WO PCT/CN2022/136278 2022-12-02 IEC210395PCT CN 202111469786.8 2021-12-03 BAILI-BIO (CHENGDU) PHARMACEUTICAL CO., LTD. Baili-Bio(Chengdu) Pharmaceutical Co., Ltd. ANTI-HUMAN TROP2 ANTIBODY-CAMPTOTHECIN DRUG CONJUGATE AND MEDICAL USE THEREOF 44 8 AA PAT source 1..8 mol_type protein organism synthetic construct GYTFTSFD 7 AA PAT source 1..7 mol_type protein organism synthetic construct IFPGDGN 11 AA PAT source 1..11 mol_type protein organism synthetic construct VRGEALYYFDY 8 AA PAT source 1..8 mol_type protein organism synthetic construct GYTFTDHV 8 AA PAT source 1..8 mol_type protein organism synthetic construct IYPGSDNS 18 AA PAT source 1..18 mol_type protein organism synthetic construct AREGYGYGKNGVGYAMDY 6 AA PAT source 1..6 mol_type protein organism synthetic construct QDINKY 000 8 AA PAT source 1..8 mol_type protein organism synthetic construct LQYDDLFT 6 AA PAT source 1..6 mol_type protein organism synthetic construct QSVSND 000 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQDYSSPWT 118 AA PAT source 1..118 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKLSCKASGYTFTSFDINWVRQAPEQRLEWMGWIFPGDGNTKYSQKFQGRATITRDTSASTAYMELSSLRSEDTAVYYCVRGEALYYFDYWGQGTLVTVSS 106 AA PAT source 1..106 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDINKYLAWYQQKPGKVPKLLIYSTSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQYDDLFTFGQGTKLEIK 125 AA PAT source 1..125 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDHVISWVRQATGQGLEWMGQIYPGSDNSYYAQKFQGRVTLTADKSINTAYMELSSLRSEDTAVYYCAREGYGYGKNGVGYAMDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCKASQSVSNDVVWYQQKPGQPPKLLIYYASNRYTGVPDRFSGSGYGTDFTLTISSLQAEDVAVYYCQQDYSSPWTFGGGTKVEIK 447 AA PAT source 1..447 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKLSCKASGYTFTSFDINWVRQAPEQRLEWMGWIFPGDGNTKYSQKFQGRATITRDTSASTAYMELSSLRSEDTAVYYCVRGEALYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 213 AA PAT source 1..213 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDINKYLAWYQQKPGKVPKLLIYSTSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQYDDLFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 454 AA PAT source 1..454 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDHVISWVRQATGQGLEWMGQIYPGSDNSYYAQKFQGRVTLTADKSINTAYMELSSLRSEDTAVYYCAREGYGYGKNGVGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCKASQSVSNDVVWYQQKPGQPPKLLIYYASNRYTGVPDRFSGSGYGTDFTLTISSLQAEDVAVYYCQQDYSSPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct ggctacaccttcacaagctttgat 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct atttttcctggagatggtaat 33 DNA PAT source 1..33 mol_type other DNA organism synthetic construct gtaagaggggaggccctgtattactttgactac 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct ggatacacattcactgaccatgtc 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct atttatcctggaagtgataatagt 54 DNA PAT source 1..54 mol_type other DNA organism synthetic construct gcaagagagggctatggttatggaaaaaacggagttggctatgctatggactac 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct caagacattaataagtat 000 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct ctgcagtatgatgatctattcacg 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct cagagtgtgagtaatgat 000 27 DNA PAT source 1..27 mol_type other DNA organism synthetic construct cagcaggattattcctctccgtggacg 355 DNA PAT source 1..355 mol_type other DNA organism synthetic construct caggtgcagctggtgcagtccggcgccgaggtgaagaagcccggcgcctccgtgaagctgagctgtaaggcctccggctacaccttcacctccttcgacattaactgggtgcggcaggcccccgagcagcgcctggagtggatgggctggatcttccccggcgacggcaacaccaagtactcccagaagttccagggaagagctaccatcaccagagatacatccgcttctacagcttacatggagctgtctagcctgagatctgaggatacagctgtgtattactgtgtgagaggagaggctctgtactattttgattattggggccagggcaccctggtgacagtgtcttctg 319 DNA PAT source 1..319 mol_type other DNA organism synthetic construct gatatccagatgacccagtctccatctagcctgtccgcttctgtgggcgatagagtgaccatcacatgcagagcttctcaggatatcaataagtatctggcttggtatcagcagaagcctggaaaggtgcctaagctgctgatctactctacatctaccctgcagtctggagtgccttctagattttctggatctggctctggcaccgattttacactgacaatctcttctctgcagcctgaggatgtggctacatattattgtctgcagtatgatgatctgttcacctttggccagggcaccaagctggagatcaagc 376 DNA PAT source 1..376 mol_type other DNA organism synthetic construct caggtgcagctggtgcagtctggggccgaggtgaaaaagccaggcgcttctgtgaaggtgtcttgcaaggcctccggctacaccttcaccgaccacgtgatctcctgggtgcgccaggccaccggccagggcctggagtggatgggccagatctaccccggctccgacaactcctactacgcccagaagttccagggcagggtgactctgaccgccgacaagtccatcaacaccgcctacatggagctgtcctccctgaggtccgaggacaccgccgtgtactactgcgccagggagggctacggctacggcaagaacggcgtgggctacgccatggattattggggccagggcaccctggtgacagtgtcttctg 322 DNA PAT source 1..322 mol_type other DNA organism synthetic construct gatatcgtgatgacacagtctcctgattctctggccgtgtctctgggcgaaagagctacaatcaactgtaaggcttctcagtctgtgtctaatgatgtggtgtggtaccagcagaagcctgggcagccccccaagctgctgatctactacgcctccaacaggtacaccggcgtgcccgacaggttctccggctccggctacggcaccgacttcaccctgaccatctcctccctgcaggccgaggacgtggccgtgtactactgccagcaggactactcctccccctggaccttcggcggcggcaccaaggtggagatcaagc 1401 DNA PAT source 1..1401 mol_type other DNA organism synthetic construct atgggctggtcctgggtgttcctgttcctgctgagcgtgaccgccggcgtgcactcccaggtgcagctggtgcagtccggcgccgaggtgaagaagcccggcgcctccgtgaagctgagctgtaaggcctccggctacaccttcacctccttcgacattaactgggtgcggcaggcccccgagcagcgcctggagtggatgggctggatcttccccggcgacggcaacaccaagtactcccagaagttccagggaagagctaccatcaccagagatacatccgcttctacagcttacatggagctgtctagcctgagatctgaggatacagctgtgtattactgtgtgagaggagaggctctgtactattttgattattggggccagggcaccctggtgacagtgtcttctgctagcaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagagagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggatgagctgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctatagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggttaa 642 DNA PAT source 1..642 mol_type other DNA organism synthetic construct gatatccagatgacccagtctccatctagcctgtccgcttctgtgggcgatagagtgaccatcacatgcagagcttctcaggatatcaataagtatctggcttggtatcagcagaagcctggaaaggtgcctaagctgctgatctactctacatctaccctgcagtctggagtgccttctagattttctggatctggctctggcaccgattttacactgacaatctcttctctgcagcctgaggatgtggctacatattattgtctgcagtatgatgatctgttcacctttggccagggcaccaagctggagatcaagcgtacggtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttag 1365 DNA PAT source 1..1365 mol_type other DNA organism synthetic construct caggtgcagctggtgcagtctggggccgaggtgaaaaagccaggcgcttctgtgaaggtgtcttgcaaggcctccggctacaccttcaccgaccacgtgatctcctgggtgcgccaggccaccggccagggcctggagtggatgggccagatctaccccggctccgacaactcctactacgcccagaagttccagggcagggtgactctgaccgccgacaagtccatcaacaccgcctacatggagctgtcctccctgaggtccgaggacaccgccgtgtactactgcgccagggagggctacggctacggcaagaacggcgtgggctacgccatggattattggggccagggcaccctggtgacagtgtcttctgctagcaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagagagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggatgagctgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctatagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggttaa 645 DNA PAT source 1..645 mol_type other DNA organism synthetic construct gatatcgtgatgacacagtctcctgattctctggccgtgtctctgggcgaaagagctacaatcaactgtaaggcttctcagtctgtgtctaatgatgtggtgtggtaccagcagaagcctgggcagccccccaagctgctgatctactacgcctccaacaggtacaccggcgtgcccgacaggttctccggctccggctacggcaccgacttcaccctgaccatctcctccctgcaggccgaggacgtggccgtgtactactgccagcaggactactcctccccctggaccttcggcggcggcaccaaggtggagatcaagcgtacggtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttag 1410 DNA PAT source 1..1410 mol_type other DNA organism synthetic construct atgaaacacctgtggttcttcctcctgctggtggcagctcccagatgggtgctgagccaggtgcagctggtgcagtctggcgccgaagtgaagaaaccaggcgccagcgtgaaggtgtcctgcaaggccagcggctacacctttaccaccgccggcatgcagtgggtgcgccaggctcctggacagggcctggaatggatgggctggatcaacacccacagcggcgtgcccaaatacgccgaggacttcaagggcagagtgaccatcagcgccgacaccagcacctccacagcctacctgcagctgagcagcctgaagtccgaggacaccgccgtgtactactgcgccagaagcggcttcggcagcagctactggtacttcgacgtgtggggccagggcaccctcgtgaccgtcagctcagcctccaccaagggcccaagcgtcttccccctggcaccctcctccaagagcacctctggcggcacagccgccctgggctgcctggtcaaggactacttccccgaacccgtgaccgtgagctggaactcaggcgccctgaccagcggcgtgcacaccttccccgctgtcctgcagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagagagttgagcccaaatcttgtgacaaaactcacacatgcccaccctgcccagcacctgaactcctggggggaccctcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccccgggaggagcagtacaacagcacgtaccgggtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggccagccccgggaaccacaggtgtacaccctgcccccatcccgggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatggccagcccgagaacaactacaagaccacccctcccgtgctggactccgacggctccttcttcctctacagcaagctcaccgtggacaagagcaggtggcagcagggcaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacccagaagagcctctccctgtctcccggcaaa 470 AA PAT source 1..470 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 702 DNA PAT source 1..702 mol_type other DNA organism synthetic construct atggtgctgcagacccaggtgttcatctccctgctgctgtggatctccggcgcgtacggcgacatccagatgacccagagccctagcagcctgagcgccagcgtgggcgacagagtgaccatcacatgcaaggccagccaggacgtgtccacagccgtggcctggtatcagcagaagcctggcaaggcccccaagctgctgatctacagcgccagctaccggtacaccggcgtgcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagcagcctgcagcccgaggacttcgccgtgtactactgccagcagcactacatcacccccctgacctttggccagggcaccaagctggaaatcaagcgtacggtggccgccccctccgtgttcatcttccccccctccgacgagcagctgaagtccggcaccgcctccgtggtgtgcctgctgaataacttctaccccagagaggccaaggtgcagtggaaggtggacaacgccctgcagtccgggaactcccaggagagcgtgaccgagcaggacagcaaggacagcacctacagcctgagcagcaccctgaccctgagcaaagccgactacgagaagcacaaggtgtacgcctgcgaggtgacccaccagggcctgagctcccccgtcaccaagagcttcaacaggggggagtgt 234 AA PAT source 1..234 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGDIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC