230005WO01 EP 23169455.5 2023-04-24 Novo Nordisk A/S Glucose sensitive insulin derivatives 23 21 AA PAT source 1..21 mol_type protein organism Homo sapiens GIVEQCCTSICSLYQLENYCN 30 AA PAT source 1..30 mol_type protein organism Homo sapiens FVNQHLCGSHLVEALYLVCGERGFFYTPKT 29 AA PAT source 1..29 mol_type protein organism Homo sapiens FVNQHLCGSHLVEALYLVCGERGFFYTPK 42 AA PAT source 1..42 mol_type protein organism synthetic construct GKPEGEQPGEQPGEQPGEQPGEQGGKPEGGGSGGGGSGGGGS 71 AA PAT source 1..71 mol_type protein organism synthetic construct GKPEGEQPGEQPGEQPGEQPGEQGGKPEGGGSGGGGSGGGGSFVNQHLCGSHLVEALYLVCGERGFFYTPK 67 AA PAT source 1..67 mol_type protein organism synthetic construct GQEPGQEPGQEPGQEPGQEGGKPGGGGSGGGGSGGGGSFVNQHLCGSHLVEALYLVCGERGFFYTPK 147 AA PAT source 1..147 mol_type protein organism synthetic construct GQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEGGKPGGGGSGGGGSGGGGSFVNQHLCGSHLVEALYLVCGERGFFYTPK 67 AA PAT source 1..67 mol_type protein organism synthetic construct GEQPGEQPGEQPGEQPGEQGGKPEGGGSGGGGSGGGGSFVNQHLCGSHLVEALYLVCGERGFFYTPK 38 AA PAT source 1..38 mol_type protein organism synthetic construct GQEPGQEPGQEPGQEPGQEGGKPGGGGSGGGGSGGGGS 118 AA PAT source 1..118 mol_type protein organism synthetic construct GQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEPGQEGGKPGGGGSGGGGSGGGGS 18 AA PAT source 1..18 mol_type protein organism synthetic construct GKPGGGGSGGGGSGGGGS 38 AA PAT source 1..38 mol_type protein organism synthetic construct GEQPGEQPGEQPGEQPGEQGGKPEGGGSGGGGSGGGGS 23 AA PAT source 1..23 mol_type protein organism synthetic construct PEGEQPGEQPGEQPGEQPGEQGG 58 AA PAT source 1..58 mol_type protein organism synthetic construct VARIANT 5 note G, E, A, S, T, P or Q VARIANT 7..21 note G, E, A, S, T, P or Q VARIANT 38 note absent or P VARIANT 39 note E or G VARIANT 1..4 note G, E, A, S, T, P, Q or absent VARIANT 22..36 note G, E, A, S, T, P, Q or absent XXXXXKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKXXGGGSGGGGSGGGGSGGGGS 53 AA PAT source 1..53 mol_type protein organism synthetic construct VARIANT 1..4 note G, E, A, S, T, P, Q or absent VARIANT 5 note G, E, A, S, T, P or Q VARIANT 7..21 note G, E, A, S, T, P or Q VARIANT 22..36 note G, E, A, S, T, P, Q or absent VARIANT 38 note absent or P VARIANT 39 note E or G XXXXXKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKXXGGGSGGGGSGGGGS 48 AA PAT source 1..48 mol_type protein organism synthetic construct VARIANT 1..4 note G, E, A, S, T, P, Q or absent VARIANT 5 note G, E, A, S, T, P or Q VARIANT 7..21 note G, E, A, S, T, P or Q VARIANT 22..36 note G, E, A, S, T, P, Q or absent VARIANT 38 note absent or P VARIANT 39 note E or G XXXXXKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKXXGGGSGGGGS 58 AA PAT source 1..58 mol_type protein organism synthetic construct VARIANT 1..4 note G, E, A, S, T, P, Q or absent VARIANT 5 note G, E, A, S, T, P or Q VARIANT 9..21 note G, E, A, S, T, P or Q VARIANT 22..36 note G, E, A, S, T, P, Q or absent XXXXXKPEXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPEGGGSGGGGSGGGGSGGGGS 53 AA PAT source 1..53 mol_type protein organism synthetic construct VARIANT 1..4 note G, E, A, S, T, P, Q or absent VARIANT 5 note G, E, A, S, T, P or Q VARIANT 9..21 note G, E, A, S, T, P or Q VARIANT 22..36 note G, E, A, S, T, P, Q or absent XXXXXKPEXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPEGGGSGGGGSGGGGS 48 AA PAT source 1..48 mol_type protein organism synthetic construct VARIANT 1..4 note G, E, A, S, T, P, Q or absent VARIANT 5 note G, E, A, S, T, P or Q VARIANT 9..21 note G, E, A, S, T, P or Q VARIANT 22..36 note G, E, A, S, T, P, Q or absent XXXXXKPEXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPEGGGSGGGGS 103 AA PAT source 1..103 mol_type protein organism synthetic construct EEAEPRGKPEGEQPGEQPGEQPGEQPGEQGGKPEGGGSGGGGSGGGGSFVNQHLCGSHLVEALYLVCGERGFFYTPKSDDMRGIVEQCCTSICSLYQLENYCN 103 AA PAT source 1..103 mol_type protein organism synthetic construct EEAEPRGKPGGEQPGEQPGEQPGEQPGEQGGKPGGGGSGGGGSGGGGSFVNQHLCGSHLVEALYLVCGERGFFYTPKSDDMRGIVEQCCTSICSLYQLENYCN 26 AA PAT source 1..26 mol_type protein organism synthetic construct SDDMRGIVEQCCTSICSLYQLENYCN 77 AA PAT source 1..77 mol_type protein organism synthetic construct EEAEPRGKPEGEQPGEQPGEQPGEQPGEQGGKPEGGGSGGGGSGGGGSFVNQHLCGSHLVEALYLVCGERGFFYTPK