0282-0002WO1 US 63/594,987 2023-11-01 IMMUNOCORE LIMITED PATEL, Viren METHOD FOR PURIFYING SMALL MULTI-DOMAIN PROTEINS 54 9 AA PAT REGION 1..9 note Synthetic source 1..9 mol_type protein organism synthetic construct SLLQHLIGL 115 AA PAT REGION 1..115 note Synthetic source 1..115 mol_type protein organism synthetic construct GDAKTTQPNSMESNEEEPVHLPCQHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILILGHSRLGNYIATFGKGTKLSVIP 7 AA PAT REGION 1..7 note Synthetic source 1..7 mol_type protein organism synthetic construct TISGTDY 5 AA PAT REGION 1..5 note Synthetic source 1..5 mol_type protein organism synthetic construct GLTSN 17 AA PAT REGION 1..17 note Synthetic source 1..17 mol_type protein organism synthetic construct CILILGHSRLGNYIATF 17 AA PAT REGION 1..17 note Synthetic source 1..17 mol_type protein organism synthetic construct IHWYRQLPSQGPEYVIH 33 AA PAT REGION 1..33 note Synthetic source 1..33 mol_type protein organism synthetic construct VNNRMASLAIAEDRKSSTLILHRATLRDAAVYY 113 AA PAT REGION 1..113 note Synthetic source 1..113 mol_type protein organism synthetic construct DGGITQSPKYLFRKEGQNVTLSCEQNLNHDAYWYRQDPGQGLRLIYYSQIMGDEQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSWWTGGASPIRFGPGTRLTVT 5 AA PAT REGION 1..5 note Synthetic source 1..5 mol_type protein organism synthetic construct LNHDA 7 AA PAT REGION 1..7 note Synthetic source 1..7 mol_type protein organism synthetic construct SQIMGDE 15 AA PAT REGION 1..15 note Synthetic source 1..15 mol_type protein organism synthetic construct CASSWWTGGASPIRF 17 AA PAT REGION 1..17 note Synthetic source 1..17 mol_type protein organism synthetic construct MYWYRQDPGQGLRLIYY 35 AA PAT REGION 1..35 note Synthetic source 1..35 mol_type protein organism synthetic construct QKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYL 201 AA PAT REGION 1..201 note Synthetic source 1..201 mol_type protein organism synthetic construct GDAKTTQPNSMESNEEEPVHLPCQHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILILGHSRLGNYIATFGKGTKLSVIPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTQVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSQKSDFACANAFQNSIIPEDT 86 AA PAT REGION 1..86 note Synthetic source 1..86 mol_type protein organism synthetic construct NIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTQVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSQKSDFACANAFQNSIIPEDT 244 AA PAT REGION 1..244 note Synthetic source 1..244 mol_type protein organism synthetic construct DGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIMGDEQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSWWTGGASPIRFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALQDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 253 AA PAT REGION 1..253 note Synthetic source 1..253 mol_type protein organism synthetic construct AIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIKGGGGSGGGGSGGGGSGGGGSGGGSEVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 5 AA PAT REGION 1..5 note Synthetic source 1..5 mol_type protein organism synthetic construct GGGGS 130 AA PAT REGION 1..130 note Synthetic source 1..130 mol_type protein organism synthetic construct EDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALQDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 5 AA PAT REGION 1..5 note Synthetic source 1..5 mol_type protein organism synthetic construct GGGSG 5 AA PAT REGION 1..5 note Synthetic source 1..5 mol_type protein organism synthetic construct GGSGG 5 AA PAT REGION 1..5 note Synthetic source 1..5 mol_type protein organism synthetic construct GSGGG 6 AA PAT REGION 1..6 note Synthetic source 1..6 mol_type protein organism synthetic construct GSGGGP 5 AA PAT REGION 1..5 note Synthetic source 1..5 mol_type protein organism synthetic construct GGEPS 7 AA PAT REGION 1..7 note Synthetic source 1..7 mol_type protein organism synthetic construct GGEGGGP 12 AA PAT REGION 1..12 note Synthetic source 1..12 mol_type protein organism synthetic construct GGEGGGSEGGGS 26 AA PAT REGION 1..26 note Synthetic source 1..26 mol_type protein organism synthetic construct GDAKTTQPNSMESNEEEPVHLPCQHS 10 AA PAT REGION 1..10 note Synthetic source 1..10 mol_type protein organism synthetic construct GKGTKLSVIP 26 AA PAT REGION 1..26 note Synthetic source 1..26 mol_type protein organism synthetic construct DGGITQSPKYLFRKEGQNVTLSCEQN 9 AA PAT REGION 1..9 note Synthetic source 1..9 mol_type protein organism synthetic construct GPGTRLTVT 107 AA PAT REGION 1..107 note Synthetic source 1..107 mol_type protein organism synthetic construct AIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIK 122 AA PAT REGION 1..122 note Synthetic source 1..122 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 6 AA PAT REGION 1..6 note Synthetic source 1..6 mol_type protein organism synthetic construct QDIRNY 000 9 AA PAT REGION 1..9 note Synthetic source 1..9 mol_type protein organism synthetic construct QQGNTLPWT 8 AA PAT REGION 1..8 note Synthetic source 1..8 mol_type protein organism synthetic construct GYSFTGYT 8 AA PAT REGION 1..8 note Synthetic source 1..8 mol_type protein organism synthetic construct INPYKGVS 15 AA PAT REGION 1..15 note Synthetic source 1..15 mol_type protein organism synthetic construct ARSGYYGDSDWYFDV 24 AA PAT REGION 1..24 note Synthetic source 1..24 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGSGGGS 253 AA PAT REGION 1..253 note Synthetic source 1..253 mol_type protein organism synthetic construct AIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIKGGGGSGGGGSGGGGSGGGGSGGGSEVQLVESGGGLVQPGGSLRLSCAASGYSFTGYAMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTFSVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 122 AA PAT REGION 1..122 note Synthetic source 1..122 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYAMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTFSVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 216 AA PAT REGION 1..216 note Synthetic source 1..216 mol_type protein organism synthetic construct APELLGGPSVFLFPPKPKDTLMISRTPEVTCVWDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 216 AA PAT REGION 1..216 note Synthetic source 1..216 mol_type protein organism synthetic construct APELLGGPSVFLFPPKPKDTLMISRTPEVTCVWDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 15 AA PAT REGION 1..15 note Synthetic source 1..15 mol_type protein organism synthetic construct EPKSSDKTHTCPPCP 1191 AA PAT REGION 1..1191 note Synthetic source 1..1191 mol_type protein organism synthetic construct AIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIKGGGGSGGGGSGGGGSGGGGSGGGSEVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSSGGGGSDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIMGDEQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSWWTGGASPIRFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALQDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADGGGSGGGGEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGSGGGGGDAKTTQPNSMESNEEEPVHLPCQHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILILGHSRLGNYIATFGKGTKLSVIPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTQVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSQKSDFACANAFQNSIIPEDTGGGSGGGGEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 1191 AA PAT REGION 1..1191 note Synthetic source 1..1191 mol_type protein organism synthetic construct AIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIKGGGGSGGGGSGGGGSGGGGSGGGSEVQLVESGGGLVQPGGSLRLSCAASGYSFTGYAMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTFSVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSSGGGGSDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIMGDEQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSWWTGGASPIRFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALQDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADGGGSGGGGEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGSGGGGGDAKTTQPNSMESNEEEPVHLPCQHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILILGHSRLGNYIATFGKGTKLSVIPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTQVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSQKSDFACANAFQNSIIPEDTGGGSGGGGEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 8 AA PAT REGION 1..8 note Synthetic source 1..8 mol_type protein organism synthetic construct GGGSGGGG 8 AA PAT REGION 1..8 note Synthetic source 1..8 mol_type protein organism synthetic construct GYSFTGYA 15 AA PAT REGION 1..15 note Synthetic source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 5 AA PAT REGION 1..5 note Synthetic source 1..5 mol_type protein organism synthetic construct EAAAK 15 AA PAT REGION 1..15 note Synthetic source 1..15 mol_type protein organism synthetic construct EAAAKEAAAKEAAAK 10 AA PAT REGION 1..10 note Synthetic source 1..10 mol_type protein organism synthetic construct DKTHTCPPCP 12 AA PAT REGION 1..12 note Synthetic source 1..12 mol_type protein organism synthetic construct ESKYGPPCPSCP 216 AA PAT source 1..216 mol_type protein organism Homo sapiens APELLGGPSVFLFPPKPKDTLMISRTPEVTCVWDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK