FP1230867P-CB CN 2023115551720 2023-11-21 JUVENTAS CO., LTD. Jinnan Xiang CD7-TARGETING HUMANIZED ANTIBODY, CHIMERIC ANTIGEN RECEPTOR, AND USE THEREOF 40 117 AA PAT source 1..117 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPEKRLEWVSSISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPDKTVKLLIYYTSSLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIK 239 AA PAT source 1..239 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPDKTVKLLIYYTSSLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPEKRLEWVSSISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGQGTTVTVSS 351 DNA PAT source 1..351 mol_type other DNA organism synthetic construct gaggtccaactggtggagtccggcgggggcctcgtgaagcctggcggcagcctgagactgagctgcgccgcctccggcctgaccttcagcagctacgccatgagctgggtgagacaagcccccgagaagagactggagtgggtgagcagcatcagcagcggcggcttcacctactaccccgacagcgtgaagggcagattcaccatcagcagagacaacgccaagaacagcctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgctagagacgaggtgagaggctacctggacgtgtggggccaaggcaccaccgtgaccgtgagcagc 321 DNA PAT source 1..321 mol_type other DNA organism synthetic construct gacattcagatgacacagagccctagcagcctgagcgcctccgtgggcgacagagtgaccatcacctgcagcgcctcccaaggcatcagcaactacctgaactggtatcagcagaagcccgacaagaccgtgaagctgctgatctactacacaagcagcctgcacagcggcgtgcctagcagattcagcggcagcggcagcggcaccgactacaccctgaccatcagcagcctgcagcctgaggacttcgccacctactactgtcagcagtacagcaagctgccctacacatttgggggcgggaccaaactcgagattaag 15 AA PAT source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 18 AA PAT source 1..18 mol_type protein organism synthetic construct GSTSGSGKPGSGEGSTKG 5 AA PAT source 1..5 mol_type protein organism synthetic construct GGGGS 45 AA PAT source 1..45 mol_type protein organism synthetic construct TTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACD 24 AA PAT source 1..24 mol_type protein organism synthetic construct IYIWAPLAGTCGVLLLSLVITLYC 112 AA PAT source 1..112 mol_type protein organism synthetic construct RVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 42 AA PAT source 1..42 mol_type protein organism synthetic construct KRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL 21 AA PAT source 1..21 mol_type protein organism synthetic construct MALPVTALLLPLALLLHAARP 483 AA PAT source 1..483 mol_type protein organism synthetic construct MALPVTALLLPLALLLHAARPDIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPDKTVKLLIYYTSSLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPEKRLEWVSSISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGQGTTVTVSSTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 1449 DNA PAT source 1..1449 mol_type other DNA organism synthetic construct atggccttaccagtgaccgccttgctcctgccgctggccttgctgctccacgccgccaggccggacattcagatgacacagagccctagcagcctgagcgcctccgtgggcgacagagtgaccatcacctgcagcgcctcccaaggcatcagcaactacctgaactggtatcagcagaagcccgacaagaccgtgaagctgctgatctactacacaagcagcctgcacagcggcgtgcctagcagattcagcggcagcggcagcggcaccgactacaccctgaccatcagcagcctgcagcctgaggacttcgccacctactactgtcagcagtacagcaagctgccctacacatttgggggcgggaccaaactcgagattaagggcgggggcgggagcggcgggggcgggtccgggggcgggggcagcgaggtccaactggtggagtccggcgggggcctcgtgaagcctggcggcagcctgagactgagctgcgccgcctccggcctgaccttcagcagctacgccatgagctgggtgagacaagcccccgagaagagactggagtgggtgagcagcatcagcagcggcggcttcacctactaccccgacagcgtgaagggcagattcaccatcagcagagacaacgccaagaacagcctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgctagagacgaggtgagaggctacctggacgtgtggggccaaggcaccaccgtgaccgtgagcagcaccacgacgccagcgccgcgaccaccaacaccggcgcccaccatcgcgtcgcagcccctgtccctgcgcccagaggcgtgccggccagcggcggggggcgcagtgcacacgagggggctggacttcgcctgtgatatctacatctgggcgcccttggccgggacttgtggggtccttctcctgtcactggttatcaccctttactgcaaacggggcagaaagaaactcctgtatatattcaaacaaccatttatgagaccagtacaaactactcaagaggaagatggctgtagctgccgatttccagaagaagaagaaggaggatgtgaactgagagtgaagttcagcaggagcgcagacgcccccgcgtaccagcagggccagaaccagctctataacgagctcaatctaggacgaagagaggagtacgatgttttggacaagagacgtggccgggaccctgagatggggggaaagccgagaaggaagaaccctcaggaaggcctgtacaatgaactgcagaaagataagatggcggaggcctacagtgagattgggatgaaaggcgagcgccggaggggcaaggggcacgatggcctttaccagggtctcagtacagccaccaaggacacctacgacgcccttcacatgcaggccctgccccctcgc 483 AA PAT source 1..483 mol_type protein organism synthetic construct MALPVTALLLPLALLLHAARPDIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPGKAPKLLIYYTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPEKRLEWVSSISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGQGTTVTVSSTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 483 AA PAT source 1..483 mol_type protein organism synthetic construct MALPVTALLLPLALLLHAARPDIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPGKTVKLLIYYTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPGKGLEWVSSISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGQGTTVTVSSTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 483 AA PAT source 1..483 mol_type protein organism synthetic construct MALPVTALLLPLALLLHAARPDIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPGKTVKLLIYYTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPEKRLEWVSSISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGQGTTVTVSSTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 483 AA PAT source 1..483 mol_type protein organism synthetic construct MALPVTALLLPLALLLHAARPDIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPGKTVKLLIYYTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPEKRLEWVASISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGAGTTVTVSSTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 484 AA PAT source 1..484 mol_type protein organism synthetic construct MALPVTALLLPLALLLHAARPDIQMTQTTSSLSASLGDRVTISCSASQGISNYLNWYQQKPDGTVKLLIYYTSSLHSGVPSRFSGSGSGTDYSLTISNLEPEDIATYYCQQYSKLPYTFGGGTKLEIKRGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLKLSCAASGLTFSSYAMSWVRQTPEKRLEWVASISSGGFTYYPDSVKGRFTISRDNARNILYLQMSSLRSEDTAMYYCARDEVRGYLDVWGAGTTVTVSSTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 5 AA PAT source 1..5 mol_type protein organism synthetic construct SYAMS 16 AA PAT source 1..16 mol_type protein organism synthetic construct SISSGGFTYYPDSVKG 9 AA PAT source 1..9 mol_type protein organism synthetic construct DEVRGYLDV 11 AA PAT source 1..11 mol_type protein organism synthetic construct SASQGISNYLN 7 AA PAT source 1..7 mol_type protein organism synthetic construct YTSSLHS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQYSKLPYT 117 AA PAT source 1..117 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPGKGLEWVSSISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGQGTTVTVSS 117 AA PAT source 1..117 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPEKRLEWVASISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGAGTTVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPGKAPKLLIYYTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPGKTVKLLIYYTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIK 117 AA PAT source 1..117 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLKLSCAASGLTFSSYAMSWVRQTPEKRLEWVASISSGGFTYYPDSVKGRFTISRDNARNILYLQMSSLRSEDTAMYYCARDEVRGYLDVWGAGTTVTVSS 108 AA PAT source 1..108 mol_type protein organism synthetic construct DIQMTQTTSSLSASLGDRVTISCSASQGISNYLNWYQQKPDGTVKLLIYYTSSLHSGVPSRFSGSGSGTDYSLTISNLEPEDIATYYCQQYSKLPYTFGGGTKLEIKR 20 RNA PAT source 1..20 mol_type other RNA organism synthetic construct cggaaccgtctgtccgtagt 20 RNA PAT source 1..20 mol_type other RNA organism synthetic construct agagtctctcagctggtaca 239 AA PAT source 1..239 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPGKTVKLLIYYTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPEKRLEWVSSISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGQGTTVTVSS 239 AA PAT source 1..239 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSASQGISNYLNWYQQKPGKTVKLLIYYTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSKLPYTFGGGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGLTFSSYAMSWVRQAPEKRLEWVASISSGGFTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDEVRGYLDVWGAGTTVTVSS 351 DNA PAT source 1..351 mol_type other DNA organism synthetic construct gaggtccaactggtggagtccggcgggggcctcgtgaagcctggcggcagcctgagactgagctgcgccgcctccggcctgaccttcagcagctacgccatgagctgggtgagacaagcccccgagaagagactggagtgggtggcctccatcagcagcggcggcttcacctactaccccgacagcgtgaagggcagattcaccatcagcagagacaacgccaagaacagcctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgctagagacgaggtgagaggctacctggacgtgtggggcgccggcaccaccgtgaccgtgagcagc 321 DNA PAT source 1..321 mol_type other DNA organism synthetic construct gacattcagatgacacagagccctagcagcctgagcgcctccgtgggcgacagagtgaccatcacctgcagcgcctcccaaggcatcagcaactacctgaactggtatcagcagaagcccggcaagaccgtgaagctgctgatctactacacaagcagcctgcacagcggcgtgcctagcagattcagcggcagcggcagcggcaccgacttcaccctgaccatcagcagcctgcagcctgaggacttcgccacctactactgtcagcagtacagcaagctgccctacacatttgggggcgggaccaaactcgagattaag 1449 DNA PAT source 1..1449 mol_type other DNA organism synthetic construct atggccttaccagtgaccgccttgctcctgccgctggccttgctgctccacgccgccaggccggacattcagatgacacagagccctagcagcctgagcgcctccgtgggcgacagagtgaccatcacctgcagcgcctcccaaggcatcagcaactacctgaactggtatcagcagaagcccggcaagaccgtgaagctgctgatctactacacaagcagcctgcacagcggcgtgcctagcagattcagcggcagcggcagcggcaccgacttcaccctgaccatcagcagcctgcagcctgaggacttcgccacctactactgtcagcagtacagcaagctgccctacacatttgggggcgggaccaaactcgagattaagggcgggggcgggagcggcgggggcgggtccgggggcgggggcagcgaggtccaactggtggagtccggcgggggcctcgtgaagcctggcggcagcctgagactgagctgcgccgcctccggcctgaccttcagcagctacgccatgagctgggtgagacaagcccccgagaagagactggagtgggtgagcagcatcagcagcggcggcttcacctactaccccgacagcgtgaagggcagattcaccatcagcagagacaacgccaagaacagcctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgctagagacgaggtgagaggctacctggacgtgtggggccaaggcaccaccgtgaccgtgagcagcaccacgacgccagcgccgcgaccaccaacaccggcgcccaccatcgcgtcgcagcccctgtccctgcgcccagaggcgtgccggccagcggcggggggcgcagtgcacacgagggggctggacttcgcctgtgatatctacatctgggcgcccttggccgggacttgtggggtccttctcctgtcactggttatcaccctttactgcaaacggggcagaaagaaactcctgtatatattcaaacaaccatttatgagaccagtacaaactactcaagaggaagatggctgtagctgccgatttccagaagaagaagaaggaggatgtgaactgagagtgaagttcagcaggagcgcagacgcccccgcgtaccagcagggccagaaccagctctataacgagctcaatctaggacgaagagaggagtacgatgttttggacaagagacgtggccgggaccctgagatggggggaaagccgagaaggaagaaccctcaggaaggcctgtacaatgaactgcagaaagataagatggcggaggcctacagtgagattgggatgaaaggcgagcgccggaggggcaaggggcacgatggcctttaccagggtctcagtacagccaccaaggacacctacgacgcccttcacatgcaggccctgccccctcgc 1449 DNA PAT source 1..1449 mol_type other DNA organism synthetic construct atggccttaccagtgaccgccttgctcctgccgctggccttgctgctccacgccgccaggccggacattcagatgacacagagccctagcagcctgagcgcctccgtgggcgacagagtgaccatcacctgcagcgcctcccaaggcatcagcaactacctgaactggtatcagcagaagcccggcaagaccgtgaagctgctgatctactacacaagcagcctgcacagcggcgtgcctagcagattcagcggcagcggcagcggcaccgacttcaccctgaccatcagcagcctgcagcctgaggacttcgccacctactactgtcagcagtacagcaagctgccctacacatttgggggcgggaccaaactcgagattaagggcgggggcgggagcggcgggggcgggtccgggggcgggggcagcgaggtccaactggtggagtccggcgggggcctcgtgaagcctggcggcagcctgagactgagctgcgccgcctccggcctgaccttcagcagctacgccatgagctgggtgagacaagcccccgagaagagactggagtgggtggcctccatcagcagcggcggcttcacctactaccccgacagcgtgaagggcagattcaccatcagcagagacaacgccaagaacagcctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgctagagacgaggtgagaggctacctggacgtgtggggcgccggcaccaccgtgaccgtgagcagcaccacgacgccagcgccgcgaccaccaacaccggcgcccaccatcgcgtcgcagcccctgtccctgcgcccagaggcgtgccggccagcggcggggggcgcagtgcacacgagggggctggacttcgcctgtgatatctacatctgggcgcccttggccgggacttgtggggtccttctcctgtcactggttatcaccctttactgcaaacggggcagaaagaaactcctgtatatattcaaacaaccatttatgagaccagtacaaactactcaagaggaagatggctgtagctgccgatttccagaagaagaagaaggaggatgtgaactgagagtgaagttcagcaggagcgcagacgcccccgcgtaccagcagggccagaaccagctctataacgagctcaatctaggacgaagagaggagtacgatgttttggacaagagacgtggccgggaccctgagatggggggaaagccgagaaggaagaaccctcaggaaggcctgtacaatgaactgcagaaagataagatggcggaggcctacagtgagattgggatgaaaggcgagcgccggaggggcaaggggcacgatggcctttaccagggtctcagtacagccaccaaggacacctacgacgcccttcacatgcaggccctgccccctcgc