US PCT/US2022/073903 2022-07-19 8123-106718-02 US 63/223,473 2021-07-19 University of Pittsburgh - Of the Commonwealth System of Higher Education MCT11 ANTIBODIES TO TREAT T CELL FUNCTIONAL EXHAUSTION AND ENHANCE CANCER IMMUNOTHERAPY 13 452 AA PAT source 1..452 mol_type protein organism synthetic construct QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGLGVGWIRQPSGKGLEWLSHIWWNDVKRYNPALESRLTISKDTSSSQVFLKIASVDTSDTATYYCARIIRSSLITGAVDYWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPG 9 AA PAT source 1..9 mol_type protein organism synthetic construct GFSLSTSGL 5 AA PAT source 1..5 mol_type protein organism synthetic construct WWNDV 13 AA PAT source 1..13 mol_type protein organism synthetic construct IIRSSLITGAVDY 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIQMTQTTSSLSASLGDRVTISCSASQGIYNYLNWYRQKPDGTVELLIYYTSSLHSGVPSRFSGSGSGTAYSLTISNLEPEDFATYYCQQYRKLPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 11 AA PAT source 1..11 mol_type protein organism synthetic construct SASQGIYNYLN 7 AA PAT source 1..7 mol_type protein organism synthetic construct YTSSLHS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQYRKLPWT 471 AA PAT source 1..471 mol_type protein organism Homo sapiens MPAPQRKHRRGGFSHRCFPTPQTAMTPQPAGPPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSFIYIGLPRALPSCGPASPPATPPPETGELLPAPQAVLLSPGGPGSTLDTTC 1726 DNA PAT source 1..1726 mol_type other DNA organism synthetic construct catttctcgccgctcccccctcccccgggcctgggggttgtgtgtgtacataattcaatccccgtgggactggcgtctggcctcacgcgcggcttgccggattggctgtttcagctcgcccccgccctccgtacaccccgcgtcccaggtggctcaggcccctgtggtgatctctgtttaccgagagagcccgtccaagttgggctccatcgctgccctcgctccccttcggggcccccgcccgcctgggaagcagagagaaagccgggcccagcccttcctcacccttcccctccccgcaccgcccggagaggtcggacggcgatgaccccccagcccgccggacccccggatgggggctggggctgggtggtggcggccgcagccttcgcgataaacgggctgtcctacgggctgctgcgctcgctgggccttgccttccctgaccttgccgagcactttgaccgaagcgcccaggacactgcgtggatcagcgccctggccctggccgtgcagcaggcagccagccccgtgggcagcgccctgagcacgcgctggggggcccgccccgtggtgatggttgggggcgtcctcgcctcgctgggcttcgtcttctcggctttcgccagcgatctgctgcatctctacctcggcctgggcctcctcgctggctttggttgggccctggtgttcgcccccgccctaggcaccctctcgcgttacttctcccgccgtcgagtcttggcggtggggctggcgctcaccggcaacggggcctcctcgctgctcctggcgcccgccttgcagcttcttctcgatactttcggctggcggggcgctctgctcctcctcggcgcgatcaccctccacctcaccccctgtggcgccctgctgctacccctggtccttcctggagaccccccagccccaccgcgtagtcccctagctgccctcggcctgagtctgttcacacgccgggccttctcaatctttgctctaggcacagccctggttgggggcgggtacttcgttccttacgtgcacttggctccccacgctttagaccggggcctggggggatacggagcagcgctggtggtggccgtggctgcgatgggggatgcgggcgcccggctggtctgcgggtggctggcagaccaaggctgggtgcccctcccgcggctgctggccgtattcggggctctgactgggctggggctgtgggtggtggggctggtgcccgtggtgggcggcgaagagagctgggggggtcccctgctggccgcggctgtggcctatgggctgagcgcggggagttacgccccgctggttttcggtgtactccccgggctggtgggcgtcggaggtgtggtgcaggccacagggctggtgatgatgctgatgagcctcggggggctcctgggccctcccctgtcaggcttcctaagggatgagacaggagacttcaccgcctctttcctcctgtctggttctttgatcctctccggcagcttcatctacatagggttgcccagggcgctgccctcctgtggtccagcctcccctccagccacgcctcccccagagacgggggagctgcttcccgctccccaggcagtcttgctgtccccaggaggccctggctccactctggacaccacttgttgattattttcttgtttgagcccctcccccaataaagaatttttatcgggttttcctgaaa 47 AA PAT source 1..47 mol_type protein organism synthetic construct VHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPLP 447 AA PAT source 1..447 mol_type protein organism Mus musculus MTPKPAGPPDGGWGWVVAAAAFAVNGLSYGLLRSLGLALPDLAEHFERSAQDTAWVSALALAVQQAASPVGSALSTRWGARPVVMVGGVLTSLGLVFSAFARSLLHLYLGLGLLAGSGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQFLLDTFGWRGALLLLGAVTLHLTPCGALLRPLALSGDPLAPPRTPLAALGLGLFKRRAFSVFALGTALIGGGYFVPYVHLGPHALDQGMGGYGAALVVAVAAVGDACARLASGWLADQGWVPLPRLLVVFGSLTGLGVLAMGLVPTVGTEEGWGAPLLAAAGAYGLSAGSYAPLVFGVLPGLVGIGGVVQATGLVMMLMSLGGLLGPPLSGFLRDKTGDFSASFLVCSSFILSGSFIYMGLPRALPSCRPASPPATPPPERGELLPVPQVSLLSAGGTGSIRDTTC 1773 DNA PAT source 1..1773 mol_type other DNA organism synthetic construct gaggcggggcgcggccaccaggtacgctcactcctcgcggttccccaaccagggctggggctcgtgtgtggataattcaatcctcgtgggactcggcgtcaggccttagccaggcctgggtggattggctgtctctctttcccccgccctcggtattcacccccacccccaccccgtgtcccaggtggcttgggcccctgtggtgatctctgtttactggagagagcggtccaagttgggctccatctctgtgctggctagctgctccgcagaaccctttctgcggaaagcgcggagaaaatccggccgaacccaccttcgccctttccctacccccaacgccgggagaggtcggcagacggcgatgacccccaagccggccggacccccggacgggggctggggctgggtggtggcggccgcagcattcgccgtgaacgggctctcctacgggctcttacgctccctgggccttgccctccccgacctcgcggagcactttgaacgaagcgcccaggacactgcgtgggtcagcgccctggccttggccgtgcagcaggcagccagcccagtgggcagcgccctgagcactcgctggggggcacgccccgtggtgatggttgggggagtcctaacctcgcttggcttggtcttctcggctttcgcccgaagcctcctgcacctctacctcggcctgggcctcctcgctggctctggctgggccctggtgtttgccccagccctgggtaccctctctcggtacttctcccgccgtcgggtcttggcggtagggttggcgctcaccggtaatggggcatcctcgctgctcctggcacctgccttgcagttcctccttgatactttcggctggcggggtgccttgctcctccttggcgctgtcacccttcacctcacaccctgtggcgccttgctaagacctttagctctctctggtgacccgctggccccacctcgcacccccctagctgcccttggcctaggtctgttcaagcgccgggccttttcagtctttgctttgggcaccgccttgatcgggggcggatacttcgtcccctacgttcatttgggtccgcatgctttagatcaaggcatgggtggttatggggcagcgttagtggtggctgtcgctgcagtgggagatgcctgtgcccgattggccagcggatggctggcagaccagggctgggtgccccttccgaggcttctggtggtgtttgggtctctgactgggttaggggtactagcaatgggactagtgcccactgtggggacagaggagggttggggggctcctctgctggccgctgctggggcctatgggctgagcgctgggagttatgccccactggttttcggtgtgctcccggggctggtgggcattggaggtgtggtgcaggccacagggctggtgatgatgctgatgagcctcgggggactcctgggccctcctctgtcaggcttcctaagggataagacaggagacttcagtgcctctttcctggtgtgcagctctttcatcctctctggcagtttcatctacatggggctgcccagagccctcccctcctgccgtccagcctcacctccagcaacccctccaccagagagaggggagctgctcccagttccacaagtctccctgctttccgcagggggtactggctccatccgggataccacttgttgatcattttcttggttgacctccttccctaataaagaatttttatcttacaaaaaaaaaaaaaaaaa