677876 JP JP 2023-019305 2023-02-10 OTSUKA PHARMACEUTICAL CO., LTD. ＴＡＵスプライススイッチングオリゴヌクレオチドおよびＴＡＵ関連疾患を治療または予防するための医薬組成物 TAU splice-switching oligonucleotide and pharmaceutical composition for treating or preventing TAU-related disease 40 135 DNA PAT source 1..135 mol_type genomic DNA organism Homo sapiens aggggagtgaattcactgagctgagagctgaggaaccattgatctgatggctgagacaccactgggaagactggagaggcttttctgggcatgcagtgccaggcacaggaggagctgagggaagatgactaagag 2559 DNA PAT source 1..2559 mol_type genomic DNA organism Homo sapiens gtactggcaaagaattcagaaattctgatggaagctttacatgttaccatcacatccatccatctatccacccatccatccacccatatcttcctccctccacccaatcatgcatacatccagtcatctatacaccacccacccacccatccatccatccatccatcccttcatccatcccatcatccatccaattatacatacatccaatcatatatctgtacataatccattcttccctcggttcatccatccatccattcatccatccatccacccatcccttccttcatccttcctatcatccatccaatcatatatctgtacataatccattcttccctcggttcatccatccatccattcatccatccatccacccatcccttccttcatccttcctatcatccatccaatcatacatatatccaatcatacatctgcacatcaccagctcatccatctatccatttatccatccatccttccttccatccatcattcatccatcatacatacatctaaccatacatctctacatcattcattcttccatcgattcatccaattatccatcattccttcctccatccatcccattatccatttgatcatacatatatcatctatacatcatccattcatccatccatccatccatccacccatatcttcatccaatcaatcatacatacatcgaatcatctacacatcacccatccatccatccatccattcatctatccacccatccatccatccatccatccattcatctatccacccatccatccatccatccatccatccatccatgtaaccatccagtcatatatccaattacacatccatccagttatacattcatacatgcatctaatcattcaattatacatacacacatccatataattctacatccaattatacctccatccaattacacattcatacacccacctaataaattattaattcatatatccatccatataattatacatcaattatacatccatctaatcattcagtaattcacccaccatccagtcatctatccaataatacattcatccaatcatccatccatccatccacccattcatccatccatccgtccgtccacccatcatggtatgagccatgatttaccacgatggtcccctgtggacagcccaggtggggcagaactgaagggaagcccagggctgcccccataaacatttgcctcctttacatggatgagaactagatccacatgtataaatcctcatgatttgaaggtgcttttaccaacattcactcatgggattctcccaggagctctaggaggaggcaggtagagttgaggtcatctcacgcattttacagatgaggaaacggaggccctgagaggcaggtccaaggccacctgaccagaaagaagtggaactgggacttgaacccagccatcttgccccttggtcccatgctctctagcctgtaactcctgcttcctggtggggcatctccaggaggaccctatcggctggccatgggcctgccctggagtcttttgctctgtgtggccatccttcctccctcaggagagtgtgtgctcccagagcacaggctgtatcttctgagcattttgtcccttcccagtacctagcactcagctctgtatacattgggctctcaagaattctcaaccttccagagtgtaaggccttgacctgctcagccctggatactgcatgatgcattgataagcccataaaataaccagggcagattgactcccagtggccaaagtgccacagggaagggacaattcagcccttctaggaggaggaggaggtagttttctcatttctattaaggcaacaaaagctgccttactaaggacattcttggtggagggcgtgactgtcaaccactgtgatcatttgggcctctcttgcccaggcttcccattctgaaaggacagttttattgtaggtacacatggctgccatttcaaatgtaactcacagcttgtccatcagtccttggaggtctttctatgaaaggagcttggtggcgtccaaacaccacccaatgtccacttagaagtaagcaccgtgtctgccctgagctgactccttttccaaggaaggggttggatcgctgagtgtttttccaggtgtctacttgttgttaattaatagcaatgacaaagcagaaggttcatgcgtagctcggctttctggtatttgctgcccgttgaccaatggaagataaacctttgcctcaggtggcaccactagctggttaagaggcactttgtcctttcacccaggagcaaacgcacatcacctgtgtcctcatctgatggccctggtgtggggcacagtcgtgttggcagggagggaggtggggttggtcccctttgtgggtttgttgcgaggccgtgttccagctgtttccacagggagcgattttcagctccacaggacactgctccccagttcctcctgagaacaaaagggggcgctggggagaggccaccgttctgagggctcactgtatgtgttccag 19 DNA PAT source 1..19 mol_type genomic DNA organism Homo sapiens ggcaaagaattcagaaatt 18 DNA PAT source 1..18 mol_type genomic DNA organism Homo sapiens ggcaaagaattcagaaat 18 DNA PAT source 1..18 mol_type genomic DNA organism Homo sapiens gcaaagaattcagaaatt 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct atttctgaattctttgcc 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct aatttctgaattctttgc 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1..5 mod_base OTHER note 2'-O-methoxyethyl nucleoside modified_base 14..18 mod_base OTHER note 2'-O-methoxyethyl nucleoside modified_base 4 mod_base m5c modified_base 12 mod_base m5c gggcgtatagacgtgtta 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1..5 mod_base OTHER note 2'-O-methoxyethyl nucleoside modified_base 14..18 mod_base OTHER note 2'-O-methoxyethyl nucleoside modified_base 1 mod_base m5c modified_base 2 mod_base m5c modified_base 8 mod_base m5c modified_base 12 mod_base m5c modified_base 13 mod_base m5c modified_base 15 mod_base m5c modified_base 16 mod_base m5c modified_base 17 mod_base m5c ccgttttcttaccaccct 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1 mod_base OTHER note Locked Nucleic Acid modified_base 3 mod_base OTHER note Locked Nucleic Acid modified_base 5 mod_base OTHER note Locked Nucleic Acid modified_base 7 mod_base OTHER note Locked Nucleic Acid modified_base 9 mod_base OTHER note Locked Nucleic Acid modified_base 11 mod_base OTHER note Locked Nucleic Acid modified_base 13 mod_base OTHER note Locked Nucleic Acid modified_base 15 mod_base OTHER note Locked Nucleic Acid modified_base 17 mod_base OTHER note Locked Nucleic Acid modified_base 3 mod_base m5c modified_base 10 mod_base m5c modified_base 15 mod_base m5c modified_base 16 mod_base m5c ttctgaattctttgccag 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1 mod_base OTHER note Locked Nucleic Acid modified_base 3 mod_base OTHER note Locked Nucleic Acid modified_base 5 mod_base OTHER note Locked Nucleic Acid modified_base 7 mod_base OTHER note Locked Nucleic Acid modified_base 9 mod_base OTHER note Locked Nucleic Acid modified_base 11 mod_base OTHER note Locked Nucleic Acid modified_base 13 mod_base OTHER note Locked Nucleic Acid modified_base 15 mod_base OTHER note Locked Nucleic Acid modified_base 17 mod_base OTHER note Locked Nucleic Acid modified_base 4 mod_base m5c modified_base 11 mod_base m5c modified_base 16 mod_base m5c modified_base 17 mod_base m5c tttctgaattctttgcca 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1 mod_base OTHER note Locked Nucleic Acid modified_base 3 mod_base OTHER note Locked Nucleic Acid modified_base 5 mod_base OTHER note Locked Nucleic Acid modified_base 7 mod_base OTHER note Locked Nucleic Acid modified_base 9 mod_base OTHER note Locked Nucleic Acid modified_base 11 mod_base OTHER note Locked Nucleic Acid modified_base 13 mod_base OTHER note Locked Nucleic Acid modified_base 15 mod_base OTHER note Locked Nucleic Acid modified_base 17 mod_base OTHER note Locked Nucleic Acid modified_base 5 mod_base m5c modified_base 12 mod_base m5c modified_base 17 mod_base m5c modified_base 18 mod_base m5c atttctgaattctttgcc 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1 mod_base OTHER note Locked Nucleic Acid modified_base 3 mod_base OTHER note Locked Nucleic Acid modified_base 5 mod_base OTHER note Locked Nucleic Acid modified_base 7 mod_base OTHER note Locked Nucleic Acid modified_base 9 mod_base OTHER note Locked Nucleic Acid modified_base 11 mod_base OTHER note Locked Nucleic Acid modified_base 13 mod_base OTHER note Locked Nucleic Acid modified_base 15 mod_base OTHER note Locked Nucleic Acid modified_base 17 mod_base OTHER note Locked Nucleic Acid modified_base 6 mod_base m5c modified_base 13 mod_base m5c modified_base 18 mod_base m5c aatttctgaattctttgc 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1 mod_base OTHER note Locked Nucleic Acid modified_base 3 mod_base OTHER note Locked Nucleic Acid modified_base 5 mod_base OTHER note Locked Nucleic Acid modified_base 7 mod_base OTHER note Locked Nucleic Acid modified_base 9 mod_base OTHER note Locked Nucleic Acid modified_base 11 mod_base OTHER note Locked Nucleic Acid modified_base 13 mod_base OTHER note Locked Nucleic Acid modified_base 15 mod_base OTHER note Locked Nucleic Acid modified_base 17 mod_base OTHER note Locked Nucleic Acid modified_base 7 mod_base m5c modified_base 14 mod_base m5c gaatttctgaattctttg 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1 mod_base OTHER note Locked Nucleic Acid modified_base 3 mod_base OTHER note Locked Nucleic Acid modified_base 5 mod_base OTHER note Locked Nucleic Acid modified_base 7 mod_base OTHER note Locked Nucleic Acid modified_base 9 mod_base OTHER note Locked Nucleic Acid modified_base 11 mod_base OTHER note Locked Nucleic Acid modified_base 13 mod_base OTHER note Locked Nucleic Acid modified_base 15 mod_base OTHER note Locked Nucleic Acid modified_base 17 mod_base OTHER note Locked Nucleic Acid modified_base 8 mod_base m5c modified_base 15 mod_base m5c agaatttctgaattcttt 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 3 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 5 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 7 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 9 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 11 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 13 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 15 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 17 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 5 mod_base m5c modified_base 12 mod_base m5c modified_base 17 mod_base m5c modified_base 18 mod_base m5c atttctgaattctttgcc 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 3 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 5 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 7 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 9 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 11 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 13 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 15 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 17 mod_base OTHER note Amido-Bridged Nucleic Acid modified_base 6 mod_base m5c modified_base 13 mod_base m5c modified_base 18 mod_base m5c aatttctgaattctttgc 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct catgcaccaagaccaagagg 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct tcacgtgaccagcagcttc 17 DNA PAT source 1..17 mol_type other DNA organism synthetic construct acagagcctcgcctttg 17 DNA PAT source 1..17 mol_type other DNA organism synthetic construct ccttgcacatgccggag 259 DNA PAT source 1..259 mol_type other DNA organism synthetic construct tcaggggggctacaccatgcaccaagaccaagagggtgacacggacgctggcctgaaagaggggagtgaattcactgagctgagagctgaggaaccattgatctgatggctgagacaccactgggaagactggagaggcttttctgggcatgcagtgccaggcacaggaggagctgagggaagatgactaagagctgaagaagcaggcattggagacacccccagcctggaagacgaagctgctggtcacgtgacccaa 125 DNA PAT source 1..125 mol_type other DNA organism synthetic construct tcaggggggctacaccatgcaccaagaccaagagggtgacacggacgctggcctgaaagctgaagaagcaggcattggagacacccccagcctggaagacgaagctgctggtcacgtgacccaag 366 DNA PAT source 1..366 mol_type other DNA organism synthetic construct gcatcgacatcgactaaccgccgagaccgcgtccgccccgcgagcacagagcctcgcctttgccgatccgccgcccgtccacacccgccgccagctcaccatggatgatgatatcgccgcgctcgtcgtcgacaacggctccggcatgtgcaaggccggcttcgcgggcgacgatgccccccgggccgtcttcccctccatcgtggggcgccccaggcaccagggcgtgatggtgggcatgggtcagaaggattcctatgtgggcgacgaggcccagagcaagagaggcatcctcaccctgaagtaccccatcgagcacggcatcgtcaccaactgggacgacatggagaaaatctggcaccacac 23 DNA PAT source 1..23 mol_type other DNA organism synthetic construct caggctttacactttatgcttcc 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct cgatttcggcctattggtta 125 DNA PAT source 1..125 mol_type other DNA organism synthetic construct tctagtaaacaataactgtcttgcttttaccccccttcatttgctgacacatacaccagctgaagaagcaggcattggagacacccccagcctggaagacgaagctgctggtcacgtgacccaag 22 DNA PAT source 1..22 mol_type other DNA organism synthetic construct agggaagatgactaagagctga 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct tcacgtgaccagcagctt 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct agacacccccagcctggaaga 17 DNA PAT source 1..17 mol_type other DNA organism synthetic construct gctggcctgaaagctga 23 DNA PAT source 1..23 mol_type other DNA organism synthetic construct cttcatttgctgacacatacacc 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct tcatccatggtgagctggcgg 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct ccatcagcaacgacctcaa 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct gcttccaggaccttgttct 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct cttcgccagcttcatcgagcg 178 DNA PAT source 1..178 mol_type other DNA organism synthetic construct cgacctgagccaggtagccgccatcagcaacgacctcaagtccatccgcacgcaggagaaggcgcagctccaggacctcaatgaccgcttcgccagcttcatcgagcgcgtgcacgagctggagcagcagaacaaggtcctggaagccgagctgctggtgctgcgccagaagcactcc 37 DNA PAT source 1..37 mol_type genomic DNA organism Homo sapiens gaggtactggcaaagaattcagaaattctgatggaag 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1..4 mod_base OTHER note Locked Nucleic Acid modified_base 15..18 mod_base OTHER note Locked Nucleic Acid atttctgaattctttgcc 18 DNA PAT source 1..18 mol_type other DNA organism synthetic construct modified_base 1..4 mod_base OTHER note Locked Nucleic Acid modified_base 15..18 mod_base OTHER note Locked Nucleic Acid aatttctgaattctttgc