CZ P1911PC00 EP EP21196175.0 2021-09-10 Ustav organicke chemie a biochemie AV CR, v.v.i. Miloslav Polasek Compounds for complexation of rare earth elements and/or s-, p-, d- block metals, their coordination compounds, peptide conjugates, method of their preparation and use thereof 29 6 AA PAT REGION 1..6 note artificial sequence source 1..6 mol_type protein organism synthetic construct GVHFYA 6 AA PAT REGION 1..6 note artificial sequence source 1..6 mol_type protein organism synthetic construct RRRRRR 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Lutetium complex TD748, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD748 (R1 is carboxyphenyl) and -NH2 group of alanine SITE 7 note X - glycine amide - the C-end of the peptide sequence containsglycine, wherein the -COOH group is replaced with -C(=O)-NH2group source 1..7 mol_type protein organism synthetic construct XAYFHVX 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Lutetium complex TD748, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD748 (R1 is carboxyphenyl) and -NH2 group of alanine source 1..7 mol_type protein organism synthetic construct XAYFHVG 6 AA PAT REGION 1..6 note synthetic peptide SITE 1 note X - Lutetium complex TD748, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD748 (R1 is carboxyphenyl) and -NH2 group of alanine source 1..6 mol_type protein organism synthetic construct XAYFHV 5 AA PAT REGION 1..5 note synthetic peptide SITE 1 note X - Lutetium complex TD748, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD748 (R1 is carboxyphenyl) and -NH2 group of alanine source 1..5 mol_type protein organism synthetic construct XAYFH 000 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Yttrium(III) complex TD785, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD785 (R1 is carboxyphenyl) and -NH2 group of alanine SITE 7 note X - glycine amide - the C-end of the peptide sequence containsglycine, wherein the -COOH group is replaced with -C(=O)-NH2group source 1..7 mol_type protein organism synthetic construct XAYFHVX 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Yttrium(III) complex TD785, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD785 (R1 is carboxyphenyl) and -NH2 group of alanine source 1..7 mol_type protein organism synthetic construct XAYFHVG 6 AA PAT REGION 1..6 note synthetic peptide SITE 1 note X - Yttrium(III) complex TD785, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD785 (R1 is carboxyphenyl) and -NH2 group of alanine source 1..6 mol_type protein organism synthetic construct XAYFHV 5 AA PAT REGION 1..5 note synthetic peptide SITE 1 note X - Yttrium(III) complex TD785, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD785 (R1 is carboxyphenyl) and -NH2 group of alanine source 1..5 mol_type protein organism synthetic construct XAYFH 000 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Lutetium complex TD891, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD891 (R1 is carboxybenzyl) and -NH2 group of alanine SITE 7 note X - glycine amide - the C-end of the peptide sequence containsglycine, wherein the -COOH group is replaced with -C(=O)-NH2group source 1..7 mol_type protein organism synthetic construct XAYFHVX 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Lutetium complex TD891, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD891 (R1 is carboxybenzyl) and -NH2 group of alanine source 1..7 mol_type protein organism synthetic construct XAYFHVG 6 AA PAT REGION 1..6 note synthetic peptide SITE 1 note X - Lutetium complex TD891, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD891 (R1 is carboxybenzyl) and -NH2 group of alanine source 1..6 mol_type protein organism synthetic construct XAYFHV 5 AA PAT REGION 1..5 note synthetic protein SITE 1 note X - Lutetium complex TD891, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD891 (R1 is carboxybenzyl) and -NH2 group of alanine source 1..5 mol_type protein organism synthetic construct XAYFH 000 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Thulium complex TD899, bound to the N-end of the peptide sequencevia a peptide bond between -COOH group of R1 group of TD899 (R1is carboxybenzyl) and -NH2 group of alanine SITE 7 note X - glycine amide - the C-end of the peptide sequence containsglycine, wherein the -COOH group is replaced with -C(=O)-NH2group source 1..7 mol_type protein organism synthetic construct XAYFHVX 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Thulium complex TD899, bound to the N-end of the peptide sequencevia a peptide bond between -COOH group of R1 group of TD899 (R1is carboxybenzyl) and -NH2 group of alanine source 1..7 mol_type protein organism synthetic construct XAYFHVG 6 AA PAT REGION 1..6 note synthetic peptide SITE 1 note X - Thulium complex TD899, bound to the N-end of the peptide sequencevia a peptide bond between -COOH group of R1 group of TD899 (R1is carboxybenzyl) and -NH2 group of alanine source 1..6 mol_type protein organism synthetic construct XAYFHV 5 AA PAT REGION 1..5 note synthetic peptide SITE 1 note X - Thulium complex TD899, bound to the N-end of the peptide sequencevia a peptide bond between -COOH group of R1 group of TD899 (R1is carboxybenzyl) and -NH2 group of alanine source 1..5 mol_type protein organism synthetic construct XAYFH 000 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Lutetium complex TD748, bound to the N-end of the peptidesequence via a peptide bond between -COOH group of R1 group ofTD748 (R1 is carboxyphenyl) and -NH2 group of D-arginine SITE 2 note D-arginine SITE 4 note D-arginine SITE 6 note D-arginine SITE 7 note X - arginine amide - the C-end of the peptide sequence containsL-arginine, wherein the -COOH group is replaced with -C(=O)-NH2group source 1..7 mol_type protein organism synthetic construct XRRRRRX 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Thulium complex TD897, bound to the N-end of the peptide sequencevia a peptide bond between -COOH group of R1 group of TD897 (R1is carboxyphenyl) and -NH2 group of D-arginine SITE 2 note D-arginine SITE 4 note D-arginine SITE 6 note D-arginine SITE 7 note X - arginine amide - the C-end of the peptide sequence containsL-arginine, wherein the -COOH group is replaced with -C(=O)-NH2group source 1..7 mol_type protein organism synthetic construct XRRRRRX 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Lutetium complex TD748, bound to the N-end of the peptide sequence via a peptide bond between -COOH group of R1 group ofTD748 (R1 is carboxyphenyl) and -NH2 group of D-arginine SITE 2 note D-arginine SITE 3 note =NH group of L-arginine at position omega is substituted with NO2 group SITE 4 note D-arginine SITE 5 note =NH group of L-arginine at position omega is substituted with NO2 group SITE 6 note D-arginine SITE 7 note X - arginine amide - the C-end of the peptide sequence contains L-arginine, wherein the -COOH group is replaced with -C(=O)-NH2 group; and wherein =NH group at position omega is substituted with NO2 group source 1..7 mol_type protein organism synthetic construct XRRRRRX 7 AA PAT REGION 1..7 note synthetic peptide SITE 1 note X - Thulium complex TD897, bound to the N-end of the peptide sequence via a peptide bond between -COOH group of R1 group of TD748 (R1is carboxyphenyl) and -NH2 group of D-arginine SITE 2 note D-arginine SITE 3 note =NH group of L-arginine at position omega is substituted with NO2 group SITE 4 note D-arginine SITE 5 note =NH group of L-arginine at position omega is substituted with NO2 group SITE 6 note D-arginine SITE 7 note X - arginine amide - the C-end of the peptide sequence containsL-arginine, wherein the -COOH group is replaced with -C(=O)-NH2group; and wherein =NH group at position omega is protected withNO2 group source 1..7 mol_type protein organism synthetic construct XRRRRRX 6 AA PAT source 1..6 mol_type protein organism synthetic construct SITE 1 note D-arginin wherein =NH group at position omega is protected with Pbf group SITE 2 note L-arginin wherein =NH group at position omega is substituted with NO2 group SITE 3 note D-arginin wherein =NH group at position omega is protected with Pbf group SITE 4 note L-arginin wherein =NH group at position omega is substituted with NO2 group SITE 5 note D-arginin wherein =NH group at position omega is protected with Pbf group SITE 6 note arginine amide - the C-end of the peptide sequence contains L-arginine, wherein the -COOH group is replaced with -C(=O)-NH2 group; and wherein =NH group at position omega is substituted with NO2 group RRRRRX 4 AA PAT source 1..4 mol_type protein organism synthetic construct SITE 1 note D-arginin wherein =NH group at position omega is protected with Pbf group SITE 2 note L-arginin wherein =NH group at position omega is substituted with NO2 group SITE 3 note D-arginin wherein =NH group at position omega is protected with Pbf group SITE 4 note arginine amide - the C-end of the peptide sequence contains L-arginine, wherein the -COOH group is replaced with -C(=O)-NH2 group; and wherein =NH group at position omega is substituted with NO2 group RRRR 6 AA PAT source 1..6 mol_type protein organism synthetic construct SITE 1 note D-arginin wherein =NH group at position omega is protected with Pbf group SITE 2 note L-arginin wherein =NH group at position omega is protected with Pbf group SITE 3 note D-arginin wherein =NH group at position omega is protected with Pbf group SITE 4 note L-arginin wherein =NH group at position omega is protected with Pbf group SITE 5 note D-arginin wherein =NH group at position omega is protected with Pbf group SITE 6 note arginine amide - the C-end of the peptide sequence contains L-arginine, wherein the -COOH group is replaced with -C(=O)-NH2 group; and wherein =NH group at position omega is protected with Pbf group RRRRRR