WO 75FS-341524-WO2 WO PCT/CN2021/124182 2021-10-15 Concept to Medicine Biotech Co., Ltd. ANTI-GLYPICAN 3 ANTIBODIES 76 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVTLSCKASGYTFSDYEMHWVKQTPVHGLEWIGAIDPETGGTAYNQKFKGKATLTADKSSSTAYMELRSLTSEDSAVYYCTRYYSYAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQSPLSLPVSLGDQASISCRSRQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCFQSIHVPYTFGGGTKLEKK 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVKLSCKALGYTFTDYEMHWVKQTPVHGLEWIGAIHPGSGGTAYNQKFKGKATLTADKFSSTGYMELSSLTSEDSAVYYCTRFYSYAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFILKISRVEAEDLGVYFCSQSIHVPYTFGGGTKLEIK 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVTLSCKASGYTFTDYEMHWVKQTPVHGLEWIGAIGPETGSTAYNQRFKGKAIVTADKSSSTAYMELRSLTSEDSAVYYCTRYYSFAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLPVSLGGQASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIFKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCFQSIHVPYTFGGGTKLEIK 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVTLSCKASGYTFTDYEIHWVKQTPVHGLEWIGAIDPATGDTAYTQKFKGKAILTADTSSNTVYMELRGLTSEDSAVHFCTRFYSYAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSLVHTNGHTYLQWYLQKSGQSPRLLIFKVSNRFSGVPDRFSGSGSGTDFKLKISRVEAEDLGVYFCSQSTHVPYTFGGGTKLEIK 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVTLSCKASGYTFTDYEIHWVKQTPVHGLEWIGAIDPETGDTAYTQKFKGKAILTADKSSNTVYMELRSLTSEDSAVYYCTRFYSYAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSLVHTNGHTYLQWYLQKSGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPYTFGGGTKLEIK 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVTLSCKASGYTFTDYEIHWVKQTPVHGLEWIGAIDPETDNTAYSQKFKGKAILTADKSSSTAYMELRSLTSEDSAVYYCTRYYSYAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSPVHRNGNTYLHWYLQKPGQSPKLLIFKVSNRFSGVPDRFSGSGSGTDFTLKISRVAAEDLGVYFCSQTTHVPYTFGGGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYEMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIDPETGGTAYNQKFKG 6 AA PAT source 1..6 mol_type protein organism synthetic construct YYSYAY 16 AA PAT source 1..16 mol_type protein organism synthetic construct RSRQSLVHSNGNTYLQ 7 AA PAT source 1..7 mol_type protein organism synthetic construct KVSNRFS 9 AA PAT source 1..9 mol_type protein organism synthetic construct FQSIHVPYT 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIHPGSGGTAYNQKFKG 6 AA PAT source 1..6 mol_type protein organism synthetic construct FYSYAY 16 AA PAT source 1..16 mol_type protein organism synthetic construct RSSQSLVHSNGNTYLQ 9 AA PAT source 1..9 mol_type protein organism synthetic construct SQSIHVPYT 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIGPETGSTAYNQRFKG 6 AA PAT source 1..6 mol_type protein organism synthetic construct YYSFAY 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYEIH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIDPATGDTAYTQKFKG 16 AA PAT source 1..16 mol_type protein organism synthetic construct RSSQSLVHTNGHTYLQ 9 AA PAT source 1..9 mol_type protein organism synthetic construct SQSTHVPYT 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIDPETGDTAYTQKFKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIDPETDNTAYSQKFKG 16 AA PAT source 1..16 mol_type protein organism synthetic construct RSSQSPVHRNGNTYLH 9 AA PAT source 1..9 mol_type protein organism synthetic construct SQTTHVPYT 6 AA PAT source 1..6 mol_type protein organism synthetic construct FYSFAY 9 AA PAT source 1..9 mol_type protein organism synthetic construct FQSTHVPYT 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVKLSCKALGYTFTDYEMHWVKQTPVHGLEWIGAIHPGSGGTAYNQKFKGKATLTADKFSSTGYMELSSLTSEDSAVYYCTRYYSYAYWGQGTLVTVSA 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWMGAIHPGSGGTAYNQKFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYYSYAYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWIGAIHPGSGGTAYNQKFKGRVTMTADTSTSTVYMELSSLRSEDTAVYYCTRYYSYAYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKALGYTFTDYEMHWVKQAPGQGLEWIGAIHPGSGGTAYNQKFKGRVTLTADTSTSTVYMELSSLRSEDTAVYYCTRYYSYAYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKALGYTFTDYEMHWVKQAPGQGLEWIGAIHPGSGGTAYNQKFKGRATMTADKFTSTVYMELSSLRSEDTAVYYCTRYYSYAYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFILKISRVEAEDLGVYFCFQSIHVPYTFGGGTKLEIK 112 AA PAT source 1..112 mol_type protein organism synthetic construct DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQSIHVPYTFGGGTKLEIK 112 AA PAT source 1..112 mol_type protein organism synthetic construct DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCFQSIHVPYTFGGGTKLEIK 112 AA PAT source 1..112 mol_type protein organism synthetic construct DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQSIHVPYTFGGGTKLEIK 112 AA PAT source 1..112 mol_type protein organism synthetic construct DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCFQSIHVPYTFGGGTKLEIK 115 AA PAT source 1..115 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWMGAIHPGSGGTAYNQKFKGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARFYSYAYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWMGAIHPGSGGTAYNQKFKGRVTMTRDTSISTAYMELSRLRSDDTAVYYCTRFYSYAYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWMGAIHPGSGGTAYNQKFKGRVTMTADTSISTAYMELSRLRSDDTAVYYCTRFYSYAYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWMGAIHPGSGGTAYNQKFKGRVTMTADKSISTAYMELSRLRSDDTAVYYCTRFYSYAYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWIGAIHPGSGGTAYNQKFKGRVTLTADKSISTAYMELSRLRSDDTAVYYCTRFYSYAYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWIGAIHPGSGGTAYNQKFKGKATLTADKSISTAYMELSRLRSDDTAVYYCTRFYSYAYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSIHVPYTFGGGTKVEIK 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCSQSIHVPYTFGGGTKVEIK 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTRYEMHWVRQAPGQGLEWIGAIHPGSGGTAYNSKFKGRVTMTADTSTSTVYMELSSLRSEDTAVYYCTRYYSYAYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRYSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCVESIHVPYTFGGGTKLEIK 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYEMHWVRQAPGQGLEWIGAIHPGSGGTAYNQKFKGRVTMTADTSTSTVYMELSSLRSEDTAVYYCTRYYSYAYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRFAGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCVESIHVPYTFGGGTKLEIK 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYRFTDYEMHWVRQAPGQGLEWIGAIHPGSGGTAYNQLFKGRVTMTADTSTSTVYMELSSLRSEDTAVYYCTRYYSYAYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRFPGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCVESIHVPYTFGGGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct RYEMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIHPGSGGTAYNSKFKG 7 AA PAT source 1..7 mol_type protein organism synthetic construct KVSNRYS 9 AA PAT source 1..9 mol_type protein organism synthetic construct VESIHVPYT 5 AA PAT source 1..5 mol_type protein organism synthetic construct GYEMH 7 AA PAT source 1..7 mol_type protein organism synthetic construct KVSNRFA 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIHPGSGGTAYNQLFKG 7 AA PAT source 1..7 mol_type protein organism synthetic construct KVSNRFP 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVKLSCKALGYTFTDYEMHWVKQTPVHGLEWIGAIHPGSGGTAYNQKFKGKATLTADKFSSTGYMELSSLTSEDSAVYYCTRFYSFAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFILKISRVEAEDLGVYFCSQSTHVPYTFGGGTKLEIK 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLQQSGAELVRPGASVKLSCKALGYTFTDYEMHWVKQTPVHGLEWIGAIHPGSGGTAYNQKFKGKATLTADKFSSTGYMELSSLTSEDSAVYYCTRYYSFAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLQWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFILKISRVEAEDLGVYFCFQSTHVPYTFGGGTKLEIK 000 17 AA PAT source 1..17 mol_type protein organism synthetic construct VARIANT 3 note X is D, G, or H VARIANT 5 note X is A, E or G VARIANT 6 note X is S or T VARIANT 7 note X is D or G VARIANT 8 note X is D, G, N or S VARIANT 12 note N, S or T VARIANT 13 note X is Q or S VARIANT 14 note X is R, K or L AIXPXXXXTAYXXXFKG 6 AA PAT source 1..6 mol_type protein organism synthetic construct VARIANT 1 note F or Y VARIANT 4 note X is F or Y XYSXAY 16 AA PAT source 1..16 mol_type protein organism synthetic construct VARIANT 3 note X is R or S VARIANT 6 note X is L or P VARIANT 9 note X is S, R or T VARIANT 12 note X is H or N VARIANT 16 note X is H or Q RSXQSXVHXNGXTYLX 7 AA PAT source 1..7 mol_type protein organism synthetic construct VARIANT 6 note X is F or Y VARIANT 7 note X is S, A or P KVSNRXX 9 AA PAT source 1..9 mol_type protein organism synthetic construct VARIANT 1 note X is F, S or V VARIANT 2 note X is Q or E VARIANT 3 note X is S or T VARIANT 4 note X is I or T XXXXHVPYT