IEC240254PCT CN 202311141587.3 2023-09-05 SHANGHAI MIRACOGEN INC. ANTIBODY DRUG CONJUGATE TARGETING GPC3 AND USE THEREOF 50 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYEMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIHPGSGGTAYNQKFKG 6 AA PAT source 1..6 mol_type protein organism synthetic construct FYSYAY 30 AA PAT source 1..30 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTFT 14 AA PAT source 1..14 mol_type protein organism synthetic construct WVRQAPGQGLEWMG 32 AA PAT source 1..32 mol_type protein organism synthetic construct RVTMTADKSISTAYMELSRLRSDDTAVYYCTR 11 AA PAT source 1..11 mol_type protein organism synthetic construct WGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWMGAIHPGSGGTAYNQKFKGRVTMTADKSISTAYMELSRLRSDDTAVYYCTRFYSYAYWGQGTLVTVSS 16 AA PAT source 1..16 mol_type protein organism synthetic construct RSSQSLVHSNGNTYLQ 7 AA PAT source 1..7 mol_type protein organism synthetic construct KVSNRFS 9 AA PAT source 1..9 mol_type protein organism synthetic construct SQSIHVPYT 23 AA PAT source 1..23 mol_type protein organism synthetic construct DVVMTQTPLSLSVTPGQPASISC 15 AA PAT source 1..15 mol_type protein organism synthetic construct WYLQKPGQSPQLLIY 32 AA PAT source 1..32 mol_type protein organism synthetic construct GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYC 10 AA PAT source 1..10 mol_type protein organism synthetic construct FGGGTKVEIK 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSIHVPYTFGGGTKVEIK 32 AA PAT source 1..32 mol_type protein organism synthetic construct GVPDRFSGSGSGTDFTLKISRVEAEDVGVYFC 112 AA PAT source 1..112 mol_type protein organism synthetic construct DVVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCSQSIHVPYTFGGGTKVEIK 330 AA PAT source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYEMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct ALDPKTGDTAYSQKFKG 6 AA PAT source 1..6 mol_type protein organism synthetic construct FYSYTY 16 AA PAT source 1..16 mol_type protein organism synthetic construct RSSQSLVHSNGNTYLH 7 AA PAT source 1..7 mol_type protein organism synthetic construct KVSNRFS 9 AA PAT source 1..9 mol_type protein organism synthetic construct SQNTHVPPT 30 AA PAT source 1..30 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFT 14 AA PAT source 1..14 mol_type protein organism synthetic construct WVRQAPGQGLEWMG 32 AA PAT source 1..32 mol_type protein organism synthetic construct RVTLTADKSTSTAYMELSSLTSEDTAVYYCTR 11 AA PAT source 1..11 mol_type protein organism synthetic construct WGQGTLVTVSS 23 AA PAT source 1..23 mol_type protein organism synthetic construct DVVMTQSPLSLPVTPGEPASISC 15 AA PAT source 1..15 mol_type protein organism synthetic construct WYLQKPGQSPQLLIY 32 AA PAT source 1..32 mol_type protein organism synthetic construct GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYC 10 AA PAT source 1..10 mol_type protein organism synthetic construct FGQGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYEMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIHPGSGDTAYNQRFKG 6 AA PAT source 1..6 mol_type protein organism synthetic construct FYSYAY 30 AA PAT source 1..30 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTHS 14 AA PAT source 1..14 mol_type protein organism synthetic construct WVRQAPGQGLEWMG 32 AA PAT source 1..32 mol_type protein organism synthetic construct RVTITADKSTSTAYMELSSLRSEDTAVYYCAR 11 AA PAT source 1..11 mol_type protein organism synthetic construct WGQGTLVTVSA 115 AA PAT source 1..115 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTHSDYEMHWVRQAPGQGLEWMGAIHPGSGDTAYNQRFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARFYSYAYWGQGTLVTVSA 16 AA PAT source 1..16 mol_type protein organism synthetic construct RSSQSLVHSNGNTYLQ 7 AA PAT source 1..7 mol_type protein organism synthetic construct KVSNRFS 9 AA PAT source 1..9 mol_type protein organism synthetic construct SQSIYVPYT 23 AA PAT source 1..23 mol_type protein organism synthetic construct DIVMTQTPLSLPVTPGEPASISC 19 AA PAT source 1..19 mol_type protein organism synthetic construct WYLQWYLQKPGQSPQLLIY 32 AA PAT source 1..32 mol_type protein organism synthetic construct GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYC 11 AA PAT source 1..11 mol_type protein organism synthetic construct FGQGTKLEIKR 117 AA PAT source 1..117 mol_type protein organism synthetic construct DIVMTQTPLSLPVTPGEPASISCRSSQSLVHSNGNTYLQWYLQWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSIYVPYTFGQGTKLEIKR