WO PCT/CN2023/075448 2023-02-10 723018CPCT CN CN202210127604.7 2022-02-11 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Jiangsu Hengrui Pharmaceuticals Co., Ltd. IMMUNOCONJUGATE AND USE THEREOF 109 288 AA PAT source 1..288 mol_type protein note PD-1 organism Homo sapiens MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL 122 AA PAT source 1..122 mol_type protein note A6 variable region organism synthetic construct EVQLVESGGGLVQAGGSLRLSCAVSGRTFSSAAMGWFRQAPGKEREFVAAISWSFGSTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAADPSIETMGGGWDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17 variable region organism synthetic construct EVQVVESGGGLVQPGGSLRLSCVASGLTFSDYSMSWYRQAPGKERELVAIISGSGVIAHYVDSVKGRFTISRDNAKSTVYLQMVSLKPEDRGVYYCRAVSDWDDYWGQGTQVTVSS 5 AA PAT source 1..5 mol_type protein note A6 CDR1 organism synthetic construct SAAMG 16 AA PAT source 1..16 mol_type protein note A6 CDR2 organism synthetic construct ISWSFGSTYYADSVKG 13 AA PAT source 1..13 mol_type protein note A6 CDR3 organism synthetic construct DPSIETMGGGWDY 5 AA PAT source 1..5 mol_type protein note A17 CDR1 organism synthetic construct DYSMS 17 AA PAT source 1..17 mol_type protein note A17 CDR1 organism synthetic construct IISGSGVIAHYVDSVKG 7 AA PAT source 1..7 mol_type protein note A17 CDR3 organism synthetic construct VSDWDDY 229 AA PAT source 1..229 mol_type protein note hIgG4 organism synthetic construct ESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 351 AA PAT source 1..351 mol_type protein note A6_hIgG4 organism synthetic construct EVQLVESGGGLVQAGGSLRLSCAVSGRTFSSAAMGWFRQAPGKEREFVAAISWSFGSTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAADPSIETMGGGWDYWGQGTQVTVSSESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 345 AA PAT source 1..345 mol_type protein note A17_ hIgG4 organism synthetic construct EVQVVESGGGLVQPGGSLRLSCVASGLTFSDYSMSWYRQAPGKERELVAIISGSGVIAHYVDSVKGRFTISRDNAKSTVYLQMVSLKPEDRGVYYCRAVSDWDDYWGQGTQVTVSSESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 116 AA PAT source 1..116 mol_type protein note A17h1 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17h2 variable region organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWVRQAPGKGLEWVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCRAVSDWDDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17h3 variable region organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWVRQAPGKGLEWVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCRAVSDWDEYWGQGTQVTVSS 122 AA PAT source 1..122 mol_type protein note A6h1 variable region organism synthetic construct EVQLLESGGGLVQAGGSLRLSCATSGRTFSSAAMGWFRQAPGKGLEWVAAISWSFGSTYYADSVKGRFTISRDNSKNTVYLQMNSLRPEDTAVYYCAADPSIETMGGGWDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m01 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m02 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m03 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGGIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m04 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVSAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m05 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m06 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDEYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m07 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m08 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWDEYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m09 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m10 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWDEYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m11 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGGIAHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m12 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGGIAHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWDEYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m13 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVSAHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m14 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVSAHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWDEYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m15 variable region organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGGITHYVDSVKGRFTISRDNAKNTVYLQMRSLTPEDRAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m0901 variable region organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m0902 variable region organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m0903 variable region organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTVYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m0905 variable region organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTVYLQMRSLRAEDRAVYYCRAVSDWEDYWGQGTQVTVSS 17 AA PAT source 1..17 mol_type protein organism synthetic construct VARIANT 7 note X is selected from the group consisting of V and G VARIANT 8 note X is selected from the group consisting of I and S VARIANT 9 note X is selected from the group consisting of T and A IISGSGXXXHYVDSVKG 7 AA PAT source 1..7 mol_type protein organism synthetic construct VARIANT 5 note X is selected from the group consisting of D and E VARIANT 6 note X is selected from the group consisting of D and E VSDWXXY 17 AA PAT source 1..17 mol_type protein note CDR2 organism synthetic construct IISGSGVITHYVDSVKG 17 AA PAT source 1..17 mol_type protein note CDR2 organism synthetic construct IISGSGGIAHYVDSVKG 17 AA PAT source 1..17 mol_type protein note CDR2 organism synthetic construct IISGSGVSAHYVDSVKG 7 AA PAT source 1..7 mol_type protein note CDR3 organism synthetic construct VSDWEDY 7 AA PAT source 1..7 mol_type protein note CDR3 organism synthetic construct VSDWDEY 495 AA PAT source 1..495 mol_type protein note The Knob chain of A-V91T organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTEMLTAKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINTIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 346 AA PAT source 1..346 mol_type protein note The Hole chain of A-V91T organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSP 621 AA PAT source 1..621 mol_type protein note The Knob chain of B-V91T organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSSGGGGSGGGGSEVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTEMLTAKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINTIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 472 AA PAT source 1..472 mol_type protein note The Hole chain of B-V91T organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSSGGGGSGGGGSEVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSP 597 AA PAT source 1..597 mol_type protein note The Knob chain of C-V91T organism synthetic construct QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTEMLTAKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINTIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 218 AA PAT source 1..218 mol_type protein note The light chain of C-V91T organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 723 AA PAT source 1..723 mol_type protein note The Knob chain of E-V91T organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSSGGGGSGGGGSQVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTEMLTAKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINTIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 574 AA PAT source 1..574 mol_type protein note The Hole chain of E-V91T organism synthetic construct EVQLQESGGGLVQPGGSLRLSCTASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVIAHYVDSVKGRFTISRDNSKNTVYLQMRSLTPEDRAVYYCRAVSDWDDYWGQGTQVTVSSGGGGSGGGGSQVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSP 369 AA PAT source 1..369 mol_type protein note The Knob chain of F-V91T organism synthetic construct APASSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTEMLTAKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINTIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLTGGGGSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 218 AA PAT source 1..218 mol_type protein note The Fab heavy chain of pembrolizumab organism synthetic construct QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 218 AA PAT source 1..218 mol_type protein note The Fab light chain of pembrolizumab organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT source 1..5 mol_type protein note The HCDR1 of pembrolizumab organism synthetic construct NYYMY 17 AA PAT source 1..17 mol_type protein note The HCDR2 of pembrolizumab organism synthetic construct GINPSNGGTNFNEKFKN 11 AA PAT source 1..11 mol_type protein note The HCDR3 of pembrolizumab organism synthetic construct RDYRFDMGFDY 15 AA PAT source 1..15 mol_type protein note The LCDR1 of pembrolizumab organism synthetic construct RASKGVSTSGYSYLH 7 AA PAT source 1..7 mol_type protein note The LCDR2 of pembrolizumab organism synthetic construct LASYLES 9 AA PAT source 1..9 mol_type protein note The LCDR3 of pembrolizumab organism synthetic construct QHSRDLPLT 133 AA PAT source 1..133 mol_type protein note IL-2v(V91T) organism synthetic construct APASSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTEMLTAKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINTIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 133 AA PAT source 1..133 mol_type protein note The IL-2 sequence in A-PC organism synthetic construct APASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 133 AA PAT source 1..133 mol_type protein note The IL-2 sequence in A-V91T-02 organism synthetic construct APASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISNINTIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 133 AA PAT source 1..133 mol_type protein note The IL-2 sequence in A-D20A organism synthetic construct APASSSTKKTQLQLEHLLLALQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 133 AA PAT source 1..133 mol_type protein note The IL-2 sequence in A-D20N organism synthetic construct APASSSTKKTQLQLEHLLLNLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 133 AA PAT source 1..133 mol_type protein note The IL-2 sequence in A-N88D organism synthetic construct APASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISDINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 133 AA PAT source 1..133 mol_type protein note The IL-2 sequence in A-N88R organism synthetic construct APASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISRINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 133 AA PAT source 1..133 mol_type protein note The IL-2 sequence in A-Q126D organism synthetic construct APASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFADSIISTLT 133 AA PAT source 1..133 mol_type protein note The IL-2 sequence in A-H16A/D84S organism synthetic construct APASSSTKKTQLQLEALLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRSLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 231 AA PAT source 1..231 mol_type protein note The Knob chain of Fc (D356, L358) organism synthetic construct EPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 230 AA PAT source 1..230 mol_type protein note The Hole chain of Fc (D356, L358) organism synthetic construct EPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 231 AA PAT source 1..231 mol_type protein note The Knob chain of Fc (E356, M358) organism synthetic construct EPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 231 AA PAT source 1..231 mol_type protein note The Hole chain of Fc (E356, M358) organism synthetic construct EPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 495 AA PAT source 1..495 mol_type protein note The Knob chain of A-D20A (D356, L358) organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLALQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 346 AA PAT source 1..346 mol_type protein note The Hole chain of A-D20A (D356, L358) organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSP 495 AA PAT source 1..495 mol_type protein note The Knob chain of A-D20A (E356, M358) organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLALQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 347 AA PAT source 1..347 mol_type protein note The Hole chain of A-D20A (E356, M358) organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 495 AA PAT source 1..495 mol_type protein note The Knob chain of A-N88D (D356, L358) organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISDINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 346 AA PAT source 1..346 mol_type protein note The Hole chain of A-N88D (D356, L358) organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 495 AA PAT source 1..495 mol_type protein note The Knob chain of A-N88D (E356, M358) organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISDINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 347 AA PAT source 1..347 mol_type protein note The Hole chain of A-N88D (E356, M358) organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 595 AA PAT source 1..595 mol_type protein note The Knob chain of IgG-PC organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNSWIGWFRQAPGQGLEWIGDIYPGGGYTNYNEIFKGKATMTADTSTNTAYMELSSLRSEDTAVYYCSRGIPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 595 AA PAT source 1..595 mol_type protein note The Knob chain of IgG-V91T organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNSWIGWFRQAPGQGLEWIGDIYPGGGYTNYNEIFKGKATMTADTSTNTAYMELSSLRSEDTAVYYCSRGIPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTEMLTAKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINTIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 595 AA PAT source 1..595 mol_type protein note The Knob chain of IgG-N88D organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNSWIGWFRQAPGQGLEWIGDIYPGGGYTNYNEIFKGKATMTADTSTNTAYMELSSLRSEDTAVYYCSRGIPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISDINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 595 AA PAT source 1..595 mol_type protein note The Knob chain of IgG-D20A organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNSWIGWFRQAPGQGLEWIGDIYPGGGYTNYNEIFKGKATMTADTSTNTAYMELSSLRSEDTAVYYCSRGIPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLALQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 446 AA PAT source 1..446 mol_type protein note The Hole chain of IgG-PC, IgG-V91T, IgG-D20A, or IgG-N88D organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNSWIGWFRQAPGQGLEWIGDIYPGGGYTNYNEIFKGKATMTADTSTNTAYMELSSLRSEDTAVYYCSRGIPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSP 220 AA PAT source 1..220 mol_type protein note The light chain of IgG-PC, IgG-V91T, IgG-D20A, or IgG-N88D organism synthetic construct DIQMTQSPSSLSASVGDRVTMSCKSSQSLLNSGDQKNYLTWYQQKPGKAPKLLIYWASTGESGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQNDYSYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 133 AA PAT source 1..133 mol_type protein note wt IL-2 organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 116 AA PAT source 1..116 mol_type protein note A17m0902M08 organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWQDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m0902M15 organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGGITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m0902M26 organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSSYSMSWYRQAPGKGRELVAIISGSGGITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWEDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m0902M27 organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSSYSMSWYRQAPGKGRELVAIISGSGGITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWQDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein note A17m0902M28 organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSSYSMSWYRQAPGKGRELVAIISGSGGITHYADSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWQDYWGQGTQVTVSS 5 AA PAT source 1..5 mol_type protein note CDR1 organism synthetic construct SYSMS 17 AA PAT source 1..17 mol_type protein note CDR2 organism synthetic construct IISGSGGITHYVDSVKG 17 AA PAT source 1..17 mol_type protein note CDR2 organism synthetic construct IISGSGGITHYADSVKG 7 AA PAT source 1..7 mol_type protein note CDR3 organism synthetic construct VSDWQDY 5 AA PAT source 1..5 mol_type protein note CDR1 organism synthetic construct VARIANT 1 note X is selected from the group consisting of D and S XYSMS 17 AA PAT source 1..17 mol_type protein note CDR2 organism synthetic construct VARIANT 7 note X is selected from the group consisting of V and G VARIANT 12 note X is selected from the group consisting of V and A IISGSGXITHYXDSVKG 7 AA PAT source 1..7 mol_type protein note CDR3 organism synthetic construct VARIANT 5 note X is selected from the group consisting of Q and E VSDWXDY 17 AA PAT source 1..17 mol_type protein note CDR2 organism synthetic construct VARIANT 7 note X is selected from the group consisting of V and G VARIANT 8 note X is selected from the group consisting of I and S VARIANT 9 note X is selected from the group consisting of T and A VARIANT 12 note X is selected from the group consisting of V and A IISGSGXXXHYXDSVKG 7 AA PAT source 1..7 mol_type protein note CDR3 organism synthetic construct VARIANT 5 note X is selected from the group consisting of Q, D, and E VARIANT 6 note X is selected from the group consisting of D and E VSDWXXY 495 AA PAT source 1..495 mol_type protein note The Knob chain of A-N88D-M08 organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWQDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAPASSSTKKTQLQLEHLLLDLQMILQGISNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLQGAQSKNFHLRPRDLISDINVIVLELKGSETTFMCEYADETATIVEFLNRWITFAQSIISTLT 347 AA PAT source 1..347 mol_type protein note The Hole chain of A-N88D-M08 organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSDYSMSWYRQAPGKGRELVAIISGSGVITHYVDSVKGRFTISRDNAKNTLYLQMRSLRAEDTAVYYCRAVSDWQDYWGQGTQVTVSSEPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 15 AA PAT source 1..15 mol_type protein note Linker 1 organism synthetic construct GGGGSGGGGSGGGGS 10 AA PAT source 1..10 mol_type protein note Linker 2 organism synthetic construct GGGGSGGGGS 5 AA PAT source 1..5 mol_type protein note Linker 1 organism synthetic construct GGGGS 100 AA PAT source 1..100 mol_type protein note Linker organism synthetic construct REGION 1..100 note A maximum of 19 GGNGT copies can be deleted GGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGTGGNGT 100 AA PAT source 1..100 mol_type protein note Linker organism synthetic construct REGION 1..100 note A maximum of 19 YGNGT copies can be deleted YGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGTYGNGT 100 AA PAT source 1..100 mol_type protein note Linker organism synthetic construct REGION 1..100 note A maximum of 19 EPKSS copies can be deleted EPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSSEPKSS