P20231550WO1 CN 202310982666.0 2023-08-04 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. DOUBLE-STRANDED RIBONUCLEIC ACID TARGETING PD-L1 58 21 DNA PAT source 1..21 mol_type other DNA note Human PD-L1 primer organism synthetic construct tggcatttgctgaacgcattt 22 DNA PAT source 1..22 mol_type other DNA note Human PD-L1 primer organism synthetic construct tgcagccaggtctaattgtttt 20 DNA PAT source 1..20 mol_type other DNA note Human PD-L1 primer organism synthetic construct tggctcccagaattaccaag 20 DNA PAT source 1..20 mol_type other DNA note Human PD-L1 primer organism synthetic construct tatggtggtgccgactacaa 20 DNA PAT source 1..20 mol_type other DNA note Mouse PD-L1 primer organism synthetic construct ccgggatgagagatggagtc 21 DNA PAT source 1..21 mol_type other DNA note Mouse PD-L1 primer organism synthetic construct tgtcgtcagaattcaccagtc 20 DNA PAT source 1..20 mol_type other DNA note Mouse GAPDH primer organism synthetic construct atgaaggggtcgttgatggc 23 DNA PAT source 1..23 mol_type other DNA note Mouse GAPDH primer organism synthetic construct gggttcctataaatacggactgc 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct agcaatatgacaattgaatga 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct tcattcaattgtcatattgctac 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct atttactgtcacggttcccaa 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct ttgggaaccgtgacagtaatagc 19 RNA PAT source 1..19 mol_type other RNA note Sense strand organism synthetic construct ctatttattttgagtctgt 21 RNA PAT source 1..21 mol_type other RNA note Antisense strand organism synthetic construct acagactcaaaataaatagga 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct tgaagatatattgtagtagat 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct atctactacaatatatcttcaaa 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct ttgtctcatgtttcatcgtaa 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct ttacgatgaaacatgagacaaaa 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct ctgtgcagtatctgttccatt 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct aatggaacagatactgcacagac 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct aatgaaaggactcacttggta 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct taccaagtgagtcctttcatttg 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct gctgcatgatcagctatggta 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct taccatagctgatcatgcagcgg 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct ggtgcttggtctcctctataa 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct ttatagaggagaccaagcacctt 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct attggtcatcccagaactaca 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct tgtagttctgggatgaccaattc 19 RNA PAT source 1..19 mol_type other RNA note Sense strand organism synthetic construct tatttattttgagtctgtg 21 RNA PAT source 1..21 mol_type other RNA note Antisense strand organism synthetic construct cacagactcaaaataaatagg 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage agcaatatgacaattgaatga 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage tcattcaattgtcatattgctac 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage atttactgtcacggttcccaa 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage ttgggaaccgtgacagtaatagc 19 RNA PAT source 1..19 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..6 mod_base OTHER note 2'-O-methyl modification modified_base 7..9 mod_base OTHER note 2'-fluoro modification modified_base 10..19 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage ctatttattttgagtctgt 21 RNA PAT source 1..21 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 19^20 mod_base OTHER note Phosphorothioate linkage modified_base 20^21 mod_base OTHER note Phosphorothioate linkage acagactcaaaataaatagga 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage tgaagatatattgtagtagat 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage atctactacaatatatcttcaaa 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage ttgtctcatgtttcatcgtaa 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage ttacgatgaaacatgagacaaaa 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage ctgtgcagtatctgttccatt 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage aatggaacagatactgcacagac 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage aatgaaaggactcacttggta 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage taccaagtgagtcctttcatttg 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage gctgcatgatcagctatggta 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage taccatagctgatcatgcagcgg 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage ggtgcttggtctcctctataa 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage ttatagaggagaccaagcacctt 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage attggtcatcccagaactaca 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage tgtagttctgggatgaccaattc 19 RNA PAT source 1..19 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..6 mod_base OTHER note 2'-O-methyl modification modified_base 7..9 mod_base OTHER note 2'-fluoro modification modified_base 10..19 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage tatttattttgagtctgtg 21 RNA PAT source 1..21 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 19^20 mod_base OTHER note Phosphorothioate linkage modified_base 20^21 mod_base OTHER note Phosphorothioate linkage cacagactcaaaataaatagg 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct atttactgtcacggttcccaa 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct ttgggaaccgtgacagtaaatgc 21 RNA PAT source 1..21 mol_type other RNA note Sense strand organism synthetic construct modified_base 1..8 mod_base OTHER note 2'-O-methyl modification modified_base 9..11 mod_base OTHER note 2'-fluoro modification modified_base 12..21 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage atttactgtcacggttcccaa 23 RNA PAT source 1..23 mol_type other RNA note Antisense strand organism synthetic construct modified_base 1 mod_base OTHER note 2'-O-methyl modification modified_base 2 mod_base OTHER note 2'-fluoro modification modified_base 3..5 mod_base OTHER note 2'-O-methyl modification modified_base 6 mod_base OTHER note 2'-fluoro modification modified_base 7..13 mod_base OTHER note 2'-O-methyl modification modified_base 14 mod_base OTHER note 2'-fluoro modification modified_base 15 mod_base OTHER note 2'-O-methyl modification modified_base 16 mod_base OTHER note 2'-fluoro modification modified_base 17..23 mod_base OTHER note 2'-O-methyl modification modified_base 1^2 mod_base OTHER note Phosphorothioate linkage modified_base 2^3 mod_base OTHER note Phosphorothioate linkage modified_base 21^22 mod_base OTHER note Phosphorothioate linkage modified_base 22^23 mod_base OTHER note Phosphorothioate linkage ttgggaaccgtgacagtaaatgc 19 DNA PAT source 1..19 mol_type other DNA note Human GAPDH primer organism synthetic construct ggtcggagtcaacggattt 19 DNA PAT source 1..19 mol_type other DNA note Human GAPDH primer organism synthetic construct ccagcatcgccccacttga