P2024-0470 CN 2023102594658 2023-03-16 GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD. 亘喜生物科技（上海）有限公司 GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD. 董琦 DONG, Qi Qi Dong 特异性结合Claudin18.2的抗体及其制法和应用 ANTIBODY SPECIFICALLY BINDING TO CLAUDIN18.2, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 69 120 AA PAT source 1..120 mol_type protein organism synthetic construct synthetic construct EVQLVGSGGGLVQPGGSLRLSCAASGSILNLMTTGWYRQAPGKQRDLVATITFGGTTNYADSVKGRFTISRDKSKNTAYLQMDNLKPEDTAVYFCYADVIVGFQDRRVAWDAGTQVTVSS 121 AA PAT source 1..121 mol_type protein organism synthetic construct synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGNILSINYMGWYRQAPGKERELVATITRGGSTNYQGNLKGRFIISGDNTKDTVYLQMNNLQPEDTAVYYCYFRINFGILGGLRDYWGQGTQVTVSS 123 AA PAT source 1..123 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQAGDSVRLSCAASGQTLSNYNVAWFRQAPGKEREFVAGATWSGRITNYSDSVRGRFTISRDNAKNTVYLQMNSLGPGDTAVYHCAANSFQLGDKPGDYHYWGQGTQVTVSS 118 AA PAT source 1..118 mol_type protein organism synthetic construct synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGQFFSLNYLAWYRQAPGSQRELIALVSSGGSTQYGDSVKGRFTISRDNAKNTVYLQMASLKPEDTAVYYCNLHTYDFLGRDYWGQGTQVTISS 123 AA PAT source 1..123 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQTGGSLRLSCAASDSTFSSYIMGWFRQAPGKEREFVAGITWSGGIKDYADSVKGRFTIARDNAKNTVYLQMNSLKPEDAAIYYCAANAIQLTRRSGDYAYWGQGTQVTVSS 121 AA PAT source 1..121 mol_type protein organism synthetic construct synthetic construct EVQLVESGGGLVQAGGSLRLSCAASGNILSINYMGWYRQAPGKERELVATITRGGSTNYQGNLKGRFIISGDNTKDTVYLQMNNLQPEDTAVYYCYFRINFGILGGLRDYWGPGTQVTVSS 118 AA PAT source 1..118 mol_type protein organism synthetic construct synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGSIFGLNFMGWWRQAPGSQRELVAIATSGGSIQYGDSVKGRFTISRDNAKNTVYLQMASLKPEDTAVYYCNVHTYDFLGRDYWGQGTQVTVSL 118 AA PAT source 1..118 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGSIFGLNFMGWWRQAPGSQRELVAIATSGGSIQYGDSVKGRFTISRDNAKNTVYLQMASLKPEDTAVYYCNVHTYDFLGRDYWGQGTQVTVSL 118 AA PAT source 1..118 mol_type protein organism synthetic construct synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGSIFGLNFMGWWRQAPGSQRELVAIATSGGSIQYGDSVKGRFTISRDNAKNTVYLQMANLKPEDTAVYYCNVHTYDFLGRDYWGQGTQVTVSL 121 AA PAT source 1..121 mol_type protein organism synthetic construct synthetic construct QVQLAESGGGLVQPGGSLRLSCAASGNILSINYMGWYRQAPGKERELVATITRGGTTNYQGDLKGRFIISGDNTKDTVYLQMNNLQPEDTAVYYCYFRINFGILGGLRDYWGQGTQVTVSS 121 AA PAT source 1..121 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGNILSINYMGWYRQAPGKERELVAIITRGGSTTYAPSLKGRFTISGDNAKDTVYLQMNSLQPEDTAVYYCNFRINFGILGGLRDYWGQGTQVTVSS 118 AA PAT source 1..118 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQAGGSLRLSCAASGSIFGLNFMGWWRQAPGSQRELVAIATSGGSIQYGDSVKGRFTISRDNAKNTVYLQMASLKPEDTAVYYCNVHTYDFLGRDYWGQGTQVTVSL 118 AA PAT source 1..118 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLAQLGGSLRLSCAASGSIFGLNFMGWWRQAPGSQRELVAIATSGGSIQYGDSVKGRFTISRDNAKNTVYLQMASLKPEDTAVYYCNVHTYDFLGRDYWGQGTQVTVSL 115 AA PAT source 1..115 mol_type protein organism synthetic construct synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGSLFSIITMGWYRQAPGKQRELVATVTRGGRLNYGDSVKGRFTISSGNVENTLDLQMNNLKPEDTAVYYCNAILESGNFWGRGTQVTVSS 128 AA PAT source 1..128 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQAGGSLRLSCAASGLTFSTSPSAMGWFRQAPGKEREFVATIGWTGGKQYYADSVKGRFTISRDNVKNTGYLQMNSLKPEDTAVYYCAARRAGYTGTPTRGDSYEHWGQGTQVTVSS 122 AA PAT source 1..122 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGFTLDYWAISWFRQAPGKEREGVSCIRFSDGSTYDADSVKGRFTISRDNAKNTVYLQMNSLKPEDTGIYYCAADMWADCGSMEYDYWGQGTQVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGSILNLMTTGWYRQAPGKQRDLVATITFGGTTNYADSVKGRFTISRDKSKNTAYLQMDNLKPEDTAVYFCYADVIVGFQDRRVAWDAGTQVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGSILNLMTTGWYRQAPGKQRDLVATITFGGTTNYADAVKGRFTISRDNAKNTVYLQMNNLEPEDTAVYFCYLDYIFGFGDRRVAWDQGTQVTVSS 121 AA PAT source 1..121 mol_type protein organism synthetic construct synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGNILSINYAGWYRQAPGKERELVALITRGGSTTYGASLKGRFTISSDNAKDTVYLQMSSLQPDDTAVYYCNFRINFGILGGLRDYWGQGTQVTVSP 121 AA PAT source 1..121 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGNILSINYMGWYRQAPGKERELVALITRGGTTNYAESLKGRFTISGDNAKDTVYLQMNSLQPEDTAVYYCYFRINFGILGGLRDYWGQGTQVTVSS 123 AA PAT source 1..123 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQTGGSLRLSCAASDSTFSSYIMGWVRQAPGKGLEWVAGITWSGGIKDYADSVKGRFTIARDNAKNTVYLQMNSLKPEDAAIYYCAANAIQLTRRSGDYAYWGQGTQVTVSS 123 AA PAT source 1..123 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQPGGSLRLSCAASDSTFSSYIMGWFRQAPGKGLEFVAGITWSGGIKDYADSVKGRFTIARDNSKNTLYLQMNSLRAEDAAVYYCAANAIQLTRRSGDYAYWGQGTLVTVSS 123 AA PAT source 1..123 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQPGGSLRLSCAASDSTFSSYIMGWFRQAPGKGLEFVAGITWSGGIKDYADSVKGRFTIARDNAKNTLYLQMNSLRAEDAAVYYCAANAIQLTRRSGDYAYWGQGTQVTVSS 140 AA PAT source 1..140 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQTGGSLRLSCAASDSTFSSYIMGWFRQAPGKGLEWVAGITWSGGIKDYADSVKGRFTIARDNAKNTVYLQMNSLKPEDAAIYYCAANAIQLTRRSGDYAYWGQGTQVTVSSTTTDYKDDDDKPAPRPP 120 AA PAT source 1..120 mol_type protein organism synthetic construct synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGSILNLMTTGWYRQAPGKGLDLVATITFGGTTNYADAVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCYLDYIFGFGDRRVAWDQGTLVTVSS 121 AA PAT source 1..121 mol_type protein organism synthetic construct synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGNILSINYMGWYRQAPGKGLELVATITRGGSTNYQGNLKGRFIISGDNSKDTLYLQMNSLRAEDTAVYYCYFRINFGILGGLRDYWGQGTLVTVSS 21 AA PAT source 1..21 mol_type protein organism synthetic construct synthetic construct MALPVTALLLPLALLLHAARP 53 AA PAT source 1..53 mol_type protein organism synthetic construct synthetic construct TTTDYKDDDDKPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACD 27 AA PAT source 1..27 mol_type protein organism synthetic construct synthetic construct FWVLVVVGGVLACYSLLVTVAFIIFWV 41 AA PAT source 1..41 mol_type protein organism synthetic construct synthetic construct RSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS 112 AA PAT source 1..112 mol_type protein organism synthetic construct synthetic construct RVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 48 AA PAT source 1..48 mol_type protein organism synthetic construct synthetic construct RFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELR 375 AA PAT source 1..375 mol_type protein organism synthetic construct synthetic construct MALPVTALLLPLALLLHAARPEVQLVESGGGLVQPGGSLRLSCAASGNILSINYMGWYRQAPGKERELVATITRGGSTNYQGNLKGRFIISGDNTKDTVYLQMNNLQPEDTAVYYCYFRINFGILGGLRDYWGQGTQVTVSSTTTDYKDDDDKPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 377 AA PAT source 1..377 mol_type protein organism synthetic construct synthetic construct MALPVTALLLPLALLLHAARPQVQLVESGGGLVQTGGSLRLSCAASDSTFSSYIMGWFRQAPGKEREFVAGITWSGGIKDYADSVKGRFTIARDNAKNTVYLQMNSLKPEDAAIYYCAANAIQLTRRSGDYAYWGQGTQVTVSSTTTDYKDDDDKPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 374 AA PAT source 1..374 mol_type protein organism synthetic construct synthetic construct MALPVTALLLPLALLLHAARPQVQLVESGGGLVQPGGSLRLSCAASGSILNLMTTGWYRQAPGKQRDLVATITFGGTTNYADAVKGRFTISRDNAKNTVYLQMNNLEPEDTAVYFCYLDYIFGFGDRRVAWDQGTQVTVSSTTTDYKDDDDKPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 5 AA PAT source 1..5 mol_type protein organism synthetic construct synthetic construct LMTTG 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct TITFGGTTNYADSVKG 12 AA PAT source 1..12 mol_type protein organism synthetic construct synthetic construct DVIVGFQDRRVA 5 AA PAT source 1..5 mol_type protein organism synthetic construct synthetic construct INYMG 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct TITRGGSTNYQGNLKG 13 AA PAT source 1..13 mol_type protein organism synthetic construct synthetic construct RINFGILGGLRDY 5 AA PAT source 1..5 mol_type protein organism synthetic construct synthetic construct NYNVA 17 AA PAT source 1..17 mol_type protein organism synthetic construct synthetic construct GATWSGRITNYSDSVRG 14 AA PAT source 1..14 mol_type protein organism synthetic construct synthetic construct NSFQLGDKPGDYHY 5 AA PAT source 1..5 mol_type protein organism synthetic construct synthetic construct LNYLA 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct LVSSGGSTQYGDSVKG 10 AA PAT source 1..10 mol_type protein organism synthetic construct synthetic construct HTYDFLGRDY 5 AA PAT source 1..5 mol_type protein organism synthetic construct synthetic construct SYIMG 17 AA PAT source 1..17 mol_type protein organism synthetic construct synthetic construct GITWSGGIKDYADSVKG 14 AA PAT source 1..14 mol_type protein organism synthetic construct synthetic construct NAIQLTRRSGDYAY 5 AA PAT source 1..5 mol_type protein organism synthetic construct synthetic construct LNFMG 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct IATSGGSIQYGDSVKG 10 AA PAT source 1..10 mol_type protein organism synthetic construct synthetic construct HTYDFLGRDY 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct TITRGGTTNYQGDLKG 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct IITRGGSTTYAPSLKG 5 AA PAT source 1..5 mol_type protein organism synthetic construct synthetic construct IITMG 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct TVTRGGRLNYGDSVKG 7 AA PAT source 1..7 mol_type protein organism synthetic construct synthetic construct ILESGNF 7 AA PAT source 1..7 mol_type protein organism synthetic construct synthetic construct TSPSAMG 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct TIGWTGGKQYYADSVK 17 AA PAT source 1..17 mol_type protein organism synthetic construct synthetic construct RRAGYTGTPTRGDSYEH 5 AA PAT source 1..5 mol_type protein organism synthetic construct synthetic construct YWAIS 17 AA PAT source 1..17 mol_type protein organism synthetic construct synthetic construct CIRFSDGSTYDADSVKG 13 AA PAT source 1..13 mol_type protein organism synthetic construct synthetic construct DMWADCGSMEYDY 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct TITFGGTTNYADAVKG 12 AA PAT source 1..12 mol_type protein organism synthetic construct synthetic construct DYIFGFGDRRVA 5 AA PAT source 1..5 mol_type protein organism synthetic construct synthetic construct INYAG 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct LITRGGSTTYGASLKG 16 AA PAT source 1..16 mol_type protein organism synthetic construct synthetic construct LITRGGTTNYAESLKG