CN PCT/CN2022/131904 2022-11-15 NP2024TC1353 CN PCT/CN2021/130896 2021-11-16 GeneQuantum Healthcare (Suzhou) Co., Ltd. Exatecan derivatives, linker-payloads, and conjugates and thereof 10 11 AA PAT source 1..11 mol_type protein organism synthetic construct REGION 1..11 note Ab0001-LCCTL-HC LCDR1 RASQDVNTAVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct REGION 1..7 note Ab0001-LCCTL-HC LCDR2 SASFLYS 9 AA PAT source 1..9 mol_type protein organism synthetic construct REGION 1..9 note Ab0001-LCCTL-HC LCDR3 QQHYTTPPT 5 AA PAT source 1..5 mol_type protein organism synthetic construct REGION 1..5 note Ab0001-LCCTL-HC HCDR1 DTYIH 17 AA PAT source 1..17 mol_type protein organism synthetic construct REGION 1..17 note Ab0001-LCCTL-HC HCDR2 RIYPTNGYTRYADSVKG 11 AA PAT source 1..11 mol_type protein organism synthetic construct REGION 1..11 note Ab0001-LCCTL-HC HCDR3 WGGDGFYAMDY 110 AA PAT source 1..110 mol_type protein organism synthetic construct REGION 1..110 note Ab0001-LCCTL-HC Light chain variable region DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTV 120 AA PAT source 1..120 mol_type protein organism synthetic construct REGION 1..120 note Ab0001-LCCTL-HC Heavy chain variable region EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS 222 AA PAT source 1..222 mol_type protein organism synthetic construct REGION 1..222 note Ab0001-LCCTL-HC Light chain full length DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGALPETGG 450 AA PAT source 1..450 mol_type protein organism synthetic construct REGION 1..450 note Ab0001-LCCTL-HC Heavy chain full length EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK