US PCT/US2023/065552 2023-04-07 TSVT-005PC US 63/329,003 2022-04-08 2SEVENTY BIO, INC. MULTIPARTITE RECEPTOR AND SIGNALING COMPLEXES 198 93 AA PAT REGION 1..93 note Synthetic: FRB* source 1..93 mol_type protein organism synthetic construct ILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISK 93 AA PAT REGION 1..93 note Synthetic: FRB source 1..93 mol_type protein organism synthetic construct ILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISK 107 AA PAT REGION 1..107 note Synthetic: FKBP12 source 1..107 mol_type protein organism synthetic construct GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE 107 AA PAT REGION 1..107 note Synthetic: FKBP12 F36V source 1..107 mol_type protein organism synthetic construct GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE 107 AA PAT REGION 1..107 note Synthetic: CH3-Ab (S354C T366W) source 1..107 mol_type protein organism synthetic construct GQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note Synthetic: CH3-IA (Y349C T366S L368A Y407V) source 1..107 mol_type protein organism synthetic construct GQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note Synthetic: CH3-DE (L351D L368E) source 1..107 mol_type protein organism synthetic construct GQPREPQVYTDPPSRDELTKNQVSLTCEVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note Synthetic: CH3-KK (L351K T366K) source 1..107 mol_type protein organism synthetic construct GQPREPQVYTKPPSRDELTKNQVSLKCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 106 AA PAT REGION 1..106 note Synthetic: CH3-GA (SEED 1) source 1..106 mol_type protein organism synthetic construct GQPREPQVYTLPPPSEELALNELVTLTCLVKGFYPSDIAVEWLQGSQELPREKYLTWAPVLDSDGSFFLYSILRVAAEDWKKGDTFSCSVMHEALHNHYTQKSLDR 106 AA PAT REGION 1..106 note Synthetic: CH3-AG (SEED 2) source 1..106 mol_type protein organism synthetic construct GQPFRPEVHLLPPSREEMTKNQWSLTCLARGFYPKDIAVEWESNGQPENNYKTTPSRQEPSQGTTTFAVTSKLTVDKSRWQQGNWFSCSVMHEALHNHYTQKTISL 5 AA PAT REGION 1..5 note Synthetic: 1xG4S linker source 1..5 mol_type protein organism synthetic construct GGGGS 10 AA PAT REGION 1..10 note Synthetic: 2xG4S linker source 1..10 mol_type protein organism synthetic construct GGGGSGGGGS 15 AA PAT REGION 1..15 note Synthetic: 3xG4S linker source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 20 AA PAT REGION 1..20 note Synthetic: 4xG4S linker source 1..20 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGS 25 AA PAT REGION 1..25 note Synthetic: 5xG4S linker source 1..25 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGSGGGGS 5 AA PAT REGION 1..5 note Synthetic: Linker source 1..5 mol_type protein organism synthetic construct DGGGS 5 AA PAT REGION 1..5 note Synthetic: Linker source 1..5 mol_type protein organism synthetic construct TGEKP 4 AA PAT REGION 1..4 note Synthetic: Linker source 1..4 mol_type protein organism synthetic construct GGRR 14 AA PAT REGION 1..14 note Synthetic: Linker source 1..14 mol_type protein organism synthetic construct EGKSSGSGSESKVD 18 AA PAT REGION 1..18 note Synthetic: Linker source 1..18 mol_type protein organism synthetic construct KESGSVSSEQLAQFRSLD 8 AA PAT REGION 1..8 note Synthetic: Linker source 1..8 mol_type protein organism synthetic construct GGRRGGGS 9 AA PAT REGION 1..9 note Synthetic: Linker source 1..9 mol_type protein organism synthetic construct LRQRDGERP 12 AA PAT REGION 1..12 note Synthetic: Linker source 1..12 mol_type protein organism synthetic construct LRQKDGGGSERP 16 AA PAT REGION 1..16 note Synthetic: Linker source 1..16 mol_type protein organism synthetic construct LRQKDGGGSGGGSERP 18 AA PAT REGION 1..18 note Synthetic: Linker source 1..18 mol_type protein organism synthetic construct GSTSGSGKPGSGEGSTKG 18 AA PAT REGION 1..18 note Synthetic: linker source 1..18 mol_type protein organism synthetic construct GSTSGSGKSSEGSGSTKG 14 AA PAT REGION 1..14 note Synthetic: linker source 1..14 mol_type protein organism synthetic construct GSTSGSGKSSEGKG 15 AA PAT REGION 1..15 note Synthetic: linker source 1..15 mol_type protein organism synthetic construct GSTSGSGKPGSGEGS 4 AA PAT REGION 1..4 note Synthetic: linker source 1..4 mol_type protein organism synthetic construct GGGS 4 AA PAT REGION 1..4 note Synthetic: yuTCR linker (uLNK) source 1..4 mol_type protein organism synthetic construct LEKT 9 AA PAT REGION 1..9 note Synthetic: uLNK + G4S linker source 1..9 mol_type protein organism synthetic construct LEKTGGGGS 185 AA PAT REGION 1..185 note Synthetic: CD3e source 1..185 mol_type protein organism synthetic construct DGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI 160 AA PAT REGION 1..160 note Synthetic: CD3y source 1..160 mol_type protein organism synthetic construct QSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN 170 AA PAT REGION 1..170 note Synthetic: CD3d source 1..170 mol_type protein organism synthetic construct EHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK 66 AA PAT REGION 1..66 note Synthetic: FceR1y - v1 source 1..66 mol_type protein organism synthetic construct GEPLCYILDAILFLYGIVLTLLYCRLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ 68 AA PAT REGION 1..68 note Synthetic: FceR1y - v2 source 1..68 mol_type protein organism synthetic construct LGEPQLCYILDAILFLYGIVLTLLYCRLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ 194 AA PAT REGION 1..194 note Synthetic: Iga/CD79a (BCR) source 1..194 mol_type protein organism synthetic construct LWMHKVPASLMVSLGEDAHFQCPHNSSNNANVTWWRVLHGNYTWPPEFLGPGEDPNGTLIIQNVNKSHGGIYVCRVQEGNESYQQSCGTYLRVRQPPPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKLGLDAGDEYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLNIGDVQLEKP 79 AA PAT REGION 1..79 note Synthetic: Igb/CD79b (BCR) source 1..79 mol_type protein organism synthetic construct MARLALSPVPSHWMVALLLLLSGTEPTTRPVGFALISSCLGPAALPPACSTLLLCLSLFTACLPLMALGPGSVGVSCTW 75 AA PAT REGION 1..75 note Synthetic: DAP10 source 1..75 mol_type protein organism synthetic construct QTTPGERSSLPAFYPGTSGSCSGCGSLSLPLLAGLVAADAVASLLIVGAVFLCARPRRSPAQEDGKVYINMPGRG 92 AA PAT REGION 1..92 note Synthetic: DAP12 source 1..92 mol_type protein organism synthetic construct LRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK 15 AA PAT REGION 1..15 note Synthetic: Minimal CD4 hinge source 1..15 mol_type protein organism synthetic construct SNIKVLPTWSTPVQP 17 AA PAT REGION 1..17 note Synthetic: Minimal CD28 hinge source 1..17 mol_type protein organism synthetic construct KGKHLCPSPLFPGPSKP 12 AA PAT REGION 1..12 note Synthetic: IgG4 hinge source 1..12 mol_type protein organism synthetic construct ESKYGPPCPSCP 45 AA PAT REGION 1..45 note Synthetic: CD8 hinge source 1..45 mol_type protein organism synthetic construct TTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACD 22 AA PAT REGION 1..22 note Synthetic: CD4 transmembrane source 1..22 mol_type protein organism synthetic construct MALIVLGGVAGLLLFIGLGIFF 27 AA PAT REGION 1..27 note Synthetic: CD28 transmembrane source 1..27 mol_type protein organism synthetic construct FWVLVVVGGVLACYSLLVTVAFIIFWV 27 AA PAT REGION 1..27 note Synthetic: CD8 transmembrane source 1..27 mol_type protein organism synthetic construct AGTGSDIYIWAPLAGTCGVLLLSLVIT 4 AA PAT REGION 1..4 note Synthetic: Truncated intracellular CD4 v1 source 1..4 mol_type protein organism synthetic construct CVRC 10 AA PAT REGION 1..10 note Synthetic: Truncated intracellular CD4 v2 source 1..10 mol_type protein organism synthetic construct CVRCRHRRRQ 246 AA PAT REGION 1..246 note Synthetic: anti-BCMA_scFv_1 source 1..246 mol_type protein organism synthetic construct DIVLTQSPPSLAMSLGKRATISCRASESVTILGSHLIHWYQQKPGQPPTLLIQLASNVQTGVPARFSGSGSRTDFTLTIDPVEEDDVAVYYCLQSRTIPRTFGGGTKLEIKGSTSGSGKPGSGEGSTKGQIQLVQSGPELKKPGETVKISCKASGYTFTDYSINWVKRAPGKGLKWMGWINTETREPAYAYDFRGRFAFSLETSASTAYLQINNLKYEDTATYFCALDYSYAMDYWGQGTSVTVSS 246 AA PAT REGION 1..246 note Synthetic: anti-BCMA_scFv_2 source 1..246 mol_type protein organism synthetic construct DIVLTQSPASLAVSLGERATINCRASESVSVIGAHLIHWYQQKPGQPPKLLIYLASNLETGVPARFSGSGSGTDFTLTISSLQAEDAAIYYCLQSRIFPRTFGQGTKLEIKGSTSGSGKPGSGEGSTKGQVQLVQSGSELKKPGASVKVSCKASGYTFTDYSINWVRQAPGQGLEWMGWINTETREPAYAYDFRGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARDYSYAMDYWGQGTLVTVSS 247 AA PAT REGION 1..247 note Synthetic: anti-BCMA_scFv_3 source 1..247 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRITITCRASQDIRNYLGWYQQKPGKAPKVLIFAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQDYIYPWTFAQGTKVEIKGGGGSGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGRNKNYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAREGEATYYDILTGPFDYWGQGTLVTVSS 242 AA PAT REGION 1..242 note Synthetic: anti-CD19_scFv source 1..242 mol_type protein organism synthetic construct DIQMTQTTSSLSASLGDRVTISCRASQDISKYLNWYQQKPDGTVKLLIYHTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPYTFGGGTKLEITGGGGSGGGGSGGGGSEVKLQESGPGLVAPSQSLSVTCTVSGVSLPDYGVSWIRQPPRKGLEWLGVIWGSETTYYNSALKSRLTIIKDNSKSQVFLKMNSLQTDDTAIYYCAKHYYYGGSYAMDYWGQGTSVTVSS 243 AA PAT REGION 1..243 note Synthetic: anti-CD20_scFv_1 source 1..243 mol_type protein organism synthetic construct EVQLQQSGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGQGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSADYYCARSNYYGSSYWFFDVWGAGTTVTVSSGGGGSGGGGSGGGGSDIVLTQSPAILSASPGEKVTMTCRASSSVNYMDWYQKKPGSSPKPWIYATSNLASGVPARFSGSGSGTSYSLTISRVEAEDAATYYCQQWSFNPPTFGGGTKLEIK 243 AA PAT REGION 1..243 note Synthetic: anti-CD20_scFv_2 source 1..243 mol_type protein organism synthetic construct QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAGGGGSGGGGSGGGGSQIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKR 249 AA PAT REGION 1..249 note Synthetic: anti-CD20_scFv_3 source 1..249 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSSGGGGSGGGGSGGGGSDIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIKRTV 236 AA PAT REGION 1..236 note Synthetic: anti-CD22_scFv source 1..236 mol_type protein organism synthetic construct QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCAREVTGDLEDAFDIWGQGTMVTVSSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQTIWSYLNWYQQRPGKAPNLLIYAASSLQSGVPSRFSGRGSGTDFTLTISSLQAEDFATYYCQQSYSIPQTFGQGTKLEIK 245 AA PAT REGION 1..245 note Synthetic: anti-CD33_scFv source 1..245 mol_type protein organism synthetic construct EIVLTQSPGSLAVSPGERVTMSCKSSQSVFFSSSQKNYLAWYQQIPGQSPRLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQPEDLAIYYCHQYLSSRTFGQGTKLEIKGGGGSGGGGSGGGGSQVQLQQPGAEVVKPGASVKMSCKASGYTFTSYYIHWIKQTPGQGLEWVGVIYPGNDDISYNQKFQGKATLTADKSSTTAYMQLSSLTSEDSAVYYCAREVRLRYFDVWGQGTTVTVSS 248 AA PAT REGION 1..248 note Synthetic: anti-CD79A_scFv source 1..248 mol_type protein organism synthetic construct DVLMTQIPLSLPVSLGDQASISCRSSQSIVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPFTFGSGTKLEIKRGGGGSGGGGSGGGGSQVQLQQSGPELVKPGASVKISCKASGYTFSTSWMNWVKQRPGQGLEWIGRIYPGDGDTNYNGKFKGKATLTADKSSNTAYMQLSSLTSVDSAVYFCERFYYGNTFAMDYWGQGTSVTVSS 238 AA PAT REGION 1..238 note Synthetic: anti-CD79B_scFv_1 source 1..238 mol_type protein organism synthetic construct QIQLVQSGPELKKPGETVKISCKASGYTFTDYSMHWVKQAPGEGLKWMGWINTETGEPTYADDFKGRFAFSLETSASTAYLQINNLKNEDTATYFCYYGSYWGQGTLVTVSAGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDGYMDWYQQKPGQPPKLLIFAASNLKSGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQTNEYPWTFGGGTKLEIK 244 AA PAT REGION 1..244 note Synthetic: Anti-CD79B_scFv_2 source 1..244 mol_type protein organism synthetic construct DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIKRGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSS 242 AA PAT REGION 1..242 note Synthetic: anti-B7H3_scFv source 1..242 mol_type protein organism synthetic construct DIVMTQSHKFMSTSIGARVSITCKASQDVRTAVAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYGTPPWTFGGGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLKLSCEASRFTFSSYAMSWVRQTPEKRLEWVAAISGGGRYTYYPDSMKGRFTISRDNAKNFLYLQMSSLRSEDTAMYYCARHYDGYLDYWGQGTTLTVSSTR 250 AA PAT REGION 1..250 note Synthetic: anti-Muc16_scFv source 1..250 mol_type protein organism synthetic construct VKLQESGGGFVKPGGSLKVSCAASGFTFSSYAMSWVRLSPEMRLEWVATISSAGGYIFYSDSVQGRFTISRDNAKNTLHLQMGSLRSGDTAMYYCARQGFGNYGDYYAMDYWGQGTTVTVSSGGGGSGGGGSGGGGSDIELTQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNQLAWYQQKPGQSPELLIYWASTRQSGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCQQSYNLLTFGPGTKLEVKR 243 AA PAT REGION 1..243 note Synthetic: anti-HER2_scFv source 1..243 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGSTSGSGKPGSGEGSGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDVWGQGTLVTVSS 241 AA PAT REGION 1..241 note Synthetic: anti-EGFR_scFv source 1..241 mol_type protein organism synthetic construct DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKGGGGSGGGGSGGGGSQVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSS 236 AA PAT REGION 1..236 note Synthetic: anti-FN-EDB_scFv source 1..236 mol_type protein organism synthetic construct EVQLLESGGGLVQPGGSLRLSCAASGFTFSSFSMSWVRQAPGKGLEWVSSISGSSGTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKPFPYFDYWGQGTLVTVSSGDGSSGGSGGASEIVLTQSPGTLSLSPGERATLSCRASQSVSSSFLAWYQQKPGQAPRLLIYYASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQTGRIPPTFGQGTKVEIK 246 AA PAT REGION 1..246 note Synthetic: anti-CLDN18.2_scFv source 1..246 mol_type protein organism synthetic construct QIQLVQSGPELKKPGETVKISCKASGYTFTNYGMNWVKQAPGKGLKWMGWINTNTGEPTYAEEFKGRFAFSLETSASTAYLQINNLKNEDTATYFCARLGFGNAMDYWGQGTSVTVSSGGGGSGGGGSGGGGSDIVMTQSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCQNDYSYPLTFGAGTKLELK 241 AA PAT REGION 1..241 note Synthetic: anti-DLL3_scFv source 1..241 mol_type protein organism synthetic construct QVQLQESGPGLVKPSETLSLTCTVSGDSISSYYWTWIRQPPGKGLEWIGYIYYSGTTNYNPSLKSRVTISVDTSKSQFSLKLSSVTAADTAVYYCASIAVRGFFFDYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASTRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGTSPLTFGGGTKVEIK 249 AA PAT REGION 1..249 note Synthetic: anti-FLT3_scFv_1 source 1..249 mol_type protein organism synthetic construct QVTLKESGPVLVKPTETLTLTCTVSGFSLINARMGVSWIRQPPGKALEWLAHIFSNAEKSYRTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARIPGYGGNGDYHYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASLGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYASSTLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNNFPWTFGQGTKVEIK 243 AA PAT REGION 1..243 note Synthetic: anti-FLT3_scFv_2 source 1..243 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCANLAPWAAYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPLSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQALQTPHTFGQGTKLEIK 239 AA PAT REGION 1..239 note Synthetic: anti-ROR1 scFv source 1..239 mol_type protein organism synthetic construct DIQMTQSPSFLSASVGDRVTINCKASQNIDRYLNWYQQKLGEAPKRLLYNTNKLQTGIPSRFSGSGSATDFTLTISSLQPEDFATYFCLQYNSLPLTFGSGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVQPGRSLKLSCAASGFIFSEHNMAWVRQAPKKGLEWVATISDDGRNTYYRDSMRGRFTISRENARSTLYLQLDSLRSEDTATYYCASHRYNLFDSWGQGVMVTVSS 116 AA PAT REGION 1..116 note Synthetic: anti-CD33_VHH_1 source 1..116 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKP 120 AA PAT REGION 1..120 note Synthetic: anti-CD33_VHH_2 source 1..120 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASGRTFSGYIMGWFRQAPGKERELVARISGNNLSTEYAESVKGRFTISRDNAKNTLYLQMSSLRAEDTAVYYCAAEYDYSSGDFVYWGQGTLVTVKP 120 AA PAT REGION 1..120 note Synthetic: anti-CD33_VHH_3 source 1..120 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASGSTLNIDHIGWYRQAPGKERELVGVISSGAGPNYAESVKGRFTISRDNAKNTVYLQMSSLRAEDTAVYYCNAWIDYGSGLPQNYWGQGTLVTVKP 120 AA PAT REGION 1..120 note Synthetic: anti-CLL1_VHH_1 source 1..120 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKP 116 AA PAT REGION 1..116 note Synthetic: anti-CLL1_VHH_2 source 1..116 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASGLLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTVYLQMSSLRAEDTAVYYCHTDEWGREYWGQGTLVTVKP 125 AA PAT REGION 1..125 note Synthetic: anti-CD123_VHH_1 source 1..125 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCTASGRAINMYAMGWFRQAPGKEREFVAAINWNGAYTQYAESVKGRFTISRDNAKNTLYLQMSSLRAEDTAVYYCSADADYNTYVSPNKRVSYWGQGTLVTVKP 126 AA PAT REGION 1..126 note Synthetic: anti-CD123_VHH_2 source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGRAINAYNMGWFRQAPGKGREFVSAINWNAARTYYAESVKGRFTISRDNAKNTLYLQMSSLRAEDTAVYYCAASGRWSAAVPSGEDQYNFWGQGTLVTVKP 121 AA PAT REGION 1..121 note Synthetic: anti-CD20_VHH source 1..121 mol_type protein organism synthetic construct QVQLQESGGGLVQAGGSLRLSCAASGRTFSNYNMGWFRQAPGKEREFVAAIDWSGGSPYYAASVRGRFTISRDNAENTVYLQMNSLKPEDTAVYYCAAPLSYGSTWLADYWGQGTQVTVSS 124 AA PAT REGION 1..124 note Synthetic: anti-EGFR_VHH source 1..124 mol_type protein organism synthetic construct QVKLEESGGGSVQTGGSLRLTCAASGRTSRSYGMGWFRQAPGKEREFVSGISWRGDSTGYADSVKGRFTISRDNAKNTVDLQMNSLKPEDTAIYYCAAAAGSAWYGTLYEYDYWGQGTQVTVSS 119 AA PAT REGION 1..119 note Synthetic: anti-BCMA_VHH_1 source 1..119 mol_type protein organism synthetic construct QVKLEESGGGLVQAGRSLRLSCAASEHTFSSHVMGWFRQAPGKERESVAVIGWRDISTSYADSVKGRFTISRDNAKKTLYLQMNSLKPEDTAVYYCAARRIDAADFDSWGQGTQVTVSS 118 AA PAT REGION 1..118 note Synthetic: anti-BCMA_VHH_2 source 1..118 mol_type protein organism synthetic construct EVQLVESGGGLVQAGGSLRLSCAASGRTFTMGWFRQAPGKEREFVAAISLSPTLAYYAESVKGRFTISRDNAKNTVVLQMNSLKPEDTALYYCAADRKSVMSIRPDYWGQGTQVTVSS 117 AA PAT REGION 1..117 note Synthetic: anti-CD19_VHH source 1..117 mol_type protein organism synthetic construct QVKLEESGGELVQPGGPLRLSCAASGNIFSINRMGWYRQAPGKQRAFVASITVRGITNYADSVKGRFTISVDKSKNTIYLQMNALKPEDTAVYYCNAVSSNRDPDYWGQGTQVTVSS 114 AA PAT REGION 1..114 note Synthetic: PD1 ectodomain source 1..114 mol_type protein organism synthetic construct NPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDSRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTE 114 AA PAT REGION 1..114 note Synthetic: PD1 high affinity ectodomain source 1..114 mol_type protein organism synthetic construct NPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDSRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKVQIKESLRAELRVTE 135 AA PAT REGION 1..135 note Synthetic: Human A Proliferation-Inducing Ligand (APRIL) source 1..135 mol_type protein organism synthetic construct SVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL 435 AA PAT REGION 1..435 note Synthetic: Trimerized human APRIL source 1..435 mol_type protein organism synthetic construct SVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKLGGGGSGGGGSGGGGSSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKLGGGGSGGGGSGGGGSSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL 134 AA PAT REGION 1..134 note Synthetic: NKG2D membrane protein source 1..134 mol_type protein organism synthetic construct FNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV 9 AA PAT REGION 1..9 note Synthetic: anti-CD33_VHH_1 CDR1 source 1..9 mol_type protein organism synthetic construct RSSGIDVMG 9 AA PAT REGION 1..9 note Synthetic: anti-CD33_VHH_1 CDR2 source 1..9 mol_type protein organism synthetic construct EISGVGDTN 9 AA PAT REGION 1..9 note Synthetic: anti-CD33_VHH_1 CDR3 source 1..9 mol_type protein organism synthetic construct HSFLDLVGA 10 AA PAT REGION 1..10 note Synthetic: anti-CLL1_VHH_1 CDR1 source 1..10 mol_type protein organism synthetic construct GFLFSIYDMN 10 AA PAT REGION 1..10 note Synthetic: anti-CLL1_VHH_1 CDR2 source 1..10 mol_type protein organism synthetic construct GITNNGYSTA 11 AA PAT REGION 1..11 note Synthetic: anti-CLL1_VHH_1 CDR3 source 1..11 mol_type protein organism synthetic construct DLTKAYDVEYA 19 AA PAT REGION 1..19 note Synthetic: IgK signal sequence source 1..19 mol_type protein organism synthetic construct ETPAQLLFLLLLWLPDTTG 20 AA PAT REGION 1..20 note Synthetic: CD8 signal sequence source 1..20 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARP 22 AA PAT REGION 1..22 note Synthetic: PD1 signal sequence source 1..22 mol_type protein organism synthetic construct QIPQAPWPVVWAVLQLGWRPGW 42 AA PAT REGION 1..42 note Synthetic: 41BB intracellular signaling domain source 1..42 mol_type protein organism synthetic construct KRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL 41 AA PAT REGION 1..41 note Synthetic: CD28 intracellular signaling domain source 1..41 mol_type protein organism synthetic construct RSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS 40 AA PAT REGION 1..40 note Synthetic: CD4 coreceptor domain source 1..40 mol_type protein organism synthetic construct CVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI 32 AA PAT REGION 1..32 note Synthetic: CD8 coreceptor domain source 1..32 mol_type protein organism synthetic construct LYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV 235 AA PAT REGION 1..235 note Synthetic: LAT domain source 1..235 mol_type protein organism synthetic construct HCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN 195 AA PAT REGION 1..195 note Synthetic: IL7 receptor alpha signaling domain source 1..195 mol_type protein organism synthetic construct KKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ 72 AA PAT REGION 1..72 note Synthetic: IL2 receptor beta signaling domain, truncated source 1..72 mol_type protein organism synthetic construct NCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLL 286 AA PAT REGION 1..286 note Synthetic: IL2 receptor beta signaling domain source 1..286 mol_type protein organism synthetic construct NCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV 86 AA PAT REGION 1..86 note Synthetic: Common gamma chain signaling domain source 1..86 mol_type protein organism synthetic construct ERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET 291 AA PAT REGION 1..291 note Synthetic: FRB.3xG4S.CD3e source 1..291 mol_type protein organism synthetic construct WHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI 266 AA PAT REGION 1..266 note Synthetic: FRB.3xG4S.CD3g source 1..266 mol_type protein organism synthetic construct WHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN 295 AA PAT REGION 1..295 note Synthetic: FKBP12.G4S.CD3e source 1..295 mol_type protein organism synthetic construct QVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI 281 AA PAT REGION 1..281 note Synthetic: FRB.G4S.CD3e source 1..281 mol_type protein organism synthetic construct WHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI 291 AA PAT REGION 1..291 note Synthetic: FRBstar.3xG4S.CD3e source 1..291 mol_type protein organism synthetic construct WHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI 307 AA PAT REGION 1..307 note Synthetic: IACH3.3xG4S.CD3e source 1..307 mol_type protein organism synthetic construct GQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI 306 AA PAT REGION 1..306 note Synthetic: CH3AG.3xG4S.CD3e source 1..306 mol_type protein organism synthetic construct GQPFRPEVHLLPPSREEMTKNQWSLTCLARGFYPKDIAVEWESNGQPENNYKTTPSRQEPSQGTTTFAVTSKLTVDKSRWQQGNWFSCSVMHEALHNHYTQKTISLGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI 307 AA PAT REGION 1..307 note Synthetic: CH3DE.3xG4S.CD3e source 1..307 mol_type protein organism synthetic construct GQPREPQVYTDPPSRDELTKNQVSLTCEVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI 167 AA PAT REGION 1..167 note Synthetic: FRBstar.2xG4S.FCER1G source 1..167 mol_type protein organism synthetic construct WHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGEPLCYILDAILFLYGIVLTLLYCRLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ 282 AA PAT REGION 1..282 note Synthetic: antiCD33.G4S.FKBP.minCD28hinge.CD28tm.CD4ic source 1..282 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVCVRCRHRRRQ 275 AA PAT REGION 1..275 note Synthetic: antiCD33.G4S.FKBP.minCD4hinge.CD4tm.CD4ic source 1..275 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 263 AA PAT REGION 1..263 note Synthetic: antiCD33.G4S.FKBP.GGR.CD4tm.CD4ic source 1..263 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEGGRMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 264 AA PAT REGION 1..264 note Synthetic: FRB.2xG4S.antiCD33.minCD4hinge.CD4tm.CD4ic source 1..264 mol_type protein organism synthetic construct WHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 280 AA PAT REGION 1..280 note Synthetic: FKBP.2xG4S.antiCD33.minCD4hinge.CD4tm.CD4ic source 1..280 mol_type protein organism synthetic construct GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEGGGGSGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 279 AA PAT REGION 1..279 note Synthetic: antiCLL1.G4S.FKBP.minCD4hinge.CD4tm.CD4ic source 1..279 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 400 AA PAT REGION 1..400 note Synthetic: antiCLL1.G4S.antiCD33.G4S.FKBP.minCD4hinge.CD4tm.CD4ic source 1..400 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 268 AA PAT REGION 1..268 note Synthetic: FRB.2xG4S.antiCLL1.minCD4hinge.CD4tm.CD4ic source 1..268 mol_type protein organism synthetic construct WHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSEVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 390 AA PAT REGION 1..390 note Synthetic: antiCLL1.G4S.FRB.2xG4S.antiCD33.minCD4hinge.CD4tm.CD4ic source 1..390 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPGGGGSLWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 310 AA PAT REGION 1..310 note Synthetic: antiCD33.G4S.FKBP.minCD4hinge.CD4tm.CD28 source 1..310 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS 311 AA PAT REGION 1..311 note Synthetic: antiCD33.G4S.FKBP.minCD4hinge.CD4tm.41BB source 1..311 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL 275 AA PAT REGION 1..275 note Synthetic: antiCD33.G4S.AbCH3.minCD4hinge.CD4tm.CD4ic source 1..275 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 274 AA PAT REGION 1..274 note Synthetic: antiCD33.G4S.CH3GA.minCD4hinge.CD4tm.CD4ic source 1..274 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGQPREPQVYTLPPPSEELALNELVTLTCLVKGFYPSDIAVEWLQGSQELPREKYLTWAPVLDSDGSFFLYSILRVAAEDWKKGDTFSCSVMHEALHNHYTQKSLDRSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 275 AA PAT REGION 1..275 note Synthetic: antiCD33.G4S.CH3KK.minCD4hinge.CD4tm.CD4ic source 1..275 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGQPREPQVYTKPPSRDELTKNQVSLKCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 305 AA PAT REGION 1..305 note Synthetic: antiCD33.G4S.FKBP.minCD4hinge.CD4tm.CD4ic-full source 1..305 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI 297 AA PAT REGION 1..297 note Synthetic: antiCD33.G4S.FKBP.minCD4hinge.CD4tm.CD8ic-full source 1..297 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFLYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV 401 AA PAT REGION 1..401 note Synthetic: CD19scFv.G4S.FKBP.minCD4hinge.CD4tm.CD4ic source 1..401 mol_type protein organism synthetic construct DIQMTQTTSSLSASLGDRVTISCRASQDISKYLNWYQQKPDGTVKLLIYHTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPYTFGGGTKLEITGGGGSGGGGSGGGGSEVKLQESGPGLVAPSQSLSVTCTVSGVSLPDYGVSWIRQPPRKGLEWLGVIWGSETTYYNSALKSRLTIIKDNSKSQVFLKMNSLQTDDTAIYYCAKHYYYGGSYAMDYWGQGTSVTVSSGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 306 AA PAT REGION 1..306 note Synthetic: PD1(A132V)ex.G4S.FKBP.minCD4hinge.CD4tm.CD4ic source 1..306 mol_type protein organism synthetic construct FLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKVQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 306 AA PAT REGION 1..306 note Synthetic: PD1ex.G4S.FKBP.minCD4hinge.CD4tm.CD4ic source 1..306 mol_type protein organism synthetic construct FLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 359 AA PAT REGION 1..359 note Synthetic: antiCD33.G4S.FKBP.CD4htm.trIL2Rb source 1..359 mol_type protein organism synthetic construct EVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFNCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLPLNTDAYLSLQELQGQDPTHLV 398 AA PAT REGION 1..398 note Synthetic: antiROR1.G4S.FKBP.minCD4hinge.CD4tm.CD4ic source 1..398 mol_type protein organism synthetic construct DIQMTQSPSFLSASVGDRVTINCKASQNIDRYLNWYQQKLGEAPKRLLYNTNKLQTGIPSRFSGSGSATDFTLTISSLQPEDFATYFCLQYNSLPLTFGSGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVQPGRSLKLSCAASGFIFSEHNMAWVRQAPKKGLEWVATISDDGRNTYYRDSMRGRFTISRENARSTLYLQLDSLRSEDTATYYCASHRYNLFDSWGQGVMVTVSSGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 325 AA PAT REGION 1..325 note Synthetic: FRBstar.CD4htm.IL7Ra source 1..325 mol_type protein organism synthetic construct ILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ 216 AA PAT REGION 1..216 note Synthetic: FRBstar.CD4htm.IL2Rg source 1..216 mol_type protein organism synthetic construct ILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET 641 AA PAT REGION 1..641 note Synthetic: SR020 - CD8ss.FRB.CD3e.P2A.IgKss.antiCD33.FKBP.minCD28hinge.CD28tm.CD4ic source 1..641 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVCVRCRHRRRQ 616 AA PAT REGION 1..616 note Synthetic: SR021 - CD8ss.FRB.CD3g.P2A.IgKss.antiCD33.FKBP.minCD28hinge.CD28tm.CD4ic source 1..616 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRNSGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVCVRCRHRRRQ 634 AA PAT REGION 1..634 note Synthetic: SR022 - CD8ss.FRB.CD3e.P2A.IgKss.antiCD33.FKBP.minCD4hinge.CD4tm.CD4ic source 1..634 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 609 AA PAT REGION 1..609 note Synthetic: SR023 - CD8ss.FRB.CD3g.P2A.IgKss.antiCD33.FKBP.minCD4hinge.CD4tm.CD4ic source 1..609 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRNSGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 622 AA PAT REGION 1..622 note Synthetic: SR024 - CD8ss.FRB.CD3e.P2A.IgKss.antiCD33.FKBP.CD4tm.CD4ic source 1..622 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEGGRMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 628 AA PAT REGION 1..628 note Synthetic: SR026 - CD8ss.FKBP.CD3e.P2A.IgKss.FRB.antiCD33.minCD4hinge.CD4tm.CD4ic source 1..628 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGLWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 628 AA PAT REGION 1..628 note Synthetic: SR028 - CD8ss.FRB.CD3e.P2A.IgKss.FKBP.antiCD33.minCD4hinge.CD4tm.CD4ic source 1..628 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSLWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEGGGGSGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 634 AA PAT REGION 1..634 note Synthetic: SR001 - CD8ss.FRBstar.CD3e.P2A.IgKss.antiCD33.FKBP.minCD4hinge.CD4tm.CD4ic source 1..634 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 638 AA PAT REGION 1..638 note Synthetic: SR003 - CD8ss.FRB.CD3e.P2A.IgKss.antiCLL1.FKBP.minCD4hinge.CD4tm.CD4ic source 1..638 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 759 AA PAT REGION 1..759 note Synthetic: SR004 - CD8ss.FRB.CD3e.P2A.IgKss.antiCLL1.antiCD33.FKBP.minCD4hinge.CD4tm.CD4ic source 1..759 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 632 AA PAT REGION 1..632 note Synthetic: SR005 - CD8ss.FKBP.CD3e.P2A.IgKss.FRB.antiCLL1.minCD4hinge.CD4tm.CD4ic source 1..632 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGLWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSEVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 753 AA PAT REGION 1..753 note Synthetic: SR006 - CD8ss.FKBP.CD3e.P2A.IgKss.antiCLL1.FRB. antiCD33.minCD4hinge.CD4tm.CD4ic source 1..753 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPGGGGSLWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 759 AA PAT REGION 1..759 note Synthetic: SR008 - CD8ss.FRBstar.CD3e.P2A.IgKss.antiCLL1. antiCD33.FKBP.minCD4hinge.CD4tm.CD4ic source 1..759 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 795 AA PAT REGION 1..795 note Synthetic: SR030 - CD8ss.FRBstar.CD3e.P2A.IgKss.antiCLL1. antiCD33.FKBP.minCD4hinge.CD4tm.41BB source 1..795 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPGGGGSEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL 669 AA PAT REGION 1..669 note Synthetic: SR001-28 CD8ss.FRBstar.CD3e.P2A.IgKss.antiCD33.FKBP.minCD4hinge.CD4tm.CD28 source 1..669 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS 680 AA PAT REGION 1..680 note Synthetic: SR001-41BB CD8ss.FRBstar.CD3e.P2A.IgKss.antiCD33.FKBP.minCD4hinge.CD4tm.41BB source 1..680 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL 648 AA PAT REGION 1..648 note Synthetic: SR292 - CD8ss.IACH3.CD3e.P2A.IgKss.antiCD33.AbCH3.minCD4hinge.CD4tm.41BB source 1..648 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 646 AA PAT REGION 1..646 note Synthetic: SR293 - CD8ss.CH3AG.CD3e.P2A.IgKss.antiCD33.CH3GA.minCD4hinge.CD4tm.CD4ic source 1..646 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSGQPFRPEVHLLPPSREEMTKNQWSLTCLARGFYPKDIAVEWESNGQPENNYKTTPSRQEPSQGTTTFAVTSKLTVDKSRWQQGNWFSCSVMHEALHNHYTQKTISLGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGQPREPQVYTLPPPSEELALNELVTLTCLVKGFYPSDIAVEWLQGSQELPREKYLTWAPVLDSDGSFFLYSILRVAAEDWKKGDTFSCSVMHEALHNHYTQKSLDRSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 648 AA PAT REGION 1..648 note Synthetic: SR296 - CD8ss.CH3DE.CD3e.P2A.IgKss.antiCD33.CH3KK.minCD4hinge.CD4tm.CD4ic source 1..648 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSGQPREPQVYTDPPSRDELTKNQVSLTCEVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGQPREPQVYTKPPSRDELTKNQVSLKCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 664 AA PAT REGION 1..664 note Synthetic: SR001-CD4 - CD8ss.FRB.CD3e.P2A.huIgKss.CD33.FKBP.minCD4hinge.CD4tm.CD4ic-full source 1..664 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI 656 AA PAT REGION 1..656 note Synthetic: SR001-CD8 - CD8ss.FRB.CD3e.P2A.huIgKss.antiCD33.FKBP.minCD4hinge.CD4tm.CD8ic-full source 1..656 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFLYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV 1268 AA PAT REGION 1..1268 note Synthetic: TCR-SR001 - TCR.T2A.SR001 source 1..1268 mol_type protein organism synthetic construct GFRLLCCVAFCLLGAGPVDSGVTQTPKHLITATGQRVTLRCSPRSGDLSVYWYQQSLDQGLQFLIQYYNGEERAKGNILERFSAQQFPDLHSELNLSSLELGDSALYFCASSGGDGDEQFFGPGTRLTVLEDLKNVFPPEVAVFEPSKAEIAHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGITSASYHQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRGRAKRGSGATNFSLLKQAGDVEENPGPMSLSSLLKVVTASLWLGPGIAQKITQTQPGMFVQEKEAVTLDCTYDTSDPSYGLFWYKQPSSGEMIFLIYQGSYDQQNATEGRYSLNFQKARKSANLVISASQLGDSAMYFCAMSGGYTGGFKTIFGAGTRLFVKANIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSSDVPCDVKLVEKSFETDTNLNFQNLLVIVLRILLLKVAGFNLLMTLRLWSSGSGEGRGSLLTCGDVEENPGPMALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 638 AA PAT REGION 1..638 note Synthetic: SR007 - CD8ss.FRBstar.CD3e.P2A.huIgKss.antiCLL1.FKBP.minCD4hinge.CD4tm.CD4ic source 1..638 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASGFLFSIYDMNWYRQAPGKEREWVAGITNNGYSTAYAESVKGRFTISRDNAKNTIYLQMSSLRAEDTAVYYCHADLTKAYDVEYAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 760 AA PAT REGION 1..760 note Synthetic: SR10168 - CD8ss.FRBstar-CD3e.P2A.IgKss.CD19scFv.FKBP.minCD4hinge.CD4tm.CD4ic source 1..760 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGDIQMTQTTSSLSASLGDRVTISCRASQDISKYLNWYQQKPDGTVKLLIYHTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPYTFGGGTKLEITGGGGSGGGGSGGGGSEVKLQESGPGLVAPSQSLSVTCTVSGVSLPDYGVSWIRQPPRKGLEWLGVIWGSETTYYNSALKSRLTIIKDNSKSQVFLKMNSLQTDDTAIYYCAKHYYYGGSYAMDYWGQGTSVTVSSGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 1003 AA PAT REGION 1..1003 note Synthetic: SR001+IL7a - CD8ss.FRBstar.CD3eP2A.huIgKss.FRBstar.CD4htm.IL7Ra.P2A.huIgKss.antiCD33.FKBP.minCD4hinge.CD4tm.CD4ic source 1..1003 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPMETPAQLLFLLLLWLPDTTGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQSGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 894 AA PAT REGION 1..894 note Synthetic: SR001+gC - CD8ss.FRBstar.CD3e.P2A.huIgKss.FRBstar.CD4htm.IL2Rg.P2A.huIgKss.antiCD33.FKBP.CD4htm.CD4ic source 1..894 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPMETPAQLLFLLLLWLPDTTGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPETSGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 718 AA PAT REGION 1..718 note Synthetic: SR001+IL2Rb - CD8ss.FRBstar.CD3e.P2A.huIgKss.antiCD33.FKBP.CD4htm.trIL2Rb source 1..718 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFNCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLPLNTDAYLSLQELQGQDPTHLV 978 AA PAT REGION 1..978 note Synthetic: SR001+IL2Rb+gC - CD8ss.FRBstar.CD3e.P2A.huIgKss.FRBstar.CD4htm.IL2Rg.P2A.huIgKss.antiCD33.FKBP.CD4htm.trIL2Rb source 1..978 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPMETPAQLLFLLLLWLPDTTGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKSNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPETSGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFNCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLPLNTDAYLSLQELQGQDPTHLV 668 AA PAT REGION 1..668 note Synthetic: SR300 - CD8ss.FRB.CD3e.P2A.PD1ss.PD1(A132V)ex.FKBP.minCD4hinge.CD4tm.CD4ic source 1..668 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKVQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 668 AA PAT REGION 1..668 note Synthetic: SR301 - CD8ss.FRB.CD3e.P2A.PD1ss.PD1ex.FKBP.minCD4hinge.CD4tm.CD4ic source 1..668 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 510 AA PAT REGION 1..510 note Synthetic: SR354 - CD8ss.FRBstar.FCER1G.P2A.huIgKss.antiCD33.FKBP.CD4tm.CD4ic source 1..510 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGEPLCYILDAILFLYGIVLTLLYCRLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQSGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGEVQLVESGGGEVQPGGSLRLSCAASRSSGIDVMGWYRQAPGKERELVAEISGVGDTNYAASLADRFTVSRDNAKNTVYLQMSSLRAEDTAVYYCNAHSFLDLVGAWGQGTLVTVKPGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 757 AA PAT REGION 1..757 note Synthetic: SR303 - CD8ss.FRBstar.CD3e.P2A.huIgKss.antiROR1.FKBP.minCD4hinge.CD4tm.CD4ic source 1..757 mol_type protein organism synthetic construct ALPVTALLLPLALLLHAARPGSILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISKGGGGSGGGGSGGGGSDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRISGSGATNFSLLKQAGDVEENPGPSMETPAQLLFLLLLWLPDTTGDIQMTQSPSFLSASVGDRVTINCKASQNIDRYLNWYQQKLGEAPKRLLYNTNKLQTGIPSRFSGSGSATDFTLTISSLQPEDFATYFCLQYNSLPLTFGSGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVQPGRSLKLSCAASGFIFSEHNMAWVRQAPKKGLEWVATISDDGRNTYYRDSMRGRFTISRENARSTLYLQLDSLRSEDTATYYCASHRYNLFDSWGQGVMVTVSSGGGGSGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct GSGATNFSLLKQAGDVEENPGP 19 AA PAT REGION 1..19 note Synthetic source 1..19 mol_type protein organism synthetic construct ATNFSLLKQAGDVEENPGP 14 AA PAT REGION 1..14 note Synthetic source 1..14 mol_type protein organism synthetic construct LLKQAGDVEENPGP 21 AA PAT REGION 1..21 note Synthetic source 1..21 mol_type protein organism synthetic construct GSGEGRGSLLTCGDVEENPGP 18 AA PAT REGION 1..18 note Synthetic source 1..18 mol_type protein organism synthetic construct EGRGSLLTCGDVEENPGP 13 AA PAT REGION 1..13 note Synthetic source 1..13 mol_type protein organism synthetic construct LLTCGDVEENPGP 23 AA PAT REGION 1..23 note Synthetic source 1..23 mol_type protein organism synthetic construct GSGQCTNYALLKLAGDVESNPGP 20 AA PAT REGION 1..20 note Synthetic source 1..20 mol_type protein organism synthetic construct QCTNYALLKLAGDVESNPGP 14 AA PAT REGION 1..14 note Synthetic source 1..14 mol_type protein organism synthetic construct LLKLAGDVESNPGP 25 AA PAT REGION 1..25 note Synthetic source 1..25 mol_type protein organism synthetic construct GSGVKQTLNFDLLKLAGDVESNPGP 22 AA PAT REGION 1..22 note Synthetic source 1..22 mol_type protein organism synthetic construct VKQTLNFDLLKLAGDVESNPGP 14 AA PAT REGION 1..14 note Synthetic source 1..14 mol_type protein organism synthetic construct LLKLAGDVESNPGP 19 AA PAT REGION 1..19 note Synthetic source 1..19 mol_type protein organism synthetic construct LLNFDLLKLAGDVESNPGP 19 AA PAT REGION 1..19 note Synthetic source 1..19 mol_type protein organism synthetic construct TLNFDLLKLAGDVESNPGP 14 AA PAT REGION 1..14 note Synthetic source 1..14 mol_type protein organism synthetic construct LLKLAGDVESNPGP 17 AA PAT REGION 1..17 note Synthetic source 1..17 mol_type protein organism synthetic construct NFDLLKLAGDVESNPGP 20 AA PAT REGION 1..20 note Synthetic source 1..20 mol_type protein organism synthetic construct QLLNFDLLKLAGDVESNPGP 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct APVKQTLNFDLLKLAGDVESNPGP 40 AA PAT REGION 1..40 note Synthetic source 1..40 mol_type protein organism synthetic construct VTELLYRMKRAETYCPRPLLAIHPTEARHKQKIVAPVKQT 18 AA PAT REGION 1..18 note Synthetic source 1..18 mol_type protein organism synthetic construct LNFDLLKLAGDVESNPGP 40 AA PAT REGION 1..40 note Synthetic source 1..40 mol_type protein organism synthetic construct LLAIHPTEARHKQKIVAPVKQTLNFDLLKLAGDVESNPGP 33 AA PAT REGION 1..33 note Synthetic source 1..33 mol_type protein organism synthetic construct EARHKQKIVAPVKQTLNFDLLKLAGDVESNPGP 4 AA PAT REGION 1..4 note Synthetic source 1..4 mol_type protein organism synthetic construct SGSG 4 AA PAT REGION 1..4 note Synthetic source 1..4 mol_type protein organism synthetic construct RAKR 000 7 AA PAT REGION 1..7 note Synthetic source 1..7 mol_type protein organism synthetic construct ENLYFQG 7 AA PAT REGION 1..7 note Synthetic source 1..7 mol_type protein organism synthetic construct ENLYFQS 10 DNA PAT misc_feature 1..10 note Synthetic source 1..10 mol_type other DNA organism synthetic construct gccrccatgg