WO PCT/CN2022/118964 2022-09-15 IEC220335PCT CN 202111088584.9 2021-09-16 SHANGHAI MIRACOGEN INC. USE OF ANTIBODY-DRUG CONJUGATE, AND COMBINED DRUG AND USE THEREOF 18 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLQESGPGLVKPSETLSLTCTVSGFSLSNYDVHWVRQAPGKGLEWLGVIWSGGNTDYNTPFTSRLTISVDTSKNQFSLKLSSVTAADTAVYYCARALDYYDYEFAYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct EIVLTQSPDFQSVTPKEKVTITCRASQSIGTNIHWYQQKPDQSPKLLIKYASESISGIPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQNNEWPTSFGQGTKLEIK 330 AA PAT source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT source 1..5 mol_type protein organism synthetic construct NYDVH 16 AA PAT source 1..16 mol_type protein organism synthetic construct VIWSGGNTDYNTPFTS 11 AA PAT source 1..11 mol_type protein organism synthetic construct ALDYYDYEFAY 30 AA PAT source 1..30 mol_type protein organism synthetic construct QVQLQESGPGLVKPSETLSLTCTVSGFSLS 14 AA PAT source 1..14 mol_type protein organism synthetic construct WVRQAPGKGLEWLG 32 AA PAT source 1..32 mol_type protein organism synthetic construct RLTISVDTSKNQFSLKLSSVTAADTAVYYCAR 11 AA PAT source 1..11 mol_type protein organism synthetic construct WGQGTLVTVSS 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASQSIGTNIH 7 AA PAT source 1..7 mol_type protein organism synthetic construct YASESIS 10 AA PAT source 1..10 mol_type protein organism synthetic construct QQNNEWPTSF 23 AA PAT source 1..23 mol_type protein organism synthetic construct EIVLTQSPDFQSVTPKEKVTITC 15 AA PAT source 1..15 mol_type protein organism synthetic construct WYQQKPDQSPKLLIK 32 AA PAT source 1..32 mol_type protein organism synthetic construct GIPSRFSGSGSGTDFTLTINSLEAEDAATYYC 9 AA PAT source 1..9 mol_type protein organism synthetic construct GQGTKLEIK