JWP-009-1 JW Therapeutics R&D (Shanghai) Co., Ltd. JW Therapeutics R&D (Shanghai) Co., Ltd. Yingjie Zhu Engineered cells expressing trimeric complexes 51 148 AA PAT source 1..148 mol_type protein organism synthetic construct QVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSN 259 AA PAT source 1..259 mol_type protein organism synthetic construct SLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGSTSLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETTLKPSLSPGNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKT 52 AA PAT source 1..52 mol_type protein organism synthetic construct KRKEVQKTCRKHRKENQGSHESPTLNPETVALKDITSDSENSNFRNEIQSLV 195 AA PAT source 1..195 mol_type protein organism synthetic construct KKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ 116 AA PAT source 1..116 mol_type protein organism synthetic construct KRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN 94 AA PAT source 1..94 mol_type protein organism synthetic construct KRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLP 53 AA PAT source 1..53 mol_type protein organism synthetic construct KRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGH 72 AA PAT source 1..72 mol_type protein organism synthetic construct KRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQ 17 AA PAT source 1..17 mol_type protein organism synthetic construct LGWLCLLLLPIPLIVWV 25 AA PAT source 1..25 mol_type protein organism synthetic construct PILLTISILSFFSVALLVILACVLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct VARIANT 10 note X1 is S or L VARIANT 12 note X2 is L or S VARIANT 14 note X3 is F or L VARIANT 15 note X4 is F or A VARIANT 16 note X5 is S or I VARIANT 17 note X6 is V or L VARIANT 18 note X7 is A or L VARIANT 19 note X8 is L or M VARIANT 20 note X9 is L or V VARIANT 21 note X10 is V or S VARIANT 22 note X11 is I or L VARIANT 24 note X12 is A or L VARIANT 25 note X13 is C or L VARIANT 26 note X14 is V or S PILLTCPTIXIXSXXXXXXXXXLXXXLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILNPCLTISILSFFSVALLVILACVLW 25 AA PAT source 1..25 mol_type protein organism synthetic construct PTCLTISILSFFSVALLVILACVLW 27 AA PAT source 1..27 mol_type protein organism synthetic construct PSANCGAISILSFFSVALLVILACVLW 29 AA PAT source 1..29 mol_type protein organism synthetic construct PILLVSCPTISILSFFSVALLVILACVLW 27 AA PAT source 1..27 mol_type protein organism synthetic construct PILLIISIQWLSFFSVALLVILACVLW 27 AA PAT source 1..27 mol_type protein organism synthetic construct NSPSCLTISILSFFSVALLVILACVLW 27 AA PAT source 1..27 mol_type protein organism synthetic construct PCLEGLTISILSFFSVALLVILACVLW 24 AA PAT source 1..24 mol_type protein organism synthetic construct PILLTISILSFFWNLLVILACVLW 25 AA PAT source 1..25 mol_type protein organism synthetic construct RFCPHISILSFFSVALLVILACVLW 21 AA PAT source 1..21 mol_type protein organism synthetic construct IKCILSFFSVALLVILACVLW 30 AA PAT source 1..30 mol_type protein organism synthetic construct PIFHPFNCGPISILSFFSVALLVILACVLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILLMCPTISILSFFSVALLVILACVLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILLTISILSFFSGPSLALLVILACVLW 29 AA PAT source 1..29 mol_type protein organism synthetic construct PILRLGCVTISILSFFSVALLVILACVLW 25 AA PAT source 1..25 mol_type protein organism synthetic construct PIPQGGCILSFFSVALLVILACVLW 22 AA PAT source 1..22 mol_type protein organism synthetic construct LQSCILSFFSVALLVILACVLW 29 AA PAT source 1..29 mol_type protein organism synthetic construct PIFPHQHCTISILSFFSVALLVILACVLW 27 AA PAT source 1..27 mol_type protein organism synthetic construct PILLTISKCHLSFFSVALLVILACVLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILLTCHLISILSFFSVALLVILACVLW 29 AA PAT source 1..29 mol_type protein organism synthetic construct PIFSCGPLTISILSFFSVALLVILACVLW 29 AA PAT source 1..29 mol_type protein organism synthetic construct PILLPPCLTISILSFFSVALLVILACVLW 32 AA PAT source 1..32 mol_type protein organism synthetic construct PILLTPPVCSVTISILSFFSVALLVILACVLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILLTCPTISILSFFSVALLVILACVLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILLTCPTISILSFFSVALLVLLLLSLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILLTCPTISILSFFSVLMVSLLLLSLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILLTCPTISILSLAILLMVSLLLLSLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILLTCPTILISSLAILLMVSLLLLSLW 28 AA PAT source 1..28 mol_type protein organism synthetic construct PILLTCPTISILSFFSVALLVILACSLW 281 AA PAT source 1..281 mol_type protein organism synthetic construct MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL 258 AA PAT source 1..258 mol_type protein organism synthetic construct MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKEPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL 277 AA PAT source 1..277 mol_type protein organism synthetic construct MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL 250 AA PAT source 1..250 mol_type protein organism synthetic construct MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL 281 AA PAT source 1..281 mol_type protein organism synthetic construct MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLEEEGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL 278 AA PAT source 1..278 mol_type protein organism synthetic construct MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLEEEGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL 277 AA PAT source 1..277 mol_type protein organism synthetic construct MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLEEEGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL 279 AA PAT source 1..279 mol_type protein organism synthetic construct MQQPMNYPCPQIFWVDSSATSSWAPPGSVFPCPSCGPRGPDQRRPPPPPPPVSPLPPPSQPLPLPPLTPLKKKDHNTNLWLPVVFFMVLVALVGMGLGMYQLFHLQKELAELREFTNQSLKVSSFEKQIANPSTPSEKKEPRSVAHLTGNPHSRSIPLEWEDTYGTALISGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNQPLNHKVYMRNSKYPEDLVLMEEKRLNYCTTGQIWAHSSYLGAVFNLTSADHLYVNISQLSLINFEESKTFFGLYKL 22 AA PAT source 1..22 mol_type protein organism synthetic construct MLLLVTSLLLCELPHPAFLLIP 355 AA PAT source 1..355 mol_type protein organism synthetic construct METDTLLLWVLLLWVPGSTGRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFM 18 AA PAT source 1..18 mol_type protein organism synthetic construct EGRGSLLTCGDVEENPGP 20 AA PAT source 1..20 mol_type protein organism synthetic construct QCTNYALLKLAGDVESNPGP