PH-9776-PCT JP JP2022-019125 2022-02-09 Daiichi Sankyo Company, Limited 環境応答性マスク抗体及びその利用 Environment-responsive masked antibodies and use thereof 81 470 AA PAT REGION 1..470 note Amino acid sequence of the full length of HT1-11 H chain source 1..470 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 234 AA PAT REGION 1..234 note Amino acid sequence of the full length of HT1-11 L chain source 1..234 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGDIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 331 AA PAT REGION 1..331 note Amino acid sequence of the full length of MHT1001 source 1..331 mol_type protein organism synthetic construct MKYLLPTAAAGLLLLAAQPAMAAMGYLALKHPWPGLAENSGSGGGGSVLVPMAMMASGGSDVNSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGQGTKLEIKRGAPSGDYKDDDDKGAAAHHHHHH 331 AA PAT REGION 1..331 note Amino acid sequence of the full length of MHT1002 source 1..331 mol_type protein organism synthetic construct MKYLLPTAAAGLLLLAAQPAMAAMGYLALKHPWPGLAENSGSGGGGSVLVPMAMMASGGSDVNSDIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGQGTKLEIKRGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSGAPSGDYKDDDDKGAAAHHHHHH 294 AA PAT REGION 1..294 note Amino acid sequence of the full length of HT1-11-scFv-HL source 1..294 mol_type protein organism synthetic construct MKYLLPTAAAGLLLLAAQPAMAADVNSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGQGTKLEIKRGAPSGDYKDDDDKGAAAHHHHHH 294 AA PAT REGION 1..294 note Amino acid sequence of the full length of HT1-11-scFv-LH source 1..294 mol_type protein organism synthetic construct MKYLLPTAAAGLLLLAAQPAMAADVNSDIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGQGTKLEIKRGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSGAPSGDYKDDDDKGAAAHHHHHH 506 AA PAT REGION 1..506 note Amino acid sequence of the full length of MHT1007 H chain source 1..506 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGSGGGGSVLVPMAMMASGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 506 AA PAT REGION 1..506 note Amino acid sequence of the full length of MHT1008 H chain source 1..506 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGSGGGGSGGGGSGGGGSGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 506 AA PAT REGION 1..506 note Amino acid sequence of the full length of MHT1009 H chain source 1..506 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGSGGSGGSGRSANAILEGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 506 AA PAT REGION 1..506 note Amino acid sequence of the full length of MHT1803 H chain source 1..506 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAEHHHSGGGGSGGGGSGGGGSHHHQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 506 AA PAT REGION 1..506 note Amino acid sequence of the full length of MHT1804 H chain source 1..506 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGSGHHHSGGGGSHHHGSGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 506 AA PAT REGION 1..506 note Amino acid sequence of the full length of MHT1805 H chain source 1..506 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGSGGGGSHHHHSGGGGSGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 506 AA PAT REGION 1..506 note Amino acid sequence of the full length of MHT1806 H chain source 1..506 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAEHHHSGGGGSHHHHSGGGGSHHHQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 508 AA PAT REGION 1..508 note Amino acid sequence of the full length of MHT1808 H chain source 1..508 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGGGGSGHHHGGHHHGGHHHGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 508 AA PAT REGION 1..508 note Amino acid sequence of the full length of MHT1809 H chain source 1..508 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGGGGSHHGGHHGGHHGGHHGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 508 AA PAT REGION 1..508 note Amino acid sequence of the full length of MHT1810 H chain source 1..508 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGGGGHGHGHGHGHGHGHGHGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 520 AA PAT REGION 1..520 note Amino acid sequence of the full length of MHT1811 H chain source 1..520 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGGGGSGGGSGHHHGGHHHGGHHHGSPLGLWAGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 508 AA PAT REGION 1..508 note Amino acid sequence of the full length of MHT1817 H chain source 1..508 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGGGGSGHHHGGHDHGGHHHGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 508 AA PAT REGION 1..508 note Amino acid sequence of the full length of MHT1818 H chain source 1..508 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGGGGSGHDHGGHHHGGHDHGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 508 AA PAT REGION 1..508 note Amino acid sequence of the full length of MHT1819 H chain source 1..508 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLAENSGGGGSGHDHGGHDHGGHDHGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 465 AA PAT REGION 1..465 note Amino acid sequence of the full length of hM23H1L1 H chain source 1..465 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSQVQLVQSGAEVKKPGASVKVSCKASGYAFSNYLIEWVRQAPGQGLEWMGVINPGSGVTNYNEKFKGRVTITADTSTSTAYMELSSLRSEDTAVYYCARAEAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 240 AA PAT REGION 1..240 note Amino acid sequence of the full length of hM23H1L1 L chain source 1..240 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 468 AA PAT REGION 1..468 note Amino acid sequence of the full length of Cetuximab H chain source 1..468 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSQVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 234 AA PAT REGION 1..234 note Amino acid sequence of the full length of Cetuximab L chain source 1..234 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGDILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 464 AA PAT REGION 1..464 note Amino acid sequence of the full length of C3022 H chain source 1..464 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSQVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGRINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSGLRSDDTAVYYCASGSVRHPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 236 AA PAT REGION 1..236 note Amino acid sequence of the full length of C3022 L chain source 1..236 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGQPVLTQPPSASGTPGQRVTISCSGSRSNIGGNIVSWYQQFPGTAPRLLTYADNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 278 AA PAT REGION 1..278 note Amino acid sequence of the full length of MhM8001 L chain source 1..278 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGENMWNDLDLVPLGILGGGGSGHHHGGHHHGGHHHGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 273 AA PAT REGION 1..273 note Amino acid sequence of the full length of MCE-2101 L chain source 1..273 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGMGLMHMEKSRSWYLSRQGGGGSGHHHGGHHHGGHHHGGSDILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 502 AA PAT REGION 1..502 note Amino acid sequence of the full length of MC3-9001 H chain source 1..502 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGETMSVFTRDYFTETPGGGGSGHHHGGHHHGGHHHGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGRINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSGLRSDDTAVYYCASGSVRHPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 506 AA PAT REGION 1..506 note Amino acid sequence of the full length of MHT1221 H chain source 1..506 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSGYLALKHPWPGLASGSGSGGGGSGGGGSGGGGSGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 465 AA PAT REGION 1..465 note Amino acid sequence of the full length of hM23-M1 H chain source 1..465 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSQVQLVQSGAEVKKPGASVKVSCKASGAAFSNYLIEWVRQAPGQGLEWMGVINPGSGVTNYNEKFKGRVTITADTSTSTAYMELSSLRSEDTAVYYCARAEAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 240 AA PAT REGION 1..240 note Amino acid sequence of the full length of hM23-M1 L chain source 1..240 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRAVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 276 AA PAT REGION 1..276 note Amino acid sequence of the full length of MhM1013 L chain source 1..276 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGSGGGGSVLVPMAMMASGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 276 AA PAT REGION 1..276 note Amino acid sequence of the full length of MhM1018-M1 L chain source 1..276 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGSGGGGSGGGGSGGGGSGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 278 AA PAT REGION 1..278 note Amino acid sequence of the full length of MhM1024-M1 L chain source 1..278 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGGGGSGHHHGGHHHGGHHHGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 10 AA PAT REGION 1..10 note Synthetic source 1..10 mol_type protein organism synthetic construct SGRSANAILE 7 AA PAT REGION 1..7 note Synthetic source 1..7 mol_type protein organism synthetic construct SGRSANA 5 AA PAT REGION 1..5 note Synthetic source 1..5 mol_type protein organism synthetic construct SGRSA 10 AA PAT REGION 1..10 note Synthetic source 1..10 mol_type protein organism synthetic construct VLVPMAMMAS 6 AA PAT REGION 1..6 note Synthetic source 1..6 mol_type protein organism synthetic construct PLGLWA 6 AA PAT REGION 1..6 note Synthetic source 1..6 mol_type protein organism synthetic construct PLGLAG 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGSHHGGHHGGHHGGHHGGS 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GGGGSHHGGHRHGGHHKGGHHGGS 23 AA PAT REGION 1..23 note Synthetic source 1..23 mol_type protein organism synthetic construct GGGGSHGHGHGHGHGHGHGHGGS 27 AA PAT REGION 1..27 note Synthetic source 1..27 mol_type protein organism synthetic construct MYKDCIESTGDYFLLCDAEGPWGIILE 20 AA PAT REGION 1..20 note Synthetic source 1..20 mol_type protein organism synthetic construct GSGGGGSVLVPMAMMASGGS 20 AA PAT REGION 1..20 note Synthetic source 1..20 mol_type protein organism synthetic construct GSGGGGSGGGGSGGGGSGGS 20 AA PAT REGION 1..20 note Synthetic source 1..20 mol_type protein organism synthetic construct GSGGSGGSGRSANAILEGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct HHHSGGGGSGGGGSGGGGSHHH 20 AA PAT REGION 1..20 note Synthetic source 1..20 mol_type protein organism synthetic construct GSGHHHSGGGGSHHHGSGGS 20 AA PAT REGION 1..20 note Synthetic source 1..20 mol_type protein organism synthetic construct GSGGGGSHHHHSGGGGSGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct HHHSGGGGSHHHHSGGGGSHHH 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGSGHHHGGHHHGGHHHGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGHGHGHGHGHGHGHGHGGS 34 AA PAT REGION 1..34 note Synthetic source 1..34 mol_type protein organism synthetic construct GGGGSGGGSGHHHGGHHHGGHHHGSPLGLWAGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGSGHHHGGHDHGGHHHGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGSGHDHGGHHHGGHDHGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGSGHDHGGHDHGGHDHGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGSGHHHGGHHHGGHHHGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGSGHHHGGHHHGGHHHGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGSGHHHGGHHHGGHHHGGS 20 AA PAT REGION 1..20 note Synthetic source 1..20 mol_type protein organism synthetic construct GSGGGGSGGGGSGGGGSGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GSGSGGGGSVLVPMAMMASGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GSGSGGGGSGGGGSGGGGSGGS 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GSGGGGSGHHHGGHHHGGHHHGGS 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GGGGSGHHHGGHRHGGHHHGGS 6 AA PAT REGION 1..6 note Synthetic source 1..6 mol_type protein organism synthetic construct PLFAAP 280 AA PAT REGION 1..280 note Amino acid sequence of the full length of MhM1026-M1 L chain source 1..280 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGGGGSGGGHHHGGHHHGGHHHGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 280 AA PAT REGION 1..280 note Amino acid sequence of the full length of MhM1028-M1 L chain source 1..280 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGGGGSGGGHHHGRHHHGGHHHGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 280 AA PAT REGION 1..280 note Amino acid sequence of the full length of MhM1042-M1 L chain source 1..280 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGGGGSGGRHHHGGHHHGGHHHGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 280 AA PAT REGION 1..280 note Amino acid sequence of the full length of MhM1043-M1 L chain source 1..280 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGGGGSGGGHHHGGHHHGRHHHGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 280 AA PAT REGION 1..280 note Amino acid sequence of the full length of MhM1044-M1 L chain source 1..280 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGGGGSGGGHHHGKHHHGGHHHGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 280 AA PAT REGION 1..280 note Amino acid sequence of the full length of MhM1045-M1 L chain source 1..280 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGGGGSGGKHHHGGHHHGGHHHGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 280 AA PAT REGION 1..280 note Amino acid sequence of the full length of MhM1046-M1 L chain source 1..280 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGGNFYHQYPWPLEILGSGGGGSGGGHHHGGHHHGKHHHGGSDIVMTQSPDSLAVSLGERATINCKSSQSLLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQRYYGYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GGGGSGGGHHHGGHHHGGHHHGGS 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GGGGSGGGHHHGRHHHGGHHHGGS 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GGGGSGGRHHHGGHHHGGHHHGGS 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GGGGSGGGHHHGGHHHGRHHHGGS 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GGGGSGGGHHHGKHHHGGHHHGGS 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GGGGSGGKHHHGGHHHGGHHHGGS 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GGGGSGGGHHHGGHHHGKHHHGGS