P2024TC3077 CN 202410052070.5 2024-01-12 杭州中美华东制药有限公司 HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD. 长效GLP-1/GIP双激动剂的药物组合物 12 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 24 note the epsilon-amino of the K side-chain is conjugated with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gama-Glu)1-CO-(CH2)16-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 28 note the epsilon-amino of the K side-chain is conjugated with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gama-Glu)1-CO-(CH2)16-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 24 note the epsilon-amino of the K side-chain is conjugatged with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gama-Glu)1-CO-(CH2)18-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 24 note the epsilon-amino of the K side-chain is conjugated with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gama-Glu)1-CO-(CH2)20-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 24 note the epsilon-amino of the K side-chain is conjugated with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gama-Glu)3-CO-(CH2)16-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 24 note the epsilon-amino of the K side-chain is conjugated with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gama-Glu)1-CO-(CH2)20-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 28 note the epsilon-amino of the K side-chain is conjugated with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gama-Glu)1-CO-(CH2)20-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 28 note the epsilon-amino of the K side-chain is conjugated with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gama-Glu)3-CO-(CH2)16-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 28 note the epsilon-amino of the K side-chain is conjugated with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gama-Glu)1-CO-(CH2)16-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 28 note the epsilon-amino of the K side-chain is conjugated with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gama-Glu)1-CO-(CH2)20-CO2H MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK 40 AA PAT source 1..40 mol_type protein organism synthetic construct MOD_RES 2 note Aib MOD_RES 6 note alpha methyl phenylalanine MOD_RES 11 note Aib MOD_RES 13 note Aib SITE 24 note the side chain epsilon amino group is chemically modified with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)a-(gama-Glu)b-CO-(CH2)c-COOH, wherein each a is independently selected from an integer of 1, 2, or 3, each b is independently selected from an integer of 1, 2 or 3, and each c is independently selected from an integer from 16, 18 or 20, wherein Z is independently selected from the group consisting of -CH3, carboxylic acids or carboxylic acid bioisosteres, phosphonates or sulfonates, preferably -CO2H. SITE 16 note the side chain epsilon amino group is chemically modified with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)a-(gama-Glu)b-CO-(CH2)c-COOH, wherein each a is independently an integer from 0 to 5, each b is independently an integer from 0 to 5, and each c is independently an integer from 10 to 24 SITE 28 note the side chain epsilon amino group is chemically modified with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)a-(gama-Glu)b-CO-(CH2)c-COOH, wherein each a is independently selected from an integer of 1, 2, or 3, each b is independently selected from an integer of 1, 2 or 3, and each c is independently selected from an integer from 16, 18 or 20, wherein Z is independently selected from the group consisting of -CH3, carboxylic acids or carboxylic acid bioisosteres, phosphonates or sulfonates, preferably -CO2H. SITE 40 note the side chain epsilon amino group is chemically modified with ([2-(2-amino-ethoxy)-ethoxy]-acetyl)a-(gama-Glu)b-CO-(CH2)c-COOH, wherein each a is independently selected from an integer of 1, 2, or 3, each b is independently selected from an integer of 1, 2 or 3, and each c is independently selected from an integer from 16, 18 or 20, wherein Z is independently selected from the group consisting of -CH3, carboxylic acids or carboxylic acid bioisosteres, phosphonates or sulfonates, preferably -CO2H. MOD_RES 40 note amidated YXEGTXTSDYXIXLDKQAQAEFVKWLLKGGPSSGAPPPSK