaatttttgaatccaaactgaatttaaagtgttgaatacttaaatcctcacaagtgaattatgaaccatttgtaaagtgtttctataactctttgtatcatgtgttggtacatcttatcaagttttttctggcatgtaattccattctaaacttatgtaaaatttctattgttgctgtaaatattacacaaatatctattccgtgataaccttcattatcagcatgaaatggttaatttttactgagcacaatgtatttttgaatggatcttcccaaatgtctttaataaaatgcagattttgcactgactgatgtgactgccaggccgtcccaatcttgagcactgtggtccttcgtgtttgaactgcgaacagctccattttagttccttcttgggaagaaagaatgcattcgaattcaaatgagggatgatgggcctttgaggttgtaatcagtttgagacagaaattaatgtaaaactaggcaaatcctgtaacttaatgatgttgatctttgttttcctatttataaagcttttttccccttacggcattttgaaaactttggtttgttttatacttgagtgttgtcacctttgcacgtcgctagacactcacgtggtagtttgaggaggatgggaagagaggccaatcttgtgctaagtgctatggagaaagcaaagatgcacagcttaataagggttttttgattctagaggagaggtgggcaagcttttcctgtaaagggccagatggtaaatattgggggctctgtggcccatcagttccctgtcaacattactcagctctgcctttgtattgcagaggctgcatggataatatgtaaatcagtaagtgtggctgtggtcccgtaaaactttacttatagaaacaggccatagtttactaacccgttttaggccctcagtttcatcatttagggtaacaccaaccgagtacatgttcaatcaggagggaaagaacttagcttttgtgataacttatagatgaaatattccccagttttctttctctttctaaacaaagggtaggagctgaaagtcagtgctctccattcttaaaagtcctctgtcaaccacctcttcactctatctccttaagtgacatggaaacttgtggcctgtgctttcaactataatcttaccaagactgaatgaaagtatttggtgcttatactttttaatgttcatagcacttactatggccaggcacaatgcccaagtgttttgctttattattattattattattattattattattattattattattattttcacaacaacccagcgaaacaggtactattattatcccctttttgtaaatgaggaaacagatttccatacttgacattaacctgcccaaggtcacccagtttggaagtggcagggccaggatttgaagccgaatatgttcattgtaaagcccatatacccttaaaagtcactgcacgtccacgtatggtaatgtggtcacaatcagtattgtttctctttagtaattcagatttattcaagtaactccaaggttcaaattttcaaaaacagtttccaacacaggttatattaaaaactttgcctgaagtttactctaggtgcagaaataaagacaacttagtcaagtgaaggaaagggtaacagacttagaaatggctatctacactgatggaataagtatactaattagagcaggtaacaagtccccacgatgtataacatattcttctctaaaagctcacaacaatttatgtgccaccttccatcccctttcccagcagatggtaattgatgcaatttgagaatagaacacttcattgaaacaagtcactggaggtcctctggggatgcagcttaaaagcccaggatcaggccaggtgtggtggctcacgcctgtaatcccagcactgtgggagactgagacgggcagatcacctgaagtcaggagttcgagaccagcctggccaatatagagaaaccccgtctgtactaaaaatacaaaaattaggtctgggcggtggctcacgcccgtaatcctagcactttgggaggccaaggtgggtggatcacgaggtcaggagttcgagaccagcctggccaacatggtgaaaccccgtctctactaaaaatacaaaaattgggtgtggtggtacatgcctgtaatcccagctgcttaggaggctgaggcaggagaatcacttgaacccaaaaggcagaggttgcagtgagccgagatcacgccactgcactccagcctggcaacagagcgagactctgtctcaaaaaaaaaaaaaaaaaaatacaaaaattagccgggaatggtggtgaatgtctataatcccagccactcgggaggctgaggcaggagaatcacttgaacccaaaaggcagaggttgcagtgagccaagatcgcaccactgcactcccacctggacgacagagcgagacgccatctcaaaaataaataaataaataaatccctaggatatagagtccgcttgcctgggtggagtcttggctccatctcctacatctcatgtgacttgaagcaaggcacttcactatgcctcagtttccttatctttaaatggaggtaatcacagtacctacctcagtgttgttgtgaagatttaatgagataataacctgcagagcacttgagagtctcaagaaatatgagctcttataacattattgctattgtaaaacattgctattacttctgtcccaatttggcagtttcaggaaattgagaaggaatgtcactgaatctttaatgccagttacacagagctcagtaggtgtccgcacagccctttagatgcacgtagcctatttgatcttcgtatcagccctgtaaggttgggcttaagaatgacccagcatggaagtactcttgggaccacaggggaagcaacagtccttgtaagctgtttgtcagtgggccttagcaaccaagccccaagtggacagaaagatggggttctgtgagcatccattccaagggtcactttaggggtgcaatcttctgggctctgagaatggattcacagcagcatctctatctggaaatacctttgctttgtccaagtaacctcctcccacacagagtacccgaatcagctcagattttttttccttaatattggcaacacttaatgctacttctttgttcgtaacatttcatttaattatttaaaaatctgcaaatgttgtgtatattttaccgcaatttttaaacaaactccagtgtagaccgtgctctagcatttctaaaaataaaagtaaatatgttaaaataaggtaagagtgagtttttcctacactatgtataatttttaattgaaagtttcccccacaaaagaaatgatacttggaagcatagtttgtgtgtttgacagcaagattctattaggcttcagatttccctcaataaaagttttagtttttatacattctgtcatgaattgaatgaagtaaataatatgctgttgtaagcaaattatctgcagataaatgtcttatgaatcgtatatcttactgtttattaaattctgaagtattgagcagtttccaatgtgaaatcccagctggcttctttgcaatgatggacaagttagttataattcatatggaaattcaaggaacccagaatagccaaaacaatcccgaagagcaaagttggaggactcacatgccccaatttcaaaacttactacaaagctacaataatgaagaaagtgaggtaatagaatttggagtccagaaataaaccctctcacatttatggtcaattgttttttgacaagggtgccaagatcattcaatgggggaaagaatagtcttttcagcaaatagtggtgggacaactggatatccacatgcaaaagaatgacgttggactcctatttcacaccatatacaaaaattaactcaaaatggaacaaagatctaactgtaagaggtagaactataaaactcatagaagaaaacataggggtaaatcttcatgaccttggatttggcagtggtttctcagatatgacaccaaaggcacaagcaaagagaaaaataaattggacttcatcaaatatttaaaattttgtgcttaagaggactctatcgagagggttaaaaagatccacagaatgggagaaaatatttgcaaatcatatccaataagggaattagaatatacaaagaattcttaaactcagtaagttgtaagccgatttaaaatgggcagaggatctgaaaaacctttatccaaagatgtacaaatggccagtaaacacatgaaaagatgctcaacatcattagtcactagggaaatgcaaatcaaaaccacagttgagatgcaacttcacacattatgggtatagtcaaagatggacagtaacaagtgttgctgaggatgtggagaaagtggaagcctcctacattgctggtggaaatgtaaaatgatgcagccacttgggataatagttcctccaaagattaaacaagagtgactgtgtgtcccagcagttttactcctaagtatatacccaagataaatgaaaacacacatccgcacaaaaacttatacacaaatgttcatagcagcattattcataatagctaaagagtggaaacccaaatatccatcaatggatgaatggataaataacaatgtgctcttgacatgatactgaacaatgatgttcagcaataaaaaggagtgacaagtgacatagtgatacacatgttataacgtggatgaactttaaaacactatgctaagtgaaagaagccagtcacgaaataccacatactatatgatttcatttatgtagaacgtccagaaggccaatctacagagacagtcgattcgtggttgcagagggcttggggtggccgatgggttggggagtgttggctgatgggtgcaggatttctctttggggtgataaactttctaaaattgatctagtgataatggttgcacaactctgaatataccaaaagtcatcaaattgtacactttaaatggatacaaattgtatgtgaacttaatctcaataaagccgtgacaaaagtttccaacatgaa 3434 DNA PAT misc_feature 1..3434 note transcript variant source 1..3434 mol_type other DNA organism synthetic construct attagttgtctctgccgctggggaaggtaaagcggcgacggcgtcctcaggagctgtggggtcccctgctagaagtgggggactcggcgggggagtcatttaatacttcatgattagaacaaatatgtgaaagttcccaccaaccagtgagaatttcttccttcagacggttttggatcttactgcacagctttctgagaagttcttttggtgccatgttttgtggcttgcatcaaaagaggagtttgtcttcatgaagattcctaacattggtaatgtgatgaataaatttgagatccttggggttgtaggtgaaggagcctatggagttgtacttaaatgcagacacaaggaaacacatgaaattgtggcgatcaagaaattcaaggacagtgaagaaaatgaagaagtcaaagaaacgactttacgagagcttaaaatgcttcggactctcaagcaggaaaacattgtggagttgaaggaagcatttcgtcggaggggaaagttgtacttggtgtttgagtatgttgaaaaaaatatgctcgaattgctggaagaaatgccaaatggagttccacctgagaaagtaaaaagctacatctatcagctaatcaaggctattcactggtgccataagaatgatattgtccatcgagatataaaaccagaaaatctcttaatcagccacaatgatgtcctaaaactgtgtgactttggttttgctcgtaatctgtcagaaggcaataatgctaattacacagagtacgttgccaccagatggtatcggtccccagaactcttacttggcgctccctatggaaagtccgtggacatgtggtcggtgggctgtattcttggggagcttagcgatggacagcctttatttcctggagaaagtgaaattgaccaactttttactattcagaaggtgctaggaccacttccatctgagcagatgaagcttttctacagtaatcctcgcttccatgggctccggtttccagctgttaaccatcctcagtccttggaaagaagataccttggaattttgaatagtgttctacttgacctaatgaagaatttactgaagttggacccagctgacagatacttgacagaacagtgtttgaatcaccctacatttcaaacccagagacttctggatcgttctccttcaaggtcagcaaaaagaaaaccttaccatgtggaaagcagcacattgtctaatagaaaccaagccggcaaaagtactgctttgcagtctcaccacagatctaacagcaaggacatccagaacctgagtgtaggcctgccccgggctgacgaaggtctccctgccaatgaaagcttcctaaatggaaaccttgctggagctagtcttagtccactgcacaccaaaacctaccaagcaagcagccagcctgggtctaccagcaaagatctcaccaacaacaacataccacaccttcttagcccaaaagaagccaagtcaaaaacagagtttgattttaatattgacccaaagccttcagaaggcccagggacaaagtacctcaagtcaaacagcagatctcagcagaaccgccactcattcatggaaagctctcaaagcaaagctgggacactgcagcccaatgaaaagcagagtcggcatagctatattgacacaattccccagtcctctaggagtccctcctacaggaccaaggccaaaagccatggggcactgagtgactccaagtctgtgagcaacctttctgaagccagggcccaaattgcggagcccagtaccagtaggtacttcccatctagctgcttagacttgaattctcccaccagcccaacccccaccagacacagtgacacgagaactttgctcagcccttctggaagaaataaccgaaatgagggaacgctggactcacgtcgaaccacaaccagacattctaagacgatggaggaattgaagctgccggagcacatggacagtagccattcccattcactgtctgcacctcacgaatctttttcttatggactgggctacaccagccccttttcttcccagcaacgtcctcataggcattctatgtatgtgacccgtgacaaagtgagagccaagggcttggatggaagcttgagcatagggcaagggatggcagctagagccaacagcctgcaactcttgtcaccccagcctggagaacagctccctccagagatgactgtggcaagatcttcggtcaaagagacctccagagaaggcacctcttccttccatacacgccagaagtctgagggtggagtgtatcatgacccacactctgatgatggcacagcccccaaagaaaatagacacctatacaatgatcctgtgccaaggagagttggtagcttttacagagtgccatctccacgtccagacaattctttccatgaaaataatgtgtcaactagagtttcttctctaccatcagagagcagttctggaaccaaccactcaaaaagacaaccagcattcgatccatggaaaagtcctgaaaatattagtcattcagagcaactcaaggaaaaagagaagcaaggatttttcaggtcaatgaaaaagaaaaagaagaaatctcaaacagtacccaattccgacagccctgatcttctgacgttgcagaaatccattcattctgctagcactccaagcagcagaccaaaggagtggcgccccgagaagatctcagatctgcagacccaaagccagccattaaaatcactgcgcaagttgttacatctctcttcggcctcaaatcacccggcttcctcagatccccgcttccagcccttaacagctcaacaaaccaaaaattccttctcagaaattcggattcaccccctgagccaggcctctggcgggagcagcaacatccggcaggaacccgcaccgaagggcaggccagccctccagctgccagacggtggatgtgatggcagaagacagagacaccattctggaccccaagatagacgcttcatgttaaggacgacagaacaacaaggagaatacttctgctgtggtgacccaaagaagcctcacactccgtgcgtcccaaaccgagcccttcatcgtccaatctccagtcctgctccctatccagtactccaggtccgaggcacttccatgtgcccgacactccaggtccgaggcactgatgctttcagctgcccaacccagcaatccgggttctctttcttcgtgagacacgttatgagggaagccctgattcacagggcccaggtaaaccaagctgcgctcctgacataccatgagaatgcggcactgacgggcaagtgacttctgcaagcctgcggctggtcccaatgccctgaatcacctctctcatggaagaaccaattaacaccaatgaatcaaccattaaaaa 1030 AA PAT REGION 1..1030 note amino acid sequence source 1..1030 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISSPAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHENAALTGK 960 AA PAT REGION 1..960 note amino acid sequence source 1..960 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL 1030 AA PAT REGION 1..1030 note amino acid sequence source 1..1030 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISSPAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHENAALTGK 2883 DNA PAT misc_feature 1..2883 note nucleic acid sequence source 1..2883 mol_type other DNA organism synthetic construct atgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctga 466 DNA PAT misc_feature 1..466 note promoter source 1..466 mol_type other DNA organism synthetic construct ctgcagagggccctgcgtatgagtgcaagtgggttttaggaccaggatgaggcggggtgggggtgcctacctgacgaccgaccccgacccactggacaagcacccaacccccattccccaaattgcgcatcccctatcagagagggggaggggaaacaggatgcggcgaggcgcgtgcgcactgccagcttcagcaccgcggacagtgccttcgcccccgcctggcggcgcgcgccaccgccgcctcagcactgaaggcgcgctgacgtcactcgccggtcccccgcaaactccccttcccggccaccttggtcgcgtccgcgccgccgccggcccagccggaccgcaccacgcgaggcgcgagataggggggcacgggcgcgaccatctgcgctgcggcgccggcgactcagcgctgcctcagtctgcggtgggcagcggaggagtcgtgtcgtgcctgagagcg 3009 DNA PAT misc_feature 1..3009 note nucleic acid sequence source 1..3009 mol_type other DNA organism synthetic construct atgaagatccccaatatcggcaacgtgatgaataagttcgagatcctgggagtggtgggagagggagcatacggcgtggtgctgaagtgcagacacaaggagacacacgagatcgtggccatcaagaagtttaaggatagcgaggagaatgaggaggtgaaggagacaaccctgcgcgagctgaagatgctgcggacactgaagcaggagaacatcgtggagctgaaggaggccttccggagaaggggcaagctgtacctggtgtttgagtacgtggagaagaacatgctggagctgctggaggagatgcctaatggcgtgccccctgagaaggtgaagagctacatctatcagctgatcaaggccatccactggtgccacaagaacgacatcgtgcaccgcgatatcaagccagagaacctgctgatcagccacaatgacgtgctgaagctgtgcgatttcggctttgcccggaacctgtccgagggcaacaacgccaattacacagagtacgtggcaaccaggtggtaccggtcccctgagctgctgctgggagcaccatacggcaagtctgtggacatgtggagcgtgggctgcatcctgggagagctgtccgacggacagccactgttccctggcgagtctgagatcgatcagctgtttaccatccagaaggtgctgggccccctgccttccgagcagatgaagctgttctactctaacccaaggttccacggcctgaggtttccagccgtgaatcacccccagtctctggagcgccggtatctgggcatcctgaacagcgtgctgctggatctgatgaagaatctgctgaagctggaccctgccgatcgctacctgaccgagcagtgtctgaatcacccaacatttcagacccagagactgctggacaggagcccctcccgctctgccaagaggaagccttatcacgtggagagctccaccctgagcaatcgcaaccaggccggcaagtccacagccctgcagtctcaccaccggagcaactccaaggacatccagaatctgagcgtgggcctgccaagggcagacgagggcctgcctgccaacgagtccttcctgaatggaaacctggcaggagcctctctgagcccactgcacacaaagacctaccaggcctctagccagcctggctccacatctaaggacctgaccaacaataacatccctcacctgctgagcccaaaggaggccaagtccaagaccgagttcgactttaatatcgatccaaagcccagcgagggcccaggcacaaagtatctgaagagcaactccagatctcagcagaataggcactctttcatggagtcctctcagagcaaggccggcaccctgcagcccaacgagaagcagagcaggcactcctacatcgataccatcccacagagctcccgcagcccctcctatcggacaaaggccaagagccacggcgccctgtctgacagcaagtccgtgtctaatctgtccgaggcaagagcacagatcgcagagccaagcacctccaggtactttccctcttcctgtctggacctgaactctccaacaagccctacaccaaccagacacagcgatacaaggaccctgctgtctcccagcggcagaaataacaggaacgagggcaccctggatagcagaaggaccacaaccagacactccaagacaatggaggagctgaagctgcccgagcacatggactcctctcactcccactctctgagcgcccctcacgagtccttctcttacggcctgggctataccagcccttttagctcccagcagcgcccacacaggcactccatgtacgtgacaagagacaaggtgagggccaagggcctggacggcagcctgtccatcggacagggaatggcagcaagggcaaatagcctgcagctgctgtccccacagcctggagagcagctgccaccagagatgaccgtggccagatctagcgtgaaggagacaagcagggagggcacctcctctttccacacaagacagaagagcgagggcggcgtgtatcacgacccacactccgacgacggaaccgcacccaaggagaacaggcacctgtacaacgatccagtgccccgccgggtgggctctttctatcgggtgcctagcccacggcccgacaactcctttcacgagaataacgtgtctaccagagtgagctccctgcctagcgagtctagctccggcacaaaccactccaagaggcagccagcctttgatccctggaagtctcctgagaatatctctcacagcgagcagctgaaggagaaggagaagcagggcttctttcgcagcatgaagaagaagaagaagaagagccagacaaccgacagcaccaacggcgagaatcctagcatcaagaagtccctgttcccactgtttaactccaagaatcacctgaagcactctagctccctgaagaagctgcccgtggtgacacctccaatggtgcccaattccgactctcctgatctgctgaccctgcagaagagcatccacagcgcctccacaccatctagcagacccaaggagtggaggccagagaagatctccgatctgcagacccagtcccagcccctgaagtctctgcggaagctgctgcacctgtcctctgccagcaaccaccctgcaagctccgaccctaggttccagccactgacagcccagcagaccaagaactcttttagcgagatcagaatccacccactgtcccaggcctctggaggctctagcaacatccgccaggagcctgccccaaagggccggccagccctgcagctgccaggacagatggaccccggctggcacgtgtcctctgtgacaagatccgccaccgagggaccatcctactctgagcagctgggagcaaagtctggaccaaacggacacccttataacaggaccaatagatccaggatgcctaatctgaacgacctgaaggagacagccctgtgatag 2835 DNA PAT misc_feature 1..2835 note nucleic acid sequence source 1..2835 mol_type other DNA organism synthetic construct atgaagatccccaatatcggcaacgtgatgaataagttcgagatcctgggagtggtgggagagggagcatacggagtggtgctgaagtgccggcacaaggagacacacgagatcgtggccatcaagaagtttaaggatagcgaggagaatgaggaggtgaaggagacaaccctgagggagctgaagatgctgcgcacactgaagcaggagaacatcgtggagctgaaggaggccttccggagaaggggcaagctgtacctggtgtttgagtacgtggagaagaacatgctggagctgctggaggagatgcctaatggcgtgccccctgagaaggtgaagagctacatctatcagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagggatatcaagccagagaacctgctgatcagccacaatgacgtgctgaagctgtgcgatttcggctttgcccgcaacctgtccgagggcaacaacgccaattacacagagtacgtggcaaccaggtggtaccggtccccagagctgctgctgggagcaccatacggcaagagcgtggacatgtggtccgtgggctgcatcctgggcgagctgtctgacggccagcctctgttcccaggcgagagcgagatcgatcagctgtttaccatccagaaggtgctgggccctctgccaagcgagcagatgaagctgttctactccaaccctaggttccacggcctgcgctttcccgccgtgaatcaccctcagagcctggagcgccggtatctgggcatcctgaactccgtgctgctggatctgatgaagaatctgctgaagctggaccccgccgataggtacctgaccgagcagtgtctgaaccaccccacattccagacccagagactgctggacaggtccccttctcgcaatcaggccggcaagtctacagccctgcagagccaccacaggagcaactccaaggacatccagaatctgagcgtgggcctgcctagggcagacgagggcctgccagcaaacgagtcctttctgaatggaaacctggcaggagcctctctgagcccactgcacacaaagacctaccaggccagctcccagccaggctccacatctaaggatctgaccaacaataacatcccacacctgctgtctcccaaggaggccaagagcaagaccgagttcgactttaatatcgatcccaagcctagcgagggcccaggcacaaagtatctgaagagcaactcccggagccagcagaatagacactccttcatggagtctagccagtctaaggccggcaccctgcagcccaacgagaagcagagccgccactcctacatcgataccatcccccagtcctctaggagcccttcctatcgcacaaaggccaagagccacggcgccctgtctgacagcaagtccgtgtctaatctgtccgaggcaagggcacagatcgcagagcccagcacctccagatactttcctagctcctgtctggacctgaactctccaacaagcccaacacccacccggcacagcgatacaagaaccctgctgtctcccagcggcagaaataacaggaacgagggcaccctggattctagaaggaccacaacccggcacagcaagacaatggaggagctgaagctgcccgagcacatggactctagccactcccactctctgagcgcccctcacgagtccttctcttacggcctgggctatacctccccattttcctctcaacagcgcccccaccggcactctatgtacgtgacacgggacaaggtgagagccaagggcctggacggcagcctgtccatcggacagggaatggcagcaagagcaaactccctgcagctgctgtctcctcagccaggagagcagctgccaccagagatgaccgtggcacggagctccgtgaaggagacaagcagagagggcacctctagcttccacacacggcagaagtccgagggcggcgtgtatcacgaccctcactctgacgacggcaccgccccaaaggagaacagacacctgtacaacgatccagtgcctaggagggtgggctccttctatcgggtgccatctccccgccctgacaatagctttcacgagaataacgtgtccacccgggtgtcctctctgccctctgagagctcctctggcacaaaccactctaagagacagcccgcctttgacccttggaagagcccagagaatatctctcacagcgagcagctgaaggagaaggagaagcagggcttctttaggagcatgaagaagaagaagaagaagagccagaccgtgcctaactccgactctcccgatctgctgaccctgcagaagagcatccacagcgcctccacaccaagctcccggcctaaggagtggcggcccgagaagatctccgatctgcagacccagagccagccactgaagtccctgcgcaagctgctgcacctgtctagcgccagcaaccaccctgcctcctctgacccaaggttccagcccctgacagcccagcagaccaagaactcttttagcgagatccgcatccacccactgtcccaagcctctggaggcagctccaacatcaggcaggagccagcaccaaagggccgccccgccctgcagctgcctggacagatggaccccggatggcacgtgtctagcgtgacacggtccgccaccgagggaccatcctactctgagcagctgggagcaaagagcggacctaacggacacccatataacagaaccaatagatccaggatgcctaatctgaacgacctgaaggagacagccctgtgatag 2958 DNA PAT misc_feature 1..2958 note nucleic acid sequence source 1..2958 mol_type other DNA organism synthetic construct atgaagatccccaatatcggcaacgtgatgaataagttcgagatcctgggagtggtgggagagggagcatacggagtggtgctgaagtgccggcacaaggagacacacgagatcgtggccatcaagaagtttaaggatagcgaggagaatgaggaggtgaaggagacaaccctgagggagctgaagatgctgcgcacactgaagcaggagaacatcgtggagctgaaggaggccttccggagaaggggcaagctgtacctggtgtttgagtacgtggagaagaacatgctggagctgctggaggagatgccaaatggcgtgccccctgagaaggtgaagtcctacatctatcagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagggatatcaagcccgagaacctgctgatctcccacaatgacgtgctgaagctgtgcgatttcggctttgcccgcaacctgagcgagggcaacaacgccaattacacagagtacgtggcaaccaggtggtaccggagccctgagctgctgctgggagcaccatacggcaagtctgtggacatgtggagcgtgggctgcatcctgggagagctgtccgacggacagccactgttccctggcgagtctgagatcgatcagctgtttaccatccagaaggtgctgggccccctgccttccgagcagatgaagctgttctactctaaccctaggttccacggcctgcgctttccagccgtgaatcacccccagtctctggagcgccggtatctgggcatcctgaacagcgtgctgctggatctgatgaagaatctgctgaagctggaccccgccgataggtacctgaccgagcagtgtctgaaccaccctacattccagacccagagactgctggacaggtccccatctcgcaatcaggccggcaagtccacagccctgcagtctcaccacaggagcaactccaaggacatccagaatctgtccgtgggcctgccaagggcagacgagggcctgcctgccaacgagagctttctgaatggaaacctggcaggagcctctctgagcccactgcacacaaagacctaccaggccagctcccagcctggctccacatctaaggacctgaccaacaataacatccctcacctgctgagcccaaaggaggccaagtccaagaccgagttcgactttaatatcgatccaaagccatccgagggaccaggaacaaagtatctgaagagcaactcccggagccagcagaatagacactctttcatggagtctagccagagcaaggccggcaccctgcagcctaacgagaagcagagccgccactcctacatcgataccatcccacagtcctctaggagcccctcctatcgcacaaaggccaagtcccacggcgccctgtctgacagcaagtccgtgtctaatctgagcgaggcaagggcacagatcgcagagccaagcacctccagatactttcccagctcctgtctggacctgaactctcccacaagccctacaccaacccggcacagcgatacaagaaccctgctgtctcctagcggcagaaataacaggaacgagggcaccctggatagcagaaggaccacaaccaggcactccaagacaatggaggagctgaagctgcctgagcacatggactctagccactcccactctctgagcgccccacacgagtccttctcttacggcctgggctataccagccctttttcctctcaacaacgcccacaccggcactccatgtacgtgacacgggacaaggtgagagccaagggcctggacggcagcctgtccatcggacagggaatggcagcaagggcaaatagcctgcagctgctgtccccacagcctggagagcagctgccaccagagatgaccgtggcacggagctccgtgaaggagacaagcagagagggcacctctagcttccacacacggcagaagagcgagggcggcgtgtatcacgacccacactccgacgacggaaccgcacctaaggagaacagacacctgtacaacgatccagtgccccgccgggtgggctctttctatcgggtgcctagcccacgccccgacaactcctttcacgagaataacgtgtctacccgggtgtcctctctgcccagcgagagctcctctggcacaaaccactccaagagacagccagcctttgatccctggaagtctcctgagaatatctctcacagcgagcagctgaaggagaaggagaagcagggcttctttcggtccatgaagaagaagaagaagaagagccagacaaccgacagcaccaacggcgagaatccaagcatcaagaagtccctgttccccctgtttaacagcaagaatcacctgaagcacagctcctctctgaagaagctgcccgtggtgacacctccaatggtgcccaattccgactctcctgatctgctgaccctgcagaagtccatccacagcgcctccacaccaagctcccggcccaaggagtggcggcccgagaagatcagcgatctgcagacccagtcccagcccctgaagtctctgagaaagctgctgcacctgtctagcgcctccaaccacccagcctcctctgaccctcggttccagccactgacagcccagcagaccaagaactcttttagcgagatccgcatccacccactgtcccaagcctctggaggcagctccaacatcaggcaggagcctgccccaaagggccgcccagccctgcagctgccaggacagatggaccccggctggcacgtgtctagcgtgacacggagcgccaccgagggaccttcctactctgagcagctgggagcaaagtctggaccaaacggacacccttataacagaaccaatagaagcaggatgccaaatctgaacgacctgaaggagacagccctgtgatag 588 DNA PAT misc_feature 1..588 note nucleic acid sequence source 1..588 mol_type other DNA organism synthetic construct tcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaaatcatcgtcctttccttggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtcttcgccttcgccctcagacgagtcggatctccctttgggccgcctccccgca 239 DNA PAT misc_feature 1..239 note nucleic acid sequence source 1..239 mol_type other DNA organism synthetic construct ggccgcttcgagcagacatgataagatacattgatgagtttggacaaaccacaactagaatgcagtgaaaaaaatgctttatttgtgaaatttgtgatgctattgctttatttgtaaccattataagctgcaataaacaagttaacaacaacaattgcattcattttatgtttcaggttcagggggagatgtgggaggttttttaaagcaagtaaaacctctacaaatgtggtaaaatc 4806 DNA PAT misc_feature 1..4806 note Vector Genome repeat_region 1..130 note 5' ITR misc_feature 130..168 note AAV2 seq upstream of 3'ITR regulatory 226..1454 note promoter - UbC promoter regulatory_class promoter misc_feature 308 note Insertion (C) misc_feature 1009 note Insertion (G) misc_feature 4353 note Deletion (G) misc_feature 4370..4391 note miRNA183 misc_feature 4396..4417 note miRNA183 misc_feature 4424..4445 note miRNA183 misc_feature 4452..4473 note miRNA183 regulatory 4482..4608 note polyA_signal - Rabbit Beta Globin polyA regulatory_class polyA_signal_sequence misc_feature 4639..4677 note AAV2 seq upstream of 3'ITR repeat_region 4677..4806 note 3'ITR source 1..4806 mol_type other DNA organism synthetic construct CDS 1470..4352 note hCDKL5_1 protein_id 30 translation MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttccttgtagttaatgattaacccgccatgctacttatctacgtagccatgctctaggaagatcctctagaactatagctagcatgctctaggaagatctggcctccgcgccgggttttggcgcctcccgcgggcgcccccctcctcacggcgagcgctgccacgtcagacgaagggcgcagcgagcgtcctgatccttccgcccggacgctcaggacagcggcccgctgctcataagactcggccttagaaccccagtatcagcagaaggacattttaggacgggacttgggtgactctagggcactggttttctttccagagagcggaacaggcgaggaaaagtagtcccttctcggcgattctgcggagggatctccgtggggcggtgaacgccgatgattatataaggacgcgccgggtgtggcacagctagttccgtcgcagccgggatttgggtcgcggttcttgtttgtggatcgctgtgatcgtcacttggtgagtagcgggctgctgggctggccggggctttcgtggccgccgggccgctcggtgggacggaagcgtgtggagagaccgccaagggctgtagtctgggtccgcgagcaaggttgccctgaactgggggttggggggagcgcagcaaaatggcggctgttcccgagtcttgaatggaagacgcttgtgaggcgggctgtgaggtcgttgaaacaaggtggggggcatggtgggcggcaagaacccaaggtcttgaggccttcgctaatgcgggaaagctcttattcgggtgagatgggctggggcaccatctggggaccctgacgtgaagtttgtcactgactggagaactcggtttgtcgtctgttgcgggggcggcagttatggcggtgccgttgggcagtgcacccgtacctttgggagcgcgcgccctcgtcgtgtcgtgacgtcacccgttctgttggcttataatgcagggtggggccacctgccggtaggtgtgcggtaggcttttctccgtcgcaggacgcagggttcgggcctagggtaggctctcctgaatcgacaggcgccggacctctggtgaggggagggataagtgaggcgtcagtttctttggtcggttttatgtacctatcttcttaagtagctgaagctccggttttgaactatgcgctcggggttggcgagtgtgttttgtgaagttttttaggcaccttttgaaatgtaatcatttgggtcaatatgtaattttcagtgttagactagtaaattgtccgctaaattctggccgtttttggcttttttgttagacgaagctttattgcggtagaattcgccgccaccatgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctgaagcttatcgataccggtagtgaattctaccagtgccataggatagtgaattctaccagtgccatacacgtgagtgaattctaccagtgccatagcatgcagtgaattctaccagtgccatagcggccgcgatctttttccctctgccaaaaattatggggacatcatgaagccccttgagcatctgacttctggctaataaaggaaatttattttcattgcaatagtgtgttggaattttttgtgtctctcactcgatcgataaggatcttcctagagcatggctacgtagataagtagcatggcgggttaatcattaactacaaggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 960 AA PAT REGION 1..960 note Synthetic Construct source 1..960 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL 4389 DNA PAT misc_feature 1..4389 note Vector Genome repeat_region 1..130 note 5' ITR misc_feature 130..168 note AAV2 seq upstream of 3' ITR regulatory 224..1021 note promoter - CBh regulatory_class promoter misc_feature 801 note A deletion misc_feature 3936 note Deletion (G) misc_feature 3953..3974 note miRNA183 misc_feature 3979..4000 note miRNA183 misc_feature 4007..4028 note miRNA183 misc_feature 4035..4056 note miRNA183 regulatory 4065..4191 note polyA_signal - Rabbit Beta Globin PolyA regulatory_class polyA_signal_sequence misc_feature 4222..4260 note AAV2 seq upstream of 3' ITR repeat_region 4260..4389 note 3' ITR source 1..4389 mol_type other DNA organism synthetic construct CDS 1053..3935 note hCDKL5-1 protein_id 32 translation MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttccttgtagttaatgattaacccgccatgctacttatctacgtagccatgctctaggaagatcctctagaactatagctagcgcccttaagggtacccgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattgacgtcaatagtaacgccaatagggactttccattgacgtcaatgggtggagtatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtacgccccctattgacgtcaatgacggtaaatggcccgcctggcattgtgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtcgaggtgagccccacgttctgcttcactctccccatctcccccccctccccacccccaattttgtatttatttattttttaattattttgtgcagcgatgggggcggggggggggggggggcgcgcgccaggcggggcggggcggggcgaggggcggggcggggcgaggcggagaggtgcggcggcagccaatcagagcggcgcgctccgaaagtttccttttatggcgaggcggcggcggcggcggccctataaaaagcgaagcgcgcggcgggcgggagtcgctgcgcgctgccttcgccccgtgccccgctccgccgccgcctcgcgccgcccgccccggctctgactgaccgcgttactcccacaggtgagcgggcgggacggcccttctcctccgggctgtaattagctgagcaagaggtaagggtttaagggatggttggttggtggggtattaatgtttaattacctggagcacctgcctgaaatcactttttttcaggttggcttaagctgcagaccggaattcgccgccaccatgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctgaagcttatcgataccggtagtgaattctaccagtgccataggatagtgaattctaccagtgccatacacgtgagtgaattctaccagtgccatagcatgcagtgaattctaccagtgccatagcggccgcgatctttttccctctgccaaaaattatggggacatcatgaagccccttgagcatctgacttctggctaataaaggaaatttattttcattgcaatagtgtgttggaattttttgtgtctctcactcgatcgataaggatcttcctagagcatggctacgtagataagtagcatggcgggttaatcattaactacaaggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 960 AA PAT REGION 1..960 note Synthetic Construct source 1..960 mol_type protein organism synthetic construct MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL 2211 DNA PAT source 1..2211 mol_type other DNA organism adeno-associated virus rh91 CDS 1..2211 note AAVrh.91 protein_id 34 translation MAADGYLPDWLEDNLSEGIREWWALKPGAPKPKANQQKQDDGRGLVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAYDQQLKAGDNPYLRYNHADAEFQERLQEDTSFGGNLGRAVFQAKKRVLEPFGLVEEAAKTAPGKKRPVEQSPQEPDSSSGIGKSGQQPAKKRLNFGQTGDSESVPDPQPLGEPPETPAAVGPTTMASGGGAPMADNNEGADGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQISSASTGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTTNDGVTTIANNLTSTVQVFSDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNRTQNQSGSAQNKDLLFSRGSPAGMSVQPKNWLPGPCYRQQRVSKTKTDNNNSNFTWTGASKYNLNGRESIINPGTAMASHKDDEDKFFPMSGVMIFGKENAGASNTALDNVMITDEEEIKATNPVATERFGTVAVNLQSSNTDPATGDVHVMGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPPAEFSATKFASFITQYSTGQVSVEIEWELQKENSKRWNPEVQYTSNYAKSANVDFTVDNNGLYTEPRPIGTRYLTRPL atggctgccgatggttatcttccagattggctcgaggacaacctctctgagggcattcgcgagtggtgggcgctgaaacctggagccccgaaacccaaagccaaccagcaaaagcaggacgacggccggggtctggtgcttcctggctacaagtacctcggacccttcaacggactcgacaagggggagcccgtcaacgcggcggacgcagcggccctcgagcacgacaaggcctacgaccagcagctcaaagcgggtgacaatccgtacctgcggtataaccacgccgacgccgagtttcaggagcgtctgcaagaagatacgtcttttgggggcaacctcgggcgagcagtcttccaggccaagaagcgggttctcgaaccttttggtctggttgaggaagcagctaagacggctcctggaaagaaacgtccggtagagcagtcgccccaagaaccagactcctcctcgggcattggcaaatcaggccagcagcccgccaaaaagagactcaatttcggtcagactggcgactcagagtcagtccccgaccctcaacctctcggagaacctccagaaacccccgctgctgtgggacctactacaatggcttcaggcggtggcgcaccaatggcagacaataacgaaggcgccgacggagtgggtaatgcctcaggaaattggcattgcgattccacatggctgggcgacagagtcatcaccaccagcacccgaacctgggcccttcctacctacaacaaccacctctacaagcaaatctccagcgcttcaacgggggccagtaacgacaaccactactttggctacagcaccccctgggggtattttgatttcaacagattccactgccacttctcaccacgtgactggcagcgactcattaacaacaactggggattccggcccaagagactcaacttcaagctcttcaacatccaggtcaaggaggtcacgacgaatgatggcgtcacaaccatcgctaataaccttaccagcacggttcaagtgttctcggactcggagtaccagctgccgtacgtcctcggttctgcgcaccagggctgcctccctccgttcccggcggacgtattcatgattcctcagtacggctacctaacgctcaacaatggcagccaggccgtaggacgttcatccttttattgcctggaatatttcccatctcaaatgctgagaacgggcaacaactttaccttcagctacacctttgaagatgtgcctttccacagcagttacgcgcacagccagagcctggacaggctaatgaatcctctaatcgaccagtacctgtattacctaaacagaactcagaatcaatccggaagtgcacaaaacaaggacttgctgtttagccgggggtctccagctggcatgtctgttcagcccaaaaactggctacccgggccctgttaccgacagcagcgtgtttctaaaacaaaaacagacaacaacaacagcaactttacctggactggtgcctccaaatacaatctgaacggacgtgaatccatcattaaccctggcaccgctatggcatcccacaaggacgacgaagacaaattttttcccatgagcggtgttatgatttttggcaaagaaaatgcaggagcatcaaacactgcattagacaatgttatgattacagatgaagaggaaattaaagctaccaaccccgtggccaccgagagatttggaactgtggcagtcaatctccaaagcagcaatacagaccctgcaacaggagacgtgcatgtcatgggggctttacctggcatggtgtggcaagacagagacgtgtacctgcagggtcccatttgggccaagattcctcacacggatggacactttcacccgtctcctcttatgggcggctttggacttaagcacccgcctcctcagatcctcatcaaaaacacgcctgttcctgcgaatcctccggcagagttttcggctacaaagtttgcttcattcatcacccagtactccacaggacaagtgagcgtggaaattgaatgggagctgcagaaagaaaacagtaagcgctggaatcctgaagtgcagtacacctccaactacgcgaaatctgccaacgttgatttcactgtggacaacaatggactttatactgagcctcgccccattggcacccgttaccttacccgtcccctttaa 736 AA PAT source 1..736 mol_type protein organism adeno-associated virus rh91 MAADGYLPDWLEDNLSEGIREWWALKPGAPKPKANQQKQDDGRGLVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAYDQQLKAGDNPYLRYNHADAEFQERLQEDTSFGGNLGRAVFQAKKRVLEPFGLVEEAAKTAPGKKRPVEQSPQEPDSSSGIGKSGQQPAKKRLNFGQTGDSESVPDPQPLGEPPETPAAVGPTTMASGGGAPMADNNEGADGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQISSASTGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTTNDGVTTIANNLTSTVQVFSDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNRTQNQSGSAQNKDLLFSRGSPAGMSVQPKNWLPGPCYRQQRVSKTKTDNNNSNFTWTGASKYNLNGRESIINPGTAMASHKDDEDKFFPMSGVMIFGKENAGASNTALDNVMITDEEEIKATNPVATERFGTVAVNLQSSNTDPATGDVHVMGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPPAEFSATKFASFITQYSTGQVSVEIEWELQKENSKRWNPEVQYTSNYAKSANVDFTVDNNGLYTEPRPIGTRYLTRPL 2211 DNA PAT source 1..2211 mol_type other DNA organism adeno-associated virus rh91 CDS 1..2211 note AAVrh.91 protein_id 36 translation MAADGYLPDWLEDNLSEGIREWWALKPGAPKPKANQQKQDDGRGLVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAYDQQLKAGDNPYLRYNHADAEFQERLQEDTSFGGNLGRAVFQAKKRVLEPFGLVEEAAKTAPGKKRPVEQSPQEPDSSSGIGKSGQQPAKKRLNFGQTGDSESVPDPQPLGEPPETPAAVGPTTMASGGGAPMADNNEGADGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQISSASTGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTTNDGVTTIANNLTSTVQVFSDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNRTQNQSGSAQNKDLLFSRGSPAGMSVQPKNWLPGPCYRQQRVSKTKTDNNNSNFTWTGASKYNLNGRESIINPGTAMASHKDDEDKFFPMSGVMIFGKENAGASNTALDNVMITDEEEIKATNPVATERFGTVAVNLQSSNTDPATGDVHVMGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPPAEFSATKFASFITQYSTGQVSVEIEWELQKENSKRWNPEVQYTSNYAKSANVDFTVDNNGLYTEPRPIGTRYLTRPL atggctgctgacggttatcttccagattggctcgaggacaacctttctgaaggcattcgtgagtggtgggctctgaaacctggagcccctaaacccaaagcgaaccaacaaaagcaggacgacggccggggtcttgtgcttccgggttacaaatacctcggacccttcaacggactcgacaaaggagagccggtcaacgcggcggacgcggcagccctcgaacacgacaaagcttacgaccagcagctcaaggccggtgacaacccgtacctccggtacaaccacgccgacgccgagtttcaggagcgtcttcaagaagatacgtcttttgggggcaaccttggcagagcagtcttccaggccaaaaagagggttcttgagccttttggtctggttgaggaagcagctaaaacggctcctggaaagaagaggcctgtagagcagtctcctcaggaaccggactcatcatctggtattggcaaatcgggccagcagcctgccaaaaaaagactaaatttcggtcagactggcgactcagagtcagtccccgaccctcaacctctcggagaacctccagaaacccccgctgctgtgggacctactacaatggcttcaggcggtggcgcaccaatggcagacaataacgaaggcgccgacggagtgggtaatgcctcaggaaattggcattgcgattccacatggctgggcgacagagtcatcaccaccagcacccgaacctgggcccttcctacctacaacaaccacctctacaagcaaatctccagcgcttcaacgggggccagtaacgacaaccactactttggctacagcaccccctgggggtattttgatttcaacagattccactgccacttctcaccacgtgactggcagcgactcattaacaacaactggggattccggcccaagagactcaacttcaagctcttcaacatccaggtcaaggaggtcacgacgaatgatggcgtcacaaccatcgctaataaccttaccagcacggttcaagtgttctcggactcggagtaccagctgccgtacgtcctcggttctgcgcaccagggctgcctccctccgttcccggcggacgtattcatgattcctcagtatggatacctcaccctgaacaacggaagtcaagcggtgggacgctcatccttttactgcctggagtacttcccttcgcagatgctaaggactggaaataacttcaccttcagctataccttcgaggatgtaccttttcacagcagctacgctcacagccagagtttggatcgcttgatgaatcctcttattgatcagtatctgtactacctgaacagaacgcaaaatcaatctggaagtgcacaaaacaaggacctgctttttagccgggggtctcctgctggcatgtctgttcagcccaaaaattggctacctgggccctgctaccggcaacagagagtttcaaagactaaaacagacaacaacaacagtaactttacctggacaggtgccagcaaatataatctcaatggccgcgaatcgatcattaatccaggaaccgctatggccagtcacaaggacgatgaagacaaatttttccctatgagcggcgttatgatatttggcaaagaaaatgcaggagcaagtaacactgcattagataatgtaatgattacggatgaagaagagattaaagctaccaatcctgtggcaacagagagatttggaactgtggcagtcaacttgcagagctcaaatacagaccccgcaactggagacgtccatgtcatgggggccttacctggcatggtgtggcaagatcgtgacgtgtaccttcaaggacctatctgggcaaagattcctcacacggatggacactttcatccttctcctctgatgggaggctttggactgaaacatccgcctcctcaaatcctcatcaaaaatactccggtaccggcaaatcctccggcagagttcagcgctacaaagtttgcttcatttatcactcagtactccactggacaggtcagcgtggaaattgagtgggagctacagaaagaaaacagcaaacgttggaatccagaggtgcagtacacttccaactacgcgaagtctgccaatgtggactttactgtagacaacaatggtctttatactgaacctcgccctattggaacccggtatctcacacgacccttgtaa 736 AA PAT source 1..736 mol_type protein organism adeno-associated virus rh91 MAADGYLPDWLEDNLSEGIREWWALKPGAPKPKANQQKQDDGRGLVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAYDQQLKAGDNPYLRYNHADAEFQERLQEDTSFGGNLGRAVFQAKKRVLEPFGLVEEAAKTAPGKKRPVEQSPQEPDSSSGIGKSGQQPAKKRLNFGQTGDSESVPDPQPLGEPPETPAAVGPTTMASGGGAPMADNNEGADGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQISSASTGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTTNDGVTTIANNLTSTVQVFSDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNRTQNQSGSAQNKDLLFSRGSPAGMSVQPKNWLPGPCYRQQRVSKTKTDNNNSNFTWTGASKYNLNGRESIINPGTAMASHKDDEDKFFPMSGVMIFGKENAGASNTALDNVMITDEEEIKATNPVATERFGTVAVNLQSSNTDPATGDVHVMGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPPAEFSATKFASFITQYSTGQVSVEIEWELQKENSKRWNPEVQYTSNYAKSANVDFTVDNNGLYTEPRPIGTRYLTRPL 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5co-A source 1..2883 mol_type other DNA organism synthetic construct atgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgtggtgggcgagggcgcctacggcgtggtgctgaagtgcaggcacaaggagacccacgagatcgtggccatcaagaagttcaaggacagcgaggagaacgaggaggtgaaggagaccaccctgagggagctgaagatgctgaggaccctgaagcaggagaacatcgtggagctgaaggaggccttcaggaggaggggcaagctgtacctggtgttcgagtacgtggagaagaacatgctggagctgctggaggagatgcccaacggcgtgccccccgagaaggtgaagagctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagggacatcaagcccgagaacctgctgatcagccacaacgacgtgctgaagctgtgcgacttcggcttcgccaggaacctgagcgagggcaacaacgccaactacaccgagtacgtggccaccaggtggtacaggagccccgagctgctgctgggcgccccctacggcaagagcgtggacatgtggagcgtgggctgcatcctgggcgagctgagcgacggccagcccctgttccccggcgagagcgagatcgaccagctgttcaccatccagaaggtgctgggccccctgcccagcgagcagatgaagctgttctacagcaaccccaggttccacggcctgaggttccccgccgtgaaccacccccagagcctggagaggaggtacttgggcatcctgaacagcgtgctgctggacctgatgaagaacctgctgaagctggaccccgccgacaggtacttgaccgagcagtgcctgaaccaccccaccttccagacccagaggctgctggacaggagccccagcaggagcgccaagaggaagccctaccacgtggagagcagcaccctgagcaacaggaaccaggccggcaagagcaccgccctgcagagccaccacaggagcaacagcaaggacatccagaacctgagcgtgggcctgcccagggccgacgagggcctgcccgccaacgagagcttcctgaacggcaacctggccggcgccagcctgagccccctgcacaccaagacctaccaggccagcagccagcccggcagcaccagcaaggacctgaccaacaacaacatcccccacctgctgagccccaaggaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcccagcgagggccccggcaccaagtacctgaagagcaacagcaggagccagcagaacaggcacagcttcatggagagcagccagagcaaggccggcaccctgcagcccaacgagaagcagagcaggcacagctacatcgacaccatcccccagagcagcaggagccccagctacaggaccaaggccaagagccacggcgccctgagcgacagcaagagcgtgagcaacctgagcgaggccagggcccagatcgccgagcccagcaccagcaggtacttccccagcagctgcctggacctgaacagccccaccagccccacccccaccaggcacagcgacaccaggaccctgctgagccccagcggcaggaacaacaggaacgagggcaccctggacagcaggaggaccaccaccaggcacagcaagaccatggaggagctgaagctgcccgagcacatggacagcagccacagccacagcctgagcgccccccacgagagcttcagctacggcctgggctacaccagccccttcagcagccagcagaggccccacaggcacagcatgtacgtgaccagggacaaggtgagggccaagggcctggacggcagcctgagcatcggccagggcatggccgccagggccaacagcctgcagctgctgagcccccagcccggcgagcagctgccccccgagatgaccgtggccaggagcagcgtgaaggagaccagcagggagggcaccagcagcttccacaccaggcagaagagcgagggcggcgtgtaccacgacccccacagcgacgacggcaccgcccccaaggagaacaggcacctgtacaacgaccccgtgcccaggagggtgggcagcttctacagggtgcccagccccaggcccgacaacagcttccacgagaacaacgtgagcaccagggtgagcagcctgcccagcgagagcagcagcggcaccaaccacagcaagaggcagcccgccttcgacccctggaagagccccgagaacatcagccacagcgagcagctgaaggagaaggagaagcagggcttcttcaggagcatgaagaagaagaagaagaagagccagaccgtgcccaacagcgacagccccgacctgctgaccctgcagaagagcatccacagcgccagcacccccagcagcaggcccaaggagtggaggcccgagaagatcagcgacctgcagacccagagccagcccctgaagagcctgaggaagctgctgcacctgagcagcgccagcaaccaccccgccagcagcgaccccaggttccagcccctgaccgcccagcagaccaagaacagcttcagcgagatcaggatccaccccctgagccaggccagcggcggcagcagcaacatcaggcaggagcccgcccccaagggcaggcccgccctgcagctgcccggccagatggaccccggctggcacgtgagcagcgtgaccaggagcgccaccgagggccccagctacagcgagcagctgggcgccaagagcggccccaacggccacccctacaacaggaccaacaggagcaggatgcccaacctgaacgacctgaaggagaccgccctgtga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5co-B source 1..2883 mol_type other DNA organism synthetic construct atgaaaattcccaatatcggtaacgtgatgaataaattcgaaatacttggagtggtaggtgagggcgcctatggtgttgtacttaaatgtagacacaaagaaacacacgaaatcgtggcgatcaagaaatttaaggattccgaggagaatgaggaagtcaaagagaccacactacgcgagttgaaaatgttacgaactctaaaacaggaaaacattgtagagttaaaggaggcttttcgccgtcgcggtaaactatacctggtctttgagtatgttgagaaaaacatgctagaactgctcgaggaaatgcctaatggcgtcccgccagaaaaagtcaaatcgtatatttaccagcttataaaggccatccattggtgtcataaaaacgatatcgttcatcgcgacattaagccagaaaatctattgatatcccacaacgacgtgctaaaactttgcgacttcggcttcgctaggaacctatccgaagggaataacgcgaattataccgaatatgttgcgacacgatggtaccgtagtcctgaacttctattaggggcgccctacggtaaatctgtagatatgtggtcagtcgggtgtatattaggagaactttcagacggtcaacctctgttcccaggcgagtccgagatcgatcagctttttacaatacagaaggtattaggtcccctcccaagtgagcaaatgaagctattctattcaaatccccggtttcatggccttagatttccggcggtgaaccaccctcagagtctggagaggcgttatctcgggatacttaattcagtcttactcgatctgatgaagaatttgctaaaactggaccctgctgatcggtaccttacagagcaatgccttaatcacccgacttttcaaactcaacgactgttggaccggagtccgtcacgctcagctaaaaggaaaccataccacgtagaatcatcgacattatcgaatcgaaaccaagcgggtaagagtaccgctttgcaaagccatcatcgatccaatagtaaagacattcagaatctgtcagtgggattgcctagagctgacgaaggattaccggcgaacgagagttttctgaacggcaacctcgcaggcgcatctctgtctccgcttcatacgaaaacttaccaagcgtcatcacagccaggcagtacgagtaaagacctgactaacaataatattccacatctgttatcaccgaaggaagctaagagcaagaccgagttcgacttcaacatagaccccaaaccctccgagggtcctggcaccaagtatctcaaatcaaactctagatctcagcagaacaggcacagcttcatggagtcctcacaaagtaaagctgggacactgcagcccaacgaaaagcaaagccgacattcttatattgacacgatccctcagagttcacgcagccctagctatcggacaaaagctaagtcccacggtgccctttctgattcgaagagtgttagtaacctttccgaagctagagcccaaattgcggagcctagtacatcgagatacttcccctccagctgcctggaccttaactctccaaccagccccactccaacgcgccactcagataccaggacactgctctcaccatccggaagaaataatagaaatgaaggaacgcttgactctcggcgcactacgacaaggcacagcaagacgatggaagaacttaagctacctgagcacatggacagttcgcattcccactcactctcggcgccacatgagtcgttttcctatggactgggttacacaagtccctttagctctcagcagcgtcctcaccgccactctatgtacgttacaagggataaagttcgcgctaaggggttggatgggagtctttccattggccaaggcatggccgcgcgggcaaattctctacaacttctttcgccacagccaggtgagcaactcccaccagaaatgaccgtcgccagaagcagtgttaaagaaacttcgagggaggggacatcatcgtttcatacccgccagaaatctgagggcggtgtatatcatgatcctcattccgacgacggaacggcccccaaagagaaccgacacctatacaatgaccctgtcccaaggagagtgggatctttctatcgagttccttcaccaagacctgataacagtttccatgagaacaacgtttccacgagggtgtcaagtctaccttcggaatcatcttccggaaccaatcactcaaaacgccagccagctttcgatccatggaaatcaccggaaaacatcagtcatagcgagcaattgaaagagaaagaaaagcaaggttttttcagaagtatgaagaagaagaaaaagaagtcacagaccgtacctaattcagatagtccagacttgttaacgctccagaaatcaattcatagcgcatcgactccatcgtcccgaccaaaggaatggcgccctgagaagatctccgatctgcagacccaatcccaacccctgaagtctctcaggaaattactccacctctcgtctgctagtaaccaccccgcatcgtctgaccctcgcttccagccgctgacagcccagcaaacaaagaacagtttctcagaaatccggattcatcctttaagccaagctagcggcggtagttctaacataagacaagagcccgctccaaagggcagacccgctctgcagttgcctgggcagatggatcccgggtggcacgtctcatcagtaacccgaagtgccaccgagggcccgtcatattcagagcagctcggagcgaaaagtggtcctaacgggcacccatataatcgaacaaaccgttcaaggatgccaaatctcaacgatctaaaggaaacggccctttaa 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5co-C source 1..2883 mol_type other DNA organism synthetic construct atgaagatccccaatatcggaaacgtgatgaacaaattcgagattctcggagtggtgggcgagggcgcctatggagtggttttaaaatgcagacacaaggagacccacgagatcgtcgctatcaaaaagttcaaagactccgaggaaaacgaagaggtcaaggagaccaccttacgtgagctcaaaatgctcagaacactgaagcaagagaatatcgtcgagctcaaggaggccttcagaaggaggggcaaactgtatttagtgttcgagtacgtggagaagaacatgctggagctgctggaggaaatgcccaacggcgtcccccccgaaaaggtgaaatcctacatttaccaactgatcaaggccattcactggtgccacaaaaatgatatcgtccatcgtgacatcaagcccgagaatctgctgatcagccataacgacgtgctgaaactgtgcgacttcggattcgccagaaatttaagcgagggcaacaacgccaattacaccgagtacgtcgccacaaggtggtataggagccccgagctgctgctcggagccccttatggcaagagcgtggacatgtggagcgtgggctgcattctgggagaactgtccgacggccagcctctgttccccggcgagtccgagattgaccagctgttcacaatccagaaagtcctcggccctctgcccagcgaacaaatgaagctcttctacagcaaccctcgtttccacggtttaaggttccccgccgtgaatcacccccagagcctcgagagaaggtatctgggcattctgaacagcgtgctgctcgatttaatgaagaatttattaaagctggaccccgctgataggtacctcacagagcagtgtttaaatcaccccaccttccagacccagagactgctcgatcgtagccctagcagatccgccaaaaggaagccttaccacgtcgagagctccactttaagcaatcgtaaccaagctggaaaatccaccgctttacagtcccaccataggtccaacagcaaagacattcagaatttaagcgtgggactgcctagggctgacgagggcctccccgccaacgaatcctttttaaatggcaatctcgccggagccagcctcagccctttacatacaaaaacctaccaagctagctcccagcccggtagcacctccaaggacctcaccaacaacaacatcccccatttactgtcccccaaggaggccaagagcaagaccgagtttgactttaatatcgaccctaagcccagcgagggacccggcacaaagtatctgaagtccaattctcgtagccagcagaatcgtcacagcttcatggagagctcccaaagcaaggccggcacactgcagcccaatgagaagcaatctcgtcattcctacatcgacaccatcccccagagctctcgtagcccctcctataggacaaaggccaagtcccacggcgctctgtccgattccaagtccgtctccaatttatccgaggctcgtgcccagatcgccgaacctagcacctctcgttatttcccctcctcttgtctggacctcaattcccccacaagccctacacctactcgtcacagcgacaccagaactttactgagccccagcggaaggaataatcgtaacgagggcactttagactctcgtagaaccaccacaaggcacagcaagaccatggaggagctgaagctgcccgaacatatggactcctcccattcccattctttatccgccccccacgagagcttcagctatggtttaggctatacatcccccttcagctcccagcagagaccccacagacactccatgtacgtgactcgtgataaggtgagggccaaaggactggatggaagcctctccatcggccaaggcatggccgctcgtgccaatagcctccagttattatccccccaacccggagaacagctgcctcccgaaatgacagtggccagaagcagcgtcaaggaaacatctcgtgagggaacctccagctttcacacaaggcagaagagcgagggcggagtctatcatgacccccactccgatgacggcacagcccccaaagagaatcgtcatctctacaacgaccccgtgcctcgtagagtcggctccttctacagagtccccagccccagacccgacaacagctttcacgagaacaacgtgagcactcgtgtctcctctttacctagcgagagctcctccggaaccaaccacagcaaaaggcagcccgccttcgacccttggaagtcccccgaaaacatcagccacagcgagcagctgaaggagaaagagaagcaaggtttcttcagaagcatgaaaaagaagaagaaaaaatcccaaaccgtgcccaactccgactcccccgatttactgaccctccagaagtccatccactccgcttccacccctagctccagacccaaggagtggaggcccgagaagatttccgatttacagacacagagccagcctctcaagtctttaagaaagctgctgcatttatccagcgccagcaatcaccccgcttccagcgaccctaggttccagcctttaaccgcccagcagaccaagaatagcttttccgagatccgtattcatcctctgagccaagctagcggaggcagctccaacatcagacaagaacccgctcctaagggcagacccgctttacaactccccggtcagatggatcccggttggcacgtgagcagcgtcacaaggagcgccacagagggccccagctatagcgaacagctgggcgccaaaagcggacccaacggccatccctacaatagaaccaatcgttccagaatgcccaatctcaacgacctcaaggaaacagctttatga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5co-D source 1..2883 mol_type other DNA organism synthetic construct atgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgtcgtcggcgaaggcgcttatggcgttgtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgcggaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaacggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcaccgggacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgaatacgtggccaccagatggtacagaagccctgagctgctgctgggagccccttatggcaagtccgtggatatgtggagcgtgggctgtatcctgggagagctgtctgatggccagcctctgtttcctggcgagtccgagatcgaccagctgttcaccatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccccgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgcctgaaccatcctacctttcagacccagagactgctggatcggagccctagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaacagaaaccaggccggcaagtctacagccctgcagagccaccacagaagcaacagcaaggacatccagaacctgtccgtgggcctgcctagagccgatgaaggactgcctgccaacgagagcttcctgaacggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggatctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaacagcagaagccagcagaaccggcactccttcatggaaagctcccagagcaaggccggcacactgcagcctaatgagaagcagagcagacacagctacatcgacacaatcccacagagcagcaggtccccaagctacaggaccaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagctcctgcctggatctgaacagcccaacaagccccacacctaccaggcacagcgacaccagaacactgctgtccccatccggcagaaacaaccggaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactccagccactctcattctctgagcgcccctcacgagtccttctcttacggcctgggctacacaagccccttcagctctcagcagaggccccacagacactctatgtacgtgacccgggacaaagtgcgcgccaaaggcctggatggctctctgtctatcggccaaggcatggccgccagagccaattctctgcagctgctgtctcctcagcctggggaacaactgcctcctgagatgaccgtggccagatccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggagtgtaccacgatcctcacagcgacgacggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaatgtgtccaccagagtgtccagcctgccttccgaaagcagctccggcaccaaccactccaagagacagcctgctttcgacccctggaagtcccctgagaacatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacggtccccaacagcgactccccagatctgctgaccctgcagaagtccatccactccgccagcacacctagcagcagacccaaagagtggcggccagagaagatcagcgatctgcagacccagtctcagcctctgaagtccctgaggaagctgctgcatctgagcagcgcctctaatcaccctgccagcagcgaccctagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagcagcaatatcagacaagagcccgctcctaagggcagacctgctctgcaactgcctggccagatggatccaggatggcacgtgtcctctgtgaccagatccgccacagagggacctagctacagcgaacagctcggcgccaagtctggccctaatggacacccctacaaccggaccaaccggtccagaatgcccaacctgaacgacctcaaagaaacagccctgtga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5coA1 source 1..2883 mol_type other DNA organism synthetic construct atgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgtcgtcggcgaaggcgcttatggcgttgtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgcggaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaacggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcaccgggacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgaatacgtggccaccagatggtacagaagccctgagctgctgctgggagccccttacggcaagtccgtggatatgtggagcgtgggctgtatcctgggagagctgtctgacggccagcctctgtttcctggcgagtccgagatcgaccagctgttcaccatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccccgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgcctgaaccatcctacctttcaaacccagagactgctggatcggagccctagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaacagaaaccaggccggcaagtctacagccctgcagagccaccacagaagcaacagcaaggacatccagaacctgtccgtgggcctgcctagagccgacgaaggactgcctgccaacgagagcttcctgaacggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggatctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaacagcagaagccagcagaaccggcactccttcatggaaagctcccagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatcccacagagcagcaggtccccaagctacaggaccaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagctcctgcctggatctgaacagcccaacaagccccacacctaccaggcacagcgacaccagaacactgctgtccccatccggcagaaacaaccggaacgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactccagccactctcattctctgagcgcccctcacgagtccttctcttacggcctgggctacacaagccccttcagctctcagcagaggccccacagacacagcatgtatgtgacccgggacaaagtgcgcgccaaaggcctggacggctctctgtctatcggccaaggcatggccgccagagccaattctctgcagctgctgtctcctcagcctggggaacaactgcctcctgagatgaccgtggccagatccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggagtgtaccacgatcctcacagcgacgacggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtccaccagagtgtccagcctgccttccgaaagcagctccggcaccaaccactccaagagacagcctgctttcgacccctggaagtcccctgagaacatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacggtccccaacagcgactccccagatctgctgaccctgcagaagtccatccactccgccagcacacctagcagcagacccaaagagtggcggccagagaagatcagcgatctgcagacccagtctcagcctctgaagtccctgaggaagctgctgcatctgagcagcgcctctaatcaccctgccagcagcgaccctagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagcagcaatatcagacaagagcccgctcctaagggcagacctgctctgcaactgcctggccagatggatccaggctggcacgtgtcctctgtgaccagatccgccacagagggacctagctacagcgaacagctcggcgccaagtctggccctaacggacacccctacaaccggaccaaccggtccagaatgcccaacctgaacgacctcaaagagactgccctttga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5coB1 source 1..2883 mol_type other DNA organism synthetic construct atgaagatccctaatatcggcaacgtgatgaataagttcgagatcctgggagtggtgggagagggagcatacggagtggtgctgaagtgccgccacaaggagacccacgagatcgtggccatcaagaagtttaaggatagcgaggagaatgaggaggtgaaggagaccacactgagagagctgaagatgctgaggacactgaagcaggagaacatcgtggagctgaaggaggccttccggagaaggggcaagctgtacctggtgtttgagtacgtggagaagaacatgctggagctgctggaggagatgcccaatggcgtgccccctgagaaggtgaagtcctacatctatcagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagatatcaagcctgagaacctgctgatctcccacaatgacgtgctgaagctgtgcgatttcggctttgccaggaacctgagcgagggcaacaacgccaattacacagagtacgtggccacccgctggtacagaagcccagagctgctgctgggagcaccatacggcaagagcgtggacatgtggtccgtgggctgcatcctgggcgagctgtctgacggccagcctctgttcccaggcgagagcgagatcgatcagctgtttaccatccagaaggtgctgggccctctgccaagcgagcagatgaagctgttctactccaaccccagattccacggcctgaggtttcccgccgtgaatcaccctcagagcctggagcgccggtatctgggcatcctgaactccgtgctgctggatctgatgaagaatctgctgaagctggaccccgccgatcgctacctgaccgagcagtgtctgaatcaccctacatttcagacccagcgcctgctggaccggagcccttccagatctgccaagaggaagccatatcacgtggagagctccaccctgtccaatagaaaccaggccggcaagtctacagccctgcagagccaccacaggagcaactccaaggacatccagaatctgtccgtgggactgcctagggcagacgagggactgccagcaaacgagagcttcctgaacggaaacctggcaggagcatctctgagcccactgcacacaaagacctaccaggcctctagccagcccggctccacatctaaggacctgaccaacaataacatcccacacctgctgtctcccaaggaggccaagagcaagaccgagttcgactttaatatcgatcccaagcctagcgagggccctggcacaaagtatctgaagagcaactcccgctctcagcagaatcggcactccttcatggagtcctctcagtctaaggccggcaccctgcagccaaacgagaagcagagcaggcactcctacatcgataccatcccccagagctccagaagcccttcctatagaacaaaggccaagtctcacggcgccctgtctgacagcaagtccgtgtctaatctgagcgaggcaagggcacagatcgcagagcccagcacctcccggtactttccttcttcctgtctggacctgaactctcctacaagcccaacacccacccgccactccgatacacggaccctgctgtctccaagcggcagaaataacaggaacgagggcaccctggattctagaaggaccacaaccagacacagcaagacaatggaggagctgaagctgccagagcacatggactcctctcactcccactctctgagcgcccctcacgagtccttctcttacggcctgggctatacctcccccttctcctcccaacaaaggccacaccggcacagcatgtatgtgacaagggacaaggtccgggcaaagggactggacggaagcctgtccatcggacagggaatggcagcaagggccaactccctgcagctgctgtctcctcagccaggagagcagctgccaccagagatgaccgtggcacgctctagcgtgaaggagacaagccgggagggcacctcctctttccacacacgccagaagtccgagggcggcgtgtatcacgacccccactctgacgacggcacagcccctaaggagaaccggcacctgtacaacgatcccgtgcctaggagggtgggatccttctatagagtgccatctcccaggcctgacaatagctttcacgagaataacgtgtccacccgcgtgagctccctgccatctgagtctagctccggcacaaaccactctaagcggcagcccgcctttgatccttggaagagcccagagaatatctctcacagcgagcagctgaaggagaaggagaagcagggcttctttagaagcatgaagaagaagaagaagaagagccagaccgtgcctaactccgactctccagacctgctgaccctgcagaagtccatccacagcgcctccacaccatctagcaggcctaaggagtggcggcctgagaagatcagcgatctgcagacccagagccagccactgaagtccctgaggaagctgctgcacctgtcctctgccagcaaccacccagccagctccgacccaagattccagcccctgacagcccagcagaccaagaacagcttcagcgagatcaggatccacccactgtcccaggcatctggaggatctagcaacatcagacaggagccagcaccaaagggcaggcccgccctgcagctgcctggccagatggacccaggctggcacgtgtcctctgtgacacgctccgccaccgagggaccatcctactctgagcagctgggagcaaagagcggacctaacggacacccatataaccggaccaatagatccaggatgcccaatctgaacgacctgaaggagacagccctgtga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5coC1 source 1..2883 mol_type other DNA organism synthetic construct atgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgtggtgggcgagggcgcctacggcgtggtgctgaagtgcaggcacaaggagacccacgagatcgtggccatcaagaagttcaaggacagcgaggagaacgaggaggtgaaggagaccaccctgagggagctgaagatgctgaggaccctgaagcaggagaacatcgtggagctgaaggaggccttcaggaggaggggcaagctgtacctggtgttcgagtacgtggagaagaacatgctggagctgctggaggagatgcccaacggcgtgccccccgagaaggtgaagagctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagggacatcaagcccgagaacctgctgatcagccacaacgacgtgctgaagctgtgcgacttcggcttcgccaggaacctgagcgagggcaacaacgccaactacaccgagtacgtggccaccaggtggtacaggagccccgagctgctgctgggcgccccctacggcaagagcgtggacatgtggagcgtgggctgcatcctgggcgagctgagcgacggccagcccctgttccccggcgagagcgagatcgaccagctgttcaccatccagaaggtgctgggccccctgcccagcgagcagatgaagctgttctacagcaaccccaggttccacggcctgaggttccccgccgtgaaccacccccagagcctggagaggaggtatctgggcatcctgaacagcgtgctgctggacctgatgaagaacctgctgaagctggaccccgccgacaggtatctgaccgagcagtgcctgaaccaccccaccttccagacccagaggctgctggacaggagccccagcaggagcgccaagaggaagccctaccacgtggagagcagcaccctgagcaacaggaaccaggccggcaagagcaccgccctgcagagccaccacaggagcaacagcaaggacatccagaacctgagcgtgggcctgcccagggccgacgagggcctgcccgccaacgagagcttcctgaacggcaacctggccggcgccagcctgagccccctgcacaccaagacctaccaggccagcagccagcccggcagcaccagcaaggacctgaccaacaacaacatcccccacctgctgagccccaaggaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcccagcgagggccccggcaccaagtacctgaagagcaacagcaggagccagcagaacaggcacagcttcatggagagcagccagagcaaggccggcaccctgcagcccaacgagaagcagagcaggcacagctacatcgacaccatcccccagagcagcaggagccccagctacaggaccaaggccaagagccacggcgccctgagcgacagcaagagcgtgagcaacctgagcgaggccagggcccagatcgccgagcccagcaccagcagatacttccccagcagctgcctggacctgaacagccccaccagccccacccccacccgccacagcgacaccaggaccctgctgagccccagcggcaggaacaacaggaacgagggcaccctggacagcaggaggaccaccaccaggcacagcaagaccatggaggagctgaagctgcccgagcacatggacagcagccacagccacagcctgagcgccccccacgagagcttcagctacggcctgggctacaccagccccttcagcagccagcagaggccccacaggcacagcatgtacgtgaccagggacaaagtgagggccaagggcctggacggcagcctgagcatcggccagggcatggccgccagggccaacagcctgcagctgctgagcccccagcccggcgagcagctgccccccgagatgaccgtggccaggagcagcgtgaaggagaccagcagggagggcaccagcagcttccacaccaggcagaagagcgagggcggcgtgtaccacgacccccacagcgacgacggcaccgcccccaaggagaacaggcacctgtacaacgaccccgtgcccaggagggtgggcagcttctacagggtgcccagccccaggcccgacaacagcttccacgagaacaatgtgagcaccagagtcagcagcctgcccagcgagagcagcagcggcaccaaccacagcaagaggcagcccgccttcgacccctggaagagccccgagaacatcagccacagcgagcagctgaaggagaaggagaagcagggcttcttcaggagcatgaagaagaagaagaagaagagccagaccgtgcccaacagcgacagccccgacctgctgaccctgcagaagagcatccacagcgccagcacccccagcagcaggcccaaggagtggaggcccgagaagatcagcgacctgcagacccagagccagcccctgaagagcctgaggaagctgctgcacctgagcagcgccagcaaccaccccgccagcagcgaccccaggttccagcccctgaccgcccagcagaccaagaacagcttcagcgagatcaggatccaccccctgagccaggccagcggcggcagcagcaacatcaggcaggagcccgcccccaagggcaggcccgccctgcagctgcccggccagatggaccccggctggcacgtgagcagcgtgaccaggagcgccaccgagggccccagctacagcgagcagctgggcgccaagagcggccccaacggccacccctacaacaggaccaacaggagcaggatgcccaacctgaacgacctgaaggagaccgccctgtga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5coD1 source 1..2883 mol_type other DNA organism synthetic construct atgaagattcccaacattgggaatgtcatgaacaagtttgagattctgggcgtggtgggagagggagcctacggcgttgttctcaagtgccgccacaaggaaactcacgagatcgtggctatcaagaaattcaaggatagtgaggaaaatgaagaagtcaaggagacaactcttcgagaattaaagatgctcagaaccttaaaacaagaaaatattgtggaattgaaagaggccttcagaagacgaggaaaactctacctggtgtttgaatatgtggagaagaacatgctggaactgttggaagagatgcctaatggggtccctcctgaaaaagtgaagtcctacatctatcagctaatcaaggccatccactggtgccacaaaaatgatattgtccaccgggacatcaaaccagagaatttgctcatcagccacaatgatgtgctcaaactttgtgattttggatttgcccgaaacctctccgaaggcaataatgccaactacaccgagtacgtggccacccgctggtatcgctctccagagcttctgcttggggccccctatggcaagtctgtggacatgtggagcgttggctgcatcctgggcgagctgtcagatgggcagccactcttcccaggggagtccgaaatcgaccagctgttcaccatccagaaagtcctggggccacttcccagcgagcaaatgaaactgttttacagcaatccaagatttcatggattacgcttccctgctgtcaaccaccctcaatccctggagaggagatacttgggcatcctcaacagtgtgctgctggacctcatgaagaatctcctcaagttggaccctgccgacagatatcttactgagcagtgcctgaaccatcccacatttcagacccagagattgctagacaggagcccatcaaggagtgccaagagaaagccttatcatgtggagagcagcacactatcaaacagaaaccaggctggaaagagtacagctttacaatctcaccaccgctccaactcaaaggacattcagaacttgtcagttggactgcccagagcagatgagggactccccgccaatgaaagcttcctgaatggaaacctggcaggtgcctccctttctcctctgcacacaaagacctaccaggcgtccagccaacctggatccacatcaaaagatctgaccaacaacaatatcccccaccttttatcaccaaaggaagccaaaagtaaaacagagttcgacttcaacatcgaccccaaaccttcagaagggcctggcaccaaatatttaaaatcaaattcaagaagccagcagaatcggcactcattcatggaatcctcacagagcaaagctgggacactccagccaaatgagaagcagtccagacatagttatattgacaccattcctcagtcatccagatccccaagctaccggacaaaagccaagagccatggcgcgctgtccgattccaagtcagtatcaaatctttcagaagcaagagctcagatcgcagagccctccacttcccgctacttcccctcttcatgtttggatctcaattcccctacttcacctacacccacccgtcatagtgacacacggaccctgctcagtccaagcggcaggaataaccggaacgagggcacactggacagccgccgcaccaccacaaggcattctaaaaccatggaggagctgaaattgcccgagcacatggactcttcacattctcattcactatctgcacctcatgaaagttttagctatggattgggatataccagccccttctccagtcagcagaggcctcacagacacagcatgtatgtcaccagggacaaggtgcgggcaaagggcctggatggatctttaagtattggccagggcatggctgccagagcaaattctcttcagctgctttcaccccagcctggggaacaactgccaccagaaatgacagtggcaaggagcagtgtaaaagagacctccagagaaggaacatccagcttccatactcgccagaagtcggaaggtggtgtgtaccacgacccacattctgatgatgggaccgctcccaaggaaaacaggcacctgtacaacgatcctgtgccccgccgcgtgggctctttctacagagttccttctcctagaccagacaactccttccacgaaaacaatgtgtccaccagagtgagcagtttaccctctgagagttctagtggaaccaatcattccaaaagacagcctgcatttgacccctggaagtccccggagaatatctcccactccgagcagctcaaagaaaaggagaaacagggattcttcaggtccatgaaaaagaagaagaaaaaaagccagacagtaccaaacagcgattctccagatcttctcactctgcaaaaatccatccattctgccagtactccatcatctcgacccaaggagtggagacctgagaaaatttcagacctgcagactcagtctcagcccctgaaatctttgaggaagttattacacctctcatcagcttccaatcacccagccagctcagatcccaggttccagccgctcacagcccagcaaacaaaaaactctttttcagaaatacgtattcatcctttgtcccaggcatcaggaggcagcagcaacatcaggcaggagccagctccaaaaggaaggcccgctctgcagctgccaggacagatggatccaggctggcatgtttcctctgtcactagatcagccacagaaggaccatcctattctgaacagctgggtgcaaaaagtggccccaatggccacccctacaatagaacaaatcgcagcagaatgcccaacttaaatgacttgaaagaaacagcactgtga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5coA2 source 1..2883 mol_type other DNA organism synthetic construct atgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgtcgtcggcgaaggcgcttatggcgttgtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgcggaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaacggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcaccgggacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgaatacgtggccaccagatggtacagaagccctgagctgctgctgggagccccttacggcaagtccgtggatatgtggagcgtgggctgtatcctgggagagctgtctgacggccagcctctgtttcctggcgagtccgagatcgaccagctgttcaccatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccccgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgcctgaaccatcctacctttcaaacccagagactgctggatcggagccctagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaacagaaaccaggccggcaagtctacagccctgcagagccaccacagaagcaacagcaaggacatccagaacctgtccgtgggcctgcctagagccgacgaaggactgcctgccaacgagagcttcctgaacggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggatctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaacagcagaagccagcagaaccggcactccttcatggaaagctcccagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatcccacagagcagcaggtccccaagctacaggaccaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagctcctgcctggatctgaacagcccaacaagccccacacctaccaggcacagcgacaccagaacactgctgtccccatccggcagaaacaaccggaacgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactccagccactctcattctctgagcgcccctcacgagtccttctcttacggcctgggctacacaagccccttcagctctcagcagaggccccacagacacagtatgtatgtgacccgggacaaagtgcgcgccaaaggcctggacggctctctgtctatcggccaaggcatggccgccagagccaattctctgcagctgctgtctcctcagcctggggaacaactgcctcctgagatgaccgtggccagatccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggagtgtaccacgatcctcacagcgacgacggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtccaccagagtgtccagcctgccttccgaaagcagctccggcaccaaccactccaagagacagcctgctttcgacccctggaagtcccctgagaacatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacggtccccaacagcgactccccagatctgctgaccctgcagaagtccatccactccgccagcacacctagcagcagacccaaagagtggcggccagagaagatcagcgatctgcagacccagtctcagcctctgaagtccctgaggaagctgctgcatctgagcagcgcctctaatcaccctgccagcagcgaccctagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagcagcaatatcagacaagagcccgctcctaagggcagacctgctctgcaactgcctggccagatggatccaggctggcacgtgtcctctgtgaccagatccgccacagagggacctagctacagcgaacagctcggcgccaagtctggccctaacggacacccctacaaccggaccaaccggtccagaatgcccaatctgaacgacctcaaagaaacggccctgtga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5coB2 source 1..2883 mol_type other DNA organism synthetic construct atgaagatcccaaatatcggcaacgtgatgaataagttcgagatcctgggagtggtgggagagggagcatatggcgtggtgctgaagtgcaggcacaaggagacccacgagatcgtggccatcaagaagtttaaggacagcgaggagaatgaggaggtgaaggagaccacactgagagagctgaagatgctgaggacactgaagcaggagaacatcgtggagctgaaggaggccttccggagaaggggcaagctgtacctggtgtttgagtacgtggagaagaacatgctggagctgctggaggagatgccaaatggcgtgccccctgagaaggtgaagtcctacatctatcagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagatatcaagcccgagaacctgctgatctcccacaatgacgtgctgaagctgtgcgatttcggctttgccaggaacctgagcgagggcaacaacgccaattacacagagtacgtggccaccaggtggtacaggagcccagagctgctgctgggagcaccatacggcaagagcgtggatatgtggtccgtgggctgcatcctgggcgagctgtctgacggccagcctctgttcccaggcgagagcgagatcgatcagctgtttaccatccagaaggtgctgggccctctgccaagcgagcagatgaagctgttctactccaaccctagattccacggcctgaggtttcccgccgtgaatcaccctcagagcctggagcgccggtatctgggcatcctgaactccgtgctgctggatctgatgaagaatctgctgaagctggaccccgccgatagatacctgaccgagcagtgtctgaatcaccctacatttcagacccagcgcctgctggaccggagcccttccagatctgccaagaggaagccatatcacgtggagagctccaccctgtccaatagaaaccaggccggcaagtctacagccctgcagagccaccacaggagcaactccaaggacatccagaatctgtccgtgggactgcctagggcagacgagggactgccagccaacgagagcttcctgaacggaaacctggcaggagcatctctgagcccactgcacacaaagacctaccaggcctctagccagcccggctccacatctaaggacctgaccaacaataacatcccacacctgctgtctcccaaggaggccaagagcaagaccgagttcgactttaatatcgatccaaagcctagcgagggaccaggcacaaagtatctgaagagcaactcccgctctcagcagaatcggcactccttcatggagtcctctcagtctaaggccggcaccctgcagcctaacgagaagcagagcagacactcctacatcgataccatcccccagagctccagaagcccttcctatagaacaaaggccaagtctcacggcgccctgtctgacagcaagtccgtgtctaatctgagcgaggcaagggcacagatcgcagagcccagcacctcccggtactttccttcttcctgtctggacctgaactctcctacaagcccaacacccacccgccacagcgatacacggaccctgctgtctccaagcggccgcaataaccggaacgagggcaccctggattctagaaggaccacaacccgccacagcaagacaatggaggagctgaagctgccagagcacatggactcctctcactcccactctctgagcgcccctcacgagtccttctcttacggcctgggctatacctcccccttctcctcccaacaaagaccccacaggcacagcatgtacgtgacaagggacaaggtccgggcaaagggactggacggaagcctgtccatcggacagggaatggcagcaagggccaactccctgcagctgctgtctcctcagccaggagagcagctgccaccagagatgaccgtggcacgctctagcgtgaaggagacaagccgggagggcacctcctctttccacacacgccagaagtccgagggaggcgtgtaccacgacccacactctgacgacggcacagcccctaaggagaaccggcacctgtacaacgatcccgtgcctaggagggtgggatccttctatagagtgccatctcccaggcctgacaatagctttcacgagaataacgtgtccacccgcgtgagctccctgccatctgagtctagctccggcacaaaccactctaagcggcagcccgcctttgacccttggaagagcccagagaatatctctcacagcgagcagctgaaggagaaggagaagcagggcttctttcgcagcatgaagaagaagaagaagaagagccagaccgtgcctaactccgactctccagacctgctgaccctgcagaagtccatccacagcgcctccacaccatctagcaggcctaaggagtggcggcctgagaagatcagcgatctgcagacccagagccagccactgaagtccctgcggaagctgctgcacctgtcctctgcctccaaccacccagcaagctccgacccaagattccagcccctgacagcccagcagaccaagaacagcttcagcgagatcaggatccaccctctgtcccaagcatctggaggatctagcaacatcagacaggagccagcaccaaagggcaggcccgccctgcagctgcctggccagatggatccaggctggcacgtgtcctctgtgacacgcagcgccaccgagggaccatcctactctgagcagctgggagcaaagagcggacctaacggacacccatataaccggaccaatagatccaggatgcccaatctgaacgacctgaaggagacagccctgtga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5coC2 source 1..2883 mol_type other DNA organism synthetic construct atgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgtggtgggcgagggcgcctacggcgtggtgctgaagtgcaggcacaaggagacccacgagatcgtggccatcaagaagttcaaggacagcgaggagaacgaggaggtgaaggagaccaccctgagggagctgaagatgctgaggaccctgaagcaggagaacatcgtggagctgaaggaggccttcaggaggaggggcaagctgtacctggtgttcgagtacgtggagaagaacatgctggagctgctggaggagatgcccaacggcgtgccccctgagaaggtgaagagctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagggacatcaagcccgagaacctgctgatcagccacaacgacgtgctgaagctgtgcgacttcggcttcgccaggaacctgagcgagggcaacaacgccaactacaccgagtacgtggccaccaggtggtacaggagccccgagctgctgctgggcgccccctacggcaagagcgtggacatgtggagcgtgggctgcatcctgggcgagctgagcgacggccagcccctgttccccggcgagagcgagatcgaccagctgttcaccatccagaaggtgctgggccccctgcccagcgagcagatgaagctgttctacagcaaccccaggttccacggcctgaggttccccgccgtgaaccacccccagagcctggagaggagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaacctgctgaagctggaccccgccgacagatacctgaccgagcagtgcctgaaccaccccaccttccagacccagaggctgctggacaggagccccagcaggagcgccaagaggaagccctaccacgtggagagcagcaccctgagcaacaggaaccaggccggcaagagcaccgccctgcagagccaccacaggagcaacagcaaggacatccagaacctgagcgtgggcctgcccagggccgacgagggcctgcccgccaacgagagcttcctgaacggcaacctggccggcgccagcctgagccccctgcacaccaagacctaccaggccagcagccagcccggcagcaccagcaaggacctgaccaacaacaacatcccccacctgctgagccccaaggaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcccagcgagggccccggcaccaagtacctgaagagcaacagcaggagccagcagaacaggcacagcttcatggagagcagccagagcaaggccggcaccctgcagcccaacgagaagcagagcaggcacagctacatcgacaccatcccccagagcagcaggagccccagctacaggaccaaggccaagagccacggcgccctgagcgacagcaagagcgtgagcaacctgagcgaggccagggcccagatcgccgagcccagcaccagcagatacttccccagcagctgcctggacctgaacagccccaccagccccacccccaccaggcacagcgacaccaggaccctgctgagccccagcggcaggaacaacaggaacgagggcaccctggacagcaggaggaccaccaccaggcacagcaagaccatggaggagctgaagctgcccgagcacatggacagcagccacagccacagcctgagcgcccctcacgagagcttcagctacggcctgggctacaccagccccttcagcagccagcagaggccccacaggcacagcatgtacgtgaccagggacaaagtgagggccaagggcctggacggcagcctgagcatcggccagggcatggccgccagggccaacagcctgcagctgctgagcccccagcccggcgagcagctgcctcccgagatgaccgtggccaggagcagcgtgaaggagaccagcagggagggcaccagcagcttccacaccaggcagaagagcgagggcggcgtgtaccacgacccccacagcgacgacggcaccgcccccaaggagaacaggcacctgtacaacgaccccgtgcccaggagggtgggcagcttctacagggtgcccagccccaggcccgacaacagcttccacgagaacaatgtgagcaccagagtgagcagcctgcccagcgagagcagcagcggcaccaaccacagcaagaggcagcccgccttcgacccctggaagagccccgagaacatcagccacagcgagcagctgaaggagaaggagaagcagggcttcttcaggagcatgaagaagaagaagaagaagagccagaccgtgcccaacagcgacagccccgacctgctgaccctgcagaagagcatccacagcgccagcacccccagcagcaggcccaaggagtggaggcccgagaagatcagcgacctgcagacccagagccagcccctgaagagcctgaggaagctgctgcacctgagcagcgccagcaaccaccccgccagcagcgaccccaggttccagcccctgaccgcccagcagaccaagaacagcttcagcgagatcaggatccaccccctgagccaggccagcggcggcagcagcaacatcaggcaggagcccgcccccaagggcaggcccgccctgcagctgcccggccagatggaccccggctggcacgtgagcagcgtgaccaggagcgccaccgagggccccagctacagcgagcagctgggcgccaagagcggccccaacggccacccctacaacaggaccaacaggagcaggatgcccaacctgaacgacctgaaggagaccgccctgtga 2883 DNA PAT misc_feature 1..2883 note engineered nucleic acid sequence CDKL5coD2 source 1..2883 mol_type other DNA organism synthetic construct atgaagatccctaacatcgggaatgtcatgaacaagtttgaaatcctgggggtggtgggggagggagcttatggagttgttttgaaatgtcgtcataaggaaactcatgaaatcgtggccattaagaagttcaaggacagtgaggagaatgaagaggtgaaggagaccactctccgcgagctgaagatgctgaggacactgaagcaggaaaacattgtggagctgaaggaggccttccgacgacggggtaagttgtacctggtgtttgagtacgtggagaaaaacatgttagaacttctggaggaaatgccaaacggtgtacctccagaaaaagtcaagtcatatatctaccagttgatcaaagccatccactggtgtcataaaaatgacatcgtccacagagatataaaaccagagaatcttctgatctctcacaatgatgtattaaaactttgtgattttggttttgcccgtaatctgtctgaaggtaataatgctaactatactgagtatgtagcaactcgctggtacagatcgcctgaactgctactgggtgctccttacggaaaaagtgtggacatgtggagcgttggttgtatcctaggagagctgagtgatgggcagccattgttcccgggggagagtgaaattgaccaactattcacaatccagaaagtgctggggccactaccaagtgaacaaatgaaacttttttattcaaatcctagatttcacggtctacgtttccccgctgtgaaccatcctcagtccttagaacggcgatatttaggcattctgaactctgttctgttagatctgatgaagaatttactaaaattagacccggctgaccgctatttgacagagcagtgtttaaatcatccaaccttccagacacagagactcctagaccgttcaccatctagaagtgcgaaaagaaaaccctaccacgttgaatcaagtaccctctccaatcgcaaccaggctgggaagagtactgccctacaatcgcaccacaggagtaatagtaaagatattcagaatctatctgtagggcttcctcgagcggacgagggtctacctgccaatgaaagtttcctcaatggtaacttagctggggcatcactgtcgccccttcatactaagacctaccaagcctcatctcaaccggggagtactagtaaagacctcaccaacaataacatcccccatttattatctcccaaggaggcgaaatccaagactgagttcgatttcaacattgacccaaagccctctgaagggcctggcaccaaatacctgaaatctaatagcagaagtcaacaaaataggcacagcttcatggagtcctcgcagagcaaagctggcacactgcaacctaatgaaaagcaaagccgacattcatatattgataccatcccccaatctagtagaagcccttcataccgcacgaaagcaaagtctcatggcgcactgtcagattctaaatccgtcagcaatctcagtgaagccagggctcagatcgccgagccctctacatctcgctactttccctcatcctgcctggacctaaactccccgacctctcccacccccacgcgtcacagcgacacccgaacattactttcaccttcgggcaggaataatcgaaatgagggcaccctagattcgcgccgtacgactacacggcattcaaaaaccatggaagaattgaaattgcctgagcacatggattcgtcacactctcacagtctatcggcccctcacgagagtttcagttacgggcttggctacaccagtcccttctccagccagcaacgcccacaccgccactccatgtatgtcacccgcgacaaggtccgtgccaaaggactcgatggcagcctaagcataggacagggcatggccgccagggccaacagtctccagttactaagtccccagcccggagaacagctgccacccgagatgactgtggctagatcgtccgtgaaagagacaagtagggaagggacctctagcttccacaccagacagaaatccgaggggggcgtgtatcatgaccctcatagtgatgatggtacagccccgaaggaaaatagacacttgtacaatgaccctgtgccccgaagagttggctccttctaccgggtgccctctccacggccagacaacagcttccatgagaacaatgtttcaacccgggtaagctccctgcctagtgaaagttcatccggaacaaatcactcgaagcgtcagccagccttcgacccctggaagtctccggagaacataagtcacagcgagcagctcaaagaaaaagaaaaacaaggcttcttcagaagcatgaagaagaaaaaaaaaaagtctcaaacagtgccaaattccgattcccccgacttattaacactacaaaagagcatccattcagcttctacgccaagcagtaggcccaaagagtggagacccgagaagatttctgatctacagacccagtctcagcctttaaaatcgctcaggaagctgctgcacctgtcttccgcttcaaaccacccggcctccagtgaccctcggtttcagccactgactgcccagcagactaaaaatagtttttcagagatcaggattcatcccttatcacaggcctctggcggcagcagcaatatccggcaggagcctgcccctaaaggccggcccgcgttgcagctgcccggccagatggacccaggctggcatgtgtcatcagttacacgcagtgccacagaaggccccagctactcagaacaattgggtgctaagtcaggacccaatggccacccatacaaccgaaccaacagatcaaggatgcccaacctcaacgacctcaaagaaacagctctctga 4827 DNA PAT source 1..4827 mol_type other DNA organism synthetic construct repeat_region 1..130 note 5' ITR regulatory 220..1448 note UbC promoter regulatory_class promoter misc_feature 1458..1466 note Kozak misc_feature 1464..4346 note nucleic acid sequence encoding hCDKL5 misc_feature 4364..4385 note miRNA183 misc_feature 4390..4411 note miRNA183 misc_feature 4418..4439 note miRNA183 misc_feature 4446..4467 note miRNA183 regulatory 4483..4609 note rabbit beta globin polyA regulatory_class polyA_signal_sequence repeat_region 4698..4827 note 3' ITR ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttccttgtagttaatgattaacccgccatgctacttatctaccagggtaatggggatcctctagaactatagctagcatgctctaggaagatctggcctccgcgccgggttttggcgcctcccgcgggcgcccccctcctcacggcgagcgctgccacgtcagacgaagggcgcagcgagcgtcctgatccttccgcccggacgctcaggacagcggcccgctgctcataagactcggccttagaaccccagtatcagcagaaggacattttaggacgggacttgggtgactctagggcactggttttctttccagagagcggaacaggcgaggaaaagtagtcccttctcggcgattctgcggagggatctccgtggggcggtgaacgccgatgattatataaggacgcgccgggtgtggcacagctagttccgtcgcagccgggatttgggtcgcggttcttgtttgtggatcgctgtgatcgtcacttggtgagtagcgggctgctgggctggccggggctttcgtggccgccgggccgctcggtgggacggaagcgtgtggagagaccgccaagggctgtagtctgggtccgcgagcaaggttgccctgaactgggggttggggggagcgcagcaaaatggcggctgttcccgagtcttgaatggaagacgcttgtgaggcgggctgtgaggtcgttgaaacaaggtggggggcatggtgggcggcaagaacccaaggtcttgaggccttcgctaatgcgggaaagctcttattcgggtgagatgggctggggcaccatctggggaccctgacgtgaagtttgtcactgactggagaactcggtttgtcgtctgttgcgggggcggcagttatggcggtgccgttgggcagtgcacccgtacctttgggagcgcgcgccctcgtcgtgtcgtgacgtcacccgttctgttggcttataatgcagggtggggccacctgccggtaggtgtgcggtaggcttttctccgtcgcaggacgcagggttcgggcctagggtaggctctcctgaatcgacaggcgccggacctctggtgaggggagggataagtgaggcgtcagtttctttggtcggttttatgtacctatcttcttaagtagctgaagctccggttttgaactatgcgctcggggttggcgagtgtgttttgtgaagttttttaggcaccttttgaaatgtaatcatttgggtcaatatgtaattttcagtgttagactagtaaattgtccgctaaattctggccgtttttggcttttttgttagacgaagctttattgcggtagaattcgccgccaccatgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctgaagcttatcgataccggtagtgaattctaccagtgccataggatagtgaattctaccagtgccatacacgtgagtgaattctaccagtgccatagcatgcagtgaattctaccagtgccatagcggcctgaggatccgatctttttccctctgccaaaaattatggggacatcatgaagccccttgagcatctgacttctggctaataaaggaaatttattttcattgcaatagtgtgttggaattttttgtgtctctcactcggaagcaattcgttgatctgaatttcgaccacccataatacccattaccctggtagataagtagcatggcgggttaatcattaactacaaggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 4390 DNA PAT source 1..4390 mol_type other DNA organism synthetic construct regulatory 1..1229 note UbC promoter regulatory_class promoter misc_feature 1239..1247 note Kozak misc_feature 1245..4127 note nucleic acid sequence encoding hCDKL5 misc_feature 4145..4166 note miRNA183 misc_feature 4171..4192 note miRNA183 misc_feature 4199..4220 note miRNA183 misc_feature 4227..4248 note miRNA183 regulatory 4264..4390 note rabbit beta globin polyA regulatory_class polyA_signal_sequence ggcctccgcgccgggttttggcgcctcccgcgggcgcccccctcctcacggcgagcgctgccacgtcagacgaagggcgcagcgagcgtcctgatccttccgcccggacgctcaggacagcggcccgctgctcataagactcggccttagaaccccagtatcagcagaaggacattttaggacgggacttgggtgactctagggcactggttttctttccagagagcggaacaggcgaggaaaagtagtcccttctcggcgattctgcggagggatctccgtggggcggtgaacgccgatgattatataaggacgcgccgggtgtggcacagctagttccgtcgcagccgggatttgggtcgcggttcttgtttgtggatcgctgtgatcgtcacttggtgagtagcgggctgctgggctggccggggctttcgtggccgccgggccgctcggtgggacggaagcgtgtggagagaccgccaagggctgtagtctgggtccgcgagcaaggttgccctgaactgggggttggggggagcgcagcaaaatggcggctgttcccgagtcttgaatggaagacgcttgtgaggcgggctgtgaggtcgttgaaacaaggtggggggcatggtgggcggcaagaacccaaggtcttgaggccttcgctaatgcgggaaagctcttattcgggtgagatgggctggggcaccatctggggaccctgacgtgaagtttgtcactgactggagaactcggtttgtcgtctgttgcgggggcggcagttatggcggtgccgttgggcagtgcacccgtacctttgggagcgcgcgccctcgtcgtgtcgtgacgtcacccgttctgttggcttataatgcagggtggggccacctgccggtaggtgtgcggtaggcttttctccgtcgcaggacgcagggttcgggcctagggtaggctctcctgaatcgacaggcgccggacctctggtgaggggagggataagtgaggcgtcagtttctttggtcggttttatgtacctatcttcttaagtagctgaagctccggttttgaactatgcgctcggggttggcgagtgtgttttgtgaagttttttaggcaccttttgaaatgtaatcatttgggtcaatatgtaattttcagtgttagactagtaaattgtccgctaaattctggccgtttttggcttttttgttagacgaagctttattgcggtagaattcgccgccaccatgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctgaagcttatcgataccggtagtgaattctaccagtgccataggatagtgaattctaccagtgccatacacgtgagtgaattctaccagtgccatagcatgcagtgaattctaccagtgccatagcggcctgaggatccgatctttttccctctgccaaaaattatggggacatcatgaagccccttgagcatctgacttctggctaataaaggaaatttattttcattgcaatagtgtgttggaattttttgtgtctctcactcg 130 DNA PAT source 1..130 mol_type other DNA note 5' ITR organism synthetic construct ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttcct 1229 DNA PAT source 1..1229 mol_type other DNA note UbC promoter organism synthetic construct ggcctccgcgccgggttttggcgcctcccgcgggcgcccccctcctcacggcgagcgctgccacgtcagacgaagggcgcagcgagcgtcctgatccttccgcccggacgctcaggacagcggcccgctgctcataagactcggccttagaaccccagtatcagcagaaggacattttaggacgggacttgggtgactctagggcactggttttctttccagagagcggaacaggcgaggaaaagtagtcccttctcggcgattctgcggagggatctccgtggggcggtgaacgccgatgattatataaggacgcgccgggtgtggcacagctagttccgtcgcagccgggatttgggtcgcggttcttgtttgtggatcgctgtgatcgtcacttggtgagtagcgggctgctgggctggccggggctttcgtggccgccgggccgctcggtgggacggaagcgtgtggagagaccgccaagggctgtagtctgggtccgcgagcaaggttgccctgaactgggggttggggggagcgcagcaaaatggcggctgttcccgagtcttgaatggaagacgcttgtgaggcgggctgtgaggtcgttgaaacaaggtggggggcatggtgggcggcaagaacccaaggtcttgaggccttcgctaatgcgggaaagctcttattcgggtgagatgggctggggcaccatctggggaccctgacgtgaagtttgtcactgactggagaactcggtttgtcgtctgttgcgggggcggcagttatggcggtgccgttgggcagtgcacccgtacctttgggagcgcgcgccctcgtcgtgtcgtgacgtcacccgttctgttggcttataatgcagggtggggccacctgccggtaggtgtgcggtaggcttttctccgtcgcaggacgcagggttcgggcctagggtaggctctcctgaatcgacaggcgccggacctctggtgaggggagggataagtgaggcgtcagtttctttggtcggttttatgtacctatcttcttaagtagctgaagctccggttttgaactatgcgctcggggttggcgagtgtgttttgtgaagttttttaggcaccttttgaaatgtaatcatttgggtcaatatgtaattttcagtgttagactagtaaattgtccgctaaattctggccgtttttggcttttttgttagacgaagctttattgcggta 127 DNA PAT source 1..127 mol_type other DNA note rabbit beta globin polyA organism synthetic construct gatctttttccctctgccaaaaattatggggacatcatgaagccccttgagcatctgacttctggctaataaaggaaatttattttcattgcaatagtgtgttggaattttttgtgtctctcactcg 130 DNA PAT source 1..130 mol_type other DNA note 3' ITR organism synthetic construct aggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 4692 DNA PAT source 1..4692 mol_type other DNA organism synthetic construct regulatory 1..36 note truncated p5 promoter regulatory_class promoter misc_feature 37..1899 note AAV2 Rep misc_feature 1919..4129 note AAVhu68 cap regulatory 4220..4350 note P5 promoter regulatory_class promoter regulatory 4398..4692 note LacZ promoter regulatory_class promoter ccattttgaagcgggaggtttgaacgcgcagccgccatgccggggttttacgagattgtgattaaggtccccagcgaccttgacgagcatctgcccggcatttctgacagctttgtgaactgggtggccgagaaggaatgggagttgccgccagattctgacatggatctgaatctgattgagcaggcacccctgaccgtggccgagaagctgcagcgcgactttctgacggaatggcgccgtgtgagtaaggccccggaggctcttttctttgtgcaatttgagaagggagagagctacttccacatgcacgtgctcgtggaaaccaccggggtgaaatccatggttttgggacgtttcctgagtcagattcgcgaaaaactgattcagagaatttaccgcgggatcgagccgactttgccaaactggttcgcggtcacaaagaccagaaatggcgccggaggcgggaacaaggtggtggatgagtgctacatccccaattacttgctccccaaaacccagcctgagctccagtgggcgtggactaatatggaacagtatttaagcgcctgtttgaatctcacggagcgtaaacggttggtggcgcagcatctgacgcacgtgtcgcagacgcaggagcagaacaaagagaatcagaatcccaattctgatgcgccggtgatcagatcaaaaacttcagccaggtacatggagctggtcgggtggctcgtggacaaggggattacctcggagaagcagtggatccaggaggaccaggcctcatacatctccttcaatgcggcctccaactcgcggtcccaaatcaaggctgccttggacaatgcgggaaagattatgagcctgactaaaaccgcccccgactacctggtgggccagcagcccgtggaggacatttccagcaatcggatttataaaattttggaactaaacgggtacgatccccaatatgcggcttccgtctttctgggatgggccacgaaaaagttcggcaagaggaacaccatctggctgtttgggcctgcaactaccgggaagaccaacatcgcggaggccatagcccacactgtgcccttctacgggtgcgtaaactggaccaatgagaactttcccttcaacgactgtgtcgacaagatggtgatctggtgggaggaggggaagatgaccgccaaggtcgtggagtcggccaaagccattctcggaggaagcaaggtgcgcgtggaccagaaatgcaagtcctcggcccagatagacccgactcccgtgatcgtcacctccaacaccaacatgtgcgccgtgattgacgggaactcaacgaccttcgaacaccagcagccgttgcaagaccggatgttcaaatttgaactcacccgccgtctggatcatgactttgggaaggtcaccaagcaggaagtcaaagactttttccggtgggcaaaggatcacgtggttgaggtggagcatgaattctacgtcaaaaagggtggagccaagaaaagacccgcccccagtgacgcagatataagtgagcccaaacgggtgcgcgagtcagttgcgcagccatcgacgtcagacgcggaagcttcgatcaactacgcagacaggtaccaaaacaaatgttctcgtcacgtgggcatgaatctgatgctgtttccctgcagacaatgcgagagaatgaatcagaattcaaatatctgcttcactcacggacagaaagactgtttagagtgctttcccgtgtcagaatctcaacccgtttctgtcgtcaaaaaggcgtatcagaaactgtgctacattcatcatatcatgggaaaggtgccagacgcttgcactgcctgcgatctggtcaatgtggatttggatgactgcatctttgaacaataaatgatttaaatcaggtatggctgccgatggttatcttccagattggctcgaggacaacctcagtgaaggcattcgcgagtggtgggctttgaaacctggagcccctcaacccaaggcaaatcaacaacatcaagacaacgctcggggtcttgtgcttccgggttacaaataccttggacccggcaacggactcgacaagggggagccggtcaacgaagcagacgcggcggccctcgagcacgacaaggcctacgaccagcagctcaaggccggagacaacccgtacctcaagtacaaccacgccgacgccgagttccaggagcggctcaaagaagatacgtcttttgggggcaacctcgggcgagcagtcttccaggccaaaaagaggcttcttgaacctcttggtctggttgaggaagcggctaagacggctcctggaaagaagaggcctgtagagcagtctcctcaggaaccggactcctccgtgggtattggcaaatcgggtgcacagcccgctaaaaagagactcaatttcggtcagactggcgacacagagtcagtccccgaccctcaaccaatcggagaacctcccgcagccccctcaggtgtgggatctcttacaatggcttcaggtggtggcgcaccagtggcagacaataacgaaggtgccgatggagtgggtagttcctcgggaaattggcattgcgattcccaatggctgggggacagagtcatcaccaccagcacccgaacctgggccctgcccacctacaacaatcacctctacaagcaaatctccaacagcacatctggaggatcttcaaatgacaacgcctacttcggctacagcaccccctgggggtattttgacttcaacagattccactgccacttctcaccacgtgactggcaaagactcatcaacaacaactggggattccggcctaagcgactcaacttcaagctcttcaacattcaggtcaaagaggttacggacaacaatggagtcaagaccatcgctaataaccttaccagcacggtccaggtcttcacggactcagactatcagctcccgtacgtgctcgggtcggctcacgagggctgcctcccgccgttcccagcggacgttttcatgattcctcagtacgggtatctaacgcttaatgatggaagccaagccgtgggtcgttcgtccttttactgcctggaatatttcccgtcgcaaatgctaagaacgggtaacaacttccagttcagctacgagtttgagaacgtacctttccatagcagctatgctcacagccaaagcctggaccgactcatgaatccactcatcgaccaatacttgtactatctctcaaagactattaacggttctggacagaatcaacaaacgctaaaattcagtgtggccggacccagcaacatggctgtccagggaagaaactacatacctggacccagctaccgacaacaacgtgtctcaaccactgtgactcaaaacaacaacagcgaatttgcttggcctggagcttcttcttgggctctcaatggacgtaatagcttgatgaatcctggacctgctatggccagccacaaagaaggagaggaccgtttctttcctttgtctggatctttaatttttggcaaacaaggaactggaagagacaacgtggatgcggacaaagtcatgataaccaacgaagaagaaattaaaactaccaacccagtagcaacggagtcctatggacaagtggccacaaaccaccagagtgcccaagcacaggcgcagaccggctgggttcaaaaccaaggaatacttccgggtatggtttggcaggacagagatgtgtacctgcaaggacccatttgggccaaaattcctcacacggacggcaactttcacccttctccgctgatgggagggtttggaatgaagcacccgcctcctcagatcctcatcaaaaacacacctgtacctgcggatcctccaacggctttcaacaaggacaagctgaactctttcatcacccagtattctactggccaagtcagcgtggagattgagtgggagctgcagaaggaaaacagcaagcgctggaacccggagatccagtacacttccaactattacaagtctaataatgttgaatttgctgttaatactgaaggtgtttattctgaaccccgccccattggcaccagatacctgactcgtaatctgtaattgcttgttaatcaataaaccgtttaattcgtttcagttgaactttggtctctgcgaagggcgaattcgtttaaacctgcaggactagaggtcctgtattagaggtcacgtgagtgttttgcgacattttgcgacaccatgtggtcacgctgggtatttaagcccgagtgagcacgcagggtctccattttgaagcgggaggtttgaacgcgcagccgccaagccgaattctgcagatatccatcacactggcggccgctcgactagagcggccgccaccgcggtggagctccagcttttgttccctttagtgagggttaattgcgcgcttggcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgc 1863 DNA PAT source 1..1863 mol_type other DNA organism adeno-associated virus 2 atgccggggttttacgagattgtgattaaggtccccagcgaccttgacgagcatctgcccggcatttctgacagctttgtgaactgggtggccgagaaggaatgggagttgccgccagattctgacatggatctgaatctgattgagcaggcacccctgaccgtggccgagaagctgcagcgcgactttctgacggaatggcgccgtgtgagtaaggccccggaggctcttttctttgtgcaatttgagaagggagagagctacttccacatgcacgtgctcgtggaaaccaccggggtgaaatccatggttttgggacgtttcctgagtcagattcgcgaaaaactgattcagagaatttaccgcgggatcgagccgactttgccaaactggttcgcggtcacaaagaccagaaatggcgccggaggcgggaacaaggtggtggatgagtgctacatccccaattacttgctccccaaaacccagcctgagctccagtgggcgtggactaatatggaacagtatttaagcgcctgtttgaatctcacggagcgtaaacggttggtggcgcagcatctgacgcacgtgtcgcagacgcaggagcagaacaaagagaatcagaatcccaattctgatgcgccggtgatcagatcaaaaacttcagccaggtacatggagctggtcgggtggctcgtggacaaggggattacctcggagaagcagtggatccaggaggaccaggcctcatacatctccttcaatgcggcctccaactcgcggtcccaaatcaaggctgccttggacaatgcgggaaagattatgagcctgactaaaaccgcccccgactacctggtgggccagcagcccgtggaggacatttccagcaatcggatttataaaattttggaactaaacgggtacgatccccaatatgcggcttccgtctttctgggatgggccacgaaaaagttcggcaagaggaacaccatctggctgtttgggcctgcaactaccgggaagaccaacatcgcggaggccatagcccacactgtgcccttctacgggtgcgtaaactggaccaatgagaactttcccttcaacgactgtgtcgacaagatggtgatctggtgggaggaggggaagatgaccgccaaggtcgtggagtcggccaaagccattctcggaggaagcaaggtgcgcgtggaccagaaatgcaagtcctcggcccagatagacccgactcccgtgatcgtcacctccaacaccaacatgtgcgccgtgattgacgggaactcaacgaccttcgaacaccagcagccgttgcaagaccggatgttcaaatttgaactcacccgccgtctggatcatgactttgggaaggtcaccaagcaggaagtcaaagactttttccggtgggcaaaggatcacgtggttgaggtggagcatgaattctacgtcaaaaagggtggagccaagaaaagacccgcccccagtgacgcagatataagtgagcccaaacgggtgcgcgagtcagttgcgcagccatcgacgtcagacgcggaagcttcgatcaactacgcagacaggtaccaaaacaaatgttctcgtcacgtgggcatgaatctgatgctgtttccctgcagacaatgcgagagaatgaatcagaattcaaatatctgcttcactcacggacagaaagactgtttagagtgctttcccgtgtcagaatctcaacccgtttctgtcgtcaaaaaggcgtatcagaaactgtgctacattcatcatatcatgggaaaggtgccagacgcttgcactgcctgcgatctggtcaatgtggatttggatgactgcatctttgaacaa 2211 DNA PAT source 1..2211 mol_type other DNA organism adeno-associated virus hu68 misc_feature 1..2211 note VP1 misc_feature 412..2211 note VP2 misc_feature 607..2211 note VP3 atggctgccgatggttatcttccagattggctcgaggacaacctcagtgaaggcattcgcgagtggtgggctttgaaacctggagcccctcaacccaaggcaaatcaacaacatcaagacaacgctcggggtcttgtgcttccgggttacaaataccttggacccggcaacggactcgacaagggggagccggtcaacgaagcagacgcggcggccctcgagcacgacaaggcctacgaccagcagctcaaggccggagacaacccgtacctcaagtacaaccacgccgacgccgagttccaggagcggctcaaagaagatacgtcttttgggggcaacctcgggcgagcagtcttccaggccaaaaagaggcttcttgaacctcttggtctggttgaggaagcggctaagacggctcctggaaagaagaggcctgtagagcagtctcctcaggaaccggactcctccgtgggtattggcaaatcgggtgcacagcccgctaaaaagagactcaatttcggtcagactggcgacacagagtcagtccccgaccctcaaccaatcggagaacctcccgcagccccctcaggtgtgggatctcttacaatggcttcaggtggtggcgcaccagtggcagacaataacgaaggtgccgatggagtgggtagttcctcgggaaattggcattgcgattcccaatggctgggggacagagtcatcaccaccagcacccgaacctgggccctgcccacctacaacaatcacctctacaagcaaatctccaacagcacatctggaggatcttcaaatgacaacgcctacttcggctacagcaccccctgggggtattttgacttcaacagattccactgccacttctcaccacgtgactggcaaagactcatcaacaacaactggggattccggcctaagcgactcaacttcaagctcttcaacattcaggtcaaagaggttacggacaacaatggagtcaagaccatcgctaataaccttaccagcacggtccaggtcttcacggactcagactatcagctcccgtacgtgctcgggtcggctcacgagggctgcctcccgccgttcccagcggacgttttcatgattcctcagtacgggtatctaacgcttaatgatggaagccaagccgtgggtcgttcgtccttttactgcctggaatatttcccgtcgcaaatgctaagaacgggtaacaacttccagttcagctacgagtttgagaacgtacctttccatagcagctatgctcacagccaaagcctggaccgactcatgaatccactcatcgaccaatacttgtactatctctcaaagactattaacggttctggacagaatcaacaaacgctaaaattcagtgtggccggacccagcaacatggctgtccagggaagaaactacatacctggacccagctaccgacaacaacgtgtctcaaccactgtgactcaaaacaacaacagcgaatttgcttggcctggagcttcttcttgggctctcaatggacgtaatagcttgatgaatcctggacctgctatggccagccacaaagaaggagaggaccgtttctttcctttgtctggatctttaatttttggcaaacaaggaactggaagagacaacgtggatgcggacaaagtcatgataaccaacgaagaagaaattaaaactaccaacccagtagcaacggagtcctatggacaagtggccacaaaccaccagagtgcccaagcacaggcgcagaccggctgggttcaaaaccaaggaatacttccgggtatggtttggcaggacagagatgtgtacctgcaaggacccatttgggccaaaattcctcacacggacggcaactttcacccttctccgctgatgggagggtttggaatgaagcacccgcctcctcagatcctcatcaaaaacacacctgtacctgcggatcctccaacggctttcaacaaggacaagctgaactctttcatcacccagtattctactggccaagtcagcgtggagattgagtgggagctgcagaaggaaaacagcaagcgctggaacccggagatccagtacacttccaactattacaagtctaataatgttgaatttgctgttaatactgaaggtgtttattctgaaccccgccccattggcaccagatacctgactcgtaatctgtaa 4809 DNA PAT source 1..4809 mol_type other DNA organism synthetic construct repeat_region 1..130 note 5'ITR regulatory 226..1454 note UbC promoter regulatory_class promoter misc_feature 1470..4352 note nucleic acid sequence encoding hCDKL5 regulatory 4376..4614 note SV4- polyA regulatory_class polyA_signal_sequence repeat_region 4680..4809 note 3' ITR ctgcgcgctcgctcgctcactgaggccgcccgggcaaagcccgggcgtcgggcgacctttggtcgcccggcctcagtgagcgagcgagcgcgcagagagggagtggccaactccatcactaggggttccttgtagttaatgattaacccgccatgctacttatctacgtagccatgctctaggaagatcctctagaactatagctagcatgctctaggaagatctggcctccgcgccgggttttggcgcctcccgcgggcgcccccctcctcacggcgagcgctgccacgtcagacgaagggcgcagcgagcgtcctgatccttccgcccggacgctcaggacagcggcccgctgctcataagactcggccttagaaccccagtatcagcagaaggacattttaggacgggacttgggtgactctagggcactggttttctttccagagagcggaacaggcgaggaaaagtagtcccttctcggcgattctgcggagggatctccgtggggcggtgaacgccgatgattatataaggacgcgccgggtgtggcacagctagttccgtcgcagccgggatttgggtcgcggttcttgtttgtggatcgctgtgatcgtcacttggtgagtagcgggctgctgggctggccggggctttcgtggccgccgggccgctcggtgggacggaagcgtgtggagagaccgccaagggctgtagtctgggtccgcgagcaaggttgccctgaactgggggttggggggagcgcagcaaaatggcggctgttcccgagtcttgaatggaagacgcttgtgaggcgggctgtgaggtcgttgaaacaaggtggggggcatggtgggcggcaagaacccaaggtcttgaggccttcgctaatgcgggaaagctcttattcgggtgagatgggctggggcaccatctggggaccctgacgtgaagtttgtcactgactggagaactcggtttgtcgtctgttgcgggggcggcagttatggcggtgccgttgggcagtgcacccgtacctttgggagcgcgcgccctcgtcgtgtcgtgacgtcacccgttctgttggcttataatgcagggtggggccacctgccggtaggtgtgcggtaggcttttctccgtcgcaggacgcagggttcgggcctagggtaggctctcctgaatcgacaggcgccggacctctggtgaggggagggataagtgaggcgtcagtttctttggtcggttttatgtacctatcttcttaagtagctgaagctccggttttgaactatgcgctcggggttggcgagtgtgttttgtgaagttttttaggcaccttttgaaatgtaatcatttgggtcaatatgtaattttcagtgttagactagtaaattgtccgctaaattctggccgtttttggcttttttgttagacgaagctttattgcggtagaattcgccgccaccatgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctgaagcttatcgataccgtcgatcgaggccgcttcgagcagacatgataagatacattgatgagtttggacaaaccacaactagaatgcagtgaaaaaaatgctttatttgtgaaatttgtgatgctattgctttatttgtaaccattataagctgcaataaacaagttaacaacaacaattgcattcattttatgtttcaggttcagggggagatgtgggaggttttttaaagcaagtaaaacctctacaaatgtggtaaaatcgataaggatcttcctagagcatggctacgtagataagtagcatggcgggttaatcattaactacaaggaacccctagtgatggagttggccactccctctctgcgcgctcgctcgctcactgaggccgggcgaccaaaggtcgcccgacgcccgggctttgcccgggcggcctcagtgagcgagcgagcgcgcag 4383 DNA PAT source 1..4383 mol_type other DNA organism synthetic construct regulatory 1..1229 note UbC Promoter regulatory_class promoter misc_feature 1245..4127 note nucliec acid sequence encoding hCDKL5 misc_feature 4145..4166 note miRNA183 misc_feature 4171..4192 note miRNA183 misc_feature 4199..4220 note miRNA183 misc_feature 4227..4248 note miRNA183 regulatory 4257..4383 note Rabbit beta globin polyA regulatory_class polyA_signal_sequence ggcctccgcgccgggttttggcgcctcccgcgggcgcccccctcctcacggcgagcgctgccacgtcagacgaagggcgcagcgagcgtcctgatccttccgcccggacgctcaggacagcggcccgctgctcataagactcggccttagaaccccagtatcagcagaaggacattttaggacgggacttgggtgactctagggcactggttttctttccagagagcggaacaggcgaggaaaagtagtcccttctcggcgattctgcggagggatctccgtggggcggtgaacgccgatgattatataaggacgcgccgggtgtggcacagctagttccgtcgcagccgggatttgggtcgcggttcttgtttgtggatcgctgtgatcgtcacttggtgagtagcgggctgctgggctggccggggctttcgtggccgccgggccgctcggtgggacggaagcgtgtggagagaccgccaagggctgtagtctgggtccgcgagcaaggttgccctgaactgggggttggggggagcgcagcaaaatggcggctgttcccgagtcttgaatggaagacgcttgtgaggcgggctgtgaggtcgttgaaacaaggtggggggcatggtgggcggcaagaacccaaggtcttgaggccttcgctaatgcgggaaagctcttattcgggtgagatgggctggggcaccatctggggaccctgacgtgaagtttgtcactgactggagaactcggtttgtcgtctgttgcgggggcggcagttatggcggtgccgttgggcagtgcacccgtacctttgggagcgcgcgccctcgtcgtgtcgtgacgtcacccgttctgttggcttataatgcagggtggggccacctgccggtaggtgtgcggtaggcttttctccgtcgcaggacgcagggttcgggcctagggtaggctctcctgaatcgacaggcgccggacctctggtgaggggagggataagtgaggcgtcagtttctttggtcggttttatgtacctatcttcttaagtagctgaagctccggttttgaactatgcgctcggggttggcgagtgtgttttgtgaagttttttaggcaccttttgaaatgtaatcatttgggtcaatatgtaattttcagtgttagactagtaaattgtccgctaaattctggccgtttttggcttttttgttagacgaagctttattgcggtagaattcgccgccaccatgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctgaagcttatcgataccggtagtgaattctaccagtgccataggatagtgaattctaccagtgccatacacgtgagtgaattctaccagtgccatagcatgcagtgaattctaccagtgccatagcggccgcgatctttttccctctgccaaaaattatggggacatcatgaagccccttgagcatctgacttctggctaataaaggaaatttattttcattgcaatagtgtgttggaattttttgtgtctctcactcg 3968 DNA PAT source 1..3968 mol_type other DNA organism synthetic construct regulatory 1..798 note CBh promoter regulatory_class promoter misc_feature 830..3712 note nucleic acid sequence encoding hCDKL5 misc_feature 3730..3751 note miRNA183 misc_feature 3756..3777 note miRNA183 misc_feature 3784..3805 note miRNA183 misc_feature 3812..3833 note miRNA183 regulatory 3842..3968 note rabbit beta globin polyA regulatory_class polyA_signal_sequence cgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattgacgtcaatagtaacgccaatagggactttccattgacgtcaatgggtggagtatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtacgccccctattgacgtcaatgacggtaaatggcccgcctggcattgtgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtcgaggtgagccccacgttctgcttcactctccccatctcccccccctccccacccccaattttgtatttatttattttttaattattttgtgcagcgatgggggcggggggggggggggggcgcgcgccaggcggggcggggcggggcgaggggcggggcggggcgaggcggagaggtgcggcggcagccaatcagagcggcgcgctccgaaagtttccttttatggcgaggcggcggcggcggcggccctataaaaagcgaagcgcgcggcgggcgggagtcgctgcgcgctgccttcgccccgtgccccgctccgccgccgcctcgcgccgcccgccccggctctgactgaccgcgttactcccacaggtgagcgggcgggacggcccttctcctccgggctgtaattagctgagcaagaggtaagggtttaagggatggttggttggtggggtattaatgtttaattacctggagcacctgcctgaaatcactttttttcaggttggcttaagctgcagaccggaattcgccgccaccatgaagatccccaacatcggcaacgtgatgaacaagttcgagatcctgggcgttgtcggagaaggcgcttatggcgtggtgctgaagtgcagacacaaagaaacccacgagatcgtggccatcaagaagttcaaggacagcgaagagaacgaggaagtgaaagagacaaccctgcgcgagctgaagatgctgagaaccctgaagcaagagaacatcgtggaactgaaagaggccttccggcggagaggcaagctgtacctggtgttcgagtacgtggaaaagaacatgctcgagctgctggaagagatgcccaatggcgtgccacctgagaaagtgaagtcctacatctaccagctgatcaaggccatccactggtgccacaagaacgacatcgtgcacagagacatcaagcccgagaacctgctgatctcccacaacgacgtgctgaagctgtgcgacttcggcttcgccagaaatctgagcgagggcaacaacgccaactacaccgagtatgtggccaccagatggtacagaagccctgaactgctgctgggagccccttacggcaagtctgtggatatgtggtccgtgggctgtatcctgggagagctgtctgatggccaacctctgtttcctggcgagtccgagatcgaccagctgttcacaatccagaaggtgctgggccctctgcctagcgagcagatgaagctgttctacagcaaccccagattccacggcctgagattccctgccgtgaatcaccctcagagcctggaaagaagatacctgggcatcctgaacagcgtgctgctggacctgatgaagaatctgctgaaactggaccccgccgacagatacctgaccgagcagtgtctgaaccatcctacctttcagacccagagactgctggatagaagccccagcagaagcgccaagagaaagccctaccacgtggaaagcagcaccctgagcaatagaaaccaggccggaaagagcactgccctgcagagccaccacagaagcaacagcaaggacatccagaacctgagcgtgggcctgcctagagctgatgaaggactgcctgccaacgagagcttcctgaatggaaatctggctggcgcctctctgagccctctgcacacaaagacataccaggccagcagccagcctggcagcacaagcaaggacctgaccaacaacaacatccctcatctgctgagccccaaagaggccaagagcaagaccgagttcgacttcaacatcgaccccaagcctagcgaaggccctggcaccaagtacctgaagtccaactccagaagccagcagaaccggcactccttcatggaaagctctcagagcaaggccggcacactgcagcctaacgagaagcagagcagacacagctacatcgacacaatccctcagtcctctcggagccccagctacagaacaaaggccaaatctcacggcgccctgagcgatagcaagagcgtgtccaatctgtccgaggctagagcccagatcgccgagcctagcaccagcagatacttccctagcagctgcctggatctgaacagccctacaagccccacacctaccaggcacagcgataccagaacactgctgtccccaagcggccggaacaacagaaatgagggcaccctggacagcagacggaccaccacaagacacagcaagaccatggaagaactgaagctgcccgagcacatggactctagccactctcattctctgagcgcccctcacgagtcctttagctacggcctgggctacacaagcccattttccagtcagcagcggccccacagacactctatgtacgtgaccagagacaaagtccgcgccaaaggcctggatggctctctgtctattggacaaggcatggccgccagagccaatagcctgcaacttctgtctcctcagcctggcgaacagctgcctcctgaaatgacagtggcccggtccagcgtgaaagaaaccagcagagagggcacctccagcttccacaccagacagaaaagcgaaggcggcgtgtaccacgatcctcactctgatgatggcacagcccctaaagagaacagacacctgtacaacgaccccgtgcctagaagagtgggctccttctacagagtgccttctcctagacctgacaactccttccacgagaacaacgtgtcaacccgggtgtccagcctgccttctgagagcagctctggcacaaaccactccaagaggcagcccgccttcgatccttggaagtcccctgagaatatcagccactccgagcagctgaaagagaaagagaagcagggctttttccggtccatgaagaagaagaaaaagaagtcccagacagtccccaacagcgacagccctgatctcctgacactgcagaagtccatccacagcgccagcacacctagcagcagacctaaagagtggcggccagagaagatcagcgacctgcaaacacagagccagcctctgaagtccctgaggaagctgctgcatctgtcctccgcctctaatcaccctgccagcagcgatcccagatttcagccactgacagcccagcagaccaagaactccttcagcgagatccggattcacccactgtctcaggccagcggcggcagctctaatatcagacaagagcccgctcctaagggcagacctgctctccaactgcctggacagatggatcctggctggcacgtgtcctctgtgacaagatctgccaccgagggacctagctattctgagcagctgggcgccaagtctggccccaatggacacccctacaaccggaccaatcggagcagaatgcccaacctgaacgacctcaaagaaacagccctctgaagcttatcgataccggtagtgaattctaccagtgccataggatagtgaattctaccagtgccatacacgtgagtgaattctaccagtgccatagcatgcagtgaattctaccagtgccatagcggccgcgatctttttccctctgccaaaaattatggggacatcatgaagccccttgagcatctgacttctggctaataaaggaaatttattttcattgcaatagtgtgttggaattttttgtgtctctcactcg 736 AA PAT source 1..736 mol_type protein organism adeno-associated virus hu68 CHAIN 1..736 note VP1 CHAIN 138..736 note VP2 CHAIN 203..736 note VP3 MAADGYLPDWLEDNLSEGIREWWALKPGAPQPKANQQHQDNARGLVLPGYKYLGPGNGLDKGEPVNEADAAALEHDKAYDQQLKAGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRLLEPLGLVEEAAKTAPGKKRPVEQSPQEPDSSVGIGKSGAQPAKKRLNFGQTGDTESVPDPQPIGEPPAAPSGVGSLTMASGGGAPVADNNEGADGVGSSSGNWHCDSQWLGDRVITTSTRTWALPTYNNHLYKQISNSTSGGSSNDNAYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTDNNGVKTIANNLTSTVQVFTDSDYQLPYVLGSAHEGCLPPFPADVFMIPQYGYLTLNDGSQAVGRSSFYCLEYFPSQMLRTGNNFQFSYEFENVPFHSSYAHSQSLDRLMNPLIDQYLYYLSKTINGSGQNQQTLKFSVAGPSNMAVQGRNYIPGPSYRQQRVSTTVTQNNNSEFAWPGASSWALNGRNSLMNPGPAMASHKEGEDRFFPLSGSLIFGKQGTGRDNVDADKVMITNEEEIKTTNPVATESYGQVATNHQSAQAQAQTGWVQNQGILPGMVWQDRDVYLQGPIWAKIPHTDGNFHPSPLMGGFGMKHPPPQILIKNTPVPADPPTAFNKDKLNSFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYYKSNNVEFAVNTEGVYSEPRPIGTRYLTRNL