083443-8001WO01 CN 202210718428.4; 202210720621.1 2022-06-23 广州银诺医药集团有限公司；上海银诺医药技术有限公司；上海银诺生物医药工程有限公司 Guangzhou Innogen Pharmaceutical Group Co., Ltd.; Shanghai Innogen Pharmaceutical Technology Co., Ltd.; Shanghai Innogen Biomedical Engineering Co., Ltd. 王庆华 QINGHUA WANG 一种改进的GLP-1受体激动剂的融合蛋白和应用 43 30 AA PAT source 1..30 mol_type protein organism synthetic construct HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR 31 AA PAT source 1..31 mol_type protein organism synthetic construct HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct HGEGTFTSDVSSYLEEQAAKEFIAWLVKGGG 16 AA PAT source 1..16 mol_type protein organism synthetic construct MPLLLLLPLLWAGALA 227 AA PAT source 1..227 mol_type protein organism synthetic construct ERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 227 AA PAT source 1..227 mol_type protein organism synthetic construct ERKSCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 271 AA PAT source 1..271 mol_type protein organism synthetic construct HGEGTFTSDVSSYLEEQAAKEFIAWLVKGGGSSGAPPPSGGGGSERKSCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 287 AA PAT source 1..287 mol_type protein organism synthetic construct MPLLLLLPLLWAGALAHGEGTFTSDVSSYLEEQAAKEFIAWLVKGGGSSGAPPPSGGGGSERKSCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 13 AA PAT source 1..13 mol_type protein organism synthetic construct SSGAPPPSGGGGS 15 AA PAT source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 20 AA PAT source 1..20 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGS 20 AA PAT source 1..20 mol_type protein organism synthetic construct GSTGGGGSGKPGSGEGGGGS 15 AA PAT source 1..15 mol_type protein organism synthetic construct ESGRSGGGGSGGGGS 14 AA PAT source 1..14 mol_type protein organism synthetic construct EGKSSGSGSESKST 15 AA PAT source 1..15 mol_type protein organism synthetic construct EGKSSGSGSESKSTQ 14 AA PAT source 1..14 mol_type protein organism synthetic construct EGKSSGSGSESKVD 14 AA PAT source 1..14 mol_type protein organism synthetic construct GSTSGSGKSSEGKG 18 AA PAT source 1..18 mol_type protein organism synthetic construct KESGSVSSEQLAQFRSLD 16 AA PAT source 1..16 mol_type protein organism synthetic construct ESGSVSSEELAFRSLD 90 AA PAT source 1..90 mol_type protein organism synthetic construct CACGCCGAGGGCACCTTCACCAGCGACGTGAGCAGCTACCTGGAGGGCCAGGCCGCCAAGGAGTTCATCGCCTGGCTGGTGAAGGGCAGG 93 AA PAT source 1..93 mol_type protein organism synthetic construct CACGCCGAGGGCACCTTCACCAGCGACGTGAGCAGCTACCTGGAGGGCCAGGCCGCCAAGGAGTTCATCGCCTGGCTGGTGAAGGGCAGGGGC 93 AA PAT source 1..93 mol_type protein organism synthetic construct CACGGCGAGGGCACCTTCACCAGCGACGTGAGCAGCTACCTGGAGGAGCAGGCCGCCAAGGAGTTCATCGCCTGGCTGGTGAAGGGCGGCGGC 48 AA PAT source 1..48 mol_type protein organism synthetic construct ATGCCCCTGCTGCTGCTGCTGCCCCTGCTGTGGGCCGGCGCCCTGGCC 681 AA PAT source 1..681 mol_type protein organism synthetic construct GAGAGGAAGTGCTGCGTGGAGTGCCCCCCCTGCCCCGCCCCCCCCGTGGCCGGCCCCAGCGTGTTCCTGTTCCCCCCCAAGCCCAAGGACACCCTGATGATCAGCAGGACCCCCGAGGTGACCTGCGTGGTGGTGGACGTGAGCCACGAGGACCCCGAGGTGCAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCACAACGCCAAGACCAAGCCCAGGGAGGAGCAGTTCAACAGCACCTTCAGGGTGGTGAGCGTGCTGACCGTGGTGCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTGAGCAACAAGGGCCTGCCCGCCCCCATCGAGAAGACCATCAGCAAGACCAAGGGCCAGCCCAGGGAGCCCCAGGTGTACACCCTGCCCCCCAGCAGGGAGGAGATGACCAAGAACCAGGTGAGCCTGACCTGCCTGGTGAAGGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAACGGCCAGCCCGAGAACAACTACAAGACCACCCCCCCCATGCTGGACAGCGACGGCAGCTTCTTCCTGTACAGCAAGCTGACCGTGGACAAGAGCAGGTGGCAGCAGGGCAACGTGTTCAGCTGCAGCGTGATGCACGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCCGGC 681 AA PAT source 1..681 mol_type protein organism synthetic construct GAGAGGAAGAGCTGCGTGGAGTGCCCCCCCTGCCCCGCCCCCCCCGTGGCCGGCCCCAGCGTGTTCCTGTTCCCCCCCAAGCCCAAGGACACCCTGATGATCAGCAGGACCCCCGAGGTGACCTGCGTGGTGGTGGACGTGAGCCACGAGGACCCCGAGGTGCAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCACAACGCCAAGACCAAGCCCAGGGAGGAGCAGTTCAACAGCACCTTCAGGGTGGTGAGCGTGCTGACCGTGGTGCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTGAGCAACAAGGGCCTGCCCAGCAGCATCGAGAAGACCATCAGCAAGACCAAGGGCCAGCCCAGGGAGCCCCAGGTGTACACCCTGCCCCCCAGCAGGGAGGAGATGACCAAGAACCAGGTGAGCCTGACCTGCCTGGTGAAGGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAACGGCCAGCCCGAGAACAACTACAAGACCACCCCCCCCATGCTGGACAGCGACGGCAGCTTCTTCCTGTACAGCAAGCTGACCGTGGACAAGAGCAGGTGGCAGCAGGGCAACGTGTTCAGCTGCAGCGTGATGCACGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCCGGC 813 AA PAT source 1..813 mol_type protein organism synthetic construct CACGGCGAGGGCACCTTCACCAGCGACGTGAGCAGCTACCTGGAGGAGCAGGCCGCCAAGGAGTTCATCGCCTGGCTGGTGAAGGGCGGCGGCAGCAGCGGCGCCCCCCCCCCCAGCGGCGGCGGCGGCAGCGAGAGGAAGAGCTGCGTGGAGTGCCCCCCCTGCCCCGCCCCCCCCGTGGCCGGCCCCAGCGTGTTCCTGTTCCCCCCCAAGCCCAAGGACACCCTGATGATCAGCAGGACCCCCGAGGTGACCTGCGTGGTGGTGGACGTGAGCCACGAGGACCCCGAGGTGCAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCACAACGCCAAGACCAAGCCCAGGGAGGAGCAGTTCAACAGCACCTTCAGGGTGGTGAGCGTGCTGACCGTGGTGCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTGAGCAACAAGGGCCTGCCCAGCAGCATCGAGAAGACCATCAGCAAGACCAAGGGCCAGCCCAGGGAGCCCCAGGTGTACACCCTGCCCCCCAGCAGGGAGGAGATGACCAAGAACCAGGTGAGCCTGACCTGCCTGGTGAAGGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAACGGCCAGCCCGAGAACAACTACAAGACCACCCCCCCCATGCTGGACAGCGACGGCAGCTTCTTCCTGTACAGCAAGCTGACCGTGGACAAGAGCAGGTGGCAGCAGGGCAACGTGTTCAGCTGCAGCGTGATGCACGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCCGGC 861 AA PAT source 1..861 mol_type protein organism synthetic construct ATGCCCCTGCTGCTGCTGCTGCCCCTGCTGTGGGCCGGCGCCCTGGCCCACGGCGAGGGCACCTTCACCAGCGACGTGAGCAGCTACCTGGAGGAGCAGGCCGCCAAGGAGTTCATCGCCTGGCTGGTGAAGGGCGGCGGCAGCAGCGGCGCCCCCCCCCCCAGCGGCGGCGGCGGCAGCGAGAGGAAGAGCTGCGTGGAGTGCCCCCCCTGCCCCGCCCCCCCCGTGGCCGGCCCCAGCGTGTTCCTGTTCCCCCCCAAGCCCAAGGACACCCTGATGATCAGCAGGACCCCCGAGGTGACCTGCGTGGTGGTGGACGTGAGCCACGAGGACCCCGAGGTGCAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCACAACGCCAAGACCAAGCCCAGGGAGGAGCAGTTCAACAGCACCTTCAGGGTGGTGAGCGTGCTGACCGTGGTGCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTGAGCAACAAGGGCCTGCCCAGCAGCATCGAGAAGACCATCAGCAAGACCAAGGGCCAGCCCAGGGAGCCCCAGGTGTACACCCTGCCCCCCAGCAGGGAGGAGATGACCAAGAACCAGGTGAGCCTGACCTGCCTGGTGAAGGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAACGGCCAGCCCGAGAACAACTACAAGACCACCCCCCCCATGCTGGACAGCGACGGCAGCTTCTTCCTGTACAGCAAGCTGACCGTGGACAAGAGCAGGTGGCAGCAGGGCAACGTGTTCAGCTGCAGCGTGATGCACGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCCGGC 39 AA PAT source 1..39 mol_type protein organism synthetic construct AGCAGCGGCGCCCCCCCCCCCAGCGGCGGCGGCGGCAGC 45 AA PAT source 1..45 mol_type protein organism synthetic construct GGCGGCGGCGGCAGCGGCGGCGGCGGCAGCGGCGGCGGCGGCAGC 60 AA PAT source 1..60 mol_type protein organism synthetic construct GGCGGCGGCGGCAGCGGCGGCGGCGGCAGCGGCGGCGGCGGCAGCGGCGGCGGCGGCAGC 60 AA PAT source 1..60 mol_type protein organism synthetic construct GGCAGCACCGGCGGCGGCGGCAGCGGCAAGCCCGGCAGCGGCGAGGGCGGCGGCGGCAGC 45 AA PAT source 1..45 mol_type protein organism synthetic construct GAGAGCGGCAGGAGCGGCGGCGGCGGCAGCGGCGGCGGCGGCAGC 42 AA PAT source 1..42 mol_type protein organism synthetic construct GAGGGCAAGAGCAGCGGCAGCGGCAGCGAGAGCAAGAGCACC 45 AA PAT source 1..45 mol_type protein organism synthetic construct GAGGGCAAGAGCAGCGGCAGCGGCAGCGAGAGCAAGAGCACCCAG 42 AA PAT source 1..42 mol_type protein organism synthetic construct GAGGGCAAGAGCAGCGGCAGCGGCAGCGAGAGCAAGGTGGAC 42 AA PAT source 1..42 mol_type protein organism synthetic construct GGCAGCACCAGCGGCAGCGGCAAGAGCAGCGAGGGCAAGGGC 54 AA PAT source 1..54 mol_type protein organism synthetic construct AAGGAGAGCGGCAGCGTGAGCAGCGAGCAGCTGGCCCAGTTCAGGAGCCTGGAC 48 AA PAT source 1..48 mol_type protein organism synthetic construct GAGAGCGGCAGCGTGAGCAGCGAGGAGCTGGCCTTCAGGAGCCTGGAC 4 AA PAT source 1..4 mol_type protein organism synthetic construct GGGS 5 AA PAT source 1..5 mol_type protein organism synthetic construct GGGGS 6 AA PAT source 1..6 mol_type protein organism synthetic construct GGGGGS 8 AA PAT source 1..8 mol_type protein organism synthetic construct GGGGGGGS 37 AA PAT source 1..37 mol_type protein organism synthetic construct HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG