C24W0634 CN CN202311415371.1 2023-10-27 Corregene Biotechnology CO., LTD. T-CELL RECEPTOR-BASED MULTI-SPECIFIC POLYPEPTIDE MOLECULE, AND COMPOSITION AND USE THEREOF 166 4 AA PAT REGION 1..4 note Human IgG1 core hinge region source 1..4 mol_type protein organism synthetic construct CPPC 609 AA PAT source 1..609 mol_type protein organism Homo sapiens MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL 20 AA PAT REGION 1..20 note Albumin-binding peptide source 1..20 mol_type protein organism synthetic construct QRLMEDICLPRWGCLWEDDF 20 AA PAT REGION 1..20 note Hinge region source 1..20 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVA 104 AA PAT REGION 1..104 note CH2 source 1..104 mol_type protein organism synthetic construct GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAK 107 AA PAT REGION 1..107 note CH3 Hole source 1..107 mol_type protein organism synthetic construct GQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note CH3 Knob source 1..107 mol_type protein organism synthetic construct GQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 86 AA PAT REGION 1..86 note TRAC source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 90 AA PAT REGION 1..90 note TRAC source 1..90 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS 94 AA PAT REGION 1..94 note TRAC source 1..94 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESS 130 AA PAT REGION 1..130 note TRBC2 source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 112 AA PAT REGION 1..112 note TRBC2 source 1..112 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFQIVSAEAWGRAD 130 AA PAT REGION 1..130 note TRBC1 source 1..130 mol_type protein organism synthetic construct EDLNKVFPPEVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 112 AA PAT REGION 1..112 note TRBC1 source 1..112 mol_type protein organism synthetic construct EDLNKVFPPEVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFQIVSAEAWGRAD 107 AA PAT REGION 1..107 note CL source 1..107 mol_type protein organism synthetic construct RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 104 AA PAT REGION 1..104 note CL source 1..104 mol_type protein organism synthetic construct RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR 102 AA PAT REGION 1..102 note CH1 source 1..102 mol_type protein organism synthetic construct AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDC 97 AA PAT REGION 1..97 note CH1 source 1..97 mol_type protein organism synthetic construct AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKI 000 000 4 AA PAT REGION 1..4 note Linker source 1..4 mol_type protein organism synthetic construct GGGS 5 AA PAT REGION 1..5 note Linker source 1..5 mol_type protein organism synthetic construct GGGGS 8 AA PAT REGION 1..8 note Linker source 1..8 mol_type protein organism synthetic construct GGGSGGGG 6 AA PAT REGION 1..6 note Linker source 1..6 mol_type protein organism synthetic construct GGSGGS 9 AA PAT REGION 1..9 note Linker source 1..9 mol_type protein organism synthetic construct GGSGGSGGS 10 AA PAT REGION 1..10 note Linker source 1..10 mol_type protein organism synthetic construct GGGGSGGGGS 15 AA PAT REGION 1..15 note Linker source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 24 AA PAT REGION 1..24 note Linker source 1..24 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGSGGGS 30 AA PAT REGION 1..30 note Linker source 1..30 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGSGGGGSGGGGS 7 AA PAT REGION 1..7 note Linker source 1..7 mol_type protein organism synthetic construct GQPKAAP 5 AA PAT REGION 1..5 note Linker source 1..5 mol_type protein organism synthetic construct TVLRT 6 AA PAT REGION 1..6 note Linker source 1..6 mol_type protein organism synthetic construct TVSSAS 5 AA PAT REGION 1..5 note Linker source 1..5 mol_type protein organism synthetic construct GGEGG 7 AA PAT REGION 1..7 note Linker source 1..7 mol_type protein organism synthetic construct GSEGGGS 29 AA PAT REGION 1..29 note Linker source 1..29 mol_type protein organism synthetic construct RTSGPGDGGKGGPGKGPGGEGTKGTGPGG 16 AA PAT REGION 1..16 note Linker source 1..16 mol_type protein organism synthetic construct GKGPGGEGTKGTGPGG 7 AA PAT REGION 1..7 note Linker source 1..7 mol_type protein organism synthetic construct TVLSSAS 5 AA PAT REGION 1..5 note Linker source 1..5 mol_type protein organism synthetic construct EDLKN 5 AA PAT REGION 1..5 note Linker source 1..5 mol_type protein organism synthetic construct EDLNK 5 AA PAT REGION 1..5 note Linker source 1..5 mol_type protein organism synthetic construct ANIQK 113 AA PAT REGION 1..113 note MAGE-A1 TRAV source 1..113 mol_type protein organism synthetic construct RGEDVEQSLFLSVREGDSSVINCTYTDSSSTYLYWYKQEPGAGLQLLTYIFSNMDMKQDQRLTVLLNKKDKHLSLRIADTQTGDSAIYFCAGSGGGTDKLIFGTGTRLQVFPN 118 AA PAT REGION 1..118 note MAGE-A1 TRBV source 1..118 mol_type protein organism synthetic construct GAVVSQHPSWVICKSGTSVKIECRSLDFQATTMFWYRQFPKQSLMLMATSDYQTCVTYEQGVEKDKFLINHASLTLSTLTVTSAHPEDSSFYICSAREPGQGPFEQYFGPGTRLTVTE 6 AA PAT REGION 1..6 note HPV E7 TRAV CDR1 source 1..6 mol_type protein organism synthetic construct NSASQS 6 AA PAT REGION 1..6 note HPV E7 TRAV CDR2 source 1..6 mol_type protein organism synthetic construct VYSSGN 10 AA PAT REGION 1..10 note HPV E7 TRAV CDR3 source 1..10 mol_type protein organism synthetic construct AVISAGTALI 5 AA PAT REGION 1..5 note HPV E7 TRBV CDR1 source 1..5 mol_type protein organism synthetic construct SGHDT 6 AA PAT REGION 1..6 note HPV E7 TRBV CDR2 source 1..6 mol_type protein organism synthetic construct YYEEEE 15 AA PAT REGION 1..15 note HPV E7 TRBV CDR3 source 1..15 mol_type protein organism synthetic construct ASSLGWRGGLYTEAF 109 AA PAT REGION 1..109 note HPV E7 TRAV source 1..109 mol_type protein organism synthetic construct RKEVEQDPGPFNVPEGATVAFNCTYSNSASQSFFWYRQDCRKEPKLLMSVYSSGNEDGRFTAQLNRASQYISLLIRDSKLSDSATYLCAVISAGTALIFGKGTTLSVSS 116 AA PAT REGION 1..116 note HPV E7 TRBV source 1..116 mol_type protein organism synthetic construct DAGVTQSPTHLIKTRGQQVTLRCSPKSGHDTVSWYQQALGQGPQFIFQYYEEEERQRGNFPDRFSGHQFPNYSSELNVNALLLGDSALYLCASSLGWRGGLYTEAFFGQGTRLTVV 6 AA PAT REGION 1..6 note KRAS TRAV CDR1 source 1..6 mol_type protein organism synthetic construct YGATPY 8 AA PAT REGION 1..8 note KRAS TRAV CDR2 source 1..8 mol_type protein organism synthetic construct YFSGDTLV 12 AA PAT REGION 1..12 note KRAS TRAV CDR3 source 1..12 mol_type protein organism synthetic construct AVGVPGGYNKLI 5 AA PAT REGION 1..5 note KRAS TRBV CDR1 source 1..5 mol_type protein organism synthetic construct SGHVS 6 AA PAT REGION 1..6 note KRAS TRBV CDR2 source 1..6 mol_type protein organism synthetic construct FQNEAQ 11 AA PAT REGION 1..11 note KRAS TRBV CDR3 source 1..11 mol_type protein organism synthetic construct ASSLDRGNTIY 114 AA PAT REGION 1..114 note KRAS TRAV source 1..114 mol_type protein organism synthetic construct AQSVTQPDIHITVSEGASLELRCNYSYGATPYLFWYVQSPGQGLQLLLKYFSGDTLVQGIKGFEAEFKRSQSSFNLRKPSVHWSDAAEYFCAVGVPGGYNKLIFGAGTRLAVHP 113 AA PAT REGION 1..113 note KRAS TRBV source 1..113 mol_type protein organism synthetic construct GAGVSQSPRYKVAKRGQDVALRCDPISGHVSLFWYQQALGQGPEFLTYFQNEAQLDKSGLPSDRFFAERPEGSVSTLKIQRTQQEDSAVYLCASSLDRGNTIYFGEGSWLTVV 6 AA PAT REGION 1..6 note KRAS TRAV CDR1 source 1..6 mol_type protein organism synthetic construct VSGNPY 8 AA PAT REGION 1..8 note KRAS TRAV CDR2 source 1..8 mol_type protein organism synthetic construct YITGDNLV 15 AA PAT REGION 1..15 note KRAS TRAV CDR3 source 1..15 mol_type protein organism synthetic construct AVRDIEGAGNNRKLI 5 AA PAT REGION 1..5 note KRAS TRBV CDR1 source 1..5 mol_type protein organism synthetic construct SGHNS 6 AA PAT REGION 1..6 note KRAS TRBV CDR2 source 1..6 mol_type protein organism synthetic construct FNNNVP 11 AA PAT REGION 1..11 note KRAS TRBV CDR1 source 1..11 mol_type protein organism synthetic construct ASSEGFYTEAF 117 AA PAT REGION 1..117 note KRAS TRAV source 1..117 mol_type protein organism synthetic construct AQSVAQPEDQVNVAEGNPLTVKCTYSVSGNPYLFWYVQYPNRGLQFLLKYITGDNLVKGSYGFEAEFNKSQTSFHLKKPSALVSDSALYFCAVRDIEGAGNNRKLIWGLGTSLAVNP 113 AA PAT REGION 1..113 note KRAS TRBV source 1..113 mol_type protein organism synthetic construct DAGVIQSPRHEVTEMGQEVTLRCKPISGHNSLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRFSAKMPNASFSTLKIQPSEPRDSAVYFCASSEGFYTEAFFGQGTRLTVV 6 AA PAT REGION 1..6 note KRAS TRAV CDR1 source 1..6 mol_type protein organism synthetic construct NSASDY 7 AA PAT REGION 1..7 note KRAS TRAV CDR2 source 1..7 mol_type protein organism synthetic construct IRSNMDK 13 AA PAT REGION 1..13 note KRAS TRAV CDR3 source 1..13 mol_type protein organism synthetic construct AENSDGTSYGKLT 5 AA PAT REGION 1..5 note KRAS TRBV CDR1 source 1..5 mol_type protein organism synthetic construct SGHAT 6 AA PAT REGION 1..6 note KRAS TRBV CDR2 source 1..6 mol_type protein organism synthetic construct FQNNGV 13 AA PAT REGION 1..13 note KRAS TRBV CDR3 source 1..13 mol_type protein organism synthetic construct ASSLVGSPDYEQY 114 AA PAT REGION 1..114 note KRAS TRAV source 1..114 mol_type protein organism synthetic construct GESVGLHLPTLGVQEGDNSIINCAYSNSASDYFIWYKQESGKGPQFIIDIRSNMDKRQGQRVTVLLNKTVKHLSLQIAATQPGDSAVYFCAENSDGTSYGKLTFGQGTILTVHP 115 AA PAT REGION 1..115 note KRAS TRBV source 1..115 mol_type protein organism synthetic construct EAGVAQSPRYKIIEKRQSVAFWCNPISGHATLYWYQQILGQGPKLLIQFQNNGVVDDSQLPKDRFSAERLKGVDSTLKIQPAKLEDSAVYLCASSLVGSPDYEQYFGPGTRLTVT 6 AA PAT REGION 1..6 note KRAS TRAV CDR1 source 1..6 mol_type protein organism synthetic construct DRGSQS 6 AA PAT REGION 1..6 note KRAS TRAV CDR2 source 1..6 mol_type protein organism synthetic construct IYSNGD 12 AA PAT REGION 1..12 note KRAS TRAV CDR3 source 1..12 mol_type protein organism synthetic construct AVNLGAAGNKLT 5 AA PAT REGION 1..5 note KRAS TRBV CDR1 source 1..5 mol_type protein organism synthetic construct SGHAT 6 AA PAT REGION 1..6 note KRAS TRBV CDR2 source 1..6 mol_type protein organism synthetic construct FQNNGV 13 AA PAT REGION 1..13 note KRAS TRBV CDR3 source 1..13 mol_type protein organism synthetic construct ASSFSDSYNSPLH 112 AA PAT REGION 1..112 note KRAS TRAV source 1..112 mol_type protein organism synthetic construct QKEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVNLGAAGNKLTFGGGTRVLVKP 115 AA PAT REGION 1..115 note KRAS TRBV source 1..115 mol_type protein organism synthetic construct EAGVAQSPRYKIIEKRQSVAFWCNPISGHATLYWYQQILGQGPKLLIQFQNNGVVDDSQLPKDRFSAERLKGVDSTLKIQPAKLEDSAVYLCASSFSDSYNSPLHFGNGTRLTVT 6 AA PAT REGION 1..6 note KRAS TRAV CDR1 source 1..6 mol_type protein organism synthetic construct NSASQS 6 AA PAT REGION 1..6 note KRAS TRAV CDR2 source 1..6 mol_type protein organism synthetic construct VYSSGN 8 AA PAT REGION 1..8 note KRAS TRAV CDR3 source 1..8 mol_type protein organism synthetic construct VVTNARLM 5 AA PAT REGION 1..5 note KRAS TRBV CDR1 source 1..5 mol_type protein organism synthetic construct MNHEY 6 AA PAT REGION 1..6 note KRAS TRBV CDR2 source 1..6 mol_type protein organism synthetic construct SMNVEV 14 AA PAT REGION 1..14 note KRAS TRBV CDR3 source 1..14 mol_type protein organism synthetic construct ASTSIVSSGRGEQF 107 AA PAT REGION 1..107 note KRAS TRAV source 1..107 mol_type protein organism synthetic construct RKEVEQDPGPFNVPEGATVAFNCTYSNSASQSFFWYRQDCRKEPKLLMSVYSSGNEDGRFTAQLNRASQYISLLIRDSKLSDSATYLCVVTNARLMFGDGTQLVVKP 115 AA PAT REGION 1..115 note KRAS TRBV source 1..115 mol_type protein organism synthetic construct EAQVTQNPRYLITVTGKKLTVTCSQNMNHEYMSWYRQDPGLGLRQIYYSMNVEVTDKGDVPEGYKVSRKEKRNFPLILESPSPNQTSLYFCASTSIVSSGRGEQFFGPGTRLTVL 108 AA PAT REGION 1..108 note gp100 TRAV source 1..108 mol_type protein organism synthetic construct SQQGEEDPQALSIQEGENATMNCSYKTSINNLQWYRQNSGRGLVHLILIRSNEREKHSGRLRVTLDTSKKSSSLLITASRAADTASYFCATDGSTPMQFGKGTRLSVI 112 AA PAT REGION 1..112 note gp100 TRBV source 1..112 mol_type protein organism synthetic construct DGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSWAQGDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSWGAPYEQYFGPGTRLTVT 108 AA PAT REGION 1..108 note gp100 TRAV source 1..108 mol_type protein organism synthetic construct SQQGEEDPQALSIQEGENATMNCSYKTSINNLQWYRQNSGRGLVHLILIRSNEREKHSGRLRVTLDTSKKSSSLLITASRACDTASYFCATDGSTPMQFGKGTRLSVI 112 AA PAT REGION 1..112 note gp100 TRBV source 1..112 mol_type protein organism synthetic construct DGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSWAQGDFQKGDIAEGYSVSREKKESFPLTVTSAQKCPTAFYLCASSWGAPYEQYFGPGTRLTVT 122 AA PAT REGION 1..122 note CD3 VH source 1..122 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKCLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 122 AA PAT REGION 1..122 note CD3 VH source 1..122 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKCLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRACDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 120 AA PAT REGION 1..120 note CD28 VH source 1..120 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWIGYIYPGNVNTNYNEKFKDRATLTVDTSISTAYMELSRLRSDDTAVYFCTRSHYGLDWNFDVWGQGTTVTVSS 120 AA PAT REGION 1..120 note CD28 VH source 1..120 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWIGYIYPGNVNTNYNEKFKDRATLTVDTSISTAYMELSRLRSCDTAVYFCTRSHYGLDWNFDVWGQGTTVTVSS 121 AA PAT REGION 1..121 note 4-1BB VH source 1..121 mol_type protein organism synthetic construct EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYDMSWVRQAPGKCLEWVSWISYSGGSIYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDAQRNSMREFDYWGQGTLVTVSS 117 AA PAT REGION 1..117 note 4-1BB VH source 1..117 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCTASGFSLNDYWMSWVRQAPGKGLEWVGYIDVGGSLYYAASVKGRFTISRDDSKSIAYLQMNSLKTEDTAVYYCARGGLTYGFDLWGQGTLVTVSS 107 AA PAT REGION 1..107 note CD3 VL source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGCGTKVEIK 107 AA PAT REGION 1..107 note CD3 VL source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPCDFATYYCQQGNTLPWTFGCGTKVEIK 107 AA PAT REGION 1..107 note CD28 VL source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCHASQNIYVWLNWYQQKPGKAPKLLIYKASNLHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGQTYPYTFGGGTKVEIK 107 AA PAT REGION 1..107 note CD28 VL source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCHASQNIYVWLNWYQQKPGKAPKLLIYKASNLHTGVPSRFSGSGSGTDFTLTISSLQPCDFATYYCQQGQTYPYTFGGGTKVEIK 110 AA PAT REGION 1..110 note 4-1BB VL source 1..110 mol_type protein organism synthetic construct QSVLTQPPSASGTPGQRVTISCSGSSSNIGNNYVTWYQQLPGTAPKLLIYADSHRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCATWDYSLSGYVFGCGTKLTVL 110 AA PAT REGION 1..110 note 4-1BB VL source 1..110 mol_type protein organism synthetic construct DIVMTQSPSSLSASVGDRVTITCQASEDISSYLAWYQQKPGKAPKRLIYGASDLASGVPSRFSASGSGTDYTFTISSLQPEDIATYYCHYYATISGLGVAFGGGTKVEIK 113 AA PAT REGION 1..113 note MAGE-A1 TRAV source 1..113 mol_type protein organism synthetic construct RGEDVEQSLFLSVREGDSSVINCTYTDSSSTYLYWYKQEPGAGLQLLTYTWPHMDMKQDQRLTVLLNKKDKHLSLRIADTQTGDSAIYFCAGSGGGTDKLIFGTGTRLQVFPN 118 AA PAT REGION 1..118 note MAGE-A1 TRBV source 1..118 mol_type protein organism synthetic construct GAVVSQHPSWVICKSGTSVKIECRSLDFQATTMFWYRQFPKQSLMLMATSNEGSKATYEQGVEKDKFLINHASLTLSTLTVTSAHPEDSSFYICSAREPGQGPYEQYFGPGTRLTVTE 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 Hole, KiH-dS PVA-AAS N297Q T366S-L368A-Y407V Y349C source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 Knob, KiH-dS PVA-AAS N297Q T366W S354C source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 Hole, KiH-dS PVA-GSS N297Q T366S-L368A-Y407V Y349C source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 Knob, KiH-dS PVA-GSS N297Q T366W S354C source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 Hole, KiH-dS PVA-GSS T366S-L368A-Y407V Y349C source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 Knob, KiH-dS PVA-GSS T366W S354C source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3, KiH-dS PVA-GSS source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3, KiH-dS PVA-GSS source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 FcK/O, KiH-dS PVA-GSS D356K D399K source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSRKELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLKSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 FcK/O, KiH-dS PVA-GSS K392D K409D source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYDTTPPVLDSDGSFFLYSDLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 FcK/O, KiH-dS PVA-GSS PPV-KKK source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTKKKLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT REGION 1..231 note Hinge-CH2-CH3 FcK/O, KiH-dS PVA-GSS TPP-DDD source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTDDDVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 12 AA PAT REGION 1..12 note Linker source 1..12 mol_type protein organism synthetic construct GGEGGGSEGGGS 000 000 21 AA PAT REGION 1..21 note IgG1 Hinge region source 1..21 mol_type protein organism synthetic construct EPKSCDKTHTCPPCPAPELLG 19 AA PAT REGION 1..19 note IgG2 Hinge region source 1..19 mol_type protein organism synthetic construct ERKCCVECPPCPAPPVAGP 18 AA PAT REGION 1..18 note IgG4 Hinge region source 1..18 mol_type protein organism synthetic construct ESKYGPPCPSCPAPEFLG 104 AA PAT REGION 1..104 note IgG1 CH2 source 1..104 mol_type protein organism synthetic construct GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK 104 AA PAT REGION 1..104 note IgG2 CH2 source 1..104 mol_type protein organism synthetic construct GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTK 104 AA PAT REGION 1..104 note IgG4 CH2 source 1..104 mol_type protein organism synthetic construct GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAK 107 AA PAT REGION 1..107 note IgG1 CH3 source 1..107 mol_type protein organism synthetic construct GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note IgG2 CH3 source 1..107 mol_type protein organism synthetic construct GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDISVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note IgG4 CH3 source 1..107 mol_type protein organism synthetic construct GQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 21 AA PAT REGION 1..21 note Hinge region source 1..21 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAG 15 AA PAT REGION 1..15 note Hinge region source 1..15 mol_type protein organism synthetic construct EPKSSDKTHTCPPCP 20 AA PAT REGION 1..20 note Hinge region source 1..20 mol_type protein organism synthetic construct PKSSDKTHTCPPCPAPPVAG 19 AA PAT REGION 1..19 note Hinge region source 1..19 mol_type protein organism synthetic construct PKSSDKTHTCPPCPAPPVA 19 AA PAT REGION 1..19 note Hinge region source 1..19 mol_type protein organism synthetic construct KSSDKTHTCPPCPAPPVAG 18 AA PAT REGION 1..18 note Hinge region source 1..18 mol_type protein organism synthetic construct KSSDKTHTCPPCPAPPVA 18 AA PAT REGION 1..18 note Hinge region source 1..18 mol_type protein organism synthetic construct SSDKTHTCPPCPAPPVAG 17 AA PAT REGION 1..17 note Hinge region source 1..17 mol_type protein organism synthetic construct SSDKTHTCPPCPAPPVA 17 AA PAT REGION 1..17 note Hinge region source 1..17 mol_type protein organism synthetic construct SDKTHTCPPCPAPPVAG 16 AA PAT REGION 1..16 note Hinge region source 1..16 mol_type protein organism synthetic construct SDKTHTCPPCPAPPVA 16 AA PAT REGION 1..16 note Hinge region source 1..16 mol_type protein organism synthetic construct DKTHTCPPCPAPPVAG 15 AA PAT REGION 1..15 note Hinge region source 1..15 mol_type protein organism synthetic construct DKTHTCPPCPAPPVA 15 AA PAT REGION 1..15 note Hinge region source 1..15 mol_type protein organism synthetic construct KTHTCPPCPAPPVAG 14 AA PAT REGION 1..14 note Hinge region source 1..14 mol_type protein organism synthetic construct KTHTCPPCPAPPVA 14 AA PAT REGION 1..14 note Hinge region source 1..14 mol_type protein organism synthetic construct THTCPPCPAPPVAG 12 AA PAT REGION 1..12 note Hinge region source 1..12 mol_type protein organism synthetic construct THTCPPCPAPPV 13 AA PAT REGION 1..13 note Hinge region source 1..13 mol_type protein organism synthetic construct HTCPPCPAPPVAG 12 AA PAT REGION 1..12 note Hinge region source 1..12 mol_type protein organism synthetic construct HTCPPCPAPPVA 12 AA PAT REGION 1..12 note Hinge region source 1..12 mol_type protein organism synthetic construct TCPPCPAPPVAG 11 AA PAT REGION 1..11 note Hinge region source 1..11 mol_type protein organism synthetic construct TCPPCPAPPVA 11 AA PAT REGION 1..11 note Hinge region source 1..11 mol_type protein organism synthetic construct CPPCPAPPVAG 10 AA PAT REGION 1..10 note Hinge region source 1..10 mol_type protein organism synthetic construct CPPCPAPPVA 10 AA PAT REGION 1..10 note Hinge region source 1..10 mol_type protein organism synthetic construct PPCPAPPVAG 9 AA PAT REGION 1..9 note Hinge region source 1..9 mol_type protein organism synthetic construct PPCPAPPVA 8 AA PAT REGION 1..8 note Hinge region source 1..8 mol_type protein organism synthetic construct CPAPPVAG 7 AA PAT REGION 1..7 note Hinge region source 1..7 mol_type protein organism synthetic construct CPAPPVA 8 AA PAT REGION 1..8 note Hinge region source 1..8 mol_type protein organism synthetic construct CPAPPVAG 6 AA PAT REGION 1..6 note Hinge region source 1..6 mol_type protein organism synthetic construct PAPPVA 104 AA PAT REGION 1..104 note CH2 source 1..104 mol_type protein organism synthetic construct GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAK 104 AA PAT REGION 1..104 note CH2 source 1..104 mol_type protein organism synthetic construct GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAK 104 AA PAT REGION 1..104 note CH2 source 1..104 mol_type protein organism synthetic construct GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAK 19 AA PAT REGION 1..19 note Signal peptide source 1..19 mol_type protein organism synthetic construct MGWSLILLFLVAVATRVHS 9 AA PAT REGION 1..9 note gp100 antigen epitope source 1..9 mol_type protein organism synthetic construct YLEPGPVTA 9 AA PAT REGION 1..9 note gp100 antigen epitope variant source 1..9 mol_type protein organism synthetic construct YLEPGPVTV