WO PCT/CN2023/108389 2023-07-20 Z230936CPWO CN 202210863441.9 2022-07-20 上海济煜医药科技有限公司 Shanghai Jemincare Pharmaceutical Co., Ltd 郑云程 ZHENG YUNCHENG ANTI-ADRENOMEDULIN NON-NEUTRALIZING ANTIBODY, METHOD FOR PREPARING SAME, AND USE THEREOF 61 16 AA PAT source 1..16 mol_type protein organism synthetic construct YRQSMNNFQGLRSFGC 21 AA PAT source 1..21 mol_type protein organism synthetic construct YRQSMNNFQGLRSFGCRFGTC 19 AA PAT source 1..19 mol_type protein organism synthetic construct YRQSMNQGSRSNGCRFGTC 52 AA PAT source 1..52 mol_type protein organism synthetic construct YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY 50 AA PAT source 1..50 mol_type protein organism synthetic construct YRQSMNQGSRSNGCRFGTCTFQKLAHQIYQLTDKDKDGMAPRNKISPQGY 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct ggacagggmtccakagttcc 28 DNA PAT source 1..28 mol_type other DNA organism synthetic construct gcacacgactgaggcacctccagatgtt 42 DNA PAT source 1..42 mol_type other DNA organism synthetic construct aagcagtggtatcaacgcagagtcatcccccccccccccccc 119 AA PAT source 1..119 mol_type protein organism synthetic construct QIQLVQSGPELRKPGETVKISCKASGYAFTTFGMSWIKQAPGQGLKWMGWINTYSRVPKYTDDFKGRFAFSLEISATTAYLLINNLKNGDTATYFCARGYGGEGGLGFSGQGTTLTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVLMTQTPFSLPVSLGDQASISCRSSQSIIDSDGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLRISRVEAEDLGVYYCFQGSHFPYTFAGGTKLELK 7 AA PAT source 1..7 mol_type protein organism synthetic construct GYAFTTF 6 AA PAT source 1..6 mol_type protein organism synthetic construct NTYSRV 10 AA PAT source 1..10 mol_type protein organism synthetic construct GYGGEGGLGF 16 AA PAT source 1..16 mol_type protein organism synthetic construct RSSQSIIDSDGNTYLE 7 AA PAT source 1..7 mol_type protein organism synthetic construct KVSNRFS 9 AA PAT source 1..9 mol_type protein organism synthetic construct FQGSHFPYT 119 AA PAT source 1..119 mol_type protein organism synthetic construct QIQLVQSGSELKKPGASVKVSCKASGYAFTTFGMSWIRQAPGQGLEWMGWINTYSRVPKYTQGFTGRFVFSLDISVTTAYLQISSLKAEDTAVYFCARGYGGEGGLGFSGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQSPLSLPVTLGQPASISCRSSQSIIDSDGNTYLEWYQQRPGQSPRLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDFGVYYCFQGSHFPYTFGQGTKLEIK 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVLMTQSPLSLPVTLGQPASISCRSSQSIIDSDGNTYLEWYQQRPGQSPRLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDFGVYYCFQGSHFPYTFAQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 330 AA PAT source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 219 AA PAT source 1..219 mol_type protein organism synthetic construct DVLMTQTPFSLPVSLGDQASISCRSSQSIIDSDGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLRISRVEAEDLGVYYCFQGSHFPYTFAGGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT source 1..449 mol_type protein organism synthetic construct QIQLVQSGPELRKPGETVKISCKASGYAFTTFGMSWIKQAPGQGLKWMGWINTYSRVPKYTDDFKGRFAFSLEISATTAYLLINNLKNGDTATYFCARGYGGEGGLGFSGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 219 AA PAT source 1..219 mol_type protein organism synthetic construct DVVMTQSPLSLPVTLGQPASISCRSSQSIIDSDGNTYLEWYQQRPGQSPRLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDFGVYYCFQGSHFPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT source 1..449 mol_type protein organism synthetic construct QIQLVQSGSELKKPGASVKVSCKASGYAFTTFGMSWIRQAPGQGLEWMGWINTYSRVPKYTQGFTGRFVFSLDISVTTAYLQISSLKAEDTAVYFCARGYGGEGGLGFSGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 219 AA PAT source 1..219 mol_type protein organism synthetic construct DVLMTQSPLSLPVTLGQPASISCRSSQSIIDSDGNTYLEWYQQRPGQSPRLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDFGVYYCFQGSHFPYTFAQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT source 1..449 mol_type protein organism synthetic construct QIQLVQSGSELKKPGASVKVSCKASGYAFTTFGMSWIRQAPGQGLEWMGWINTYSRVPKYTQGFTGRFVFSLDISVTTAYLQISSLKAEDTAVYFCARGYGGEGGLGFSGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISAYNGNTNYAQKLQGRVTMTRDTSTSTAYMELRSLRSDDTAVYYCAREGRSGGSFDIWGQGTMVTVSS 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISAYQGNTNYAQKLQGRVTMTRDTSTSTAYMELRSLRSDDTAVYYCAREGRSGGSFDIWGQGTMVTVSS 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISAYQGNTNYAQKLQGRVTMTRDTSTSTAYMELRSLRSDDTAVYYCAREGRWGGSFNIWGQGTMVTVSS 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTQYGIAWVRQAPGQGLEWMGWISAYQGNTNYAQKLQGRVTMTRDTSTSTAYMELRSLRSDDTAVYYCAREGRWGGSFNIWGQGTMVTVSS 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISPYSGNTNYAQKLQGRVTMTRDTSTSTAYMELRSLRSDDTAVYYCAREGRWGGSFNIWGQGTMVTVSS 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTHYGIAWVRQAPGQGLEWMGWISAYQGNTNYAQKLQGRVTMTRDTSTSTAYMELRSLRSDDTAVYYCAREGRWGGSFNIWGQGTMVTVSS 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISPYTGKTNYAQKLQGRVTMTRDTSTSTAYMELRSLRSDDTAVYYCAREGRWGGSFNIWGQGTMVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGISSYLAWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDNLPLTFGGGTKVEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASEGISEYLAWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDNLPLTFGGGTKVEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRAAEGIGSYLAWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDNLPLTFGGGTKVEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGISSYLAWYQQKPGKAPKLLIYDVSILDAGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDNLPLTFGGGTKVEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGISSYLAWYQQKPGKAPKLLIYDASNVDTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDNLPLTFGGGTKVEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGISSYLAWYQQKPGKAPKLLIYDTSDLDTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDNLPLTFGGGTKVEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGISSYLAWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDDLDLTFGGGTKVEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGISSYLAWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDDLPLSFGGGTKVEIK 7 AA PAT source 1..7 mol_type protein organism synthetic construct GYTFTSY 6 AA PAT source 1..6 mol_type protein organism synthetic construct SAYNGN 10 AA PAT source 1..10 mol_type protein organism synthetic construct EGRSGGSFDI 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASQGISSYLA 7 AA PAT source 1..7 mol_type protein organism synthetic construct DASNLET 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQYDNLPLT 6 AA PAT source 1..6 mol_type protein organism synthetic construct SAYQGN 10 AA PAT source 1..10 mol_type protein organism synthetic construct EGRWGGSFNI 7 AA PAT source 1..7 mol_type protein organism synthetic construct GYTFTQY 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASEGISEYLA 11 AA PAT source 1..11 mol_type protein organism synthetic construct RAAEGIGSYLA 6 AA PAT source 1..6 mol_type protein organism synthetic construct SPYSGN 7 AA PAT source 1..7 mol_type protein organism synthetic construct GYTFTHY 7 AA PAT source 1..7 mol_type protein organism synthetic construct DVSILDA 7 AA PAT source 1..7 mol_type protein organism synthetic construct DASNVDT 6 AA PAT source 1..6 mol_type protein organism synthetic construct SPYTGK 7 AA PAT source 1..7 mol_type protein organism synthetic construct DTSDLDT 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQYDDLDLT 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQYDDLPLS