CN PCT/CN2023/121083 2023-09-25 BACN2537PCT CN 202211174484.2 2022-09-26 西雅图免疫公司 SYSTIMMUNE, INC. ANTI-CD33 ANTIBODY AND ANTI-CD33 ANTIBODY-DRUG CONJUGATE AND USE THEREOF 抗CD33抗体和抗CD33抗体-药物偶联物及其用途 28 116 AA PAT source 1..116 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGSSVKVSCKASGYTITDSNIHWVRQAPGQSLEWIGYIYPYNGGTDYNQKFKNRATLTVDNPTNTAYMELSSLRSEDTAFYYCVNGNPWLAYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct DSNIH 17 AA PAT source 1..17 mol_type protein organism synthetic construct YIYPYNGGTDYNQKFKN 7 AA PAT source 1..7 mol_type protein organism synthetic construct GNPWLAY 445 AA PAT source 1..445 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGSSVKVSCKASGYTITDSNIHWVRQAPGQSLEWIGYIYPYNGGTDYNQKFKNRATLTVDNPTNTAYMELSSLRSEDTAFYYCVNGNPWLAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 329 AA PAT source 1..329 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 111 AA PAT source 1..111 mol_type protein organism synthetic construct DIQLTQSPSTLSASVGDRVTITCRASESLDNYGIRFLTWFQQKPGKAPKLLMYAASNQGSGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQTKEVPWSFGQGTKVEVK 15 AA PAT source 1..15 mol_type protein organism synthetic construct RASESLDNYGIRFLT 7 AA PAT source 1..7 mol_type protein organism synthetic construct AASNQGS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQTKEVPWS 218 AA PAT source 1..218 mol_type protein organism synthetic construct DIQLTQSPSTLSASVGDRVTITCRASESLDNYGIRFLTWFQQKPGKAPKLLMYAASNQGSGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQTKEVPWSFGQGTKVEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 107 AA PAT source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 348 DNA PAT source 1..348 mol_type other DNA organism synthetic construct gaggtgcagctggtgcagagtggagctgaggtgaagaagccaggctcctctgtgaaggtgtcctgcaaggcctctggctacaccatcacagacagcaacatccactgggtgaggcaggccccaggccagagcctggagtggattggctacatctacccctacaatggaggcacagactacaaccagaagttcaagaacagagccaccctgactgtggacaaccccaccaacacagcctacatggagctgagctccctgagaagtgaagacacagccttctactactgtgtgaatgggaacccctggctggcctactggggccagggcaccctggtgactgtgtcctct 15 DNA PAT source 1..15 mol_type other DNA organism synthetic construct gacagcaacatccac 51 DNA PAT source 1..51 mol_type other DNA organism synthetic construct tacatctacccctacaatggaggcacagactacaaccagaagttcaagaac 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct gggaacccctggctggcctac 1338 DNA PAT source 1..1338 mol_type other DNA organism synthetic construct gaggtgcagctggtgcagagtggagctgaggtgaagaagccaggctcctctgtgaaggtgtcctgcaaggcctctggctacaccatcacagacagcaacatccactgggtgaggcaggccccaggccagagcctggagtggattggctacatctacccctacaatggaggcacagactacaaccagaagttcaagaacagagccaccctgactgtggacaaccccaccaacacagcctacatggagctgagctccctgagaagtgaagacacagccttctactactgtgtgaatgggaacccctggctggcctactggggccagggcaccctggtgactgtgtcctctgctagcaccaagggcccctctgtgttccctctggctccctcctccaagagcacctctggaggcacagctgccctgggctgcctggtgaaggactacttcccagagcctgtgactgtgtcctggaactctggagccctgacctctggagtgcacaccttcccagctgtgctgcagagctctggcctctacagcctgtcctctgtggtgactgtgccctcctcctccctgggaacccagacctacatctgcaatgtgaaccacaagccctccaacaccaaggtggacaagagagtggagcccaagagctgtgacaagacccacacctgcccaccctgcccagccccagagctgctgggaggaccctctgtgttcctctttccacccaagcccaaggacaccctgatgatctccagaaccccagaggtgacctgtgtggtggtggatgtgtcccatgaagacccagaagtgaagttcaactggtatgtggatggagtggaagtgcacaatgccaagaccaagcccagagaagagcagtacaacagcacctacagagtggtgtctgtgctgactgtgctgcaccaggactggctgaatggcaaagagtacaagtgcaaagtgtccaacaaggccctgccagctcccattgagaagaccatctccaaggccaagggccagcccagagagcctcaggtgtacaccctgccaccatccagagatgagctgaccaagaaccaggtgtccctgacctgcctggtgaaaggcttctacccctctgacattgctgtggagtgggagagcaatggccagccagagaacaactacaagaccacaccacctgtgctggactctgatggcagcttcttcctgtacagcaagctgactgtggacaagagcagatggcagcagggcaatgtcttctcctgctctgtgatgcatgaagctctgcacaaccactacacccagaagagcctgtccctgtctccagggtga 990 DNA PAT source 1..990 mol_type other DNA organism synthetic construct gctagcaccaagggcccctctgtgttccctctggctccctcctccaagagcacctctggaggcacagctgccctgggctgcctggtgaaggactacttcccagagcctgtgactgtgtcctggaactctggagccctgacctctggagtgcacaccttcccagctgtgctgcagagctctggcctctacagcctgtcctctgtggtgactgtgccctcctcctccctgggaacccagacctacatctgcaatgtgaaccacaagccctccaacaccaaggtggacaagagagtggagcccaagagctgtgacaagacccacacctgcccaccctgcccagccccagagctgctgggaggaccctctgtgttcctctttccacccaagcccaaggacaccctgatgatctccagaaccccagaggtgacctgtgtggtggtggatgtgtcccatgaagacccagaagtgaagttcaactggtatgtggatggagtggaagtgcacaatgccaagaccaagcccagagaagagcagtacaacagcacctacagagtggtgtctgtgctgactgtgctgcaccaggactggctgaatggcaaagagtacaagtgcaaagtgtccaacaaggccctgccagctcccattgagaagaccatctccaaggccaagggccagcccagagagcctcaggtgtacaccctgccaccatccagagatgagctgaccaagaaccaggtgtccctgacctgcctggtgaaaggcttctacccctctgacattgctgtggagtgggagagcaatggccagccagagaacaactacaagaccacaccacctgtgctggactctgatggcagcttcttcctgtacagcaagctgactgtggacaagagcagatggcagcagggcaatgtcttctcctgctctgtgatgcatgaagctctgcacaaccactacacccagaagagcctgtccctgtctccagggtga 333 DNA PAT source 1..333 mol_type other DNA organism synthetic construct gacatccagctgacccagagcccctccaccctgtctgcctctgtgggagacagagtgaccatcacctgcagagcctctgagagcctggacaactatggcatcagattcctgacctggttccagcagaagccagggaaagcccccaagctgctgatgtatgctgcctccaaccagggcagtggagtgccctccagattctctggctctggctctggcacagagttcaccctgaccatctcctccctgcagccagatgactttgccacctactactgccagcagaccaaggaggtgccctggagctttggacagggcaccaaggtggaggtgaag 45 DNA PAT source 1..45 mol_type other DNA organism synthetic construct agagcctctgagagcctggacaactatggcatcagattcctgacc 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct gctgcctccaaccagggcagt 27 DNA PAT source 1..27 mol_type other DNA organism synthetic construct cagcagaccaaggaggtgccctggagc 657 DNA PAT source 1..657 mol_type other DNA organism synthetic construct gacatccagctgacccagagcccctccaccctgtctgcctctgtgggagacagagtgaccatcacctgcagagcctctgagagcctggacaactatggcatcagattcctgacctggttccagcagaagccagggaaagcccccaagctgctgatgtatgctgcctccaaccagggcagtggagtgccctccagattctctggctctggctctggcacagagttcaccctgaccatctcctccctgcagccagatgactttgccacctactactgccagcagaccaaggaggtgccctggagctttggacagggcaccaaggtggaggtgaagcgtacggtggctgctccctctgtgttcatcttcccaccctctgatgagcagctgaagtctggcacagcctctgtggtgtgcctgctgaacaacttctaccccagagaagccaaggtgcagtggaaagtggacaatgccctgcagagtgggaacagccaggagagtgtgacagagcaggacagcaaggacagcacctacagcctgtcctccaccctgaccctgtccaaagctgactatgagaagcacaaagtgtatgcctgtgaagtgacccaccagggcctgtcctctcctgtgaccaagagcttcaacagaggagagtgctga 324 DNA PAT source 1..324 mol_type other DNA organism synthetic construct cgtacggtggctgctccctctgtgttcatcttcccaccctctgatgagcagctgaagtctggcacagcctctgtggtgtgcctgctgaacaacttctaccccagagaagccaaggtgcagtggaaagtggacaatgccctgcagagtgggaacagccaggagagtgtgacagagcaggacagcaaggacagcacctacagcctgtcctccaccctgaccctgtccaaagctgactatgagaagcacaaagtgtatgcctgtgaagtgacccaccagggcctgtcctctcctgtgaccaagagcttcaacagaggagagtgctga 219 AA PAT source 1..219 mol_type protein organism synthetic construct DIQLTQSPSTLSASVGDRVTITCRASESLDNYGIRFLTWFQQKPGKAPKLLMYAASNQGSGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQTKEVPWSFGQGTKVEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVCTKSFNRGEC 108 AA PAT source 1..108 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVCTKSFNRGEC 660 DNA PAT source 1..660 mol_type other DNA organism synthetic construct gacatccagctgacccagagcccctccaccctgtctgcctctgtgggagacagagtgaccatcacctgcagagcctctgagagcctggacaactatggcatcagattcctgacctggttccagcagaagccagggaaagcccccaagctgctgatgtatgctgcctccaaccagggcagtggagtgccctccagattctctggctctggctctggcacagagttcaccctgaccatctcctccctgcagccagatgactttgccacctactactgccagcagaccaaggaggtgccctggagctttggacagggcaccaaggtggaggtgaagcgtacggtggctgctccctctgtgttcatcttcccaccctctgatgagcagctgaagtctggcacagcctctgtggtgtgcctgctgaacaacttctaccccagagaagccaaggtgcagtggaaagtggacaatgccctgcagagtgggaacagccaggagagtgtgacagagcaggacagcaaggacagcacctacagcctgtcctccaccctgaccctgtccaaagctgactatgagaagcacaaagtgtatgcctgtgaagtgacccaccagggcctgtcctctcctgtgtgcaccaagagcttcaacagaggagagtgctga 327 DNA PAT source 1..327 mol_type other DNA organism synthetic construct cgtacggtggctgctccctctgtgttcatcttcccaccctctgatgagcagctgaagtctggcacagcctctgtggtgtgcctgctgaacaacttctaccccagagaagccaaggtgcagtggaaagtggacaatgccctgcagagtgggaacagccaggagagtgtgacagagcaggacagcaaggacagcacctacagcctgtcctccaccctgaccctgtccaaagctgactatgagaagcacaaagtgtatgcctgtgaagtgacccaccagggcctgtcctctcctgtgtgcaccaagagcttcaacagaggagagtgctga