CN IEC220557PCT CN 202310082754.5 2023-01-17 BAILI-BIO (CHENGDU) PHARMACEUTICAL CO., LTD. CONJUGATE OF ERIBULIN DRUG 30 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASQDINKYLA 7 AA PAT source 1..7 mol_type protein organism synthetic construct STSTLQS 8 AA PAT source 1..8 mol_type protein organism synthetic construct LQYDDLFT 5 AA PAT source 1..5 mol_type protein organism synthetic construct SFDIN 17 AA PAT source 1..17 mol_type protein organism synthetic construct WIFPGDGNTKYSQKFQG 9 AA PAT source 1..9 mol_type protein organism synthetic construct GEALYYFDY 106 AA PAT source 1..106 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDINKYLAWYQQKPGKVPKLLIYSTSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQYDDLFTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 213 AA PAT source 1..213 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDINKYLAWYQQKPGKVPKLLIYSTSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQYDDLFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 106 AA PAT source 1..106 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDINKYLAWYQQKPGKVPKLLIYSTSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQYDDLFTFGQGTKLEIK 108 AA PAT source 1..108 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVCTKSFNRGEC 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDINKYLAWYQQKPGKVPKLLIYSTSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQYDDLFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVCTKSFNRGEC 118 AA PAT source 1..118 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKLSCKASGYTFTSFDINWVRQAPEQRLEWMGWIFPGDGNTKYSQKFQGRATITRDTSASTAYMELSSLRSEDTAVYYCVRGEALYYFDYWGQGTLVTVSS 329 AA PAT source 1..329 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 447 AA PAT source 1..447 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKLSCKASGYTFTSFDINWVRQAPEQRLEWMGWIFPGDGNTKYSQKFQGRATITRDTSASTAYMELSSLRSEDTAVYYCVRGEALYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 33 DNA PAT source 1..33 mol_type other DNA organism synthetic construct agagcttctcaggatatcaataagtatctggct 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct tctacatctaccctgcagtct 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct ctgcagtatgatgatctgttcacc 15 DNA PAT source 1..15 mol_type other DNA organism synthetic construct tccttcgacattaac 51 DNA PAT source 1..51 mol_type other DNA organism synthetic construct tggatcttccccggcgacggcaacaccaagtactcccagaagttccaggga 27 DNA PAT source 1..27 mol_type other DNA organism synthetic construct ggagaggctctgtactattttgattat 318 DNA PAT source 1..318 mol_type other DNA organism synthetic construct gatatccagatgacccagtctccatctagcctgtccgcttctgtgggcgatagagtgaccatcacatgcagagcttctcaggatatcaataagtatctggcttggtatcagcagaagcctggaaaggtgcctaagctgctgatctactctacatctaccctgcagtctggagtgccttctagattttctggatctggctctggcaccgattttacactgacaatctcttctctgcagcctgaggatgtggctacatattattgtctgcagtatgatgatctgttcacctttggccagggcaccaagctggagatcaag 324 DNA PAT source 1..324 mol_type other DNA organism synthetic construct cgtacggtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttag 642 DNA PAT source 1..642 mol_type other DNA organism synthetic construct gatatccagatgacccagtctccatctagcctgtccgcttctgtgggcgatagagtgaccatcacatgcagagcttctcaggatatcaataagtatctggcttggtatcagcagaagcctggaaaggtgcctaagctgctgatctactctacatctaccctgcagtctggagtgccttctagattttctggatctggctctggcaccgattttacactgacaatctcttctctgcagcctgaggatgtggctacatattattgtctgcagtatgatgatctgttcacctttggccagggcaccaagctggagatcaagcgtacggtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttag 318 DNA PAT source 1..318 mol_type other DNA organism synthetic construct gatatccagatgacccagtctccatctagcctgtccgcttctgtgggcgatagagtgaccatcacatgcagagcttctcaggatatcaataagtatctggcttggtatcagcagaagcctggaaaggtgcctaagctgctgatctactctacatctaccctgcagtctggagtgccttctagattttctggatctggctctggcaccgattttacactgacaatctcttctctgcagcctgaggatgtggctacatattattgtctgcagtatgatgatctgttcacctttggccagggcaccaagctggagatcaag 327 DNA PAT source 1..327 mol_type other DNA organism synthetic construct cgtacggtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtctgtacaaagagcttcaacaggggagagtgttag 645 DNA PAT source 1..645 mol_type other DNA organism synthetic construct gatatccagatgacccagtctccatctagcctgtccgcttctgtgggcgatagagtgaccatcacatgcagagcttctcaggatatcaataagtatctggcttggtatcagcagaagcctggaaaggtgcctaagctgctgatctactctacatctaccctgcagtctggagtgccttctagattttctggatctggctctggcaccgattttacactgacaatctcttctctgcagcctgaggatgtggctacatattattgtctgcagtatgatgatctgttcacctttggccagggcaccaagctggagatcaagcgtacggtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtctgtacaaagagcttcaacaggggagagtgttag 354 DNA PAT source 1..354 mol_type other DNA organism synthetic construct caggtgcagctggtgcagtccggcgccgaggtgaagaagcccggcgcctccgtgaagctgagctgtaaggcctccggctacaccttcacctccttcgacattaactgggtgcggcaggcccccgagcagcgcctggagtggatgggctggatcttccccggcgacggcaacaccaagtactcccagaagttccagggaagagctaccatcaccagagatacatccgcttctacagcttacatggagctgtctagcctgagatctgaggatacagctgtgtattactgtgtgagaggagaggctctgtactattttgattattggggccagggcaccctggtgacagtgtcttct 990 DNA PAT source 1..990 mol_type other DNA organism synthetic construct gctagcaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagagagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggatgagctgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctatagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggttaa 1344 DNA PAT source 1..1344 mol_type other DNA organism synthetic construct caggtgcagctggtgcagtccggcgccgaggtgaagaagcccggcgcctccgtgaagctgagctgtaaggcctccggctacaccttcacctccttcgacattaactgggtgcggcaggcccccgagcagcgcctggagtggatgggctggatcttccccggcgacggcaacaccaagtactcccagaagttccagggaagagctaccatcaccagagatacatccgcttctacagcttacatggagctgtctagcctgagatctgaggatacagctgtgtattactgtgtgagaggagaggctctgtactattttgattattggggccagggcaccctggtgacagtgtcttctgctagcaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagagagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggatgagctgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctatagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggttaa