CN 089975-8002WO01 CN 202310900474.0 2023-07-21 Visirna Therapeutics (Suzhou) Co., Ltd. ZOU, Xiaoming DOUBLE-STRANDED OLIGONUCLEOTIDE AGENTS AND USES THEREOF 194 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct acgggacagtattctcagtga 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct accagtcgtcccagaataact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct tgagcaagatttgcaacttga 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ggttaacaccatttacttcaa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ggctacgaaaatccaacctaa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct cactttaatcctctatccaga 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct cctttggaataaagctgcctt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gcaggaagcactgagattcgt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct atgcagattatgcggatcaaa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagta 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gagccgttctctacaattact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct aagcaagatatttttataata 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct tgggatttcatgtaaccaaga 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtaca 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtaca 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtaca 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtaca 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtaca 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtaca 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtaca 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtaca 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagta 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagta 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagta 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagta 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagta 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagta 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagta 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagta 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gctcaacatatttgatcagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtacg 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtacc 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgg 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgc 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ctagacctgttttgcttttgt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gtcatccacaatgagagtaca 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct accagtcgtcccagaataact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct accagtcgtcccagaataact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct aagcaagatatttttataata 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct aagcaagatatttttataata 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ggttaacaccatttacttcaa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ggttaacaccatttacttcaa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gagccgttctctacaattact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gagccgttctctacaattact 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct cattttaatcctcactctaaa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct cattttaatcctcactctaat 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct cattttaatcctcactctaat 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct cattttaatcctcactctaat 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct cattttaatcctcactctaaa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct cattttaatcctcactctaat 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ggctacgaaaatccaacctaa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct ggctacgaaaatccaacctaa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct aacagtgttcttgctctataa 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct aacagtgttcttgctctataa 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct acgatcactgagaatactgtcccgttt 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct ctgaagttattctgggacgactggtct 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct acgatcaagttgcaaatcttgctcatg 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct ccgattgaagtaaatggtgttaaccag 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct tcgattaggttggattttcgtagccgt 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct aggatctggatagaggattaaagtgag 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct ccgtaaggcagctttattccaaagggc 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct ccgaacgaatctcagtgcttcctgcac 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct tggaacaaaagcaaaacaggtctagaa 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct acgatttgatccgcataatctgcatgg 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct ccgatactgatcaaatatgttgagctt 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct gcgaagtaattgtagagaacggctcgg 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct acgttattataaaaatatcttgctttt 27 RNA PAT source 1..27 mol_type other RNA organism synthetic construct ccgatcttggttacatgaaatcccatc 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ctttgtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cattgtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ccttgtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgttgtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ctatgtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct caatgtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ccatgtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgatgtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cttagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct catagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cctagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgtagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ctaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct caaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ccaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ctttactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cattactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ccttactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgttactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ctatactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct caatactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ccatactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgatactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cttaactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cataactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cctaactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgtaactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ctaaactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct caaaactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ccaaactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaaactgatcaaatatgttgagcaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgtagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cggagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgcagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ggaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct tgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgacgtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaggtacgctcattgtggatgacga 30 RNA PAT source 1..30 mol_type other RNA organism synthetic construct ccgccgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaacaaaagcaaaacaggtctagaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgtacaaaagcaaaacaggtctagaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cggacaaaagcaaaacaggtctagaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgcacaaaagcaaaacaggtctagaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct agaacaaaagcaaaacaggtctagaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct ggtacaaaagcaaaacaggtctagaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaccaaaagcaaaacaggtctagaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgagcaaaagcaaaacaggtctagaa 30 RNA PAT source 1..30 mol_type other RNA organism synthetic construct gcttcgaacaaaagcaaaacaggtctagaa 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtacgctcattgtggatgacga 23 RNA PAT source 1..23 mol_type other RNA organism synthetic construct tgtacgctcattgtggatgacga 23 RNA PAT source 1..23 mol_type other RNA organism synthetic construct agttattctgggacgactggtct 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagttattctgggacgactggtct 23 RNA PAT source 1..23 mol_type other RNA organism synthetic construct tattataaaaatatcttgctttt 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgatattataaaaatatcttgctttt 23 RNA PAT source 1..23 mol_type other RNA organism synthetic construct ttgaagtaaatggtgttaaccag 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgattgaagtaaatggtgttaaccag 23 RNA PAT source 1..23 mol_type other RNA organism synthetic construct agtaattgtagagaacggctcgg 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaagtaattgtagagaacggctcgg 23 RNA PAT source 1..23 mol_type other RNA organism synthetic construct tttagagtgaggattaaaatgag 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaattagagtgaggattaaaatgag 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaattagagtgaggattaaaatgag 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaattagagtgaggattaaaatgag 23 RNA PAT source 1..23 mol_type other RNA organism synthetic construct tttagagtgaggattaaaatgag 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgaattagagtgaggattaaaatgag 23 RNA PAT source 1..23 mol_type other RNA organism synthetic construct ttaggtgggattttcgtagccgt 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgattaggtgggattttcgtagccgt 23 RNA PAT source 1..23 mol_type other RNA organism synthetic construct ttatagagcaagaacactgtttt 26 RNA PAT source 1..26 mol_type other RNA organism synthetic construct cgattatagagcaagaacactgtttt