SPIC228081 CN 202111196510.7 2021-10-14 Latticon (Suzhou) Biopharmaceuticals Co., Ltd. Latticon (Suzhou) Biopharmaceuticals Co., Ltd. NOVEL ANTIBODY-CYTOKINE FUSION PROTEIN, PREPARATION METHOD THEREFOR AND USE THEREOF 237 133 AA PAT source 1..133 mol_type protein organism Homo sapiens APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note hIL2-DM source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note hIL2-TM source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFECEYADETATIVEFLNRWITFCQSIISTLT 149 AA PAT source 1..149 mol_type protein organism Mus musculus APTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIISTSPQ 123 AA PAT REGION 1..123 note S4B6 - VH source 1..123 mol_type protein organism synthetic construct EVQLQESGAELVRPGTSVKLSCKVSGDTITAYYLHFVRQRPGQGLEWIGRIDPEDDSTKYAENFKNKATFTADASSNTAYLRLSSLTSEDTATYFCTTVTFYYSRELRWFAYWGQGTLVTVSS 107 AA PAT REGION 1..107 note S4B6 - VL source 1..107 mol_type protein organism synthetic construct DIQVTQSPASLSASLEEIVTITCQASQDIGNYLSWYQQKLGKSPQLLIHSATSLADGVPSRFSGSRSGTQYSLKINRLQVEDTGIYYCLQHYSTPYTFGAGTKLELK 5 AA PAT REGION 1..5 note HCDR1 of S4B6, Humanized Antibodies, hS4B6-H6K3-hu01, hS4B6-H6K3-hu02 and hS4B6-H6K3-hu05 to hS4B6-H6K3-hu12 source 1..5 mol_type protein organism synthetic construct AYYLH 17 AA PAT REGION 1..17 note HCDR2 of S4B6, Humanized Antibodies, hS4B6-H6K3-hu01 to hS4B6-H6K3-hu05 and hS4B6-H6K3-hu08 to hS4B6-H6K3-hu12 source 1..17 mol_type protein organism synthetic construct RIDPEDDSTKYAENFKN 14 AA PAT REGION 1..14 note HCDR3 of S4B6, Humanized Antibodies, hS4B6-H6K3-hu01 to hS4B6-H6K3-hu12, hS4B6-H6K3(H), K1G1, K1G3, K2G1, K2G3, K3G1, K3G3, K4G1, K4G3, and H6K3(H)-Cy01 to H6K3(H)-Cy06 source 1..14 mol_type protein organism synthetic construct VTFYYSRELRWFAY 11 AA PAT REGION 1..11 note LCDR1 of S4B6, Humanized Antibody, hS4B6-H6K3-hu01 to hS4B6-H6K3-hu12, hS4B6-H6K3(H), H6K3(H)-Cy03 to H6K3(H)-Cy08, H6K3(H)-Cy10, and H6K3(H)-Cy08-DE source 1..11 mol_type protein organism synthetic construct QASQDIGNYLS 7 AA PAT REGION 1..7 note LCDR2 of S4B6, Humanized Antibodies, hS4B6-H6K3-hu01 to hS4B6-H6K3-hu08, hS4B6-H6K3-hu11 to hS4B6-H6K3-hu12 source 1..7 mol_type protein organism synthetic construct SATSLAD 9 AA PAT REGION 1..9 note LCDR3 of S4B6, Humanized Antibodies, hS4B6-H6K3-hu01 to hS4B6-H6K3-hu12, hS4B6-H6K3(H), Antibodies engineered by Affinity maturation, H6K3(H)-Cy01 to H6K3(H)-Cy08 and H6K3(H)-Cy10, Each Mutant of H6K3(H)-Cy08, and K2G11-Cy01 to K2G11-Cy08 and K2G11-Cy10 to K2G11-Cy12 source 1..9 mol_type protein organism synthetic construct LQHYSTPYT 5 AA PAT REGION 1..5 note HCDR1 of Deeply Humanized Antibody hS4B6-H6K3-hu03 source 1..5 mol_type protein organism synthetic construct DYYLH 5 AA PAT REGION 1..5 note HCDR1 of hS4B6-H6K3-hu04, hS4B6-H6K3(H), Antibodies engineered by Affinity maturation, H6K3(H)-Cy-01 to H6K3(H)-Cy-08 and H6K3(H)-Cy-10, Each Mutant of H6K3(H)-Cy-08, and K2G11-Cy01 to K2G11-Cy12 source 1..5 mol_type protein organism synthetic construct AYYMH 17 AA PAT REGION 1..17 note HCDR2 of H6K3-hu07, H6K3 (H), K1G1, K1G2, K1G4, K1G5, K1G7, K1G8, K1G9; K2G1, K2G2, K2G4, K2G5, K2G7, K2G8, K2G9; K3G1, K3G2, K3G4, K3G5, K3G7, K3G8, K3G9; K4G1, K4G2, K4G4, K4G5, K4G7, K4G8, K4G9; H6K3(H)-Cy-01 to H6K3(H)-Cy08 and H6K3(H)-Cy10, Each Mutant of H6K3(H)-Cy08 source 1..17 mol_type protein organism synthetic construct RIDPEDDSTKYAENFKG 17 AA PAT REGION 1..17 note HCDR2 of hS4B6-H6K3-hu06 source 1..17 mol_type protein organism synthetic construct RIDPEDDSTKYAENFKS 7 AA PAT REGION 1..7 note LCDR2 of hS4B6-H6K3-hu09, hS4B6-H6K3(H), K2G1 to K2G12, K4G1 to K4G12, H6K3(H)-Cy01, H6K3(H)-Cy02, H6K3(H)-Cy05 to H6K3(H)-Cy08 and H6K3(H)-Cy10, Each Mutant of H6K3(H)-Cy08, K2G11-Cy01, K2G11-Cy02, and K2G11-Cy05 to K2G11-Cy12 source 1..7 mol_type protein organism synthetic construct SATSLAS 7 AA PAT REGION 1..7 note LCDR2 of hS4B6-H6K3-hu10 source 1..7 mol_type protein organism synthetic construct SATSLAT 17 AA PAT REGION 1..17 note HCDR2 of K1G3, K1G6, K1G10, K1G11, K1G12, K2G3, K2G6, K2G10, K2G11, K2G12, K3G3, K3G6, K3G10, K3G11, K3G12, K4G3, K4G6, K4G10, K4G11, K4G12,and K2G11-Cy01 to K2G11-Cy12 source 1..17 mol_type protein organism synthetic construct RIDPDDDSTKYAENFKG 14 AA PAT REGION 1..14 note HCDR3 of K1G2, K1G6, K2G2, K2G6, K3G2, K3G6, K4G2, and K4G6 source 1..14 mol_type protein organism synthetic construct ITFYYSRELRWFAY 14 AA PAT REGION 1..14 note HCDR3 of K1G4, K2G4, K3G4, and K4G4 source 1..14 mol_type protein organism synthetic construct VTFLYSRELRWFAY 14 AA PAT REGION 1..14 note HCDR3 of K1G5, K2G5, K3G5, and K4G5 source 1..14 mol_type protein organism synthetic construct VTFYYTRELRWFAY 14 AA PAT REGION 1..14 note HCDR3 of K1G7, K1G10, K2G7, K2G10, K3G7, K3G10, K3G7, K3G10, K4G7, and K4G10 source 1..14 mol_type protein organism synthetic construct ITFYYTRELRWFAY 14 AA PAT REGION 1..14 note HCDR3 of K1G8, K1G11, K2G8, K2G11, K3G8, K3G11, K4G8, K4G11, K2G11-Cy01 to K2G11-Cy06, K2G11-Cy09, K2G11-Cy11, and K2G11-Cy12 source 1..14 mol_type protein organism synthetic construct ITFLYSRELRWFAY 14 AA PAT REGION 1..14 note HCDR3 of K1G9, K1G12, K2G9, K2G12, K3G9, K3G12, K4G9, and K4G12 source 1..14 mol_type protein organism synthetic construct ITFLYTRELRWFAY 11 AA PAT REGION 1..11 note LCDR1 of K1G1 to K1G12, K2G2 to K2G12, and K2G11-Cy03 to K2G11-Cy10 source 1..11 mol_type protein organism synthetic construct QASQYISNYLS 11 AA PAT REGION 1..11 note LCDR1 of K3G1 to K3G12, and K4G1 to K4G12 source 1..11 mol_type protein organism synthetic construct QASQYIGNYLS 7 AA PAT REGION 1..7 note LCDR2 of K1G1 to K1G12, and K3G1 to K3G12 source 1..7 mol_type protein organism synthetic construct QATSLAS 14 AA PAT REGION 1..14 note HCDR3 of H6K3(H)-Cy07, H6K3(H)-Cy08, H6K3(H)-Cy10, and Each Mutant of H6K3(H)-Cy08 source 1..14 mol_type protein organism synthetic construct VTCYYSRELRWFAY 11 AA PAT REGION 1..11 note LCDR1 of H6K3(H)-Cy01 source 1..11 mol_type protein organism synthetic construct QASQDICNYLS 11 AA PAT REGION 1..11 note LCDR1 of H6K3(H)-Cy02 source 1..11 mol_type protein organism synthetic construct QASQDIGCYLS 7 AA PAT REGION 1..7 note LCDR2 of H6K3(H)-Cy03 and K2G11-Cy03 source 1..7 mol_type protein organism synthetic construct CATSLAS 7 AA PAT REGION 1..7 note LCDR2 of H6K3(H)-Cy04 and K2G11-Cy04 source 1..7 mol_type protein organism synthetic construct SACSLAS 14 AA PAT REGION 1..14 note HCDR3 of K2G11-Cy07, K2G11-Cy08, and K2G11-Cy10 source 1..14 mol_type protein organism synthetic construct ITCLYSRELRWFAY 11 AA PAT REGION 1..11 note LCDR1 of K2G11-Cy01 and K2G11-Cy11 source 1..11 mol_type protein organism synthetic construct QASQYICNYLS 11 AA PAT REGION 1..11 note LCDR1 of K2G11-Cy02 source 1..11 mol_type protein organism synthetic construct QASQYISCYLS 11 AA PAT REGION 1..11 note LCDR1 of K2G11-Cy12 source 1..11 mol_type protein organism synthetic construct QASQYISNCLS 9 AA PAT REGION 1..9 note LCDR3 of K2G11-Cy09 source 1..9 mol_type protein organism synthetic construct LQHCSTPYT 11 AA PAT REGION 1..11 note LCDR1 of H6K3(H)-Cy08-QD source 1..11 mol_type protein organism synthetic construct QASDDIGNYLS 11 AA PAT REGION 1..11 note LCDR1 of H6K3(H)-Cy08-QE source 1..11 mol_type protein organism synthetic construct QASEDIGNYLS 11 AA PAT REGION 1..11 note LCDR1 of H6K3(H)-Cy08-QS source 1..11 mol_type protein organism synthetic construct QASSDIGNYLS 11 AA PAT REGION 1..11 note LCDR1 of H6K3(H)-Cy08-QG source 1..11 mol_type protein organism synthetic construct QASGDIGNYLS 11 AA PAT REGION 1..11 note LCDR1 of H6K3(H)-Cy08-QK source 1..11 mol_type protein organism synthetic construct QASKDIGNYLS 11 AA PAT REGION 1..11 note LCDR1 of H6K3(H)-Cy08-QR source 1..11 mol_type protein organism synthetic construct QASRDIGNYLS 123 AA PAT REGION 1..123 note hS4B6-H1 source 1..123 mol_type protein organism synthetic construct QVQLQESGPGLVKPSETLSLTCTVSGDTITAYYLHWIRQPPGKGLEWIGRIDPEDDSTKYAENFKNRVTISVDTSKNQFSLKLSSVTAADTAVYYCTTVTFYYSRELRWFAYWGQGTTVTVSS 107 AA PAT REGION 1..107 note hS4B6-K1 source 1..107 mol_type protein organism synthetic construct DIVLTQSPGTLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLADGIPDRFSGSRSGTDYTLTISRLEPEDFAVYYCLQHYSTPYTFGQGTKVEIK 123 AA PAT REGION 1..123 note hS4B6-H3 source 1..123 mol_type protein organism synthetic construct QVTLKESGPVLVKPTQTLTLTCTVSGDTITAYYLHWIRQPPGKALEWIGRIDPEDDSTKYAENFKNRLTFSADTSKNQVVLTMTNMDPVDTATYYCARVTFYYSRELRWFAYWGQGTLVTVSS 107 AA PAT REGION 1..107 note hS4B6-K3 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLADGIPARFSGSRSGTDYTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 123 AA PAT REGION 1..123 note hS4B6-H6 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYLHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKNRVTITADTSTNTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 107 AA PAT REGION 1..107 note hS4B6-K7 source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCQASQDIGNYLSWYQQKPGKAPKLLIHSATSLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQHYSTPYTFGGGTKVEIK 123 AA PAT REGION 1..123 note H6K3-hu01-VH source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGYTITAYYLHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKNRVTITADTSTNTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note H6K3-hu02-VH source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTFTAYYLHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKNRVTITADTSTNTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note H6K3-hu03-VH source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITDYYLHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKNRVTITADTSTNTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note H6K3-hu04-VH source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKNRVTITADTSTNTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note H6K3-hu05-VH source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYLHWVRQAPGQGLEWMGRIDPEDDSTKYAENFKNRVTITADTSTNTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note H6K3-hu06-VH source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYLHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKSRVTITADTSTNTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note H6K3-hu07-VH source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYLHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTNTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note H6K3-hu08-VH source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYLHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKNRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 107 AA PAT REGION 1..107 note H6K3-hu09-VL source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDYTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note H6K3-hu10-VL source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLATGIPARFSGSRSGTDYTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note H6K3-hu11-VL source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLADGIPARFSGSGSGTDYTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note H6K3-hu12-VL source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLADGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 123 AA PAT REGION 1..123 note VH of hS4B6-H6K3(H), K1G1, K2G1, K3G1, K4G1, and H6K3(H)-Cy01 to H6K3(H)-Cy06 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 107 AA PAT REGION 1..107 note VL of hS4B6-H6K3(H), H6K3(H)-Cy07, H6K3(H)-Cy08, and H6K3(H)-Cy10 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 123 AA PAT REGION 1..123 note VH of K1G2, K2G2, K3G2, K4G2 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G3, K2G3, K3G3, K4G3 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G4, K2G4, K3G4, K4G4 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFLYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G5, K2G5, K3G5, K4G5 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYTRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G6, K2G6, K3G6, K4G6 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFYYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G7, K2G7, K3G7, K4G7 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFYYTRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G8, K2G8, K3G8, K4G8 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFLYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G9, K2G9, K3G9, K4G9 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFLYTRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G10, K2G10, K3G10, K4G10 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFYYTRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G11, K2G11, K3G11, K4G11, and K2G11-Cy01 to K2G11-Cy06, K2G11-Cy09, K2G11-Cy11, and K2G11-Cy12 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFLYSRELRWFAYWGQGTLVTVSS 123 AA PAT REGION 1..123 note VH of K1G12, K2G12, K3G12, K4G12 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFLYTRELRWFAYWGQGTLVTVSS 107 AA PAT REGION 1..107 note VL of K1G1 to K1G12 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYISNYLSWYQQKPGQAPRLLIYQATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K2G1 to K2G12, and K2G11-Cy07, K2G11-Cy08, and K2G11-Cy10 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYISNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K3G1 to K3G12 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYIGNYLSWYQQKPGQAPRLLIYQATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K4G1 to K4G12 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy01 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDICNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy02 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGCYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy03 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYCATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy04 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSACSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy05 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRCGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy06 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSCTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 123 AA PAT REGION 1..123 note VH of H6K3(H)-Cy07, H6K3(H)-Cy08, H6K3(H)-Cy10, and Each Mutant of H6K3(H)-Cy08 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy08-DE source 1..107 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCQASQDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy08-QD source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASDDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy08-QE source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASEDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy08-QS source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASSDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy08-QG source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASGDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy08-QK source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASKDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of H6K3(H)-Cy08-QR source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASRDIGNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 20 AA PAT REGION 1..20 note linker source 1..20 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGS 276 AA PAT REGION 1..276 note The first polypeptide of H6K3(H)-Cy01 source 1..276 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLECELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 276 AA PAT REGION 1..276 note The first polypeptide of H6K3(H)-Cy02 source 1..276 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLECELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 276 AA PAT REGION 1..276 note The first polypeptide of H6K3(H)-Cy03 source 1..276 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLECELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 276 AA PAT REGION 1..276 note The first polypeptide of H6K3(H)-Cy04 source 1..276 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFCCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 276 AA PAT REGION 1..276 note The first polypeptide of H6K3(H)-Cy05 source 1..276 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETCFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 276 AA PAT REGION 1..276 note The first polypeptide of H6K3(H)-Cy06 source 1..276 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETCFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTFYYSRELRWFAYWGQGTLVTVSS 276 AA PAT REGION 1..276 note The first polypeptide of H6K3(H)-Cy07 source 1..276 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELCPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 276 AA PAT REGION 1..276 note The first polypeptide of H6K3(H)-Cy08 source 1..276 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of H6K3(H)-Cy10 source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTCKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 107 AA PAT REGION 1..107 note VL of K2G11-Cy01,and K2G11-Cy11 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYICNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K2G11-Cy02 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYISCYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K2G11-Cy03 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYISNYLSWYQQKPGQAPRLLIYCATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K2G11-Cy04 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYISNYLSWYQQKPGQAPRLLIYSACSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K2G11-Cy05 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYISNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRCGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K2G11-Cy06 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYISNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSCTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K2G11-Cy09 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYISNYLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHCSTPYTFGQGTKLEIK 107 AA PAT REGION 1..107 note VL of K2G11-Cy12 source 1..107 mol_type protein organism synthetic construct DIVLTQSPATLSLSPGERATLSCQASQYISNCLSWYQQKPGQAPRLLIYSATSLASGIPARFSGSRSGTDFTLTISSLEPEDFAVYYCLQHYSTPYTFGQGTKLEIK 123 AA PAT REGION 1..123 note VH of K2G11-Cy07, K2G11-Cy08, and K2G11-Cy10 source 1..123 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITCLYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of K2G11-Cy01, K2G11-Cy02, and K2G11-Cy03 source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLECELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFLYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of K2G11-Cy04 source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFCCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFLYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of K2G11-Cy05 and K2G11-Cy06 source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETCFMCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFLYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of K2G11-Cy07 source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELCPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITCLYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of K2G11-Cy08 source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITCLYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of K2G11-Cy09 and K2G11-Cy12 source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELCPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFLYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of K2G11-Cy10 source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTCKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITCLYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of K2G11-Cy11 source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLCEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPDDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTITFLYSRELRWFAYWGQGTLVTVSS 133 AA PAT REGION 1..133 note hIL-2 mutant (hIL2-DM) introdued with the amino acid mutation E61C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLECELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note hIL-2 mutant (hIL2-DM) introdued with the amino acid mutation M104C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFCCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note hIL-2 mutant (hIL2-DM) introdued with the amino acid mutation T102C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETCFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note hIL-2 mutant (hIL2-DM) introdued with the amino acid mutation K64C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELCPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note hIL-2 mutant (hIL2-DM) introdued with the amino acid mutation P65C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 130 AA PAT REGION 1..130 note hIL-2 mutant (hIL2-DM) in which Cys substitution E61C is introduced, and the first 3 amino acids of N-terminal are deleted and the amino acid mutation C125L is introduced source 1..130 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLECELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLT 130 AA PAT REGION 1..130 note hIL-2 mutant (hIL2-DM) in which Cys substitution M104C is introduced, and the first 3 amino acids of N-terminal are deleted and the amino acid mutation C125L is introduced source 1..130 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFCCEYADETATIVEFLNRWITFLQSIISTLT 130 AA PAT REGION 1..130 note hIL-2 mutant (hIL2-DM) in which Cys substitution T102C is introduced, and the first 3 amino acids of N-terminal are deleted and the amino acid mutation C125L is introduced source 1..130 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETCFMCEYADETATIVEFLNRWITFLQSIISTLT 130 AA PAT REGION 1..130 note hIL-2 mutant (hIL2-DM) in which Cys substitution K64C is introduced, and the first 3 amino acids of N-terminal are deleted and the amino acid mutation C125L is introduced source 1..130 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELCPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLT 130 AA PAT REGION 1..130 note hIL-2 mutant (hIL2-DM) in which Cys substitution P65C is introduced, and the first 3 amino acids of N-terminal are deleted and the amino acid mutation C125L is introduced source 1..130 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLT 130 AA PAT REGION 1..130 note hIL-2 mutant (hIL2-DM) in which Cys substitution F42C is introduced, and the first 3 amino acids of N-terminal are deleted and the amino acid mutation C125L is introduced source 1..130 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTCKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLT 130 AA PAT REGION 1..130 note hIL-2 mutant (hIL2-DM) in which Cys substitution E60C is introduced, and the first 3 amino acids of N-terminal are deleted and the amino acid mutation C125L is introduced source 1..130 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLCEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLT 273 AA PAT REGION 1..273 note The first polypeptide of IC-Cy08 (delta 3, WT) source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of IC-Cy08 (delta 3, C125A) source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of IC-Cy08 (delta 3, C125L) source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of IC-Cy08 (delta 3, C125S) source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFSQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of IC-Cy08 (delta 3, C125Q) source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFQQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 273 AA PAT REGION 1..273 note The first polypeptide of IC-Cy08 (delta 3, C125V) source 1..273 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGCLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFVQSIISTLTGGGGSGGGGSGGGGSGGGGSQVQLVQSGAEVKKPGATVKISCKVSGDTITAYYMHWVRQAPGQGLEWIGRIDPEDDSTKYAENFKGRVTITADTSTDTAYMELSSLRSEDTAVYYCTTVTCYYSRELRWFAYWGQGTLVTVSS 130 AA PAT REGION 1..130 note hIL2-DM(delta 3, C125L) source 1..130 mol_type protein organism synthetic construct SSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELGPLEEVLNLAQSKNFHLRPRDLISNIRVIVLELKGSETTFMCEYADETATIVEFLNRWITFLQSIISTLT 121 AA PAT REGION 1..121 note VH of NARA1, NARA1-Cy04 to NARA1-Cy08 source 1..121 mol_type protein organism synthetic construct QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPGSGGTNYNEKFKGKATLTADKSSSTAYMQLSSLTSDDSAVYFCARWRGDGYYAYFDVWGAGTTVTVSS 111 AA PAT REGION 1..111 note VL of NARA1, NARA1-Cy01 to NARA1-Cy03, NARA1-Cy09 to NARA1-Cy11 source 1..111 mol_type protein organism synthetic construct DIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 5 AA PAT REGION 1..5 note HCDR1 of NARA1, NARA1-Cy01 to NARA1-Cy08, NARA1-Cy10, NARA1-Cy11 source 1..5 mol_type protein organism synthetic construct NYLIE 17 AA PAT REGION 1..17 note HCDR2 of NARA1, NARA1-Cy02 to NARA1-Cy09 source 1..17 mol_type protein organism synthetic construct VINPGSGGTNYNEKFKG 12 AA PAT REGION 1..12 note HCDR3 of NARA1, NARA1-Cy01, NARA1-Cy04 to NARA1-Cy11 source 1..12 mol_type protein organism synthetic construct WRGDGYYAYFDV 15 AA PAT REGION 1..15 note LCDR1 of NARA1, NARA1-Cy01 to NARA1-Cy03, NARA1-Cy06 to NARA1-Cy11 source 1..15 mol_type protein organism synthetic construct KASQSVDYDGDSYMN 7 AA PAT REGION 1..7 note LCDR2 of NARA1, NARA1-Cy01 to NARA1-Cy11 source 1..7 mol_type protein organism synthetic construct AASNLES 9 AA PAT REGION 1..9 note HCDR1 of NARA1-Cy09 source 1..9 mol_type protein organism synthetic construct QQSNEDPYT 5 AA PAT REGION 1..5 note HCDR1 source 1..5 mol_type protein organism synthetic construct CYLIE 17 AA PAT REGION 1..17 note HCDR2 of NARA1-Cy01 source 1..17 mol_type protein organism synthetic construct VINPGCGGTNYNEKFKG 17 AA PAT REGION 1..17 note HCDR2 of NARA1-Cy10 source 1..17 mol_type protein organism synthetic construct VCNPGSGGTNYNEKFKG 17 AA PAT REGION 1..17 note HCDR2 of NARA1-Cy11 source 1..17 mol_type protein organism synthetic construct VINPGSGCTNYNEKFKG 12 AA PAT REGION 1..12 note HCDR3 of NARA1-Cy02 source 1..12 mol_type protein organism synthetic construct WRCDGYYAYFDV 12 AA PAT REGION 1..12 note HCDR3 of NARA1-Cy03 source 1..12 mol_type protein organism synthetic construct WRGDGYYCYFDV 15 AA PAT REGION 1..15 note LCDR1 of NARA1-Cy04 and NARA1-Cy05 source 1..15 mol_type protein organism synthetic construct KASQSVDYCGDSYMN 9 AA PAT REGION 1..9 note LCDR3 of NARA1-Cy06 source 1..9 mol_type protein organism synthetic construct QQCNEDPYT 9 AA PAT REGION 1..9 note LCDR3 of NARA1-Cy07 source 1..9 mol_type protein organism synthetic construct QQSCEDPYT 9 AA PAT REGION 1..9 note LCDR3 of NARA1-Cy08 source 1..9 mol_type protein organism synthetic construct QQSNECPYT 121 AA PAT REGION 1..121 note VH of NARA1-Cy01 source 1..121 mol_type protein organism synthetic construct QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPGCGGTNYNEKFKGKATLTADKSSSTAYMQLSSLTSDDSAVYFCARWRGDGYYAYFDVWGAGTTVTVSS 121 AA PAT REGION 1..121 note VH of NARA1-Cy02 source 1..121 mol_type protein organism synthetic construct QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPGSGGTNYNEKFKGKATLTADKSSSTAYMQLSSLTSDDSAVYFCARWRCDGYYAYFDVWGAGTTVTVSS 121 AA PAT REGION 1..121 note VH of NARA1-Cy03 source 1..121 mol_type protein organism synthetic construct QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPGSGGTNYNEKFKGKATLTADKSSSTAYMQLSSLTSDDSAVYFCARWRGDGYYCYFDVWGAGTTVTVSS 121 AA PAT REGION 1..121 note VH of NARA1-Cy09 source 1..121 mol_type protein organism synthetic construct QVQLQQSGAELVRPGTSVKVSCKASGYAFTCYLIEWVKQRPGQGLEWIGVINPGSGGTNYNEKFKGKATLTADKSSSTAYMQLSSLTSDDSAVYFCARWRGDGYYAYFDVWGAGTTVTVSS 121 AA PAT REGION 1..121 note VH of NARA1-Cy10 source 1..121 mol_type protein organism synthetic construct QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVCNPGSGGTNYNEKFKGKATLTADKSSSTAYMQLSSLTSDDSAVYFCARWRGDGYYAYFDVWGAGTTVTVSS 121 AA PAT REGION 1..121 note VH of NARA1-Cy11 source 1..121 mol_type protein organism synthetic construct QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPGSGCTNYNEKFKGKATLTADKSSSTAYMQLSSLTSDDSAVYFCARWRGDGYYAYFDVWGAGTTVTVSS 111 AA PAT REGION 1..111 note VL of NARA1-Cy04, NARA1-Cy05 source 1..111 mol_type protein organism synthetic construct DIVLTQSPASLAVSLGQRATISCKASQSVDYCGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 111 AA PAT REGION 1..111 note VL of NARA1-Cy06 source 1..111 mol_type protein organism synthetic construct DIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQCNEDPYTFGGGTKLEIK 111 AA PAT REGION 1..111 note VL of NARA1-Cy07 source 1..111 mol_type protein organism synthetic construct DIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSCEDPYTFGGGTKLEIK 111 AA PAT REGION 1..111 note VL of NARA1-Cy08 source 1..111 mol_type protein organism synthetic construct DIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNECPYTFGGGTKLEIK 121 AA PAT REGION 1..121 note VH of TCB2, TCB2-Cy06 to TCB2-Cy11 source 1..121 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTTYWIQWVRQAPGQGLEWMGAIYPGDGDTRYIQNFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARSLATRGFYAMDYWGQGTLVTVSS 107 AA PAT REGION 1..107 note VL of TCB2, TCB2-Cy01 to TCB2-Cy05 source 1..107 mol_type protein organism synthetic construct DIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDNLPYTFGGGTKLEIK 5 AA PAT REGION 1..5 note HCDR1 of TCB2, TCB2-Cy01 to TCB2-Cy11 source 1..5 mol_type protein organism synthetic construct TYWIQ 17 AA PAT REGION 1..17 note HCDR2 of TCB2, TCB2-Cy01 to TCB2-Cy04, TCB2-Cy06 to TCB2-Cy11 source 1..17 mol_type protein organism synthetic construct AIYPGDGDTRYIQNFKG 12 AA PAT REGION 1..12 note HCDR3 of TCB2, TCB2-Cy05 to TCB2-Cy11 source 1..12 mol_type protein organism synthetic construct SLATRGFYAMDY 11 AA PAT source 1..11 mol_type protein organism synthetic construct REGION 1..11 note LCDR1 of TCB2, TCB2-Cy01 to TCB2-Cy05, TCB2-Cy07 to TCB2-Cy11 ITSTDIDDDMN 7 AA PAT REGION 1..7 note LCDR2 of TCB2, TCB2-Cy01 to TCB2-Cy11 source 1..7 mol_type protein organism synthetic construct EGNTLRP 9 AA PAT REGION 1..9 note LCDR3 of TCB2, TCB2-Cy01 to TCB2-Cy06 source 1..9 mol_type protein organism synthetic construct LQSDNLPYT 17 AA PAT REGION 1..17 note HCDR2 of TCB2-Cy05 source 1..17 mol_type protein organism synthetic construct AIYPGCGDTRYIQNFKG 12 AA PAT REGION 1..12 note HCDR3 of TCB2-Cy01 source 1..12 mol_type protein organism synthetic construct SLCTRGFYAMDY 12 AA PAT REGION 1..12 note HCDR3 of TCB2-Cy02 source 1..12 mol_type protein organism synthetic construct SLATCGFYAMDY 12 AA PAT REGION 1..12 note HCDR3 of TCB2-Cy03 source 1..12 mol_type protein organism synthetic construct SLATRCFYAMDY 12 AA PAT REGION 1..12 note HCDR3 of TCB2-Cy04 source 1..12 mol_type protein organism synthetic construct SLATRGCYAMDY 11 AA PAT REGION 1..11 note LCDR1 of TCB2-Cy06 source 1..11 mol_type protein organism synthetic construct ITSCDIDDDMN 9 AA PAT REGION 1..9 note LCDR3 of TCB2-Cy07 source 1..9 mol_type protein organism synthetic construct LQSCNLPYT 9 AA PAT REGION 1..9 note LCDR3 of TCB2-Cy08 to TCB2-Cy10 source 1..9 mol_type protein organism synthetic construct LQSDCLPYT 9 AA PAT REGION 1..9 note LCDR3 of TCB2-Cy011 source 1..9 mol_type protein organism synthetic construct LQSDNCPYT 121 AA PAT REGION 1..121 note VH of TCB2-Cy01 source 1..121 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTTYWIQWVRQAPGQGLEWMGAIYPGDGDTRYIQNFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARSLCTRGFYAMDYWGQGTLVTVSS 121 AA PAT REGION 1..121 note VH of TCB2-Cy02 source 1..121 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTTYWIQWVRQAPGQGLEWMGAIYPGDGDTRYIQNFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARSLATCGFYAMDYWGQGTLVTVSS 121 AA PAT REGION 1..121 note VH of TCB2-Cy03 source 1..121 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTTYWIQWVRQAPGQGLEWMGAIYPGDGDTRYIQNFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARSLATRCFYAMDYWGQGTLVTVSS 121 AA PAT REGION 1..121 note VH of TCB2-Cy04 source 1..121 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTTYWIQWVRQAPGQGLEWMGAIYPGDGDTRYIQNFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARSLATRGCYAMDYWGQGTLVTVSS 121 AA PAT REGION 1..121 note VH of TCB2-Cy05 source 1..121 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTTYWIQWVRQAPGQGLEWMGAIYPGCGDTRYIQNFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARSLATRGFYAMDYWGQGTLVTVSS 107 AA PAT REGION 1..107 note VL of TCB2-Cy06 source 1..107 mol_type protein organism synthetic construct DIVMTQSPSSLSASVGDRVTIRCITSCDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDNLPYTFGGGTKLEIK 107 AA PAT REGION 1..107 note VL of TCB2-Cy07 source 1..107 mol_type protein organism synthetic construct DIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSCNLPYTFGGGTKLEIK 107 AA PAT REGION 1..107 note VL of TCB2-Cy08 to TCB2-Cy10 source 1..107 mol_type protein organism synthetic construct DIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDCLPYTFGGGTKLEIK 107 AA PAT REGION 1..107 note VL of TCB2-Cy11 source 1..107 mol_type protein organism synthetic construct DIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDNCPYTFGGGTKLEIK 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution T111C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADECATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution A73C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLCQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution P34C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNCKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution S75C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQCKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution N77C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKCFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution T37C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLCRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution E68C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLECVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution T41C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLCFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution F42C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTCKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution R38C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTCMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution D109C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYACETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note The wild-type hIL-2 introduced with Cys substitution L36C source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKCTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy01 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADECATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy02 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLCQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy03 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNCKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy04 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQCKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYCGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy05 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKCFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYCGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy06 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNCKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQCNEDPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy07 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNCKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSCEDPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy08 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLCRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNECPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy09 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLECVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy10 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLCFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 264 AA PAT REGION 1..264 note The first polypeptide of NARA1-Cy11 source 1..264 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTCKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy01 and TCB2-Cy03 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLECVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDNLPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy02 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTCKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDNLPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy04 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTCMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDNLPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy05 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYACETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDNLPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy06 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNCKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSCDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDNLPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy07 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNCKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSCNLPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy08 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNCKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDCLPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy09 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKCTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDCLPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy10 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLCRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDCLPYTFGGGTKLEIK 260 AA PAT REGION 1..260 note The first polypeptide of TCB2-Cy11 source 1..260 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLCRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTGGGGSGGGGSGGGGSGGGGSDIVMTQSPSSLSASVGDRVTIRCITSTDIDDDMNWYQQKPGKAPKLLISEGNTLRPGVPSRFSGSGYGTDFTFTISSLQPEDIADYYCLQSDNCPYTFGGGTKLEIK 330 AA PAT REGION 1..330 note The wild-type IgG1 constant region source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT REGION 1..330 note IgG1 constant region / pI TM mutant source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVDHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSPGK 153 AA PAT REGION 1..153 note Full-length human IL-2 (comprising signal peptide) source 1..153 mol_type protein organism synthetic construct MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 17 AA PAT source 1..17 mol_type protein organism synthetic construct REGION 1..17 note HCDR2 MUTAGEN 5 note Z at position 5 is Z1 and represents E or D MUTAGEN 17 note X at position 17 is X3 and represents N, S or G RIDPZDDSTKYAENFKX 14 AA PAT source 1..14 mol_type protein organism synthetic construct REGION 1..14 note HCDR3 MUTAGEN 1 note Z at position 1 is Z2 and represents V, I, R or T MUTAGEN 4 note Z at positin 4 is Z3 and represents Y, L, H or W MUTAGEN 6 note Z at position 6 is Z4 and represents S, T, A, R, N, D, Q, E, H, I, L, K, F, P, W, Y or V ZTFZYZRELRWFAY 11 AA PAT source 1..11 mol_type protein organism synthetic construct REGION 1..11 note LCDR1 MUTAGEN 5 note Z at position 5 is Z5 and represents D, Y, N, H, I, L or F MUTAGEN 7 note Z at position 7 is Z6 and represents G, S, A, R, N, Q, I, L, T or D QASQZIZNYLS 7 AA PAT source 1..7 mol_type protein organism synthetic construct REGION 1..7 note LCDR2 MUTAGEN 1 note Z at position 1 is Z7 and represents S, Q, R, T, W or Y MUTAGEN 3 note Z at position 3 is Z8 and represents T or G MUTAGEN 7 note X at position 7 is X4 and represnts D, S or T ZAZSLAX 14 AA PAT source 1..14 mol_type protein organism synthetic construct REGION 1..14 note HCDR3 MUTAGEN 1 note Z at position 1 is Z2 and represents V or I MUTAGEN 3 note X at position 3 is XII and represents F or C MUTAGEN 4 note Z at position 4 is Z3 and represents Y or L MUTAGEN 6 note Z at position 6 is Z4 and represnts S or T ZTXZYZRELRWFAY 11 AA PAT source 1..11 mol_type protein organism synthetic construct REGION 1..11 note LCDR1 MUTAGEN 5 note Z at position 5 is Z5 and represents D or Y MUTAGEN 7 note Z at position 7 is Z6 and represents G, S or C MUTAGEN 8 note X at position 8 is XI and represents N or C MUTAGEN 9 note X at position 9 is XIV and represents Y or C QASQZIZXXLS 7 AA PAT source 1..7 mol_type protein organism synthetic construct REGION 1..7 note LCDR2 MUTAGEN 1 note Z at position 1 is Z7 and represnts S, Q or C MUTAGEN 3 note Z at position 3 is Z8 and represents T or C MUTAGEN 7 note X at position 7 is X4 and represents S ZAZSLAX 9 AA PAT source 1..9 mol_type protein organism synthetic construct REGION 1..9 note LCDR3 MUTAGEN 4 note X at position 4 is XIII and represnts Y or C LQHXSTPYT