CN PCT/CN2024/111721 2024-08-13 IEC240177PCT CN 202311018785.0 2023-08-14 MINGHUI PHARMACEUTICAL (HANGZHOU) LIMITED Anti-c-MET nanobody and use thereof 16 126 AA PAT source 1..126 mol_type protein note MHAB07-3 VHH organism synthetic construct QLQLVESGGGLVQAGGSLRLSCAASGRITNTYVMGWFRQAPGKERELQAAITWTVGSTYYVDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAASRFSAWPPRGTLGEWNSWGQGTQVTVSS 5 AA PAT source 1..5 mol_type protein note MHAB07-3 VHH-CDR1 (Kabat definition) organism synthetic construct TYVMG 17 AA PAT source 1..17 mol_type protein note MHAB07-3 VHH-CDR2 (Kabat definition) organism synthetic construct AITWTVGSTYYVDSVKG 17 AA PAT source 1..17 mol_type protein note MHAB07-3 VHH-CDR3 (Kabat definition) organism synthetic construct SRFSAWPPRGTLGEWNS 7 AA PAT source 1..7 mol_type protein note MHAB07-3 VHH-CDR1 (Chothia definition) organism synthetic construct GRITNTY 6 AA PAT source 1..6 mol_type protein note MHAB07-3 VHH-CDR2 (Chothia definition) organism synthetic construct TWTVGS 17 AA PAT source 1..17 mol_type protein note MHAB07-3 VHH-CDR3 (Chothia definition) organism synthetic construct SRFSAWPPRGTLGEWNS 8 AA PAT source 1..8 mol_type protein note MHAB07-3 VHH-CDR1 (IMGT definition) organism synthetic construct GRITNTYV 8 AA PAT source 1..8 mol_type protein note MHAB07-3 VHH-CDR2 (IMGT definition) organism synthetic construct ITWTVGST 19 AA PAT source 1..19 mol_type protein note MHAB07-3 VHH-CDR3 (IMGT definition) organism synthetic construct AASRFSAWPPRGTLGEWNS 358 AA PAT source 1..358 mol_type protein note MHAB07-3 organism synthetic construct QLQLVESGGGLVQAGGSLRLSCAASGRITNTYVMGWFRQAPGKERELQAAITWTVGSTYYVDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAASRFSAWPPRGTLGEWNSWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 358 AA PAT source 1..358 mol_type protein note MHAB07-3-1 organism synthetic construct QLQLVESGGGLVQPGGSLRLSCAASGRITNTYVMGWVRQAPGKEREFQAAITWTVGSTYYVDSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYYCAASRFSAWPPRGTLGEWNSWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 358 AA PAT source 1..358 mol_type protein note MHAB07-3-2 organism synthetic construct QLQLVESGGGLVQPGGSLRLSCAASGRITNTYVMGWVRQAPGKEREFVAAITWTVGSTYYVDSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYYCAASRFSAWPPRGTLGEWNSWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 126 AA PAT source 1..126 mol_type protein note MHAB07-3-1 VHH organism synthetic construct QLQLVESGGGLVQPGGSLRLSCAASGRITNTYVMGWVRQAPGKEREFQAAITWTVGSTYYVDSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYYCAASRFSAWPPRGTLGEWNSWGQGTQVTVSS 126 AA PAT source 1..126 mol_type protein note MHAB07-3-2 VHH organism synthetic construct QLQLVESGGGLVQPGGSLRLSCAASGRITNTYVMGWVRQAPGKEREFVAAITWTVGSTYYVDSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYYCAASRFSAWPPRGTLGEWNSWGQGTQVTVSS 232 AA PAT source 1..232 mol_type protein note Fc (LALA) of human IgG1 organism synthetic construct EPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK