WO A1407.70001WO00 US 63/489,414 2023-03-09 Triveni Bio, Inc. DUAL INHIBITOR KALLIKREIN ANTIBODIES AND USES THEREOF 33 11 AA PAT source 1..11 mol_type protein organism synthetic construct GSISSSDYYWG 16 AA PAT source 1..16 mol_type protein organism synthetic construct SIYYSGSTYYNPSLKS 19 AA PAT source 1..19 mol_type protein organism synthetic construct ARGRPLGYGARHYYYGMDV 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASQSISSYLN 7 AA PAT source 1..7 mol_type protein organism synthetic construct SASSLQS 10 AA PAT source 1..10 mol_type protein organism synthetic construct QQSPPFPPLT 127 AA PAT source 1..127 mol_type protein organism synthetic construct QLQLQESGPGLVKPSETLSLTCTVSGGSISSSDYYWGWIRQPPGKGLEWIGSIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGRPLGYGARHYYYGMDVWGQGTTVTVSS 108 AA PAT source 1..108 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYSASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSPPFPPLTFGGGTKVEIK 11 AA PAT source 1..11 mol_type protein organism synthetic construct GSISSDDYYWV 16 AA PAT source 1..16 mol_type protein organism synthetic construct SIDYFASTYYNPSLKS 19 AA PAT source 1..19 mol_type protein organism synthetic construct ARGRPLGYGARHDYYGMDV 10 AA PAT source 1..10 mol_type protein organism synthetic construct QQSPYFPPLT 127 AA PAT source 1..127 mol_type protein organism synthetic construct QLQLQESGPGLVKPSETLSLTCTVSGGSISSDDYYWVWIRQPPGKGLEWIGSIDYFASTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGRPLGYGARHDYYGMDVWGQGTTVTVSS 108 AA PAT source 1..108 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYSASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSPYFPPLTFGGGTKVEIK 16 AA PAT source 1..16 mol_type protein organism synthetic construct SIDYYASTYYSPSLKS 19 AA PAT source 1..19 mol_type protein organism synthetic construct ARGRPLGYGAKHYYYGMDV 127 AA PAT source 1..127 mol_type protein organism synthetic construct QLQLQESGPGLVKPSETLSLTCTVSGGSISSDDYYWVWIRQPPGKGLEWIGSIDYYASTYYSPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGRPLGYGAKHYYYGMDVWGQGTTVTVSS 11 AA PAT source 1..11 mol_type protein organism synthetic construct GSISSLDYYWV 16 AA PAT source 1..16 mol_type protein organism synthetic construct SIDYSGDTYYNPSLKS 19 AA PAT source 1..19 mol_type protein organism synthetic construct ARGRPLGYGARHYYYAMDV 127 AA PAT source 1..127 mol_type protein organism synthetic construct QLQLQESGPGLVKPSETLSLTCTVSGGSISSLDYYWVWIRQPPGKGLEWIGSIDYSGDTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGRPLGYGARHYYYAMDVWGQGTTVTVSS 381 DNA PAT source 1..381 mol_type other DNA organism synthetic construct cagctgcaattgcaagagtccggacccggactcgtcaagccgagcgaaactctgagcctcacctgtactgtgtccggaggctccatttcgtcctccgactactactgggggtggattaggcagccacctggaaaggggctggaatggatcggttccatctactattcgggctcgacctactacaacccctcactgaaatcgcgcgtcaccatctctgtggacacctccaagaaccagttcagccttaagctgtcctcagtgacggccgcagacactgccgtgtactactgcgcgagaggcagaccgctgggatacggtgcccggcactattactacgggatggatgtctggggccagggaactaccgtgaccgtgtccagc 324 DNA PAT source 1..324 mol_type other DNA organism synthetic construct gacattcaaatgacccagtccccgtcgtccctgtctgcgtccgtgggcgacagagtgacgatcacttgccgggcttcccaaagcatctcctcctatctgaactggtaccagcagaagcccggaaaagcccccaagctgctcatctactccgcctcgagcttgcagtcaggagtgccgtcccgcttctcgggatcaggctccgggaccgacttcaccctgaccattagcagcctgcagccggaagatttcgccacttactactgtcagcagtcgcctccctttcctccactcactttcgggggtggcaccaaggtcgagatcaag 381 DNA PAT source 1..381 mol_type other DNA organism synthetic construct cagctgcaactgcaagaatcgggccccgggctcgtgaagccctccgaaactctgtccctgacttgcaccgtgtccggcggatctatcagcagcgacgattactactgggtctggattagacagccgcctggaaagggtcttgagtggatcgggtcaatcgactacttcgcctccacctactacaacccatcactgaagtccagggtcaccattagcgtggacacctcgaagaaccagttcagcctgaaattgtcgtccgtgaccgcggcagacaccgccgtgtactactgtgctcggggtcggccgctcggctacggcgcccgccacgactattacggaatggatgtctggggacagggaacgaccgtgactgtgtcctcc 324 DNA PAT source 1..324 mol_type other DNA organism synthetic construct gacattcaaatgacccagtccccatcgtcactctccgcctccgtgggagacagagtgaccatcacctgtcgcgctagccagtccatttcctcctacttgaactggtaccagcagaagcccgggaaggccccgaagctgctgatctatagcgccagcagccttcagtcgggagtgccctctcggttctcggggtcgggttccggaactgatttcactctcaccatctcatccctgcaacctgaggacttcgcgacttactactgccaacagtccccgtacttccctccgctgacgtttggcggcggcaccaaagtcgaaatcaag 381 DNA PAT source 1..381 mol_type other DNA organism synthetic construct cagctccaactgcaagaatccggtccggggcttgtgaagccatctgaaaccctgtccctgacgtgtaccgtgtccgggggaagcatctccagcgacgattactactgggtctggattcgccagcctcccggaaagggtctggagtggatcggctccattgactactatgcctcgacctactactcaccgtccctgaagtcgagagtgaccatctccgtggacacctcgaaaaaccagttcagcctgaagctcagctcagtgactgccgccgataccgcggtgtactattgcgcacggggcaggcccttgggatacggcgctaagcactactactacggaatggacgtctggggccagggaactactgtgaccgtgtcctcc 381 DNA PAT source 1..381 mol_type other DNA organism synthetic construct cagctgcaacttcaagaatccggccccggactcgtgaagccttctgagactctgtccctgacttgcaccgtgtcgggtggcagcatttcctcactggactactactgggtctggatcagacagccacccggaaagggactggaatggatcggatccatcgactactccggggacacctactacaacccgtcgctgaagtccagggtcaccattagcgtggacacgtccaagaaccagttcagcctgaaattgtcgtcagtgactgcagccgataccgcggtgtactactgtgcccggggccgcccgctcggatacggtgctcggcactactactatgccatggatgtctggggccaggggaccaccgtgaccgtgtccagc 11 AA PAT source 1..11 mol_type protein organism synthetic construct VARIANT 6 note is S, D, or L VARIANT 11 note is G or V GSISSXDYYWX 16 AA PAT source 1..16 mol_type protein organism synthetic construct VARIANT 3 note is Y or D VARIANT 5 note is S, F, or Y VARIANT 6 note is G or A VARIANT 7 note is S or D VARIANT 11 note is N or S SIXYXXXTYYXPSLKS 19 AA PAT source 1..19 mol_type protein organism synthetic construct VARIANT 11 note is R or K VARIANT 13 note is Y or D ARGRPLGYGAXHXYYGMDV 10 AA PAT source 1..10 mol_type protein organism synthetic construct VARIANT 5 note is P or Y QQSPXFPPLT 324 DNA PAT source 1..324 mol_type other DNA organism synthetic construct gacattcaaatgacccagtcaccgagctccctgtccgcctccgtgggtgatcgcgtgaccatcacttgtcgggcgtcgcagagcatttcctcctaccttaactggtaccagcagaaacccggaaaggctcctaagctgctcatctattcggcctcctccttgcaatccggggtgccgtcgagattcagcggcagcggatccgggaccgacttcaccctcactatctcttcgctgcaacctgaagatttcgccacctactactgccagcagtcaccctacttcccgccactgacgtttggcggcggaactaaggtcgagatcaag 324 DNA PAT source 1..324 mol_type other DNA organism synthetic construct gacatccaaatgactcagtccccgtcctcgctctcggctagcgtgggcgacagagtgaccattacttgccgcgcgtcacaatccatctcttcatacttgaactggtaccagcagaagcctgggaaagccccgaagctcctgatctattccgcctcgagcctgcagtcgggagtgccctcccggttctccgggagcggtagcggaaccgacttcactcttacgatctcctccctgcaacccgaagattttgccacctactactgtcagcagtccccgtacttccctccactgaccttcggcggcggaaccaaggtcgagattaag