C24W9311 CN PCT/CN2023/101881 2023-06-21 Corregene Biotechnology CO., LTD. MODIFIED TCR CONSTANT REGION AND USE THEREOF IN TCR FUSION PROTEIN 101 91 AA PAT source 1..91 mol_type protein organism Homo sapiens NIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSP 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYRLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism Homo sapiens NIQKPDPAVYQLRDSKSSDKIVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDPCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRDMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMREMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRNMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSEIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDPCVLDMRDMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKIVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRDMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKIVCLFTDFDSQTNVSQSKDSDVYITDPCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 86 AA PAT source 1..86 mol_type protein organism synthetic construct NIQKPDPAVYQLRDSKSSDKIVCLFTDFDSQTNVSQSKDSDVYITDPCVLDMRDMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVPATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVEATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVDATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVLATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVNATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSADFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVLFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 130 AA PAT source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSADFWQDPRNHFRCQVLFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 112 AA PAT source 1..112 mol_type protein organism synthetic construct RKEVEQDPGPFNVPEGATVAFNCTYSNSASQSFFWYRQDCRKEPKLLMSVYSSGNEDGRFTAQLNRASQYISLLIRDSKLSDSATYLCVVPGGTGGGNKLTFGTGTQLKVEL 113 AA PAT source 1..113 mol_type protein organism synthetic construct DTAVSQTPKYLVTQMGNDKSIKCEQNLGHDTMDWYKQDSKKFLKIMFSYNNKELIINETVPNRFSPKSPDKAHLNLHINSLELGDSAVYFCASSHWGAQETQYFGPGTRLLVL 114 AA PAT source 1..114 mol_type protein organism synthetic construct GESVGLHLPTLGVQEGDNSIINCAYSNSASDYFIWYKQESGKGPQFIIDIRSNMDKRQGQRVTVLLNKTVKHLSLQIAATQPGDSAVYFCAENSDGTSYGKLTFGQGTILTVHP 115 AA PAT source 1..115 mol_type protein organism synthetic construct EAGVAQSPRYKIIEKRQSVAFWCNPISGHATLYWYQQILGQGPKLLIQFQNNGVVDDSQLPKDRFSAERLKGVDSTLKIQPAKLEDSAVYLCASSLVGSPDYEQYFGPGTRLTVT 117 AA PAT source 1..117 mol_type protein organism synthetic construct AQSVAQPEDQVNVAEGNPLTVKCTYSVSGNPYLFWYVQYPNRGLQFLLKYITGDNLVKGSYGFEAEFNKSQTSFHLKKPSALVSDSALYFCAVRDIEGAGNNRKLIWGLGTSLAVNP 113 AA PAT source 1..113 mol_type protein organism synthetic construct DAGVIQSPRHEVTEMGQEVTLRCKPISGHNSLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRFSAKMPNASFSTLKIQPSEPRDSAVYFCASSEGFYTEAFFGQGTRLTVV 111 AA PAT source 1..111 mol_type protein organism synthetic construct GEDVEQSLFLSVREGDSSVINCTYTDSSMTYLYWYKQEPGAGLQLLTYIFAFESMKQDQRLTVLLNKKDKHLSLRIADTQTGDSAIYFCAGSGGGTDKLIFGTGTRLQVFP 117 AA PAT source 1..117 mol_type protein organism synthetic construct GAVVSQHPSWVICKSGTSVKIECRSLDFEATTMFWYRQFPKQSLMLMATTDYGSKATYEQGVEKDKFLINHASLTLSTLTVTSAHPEDSSFYICSAREPGQGPWEQYFGPGTRLTVT 111 AA PAT source 1..111 mol_type protein organism synthetic construct GEDVEQSLFLSVREGDSSVINCTYTDSSMTYLYWYKQEPGAGLQLLTYIFFYQDMKQDQRLTVLLNKKDKHLSLRIADTQTGDSAIYFCAGSGGGTDKLIFGTGTRLQVFP 117 AA PAT source 1..117 mol_type protein organism synthetic construct GAVVSQHPSWVICKSGTSVKIECRSLDFEATTMFWYRQFPKQSLMLMATTDYGSKATYEQGVEKDKFLINHASLTLSTLTVTSAHPEDSSFYICSAREPGQAWSDQYFGPGTRLTVT 107 AA PAT source 1..107 mol_type protein organism synthetic construct RKEVEQDPGPFNVPEGATVAFNCTYSNSASQSFFWYRQDCRKEPKLLMSVYSSGNEDGRFTAQLNRASQYISLLIRDSKLSDSATYLCVVTNARLMFGDGTQLVVKP 114 AA PAT source 1..114 mol_type protein organism synthetic construct EAQVTQNPRYLITVTGKKLTVTCSQNMNHEYMSWYRQDPGLGLRQIYYSMNVEVTDKGDVPEGYKVSRKEKNFPLILESPSPNQTSLYFCASTSIVSSGRGEQFFGPGTRLTVL 11 AA PAT source 1..11 mol_type protein organism synthetic construct ANIGGGSGGGG 9 AA PAT source 1..9 mol_type protein organism synthetic construct GGGSGGGGD 6 AA PAT source 1..6 mol_type protein organism synthetic construct NSASQS 6 AA PAT source 1..6 mol_type protein organism synthetic construct VYSSGN 13 AA PAT source 1..13 mol_type protein organism synthetic construct VVPGGTGGGNKLT 5 AA PAT source 1..5 mol_type protein organism synthetic construct LGHDT 6 AA PAT source 1..6 mol_type protein organism synthetic construct YNNKEL 12 AA PAT source 1..12 mol_type protein organism synthetic construct ASSHWGAQETQY 6 AA PAT source 1..6 mol_type protein organism synthetic construct NSASDY 7 AA PAT source 1..7 mol_type protein organism synthetic construct IRSNMDK 13 AA PAT source 1..13 mol_type protein organism synthetic construct AENSDGTSYGKLT 5 AA PAT source 1..5 mol_type protein organism synthetic construct SGHAT 6 AA PAT source 1..6 mol_type protein organism synthetic construct FQNNGV 13 AA PAT source 1..13 mol_type protein organism synthetic construct ASSLVGSPDYEQY 6 AA PAT source 1..6 mol_type protein organism synthetic construct VSGNPY 8 AA PAT source 1..8 mol_type protein organism synthetic construct YITGDNLV 15 AA PAT source 1..15 mol_type protein organism synthetic construct AVRDIEGAGNNRKLI 5 AA PAT source 1..5 mol_type protein organism synthetic construct SGHNS 6 AA PAT source 1..6 mol_type protein organism synthetic construct FNNNVP 11 AA PAT source 1..11 mol_type protein organism synthetic construct ASSEGFYTEAF 6 AA PAT source 1..6 mol_type protein organism synthetic construct DSSMTY 7 AA PAT source 1..7 mol_type protein organism synthetic construct IFAFESM 9 AA PAT source 1..9 mol_type protein organism synthetic construct AGSGGGTDK 6 AA PAT source 1..6 mol_type protein organism synthetic construct DFEATT 7 AA PAT source 1..7 mol_type protein organism synthetic construct TDYGSKA 11 AA PAT source 1..11 mol_type protein organism synthetic construct SAREPGQGPWE 6 AA PAT source 1..6 mol_type protein organism synthetic construct DSSMTY 7 AA PAT source 1..7 mol_type protein organism synthetic construct IFFYQDM 9 AA PAT source 1..9 mol_type protein organism synthetic construct AGSGGGTDK 6 AA PAT source 1..6 mol_type protein organism synthetic construct DFEATT 7 AA PAT source 1..7 mol_type protein organism synthetic construct TDYGSKA 11 AA PAT source 1..11 mol_type protein organism synthetic construct SAREPGQAWSD 112 AA PAT source 1..112 mol_type protein organism synthetic construct GEDVEQSLFLSVREGDSSVINCTYTDSSSTYLYWYKQEPGAGLQLLTYIFSNMDMKQDQRLTVLLNKKDKHLSLRIADTQTGDSAIYFCAGSGGGTDKLIFGTGTRLQVFPN 118 AA PAT source 1..118 mol_type protein organism synthetic construct GAVVSQHPSWVICKSGTSVKIECRSLDFQATTMFWYRQFPKQSLMLMATSDYQTCVTYEQGVEKDKFLINHASLTLSTLTVTSAHPEDSSFYICSAREPGQGPFEQYFGPGTRLTVTE 6 AA PAT source 1..6 mol_type protein organism synthetic construct NSASQS 6 AA PAT source 1..6 mol_type protein organism synthetic construct VYSSGN 10 AA PAT source 1..10 mol_type protein organism synthetic construct AVISAGTALI 5 AA PAT source 1..5 mol_type protein organism synthetic construct SGHDT 6 AA PAT source 1..6 mol_type protein organism synthetic construct YYEEEE 15 AA PAT source 1..15 mol_type protein organism synthetic construct ASSLGWRGGLYTEAF 109 AA PAT source 1..109 mol_type protein organism synthetic construct RKEVEQDPGPFNVPEGATVAFNCTYSNSASQSFFWYRQDCRKEPKLLMSVYSSGNEDGRFTAQLNRASQYISLLIRDSKLSDSATYLCAVISAGTALIFGKGTTLSVSS 116 AA PAT source 1..116 mol_type protein organism synthetic construct DAGVTQSPTHLIKTRGQQVTLRCSPKSGHDTVSWYQQALGQGPQFIFQYYEEEERQRGNFPDRFSGHQFPNYSSELNVNALLLGDSALYLCASSLGWRGGLYTEAFFGQGTRLTVV 6 AA PAT source 1..6 mol_type protein organism synthetic construct NSASQS 6 AA PAT source 1..6 mol_type protein organism synthetic construct VYSSGN 8 AA PAT source 1..8 mol_type protein organism synthetic construct VVTNARLM 5 AA PAT source 1..5 mol_type protein organism synthetic construct MNHEY 6 AA PAT source 1..6 mol_type protein organism synthetic construct SMNVEV 14 AA PAT source 1..14 mol_type protein organism synthetic construct ASTSIVSSGRGEQF 6 AA PAT source 1..6 mol_type protein organism synthetic construct DRGSQS 6 AA PAT source 1..6 mol_type protein organism synthetic construct IYSNGD 12 AA PAT source 1..12 mol_type protein organism synthetic construct AVNLGAAGNKLT 5 AA PAT source 1..5 mol_type protein organism synthetic construct SGHAT 6 AA PAT source 1..6 mol_type protein organism synthetic construct FQNNGV 13 AA PAT source 1..13 mol_type protein organism synthetic construct ASSFSDSYNSPLH 108 AA PAT source 1..108 mol_type protein organism synthetic construct QKEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVNLGAAGNKLTFGGGTRV 115 AA PAT source 1..115 mol_type protein organism synthetic construct EAGVAQSPRYKIIEKRQSVAFWCNPISGHATLYWYQQILGQGPKLLIQFQNNGVVDDSQLPKDRFSAERLKGVDSTLKIQPAKLEDSAVYLCASSFSDSYNSPLHFGNGTRLTVT 330 AA PAT source 1..330 mol_type protein organism synthetic construct RKEVEQDPGPFNVPEGATVAFNCTYSNSASQSFFWYRQDCRKEPKLLMSVYSSGNEDGRFTAQLNRASQYISLLIRDSKLSDSATYLCVVPGGTGGGNKLTFGTGTQLKVELANIGGGSGGGGEVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKCLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSSSQKPDPAVYQLRDSKSSDKIVCLFTDFDSQTNVSQSKDSDVYITDPCVLDMRDMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 358 AA PAT source 1..358 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGCGTKVEIKGGGSGGGGDTAVSQTPKYLVTQMGNDKSIKCEQNLGHDTMDWYKQDSKKFLKIMFSYNNKELIINETVPNRFSPKSPDKAHLNLHINSLELGDSAVYFCASSHWGAQETQYFGPGTRLLVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSADFWQDPRNHFRCQVLFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 108 AA PAT source 1..108 mol_type protein organism synthetic construct SQQGEEDPQALSIQEGENATMNCSYKTSINNLQWYRQNSGRGLVHLILIRSNEREKHSGRLRVTLDTSKKSSSLLITASRAADTASYFCATDGSTPMQFGKGTRLSVI 112 AA PAT source 1..112 mol_type protein organism synthetic construct DGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSWAQGDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSWGAPYEQYFGPGTRLTVT 122 AA PAT source 1..122 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKCLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGCGTKVEIK 10 AA PAT source 1..10 mol_type protein organism synthetic construct GGGGSGGGGS 15 AA PAT source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 231 AA PAT source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 231 AA PAT source 1..231 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK