SG D-CF230976SG WO PCT/CN2023/101880 2023-06-21 NANJING ANJI BIOTECHNOLOGY CO., LTD. MODIFIED POLYPEPTIDE AND USE THEREOF IN FIELD OF ANALGESIA 34 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 9 note D-Cysteine GSCSTPPSXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct SITE 5 note D-Threonine SITE 9 note D-cysteine DISULFID 3..9 note interchain disulfide bond GSCSXPPSXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-Threonine SITE 9 note D-Cysteine SITE 13 note Serine-NH2 GSCSXPPSXVLYX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 3 note D-Cysteine SITE 5 note D-Threonine SITE 9 note D-Cysteine GSXSXPPSXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 2 note D-Serine SITE 3 note D-Cysteine SITE 4 note D-Serine SITE 5 note D-Threonine SITE 6 note D-Proline SITE 7 note D-Proline SITE 8 note D-Serine SITE 9 note D-Cysteine SITE 10 note D-Valine SITE 11 note D-Leucine SITE 12 note D-Tyrosine SITE 13 note D-Serine GSCSTPPSCVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 1 note Sarcosine SITE 5 note D-threonine SITE 9 note D-cysteine XSCSXPPSXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cysteine ASCSXPPSXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cysteine GACSXPPSXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cysteine GSCAXPPSXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 6 note Hydroxyproline SITE 9 note D-cysteine GSCSXXPSXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 7 note Hydroxyproline SITE 9 note D-cysteine GSCSXPXSXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cysteine GSCSXPPAXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchian disulfide bond SITE 5 note D-threonine SITE 9 note D-cysteine GSCSXPPSXALYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cysteine GSCSXPPSXVAYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine GSCSXPPSXVLAS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine GSCSXPPSXVLYA 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine GSCSXPPGXVLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine SITE 10 note Aib GSCSXPPSXXLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine GSCSXPPSXGLYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct SITE 5 note D-threonine SITE 9 note D-cystenine DISULFID 3..9 note interchain disulfide bond GSCSXPPSXVIYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine SITE 11 note ABu GSCSXPPSXVXYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine SITE 11 note Nle GSCSXPPSXVXYS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine GSCSXPPSXVLWS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine SITE 12 note Biphenylalanine GSCSXPPSXVLXS 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine SITE 13 note Orn-NH2 GSCSXPPSXVLYX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 9 note D-cystenine SITE 6 note Hydroxyproline SITE 7 note Hydroxyproline SITE 11 note Nle SITE 12 note Biphenylalanine SITE 13 note Orn-NH2 GSCSXXXSXVXXX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 6 note Hydroxyproline SITE 7 note Hydroxyproline SITE 9 note D-cystenine SITE 11 note Nle SITE 12 note Biphenylalanine SITE 13 note Orn-NH2 GSCSXXXAXVXXX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 6 note Hydroxyproline SITE 7 note Hydroxyproline SITE 9 note D-cystenine SITE 8 note Aib SITE 11 note Nle SITE 12 note Biphenylalanine SITE 13 note Orn-NH2 GSCSXXXXXVXXX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 6 note Hydroxyproline SITE 7 note Hydroxyproline SITE 9 note D-cystenine SITE 11 note Nle SITE 13 note Orn-NH2 GSCSXXXSXVXFX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 6 note Hydroxyproline SITE 7 note Hydroxyproline SITE 9 note D-cystenine SITE 11 note Nle SITE 13 note Orn-NH2 GSCSXXXAXVXFX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 6 note Hydroxyproline SITE 7 note Hydroxyproline SITE 8 note Aib SITE 9 note D-cystenine SITE 11 note Nle SITE 13 note Orn-NH2 GSCSXXXXXVXFX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 6 note Hydroxyproline SITE 7 note Hydroxyproline SITE 9 note D-cystenine SITE 11 note Nle SITE 13 note Orn-NH2 GSCSXXXSXVXWX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 6 note Hydroxyproline SITE 7 note Hydroxyproline SITE 9 note D-cystenine SITE 11 note Nle SITE 13 note Orn-NH2 GSCSXXXAXVXWX 13 AA PAT source 1..13 mol_type protein organism synthetic construct DISULFID 3..9 note interchain disulfide bond SITE 5 note D-threonine SITE 6 note Hydroxyproline SITE 7 note hydroxyproline SITE 8 note Aib SITE 9 note D-cystenine SITE 11 note Nle SITE 13 note Orn-NH2 GSCSXXXXXVXWX