WO HOPA-034/01WO 308248-3187 US 63/249,552 2021-09-28 VIELA BIO, INC. CD40L-SPECIFIC TN3-DERIVED SCAFFOLDS AND METHODS OF USING THE SAME IN THE TREATMENT AND PREVENTION OF RHEUMATOID ARTHRITIS 25 785 AA PAT source 1..785 mol_type protein organism synthetic construct SQIEVKDVTDTTALITWSDDFGEYVWCELTYGIKDVPGDRTTIDLWYHHAHYSIGNLKPDTEYEVSLICRSGDMSSNPAKETFTTGGGGGGGGGGGGGGGRLDAPSQIEVKDVTDTTALITWSDDFGEYVWCELTYGIKDVPGDRTTIDLWYHHAHYSIGNLKPDTEYEVSLICRSGDMSSNPAKETFTTGGGGGGGGGGDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQSPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL 83 AA PAT source 1..83 mol_type protein organism synthetic construct IEVKDVTDTTALITWSDDFGEYVWCELTYGIKDVPGDRTTIDLWYHHAHYSIGNLKPDTEYEVSLICRRGDMSSNPAKETFTT 83 AA PAT source 1..83 mol_type protein organism synthetic construct IEVKDVTDTTALITWSDDFGEYVWCELTYGIKDVPGDRTTIDLWYHHAHYSIGNLKPDTEYEVSLICRSGDMSSNPAKETFTT 585 AA PAT source 1..585 mol_type protein organism synthetic construct DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQSPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL 000 5 AA PAT source 1..5 mol_type protein organism synthetic construct ALITW 10 AA PAT REGION 1..10 note linker source 1..10 mol_type protein organism synthetic construct GGGGSGGGGS 15 AA PAT REGION 1..15 note linker source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 10 AA PAT REGION 1..10 note linker source 1..10 mol_type protein organism synthetic construct GGGGGGGGGG 15 AA PAT REGION 1..15 note linker source 1..15 mol_type protein organism synthetic construct GGGGGGGGGGGGGGG 7 AA PAT source 1..7 mol_type protein organism synthetic construct KDVTDTT 9 AA PAT source 1..9 mol_type protein organism synthetic construct SDDFGEYVW 7 AA PAT source 1..7 mol_type protein organism synthetic construct KDVPGDR 6 AA PAT source 1..6 mol_type protein organism synthetic construct WYHHAH 8 AA PAT source 1..8 mol_type protein organism synthetic construct GNLKPDTE 10 AA PAT source 1..10 mol_type protein organism synthetic construct RSGDMSSNPA 7 AA PAT source 1..7 mol_type protein organism synthetic construct CELTYGI 5 AA PAT source 1..5 mol_type protein organism synthetic construct TTIDL 000 7 AA PAT source 1..7 mol_type protein organism synthetic construct YEVSLIC 6 AA PAT source 1..6 mol_type protein organism synthetic construct KETFTT 85 AA PAT source 1..85 mol_type protein organism synthetic construct SQIEVKDVTDTTALITWSDDFGEYVWCELTYGIKDVPGDRTTIDLWYHHAHYSIGNLKPDTEYEVSLICRSGDMSSNPAKETFTT 10 AA PAT source 1..10 mol_type protein organism synthetic construct RLDAPSQIEV 5 AA PAT source 1..5 mol_type protein organism synthetic construct SQIEV 90 AA PAT source 1..90 mol_type protein organism synthetic construct RLDAPSQIEVKDVTDTTALITWSDDFGEYVWCELTYGIKDVPGDRTTIDLWYHHAHYSIGNLKPDTEYEVSLICRSGDMSSNPAKETFTT