P24416826SG CN 202210355452.6 2022-04-06 GUANGZHOU REFORGENE MEDICINE CO., LTD. METHOD FOR REPAIRING HBA2 GENE MUTATIONS BY SINGLE BASE EDITING AND USE THEREOF 69 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct ccgtcaagctggagcctcgg 15 DNA PAT source 1..15 mol_type other DNA organism synthetic construct aagctggagcctcgg 16 DNA PAT source 1..16 mol_type other DNA organism synthetic construct caagctggagcctcgg 17 DNA PAT source 1..17 mol_type other DNA organism synthetic construct tcaagctggagcctcgg 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct gtcaagctggagcctcgg 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct cgtcaagctggagcctcgg 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct accgtcaagctggagcctcgg 22 DNA PAT source 1..22 mol_type other DNA organism synthetic construct taccgtcaagctggagcctcgg 23 DNA PAT source 1..23 mol_type other DNA organism synthetic construct ataccgtcaagctggagcctcgg 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct aataccgtcaagctggagcctcgg 25 DNA PAT source 1..25 mol_type other DNA organism synthetic construct aaataccgtcaagctggagcctcgg 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct cgtcaagcaggagcctcgg 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct tctcaagctggagcctcgg 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct cgtcactgaggagcctcgg 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct accgtcaagctggagcctcg 15 DNA PAT source 1..15 mol_type other DNA organism synthetic construct caagctggagcctcg 16 DNA PAT source 1..16 mol_type other DNA organism synthetic construct tcaagctggagcctcg 17 DNA PAT source 1..17 mol_type other DNA organism synthetic construct gtcaagctggagcctcg 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct cgtcaagctggagcctcg 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct ccgtcaagctggagcctcg 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct taccgtcaagctggagcctcg 22 DNA PAT source 1..22 mol_type other DNA organism synthetic construct ataccgtcaagctggagcctcg 23 DNA PAT source 1..23 mol_type other DNA organism synthetic construct aataccgtcaagctggagcctcg 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct aaataccgtcaagctggagcctcg 25 DNA PAT source 1..25 mol_type other DNA organism synthetic construct caaataccgtcaagctggagcctcg 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct ataccgtcaagctggagcct 15 DNA PAT source 1..15 mol_type other DNA organism synthetic construct gtcaagctggagcct 16 DNA PAT source 1..16 mol_type other DNA organism synthetic construct cgtcaagctggagcct 17 DNA PAT source 1..17 mol_type other DNA organism synthetic construct ccgtcaagctggagcct 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct accgtcaagctggagcct 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct taccgtcaagctggagcct 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct aataccgtcaagctggagcct 22 DNA PAT source 1..22 mol_type other DNA organism synthetic construct aaataccgtcaagctggagcct 23 DNA PAT source 1..23 mol_type other DNA organism synthetic construct caaataccgtcaagctggagcct 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct ccaaataccgtcaagctggagcct 25 DNA PAT source 1..25 mol_type other DNA organism synthetic construct tccaaataccgtcaagctggagcct 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct cgtcaagctggagcctcggt 15 DNA PAT source 1..15 mol_type other DNA organism synthetic construct agctggagcctcggt 16 DNA PAT source 1..16 mol_type other DNA organism synthetic construct aagctggagcctcggt 17 DNA PAT source 1..17 mol_type other DNA organism synthetic construct caagctggagcctcggt 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct tcaagctggagcctcggt 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct gtcaagctggagcctcggt 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct ccgtcaagctggagcctcggt 22 DNA PAT source 1..22 mol_type other DNA organism synthetic construct accgtcaagctggagcctcggt 23 DNA PAT source 1..23 mol_type other DNA organism synthetic construct taccgtcaagctggagcctcggt 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct ataccgtcaagctggagcctcggt 25 DNA PAT source 1..25 mol_type other DNA organism synthetic construct aataccgtcaagctggagcctcggt 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct taccgtcaagctggagcctc 15 DNA PAT source 1..15 mol_type other DNA organism synthetic construct tcaagctggagcctc 16 DNA PAT source 1..16 mol_type other DNA organism synthetic construct gtcaagctggagcctc 17 DNA PAT source 1..17 mol_type other DNA organism synthetic construct cgtcaagctggagcctc 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct ccgtcaagctggagcctc 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct accgtcaagctggagcctc 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct ataccgtcaagctggagcctc 22 DNA PAT source 1..22 mol_type other DNA organism synthetic construct aataccgtcaagctggagcctc 23 DNA PAT source 1..23 mol_type other DNA organism synthetic construct aaataccgtcaagctggagcctc 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct caaataccgtcaagctggagcctc 25 DNA PAT source 1..25 mol_type other DNA organism synthetic construct ccaaataccgtcaagctggagcctc 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct aataccgtcaagctggagcc 16 DNA PAT source 1..16 mol_type other DNA organism synthetic construct ccgtcaagctggagcc 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct gtcaagctggagcctcggta 16 DNA PAT source 1..16 mol_type other DNA organism synthetic construct agctggagcctcggta 289 DNA PAT source 1..289 mol_type other DNA organism synthetic construct ttctgtgagcaccgtgctgacctccaaataccgtcaagctggagcctcggtagccgttcctcctgcccgctgggcctcccaacgggccctcctcccctccttgcaccggcccttcctggtctttgaataaagtctgagtgggcagcagcctgtgtgtgcctgggttctctctatcccggaatgtgccaacaatggaggtgtttacctgtctcagaccaaggacctctctgcagctgcatggggctggggagggagaactgcagggagtatgggaggggaagctgaggtg 101 DNA PAT source 1..101 mol_type other DNA organism synthetic construct ccgttgggaggcccagcgggcaggaggaacggctaccgaggctccagcttaacggtatttggaggtcagcacggtgctcacagaagccaggaacttgtcca 80 RNA PAT source 1..80 mol_type other RNA organism synthetic construct gttttagagctagaaatagcaagttaaaataaggctagtccgttatcaacttgaaaaagtggcaccgagtcggtgctttt 100 RNA PAT source 1..100 mol_type other RNA organism synthetic construct ccgtcaagctggagcctcgggttttagagctagaaatagcaagttaaaataaggctagtccgttatcaacttgaaaaagtggcaccgagtcggtgctttt 76 RNA PAT source 1..76 mol_type other RNA organism synthetic construct gttttagagctagaaatagcaagttaaaataaggctagtccgttatcaacttgaaaaagtggcaccgagtcggtgc 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct cgacaagcagaagaacggcatcaa 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct cagctgcagagaggtccttg