076636-8002WO02 CN PCT/CN2021/127544 2021-10-29 INMAGENE BIOPHARMACEUTICALS (HANGZHOU) CO., LTD. NOVEL ANTI-IL-36R ANTIBODIES 212 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct EVKLVESGGGLVQPGGSLSLSCAASGFAFTDYYMNWVRQPPGKALEWLALIRNKAAGYTIYYSASVKGRFTISRDNSQSILYLQMTALRPEDSATYYCVRDMTIYDGYYVDYALDYWGQGTSVTVSS 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct DIQMNQSPSSLSASLGDTITITCRASQNINIWLSWYQQKPGNIPKLFIYKASNLHTGVPSRFSGSGSGTDFTLTISSLQPEDIATYYCQQSQSYPLTFGAGTKLELK 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct DYYMN 19 AA PAT REGION 1..19 note synthetic source 1..19 mol_type protein organism synthetic construct LIRNKAAGYTIYYSASVKG 16 AA PAT REGION 1..16 note synthetic source 1..16 mol_type protein organism synthetic construct DMTIYDGYYVDYALDY 11 AA PAT REGION 1..11 note synthetic source 1..11 mol_type protein organism synthetic construct RASQNINIWLS 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct KASNLHT 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct QQSQSYPLT 000 000 000 000 000 000 000 000 119 AA PAT REGION 1..119 note synthetic source 1..119 mol_type protein organism synthetic construct QVQLQQSGPGLMAPSQSLSITCTVSGFSLTSYDVSWIRQSPGKGLEWLGVIWTGGGTDYNSAFMSRLSITKDNSKSQVFLKMSSLQTDDTAIYYCVRVYYDPYYAMDYWGQGTSVTVSS 108 AA PAT REGION 1..108 note synthetic source 1..108 mol_type protein organism synthetic construct DIVLTQSPAIMSASPGEKVTMTCSASSSVSSRYLHWYQQKSGASPKLWIYGTSNLASGVPARFSGSGSGTSYSLTISSVEAEDAATYYCQQYHSDPLTFGAGTKLELK 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct SYDVS 16 AA PAT REGION 1..16 note synthetic source 1..16 mol_type protein organism synthetic construct VIWTGGGTDYNSAFMS 11 AA PAT REGION 1..11 note synthetic source 1..11 mol_type protein organism synthetic construct VYYDPYYAMDY 12 AA PAT REGION 1..12 note synthetic source 1..12 mol_type protein organism synthetic construct SASSSVSSRYLH 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct GTSNLAS 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct QQYHSDPLT 000 000 000 000 000 000 117 AA PAT REGION 1..117 note synthetic source 1..117 mol_type protein organism synthetic construct EVQLQQSGPELVKPGASVKMSCKASGYTFTDYHMNWVKRSPGKSLEWIGRINPDYGDARYDQKFKGKATLTVDKSLSTAYMQLNRLTYEDSAVYYCARDGYYVFDYWGQGSTLTVSS 112 AA PAT REGION 1..112 note synthetic source 1..112 mol_type protein organism synthetic construct DIVMTQAAFSNPVSLGTSASISCRSSKSLLHSDGITYLSWYLQRPGQSPQLLIYRMSNLVSGVPDRFSGSGSGTDFTLRISRVEAEDVGVYYCAQTLEFPLTFGAGTKLELK 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct DYHMN 17 AA PAT REGION 1..17 note synthetic source 1..17 mol_type protein organism synthetic construct RINPDYGDARYDQKFKG 8 AA PAT REGION 1..8 note synthetic source 1..8 mol_type protein organism synthetic construct DGYYVFDY 16 AA PAT REGION 1..16 note synthetic source 1..16 mol_type protein organism synthetic construct RSSKSLLHSDGITYLS 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct RMSNLVS 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct AQTLEFPLT 000 000 000 000 000 000 000 116 AA PAT REGION 1..116 note synthetic source 1..116 mol_type protein organism synthetic construct QVQLQQPGTELVKPGASVKLSCKASGYTFTRYWMHWVRQRPGQGLEWIGNINPNIGRANYNEKFKNKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARPGETTDYWGQGTTLTVSS 112 AA PAT REGION 1..112 note synthetic source 1..112 mol_type protein organism synthetic construct DVVMTQTPLILSVTIGQPASISCKSSQSLLYTDGKTYLNWLLQRPGQSPKRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAVDLGVYYCLQSTHYPFTFGTGTKLEIK 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct RYWMH 17 AA PAT REGION 1..17 note synthetic source 1..17 mol_type protein organism synthetic construct NINPNIGRANYNEKFKN 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct PGETTDY 16 AA PAT REGION 1..16 note synthetic source 1..16 mol_type protein organism synthetic construct KSSQSLLYTDGKTYLN 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct LVSKLDS 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct LQSTHYPFT 000 000 000 000 000 000 000 000 125 AA PAT REGION 1..125 note synthetic source 1..125 mol_type protein organism synthetic construct QVQLQQSGAELVKPGASVRLSCKASGYTFTEFTIHWVKQRSGQGLEWIGWFYPGSDFIKYNEKFKDKATLTADKSSNTVYMELLRLTSEDSAVYFCARHEDRLSDYSYEWYFDVWGAGTAVTVSS 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct DIQMTQSPASLSASVGETVTITCRASENIDSYLAWYQQKQGKSPQLLVYGATLLADGVPSRFSGSGSGTQYSLKINSLQSEDVAEYFCQHYYSIPLTFGAGTKLELK 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct EFTIH 17 AA PAT REGION 1..17 note synthetic source 1..17 mol_type protein organism synthetic construct WFYPGSDFIKYNEKFKD 16 AA PAT REGION 1..16 note synthetic source 1..16 mol_type protein organism synthetic construct HEDRLSDYSYEWYFDV 11 AA PAT REGION 1..11 note synthetic source 1..11 mol_type protein organism synthetic construct RASENIDSYLA 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct GATLLAD 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct QHYYSIPLT 000 000 000 000 000 000 000 121 AA PAT REGION 1..121 note synthetic source 1..121 mol_type protein organism synthetic construct QVQLQQSGPELVKPGASVKISCKASGYAFSHSWMNWVKQRPGKGLEWIGWIHLGDGDTYYNGKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYFCARSDGNYVPYAMDYWGQGTSVTVSS 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct DIVITQTTSSLSASLGDRVTISCRASQDISNYLSWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISSLEQEDIATYFCQQDSEHPWTFGGGTELDVR 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct HSWMN 17 AA PAT REGION 1..17 note synthetic source 1..17 mol_type protein organism synthetic construct WIHLGDGDTYYNGKFKG 12 AA PAT REGION 1..12 note synthetic source 1..12 mol_type protein organism synthetic construct SDGNYVPYAMDY 11 AA PAT REGION 1..11 note synthetic source 1..11 mol_type protein organism synthetic construct RASQDISNYLS 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct YTSRLHS 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct QQDSEHPWT 000 000 000 000 000 000 000 116 AA PAT REGION 1..116 note synthetic source 1..116 mol_type protein organism synthetic construct EVQVQQSGTELVKPGASVKLSCKASGYTFTNYWLHWVKQRPGQGLEWIGNINPSNGGTNYNEKFKTKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARYSTGFAYWGQGTLVTVSA 111 AA PAT REGION 1..111 note synthetic source 1..111 mol_type protein organism synthetic construct DIVLTQTTASLAVSLGQRATISCRASESVDTYGASFMHWYQQKPGQPPKLLIYRASNLESGIPARFSGSGSRTDFTLTVNPVEADDVATYYCQQSNEDPRTFGGGTKLEIK 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct NYWLH 17 AA PAT REGION 1..17 note synthetic source 1..17 mol_type protein organism synthetic construct NINPSNGGTNYNEKFKT 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct YSTGFAY 15 AA PAT REGION 1..15 note synthetic source 1..15 mol_type protein organism synthetic construct RASESVDTYGASFMH 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct RASNLES 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct QQSNEDPRT 000 000 000 000 000 000 000 117 AA PAT REGION 1..117 note synthetic source 1..117 mol_type protein organism synthetic construct EVQLQQSGPELVKPGDSVKISCKASGYSFTGYFMNWVMQSHGKSLEWIGRINPYNGDTFYNQKFKGKATLTVDKSSSTAHMELRSLTSEDSAVYYCAGLGHWYFDVWGTGTTVTVSS 112 AA PAT REGION 1..112 note synthetic source 1..112 mol_type protein organism synthetic construct DIVMTQSTLSLPVSLGDQASISCRSSQSIVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPWTFGGGTKLEIK 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct GYFMN 17 AA PAT REGION 1..17 note synthetic source 1..17 mol_type protein organism synthetic construct RINPYNGDTFYNQKFKG 8 AA PAT REGION 1..8 note synthetic source 1..8 mol_type protein organism synthetic construct LGHWYFDV 16 AA PAT REGION 1..16 note synthetic source 1..16 mol_type protein organism synthetic construct RSSQSIVHSNGNTYLE 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct KVSNRFS 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct FQGSHVPWT 000 000 000 000 000 000 000 120 AA PAT REGION 1..120 note synthetic source 1..120 mol_type protein organism synthetic construct QVQLEQSGGDLVKPGGSLKLSCAASGFTFSSYGMSWVRQTPDKRLEWVATISSYGSYTSYPDTVKGRFTISRDNAKNTLYLQMSSLKSEDTAMYYCARPDYYVSTGFDYWGQGTTLTVSS 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct DIVITQSTATLSVTPGDRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYASQSISGIPSRFSGSGSGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFGSGTKLEIK 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct SYGMS 17 AA PAT REGION 1..17 note synthetic source 1..17 mol_type protein organism synthetic construct TISSYGSYTSYPDTVKG 11 AA PAT REGION 1..11 note synthetic source 1..11 mol_type protein organism synthetic construct PDYYVSTGFDY 11 AA PAT REGION 1..11 note synthetic source 1..11 mol_type protein organism synthetic construct RASQSISDYLH 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct YASQSIS 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct QNGHSFPFT 000 000 000 000 000 000 000 118 AA PAT REGION 1..118 note synthetic source 1..118 mol_type protein organism synthetic construct QVQAQQSGAVLVQPGASVKLSCKASGYTFTDYTIHWIKQRSGQGLEWIGWFYPGSGGLKYHEKFKDKATLTADKSSSTVYMELSRLTSEDSAVYFCTRHGNYDGFAYWGQGTLVTVSA 112 AA PAT REGION 1..112 note synthetic source 1..112 mol_type protein organism synthetic construct DIVLTQTPLSLPVSLGDQASISYRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPFTFGSGTKLEIK 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct DYTIH 17 AA PAT REGION 1..17 note synthetic source 1..17 mol_type protein organism synthetic construct WFYPGSGGLKYHEKFKD 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct HGNYDGFAY 16 AA PAT REGION 1..16 note synthetic source 1..16 mol_type protein organism synthetic construct RSSQSLVHSNGNTYLH 7 AA PAT REGION 1..7 note synthetic source 1..7 mol_type protein organism synthetic construct KVSNRFS 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct SQSTHVPFT 000 000 000 000 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFAFGDYYMNWVRQAPGKGLEWVALIRNKAAGYTIYYSAPVKGRFTISRDDSKSTLYLQMNSLKTEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct DIVMTQSPSSVSASVGDRVTITCRASRNINIWLSWYQQKPGKAPKLFIYKASNLHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQSQSYPLTFGQGTKLEIK 19 AA PAT REGION 1..19 note synthetic source 1..19 mol_type protein organism synthetic construct LIRNKAAGYTIYYSAPVKG 11 AA PAT REGION 1..11 note synthetic source 1..11 mol_type protein organism synthetic construct RASRNINIWLS 9 AA PAT REGION 1..9 note synthetic source 1..9 mol_type protein organism synthetic construct LQSQSYPLT 30 AA PAT REGION 1..30 note synthetic source 1..30 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFAFG 14 AA PAT REGION 1..14 note synthetic source 1..14 mol_type protein organism synthetic construct WVRQAPGKGLEWVA 32 AA PAT REGION 1..32 note synthetic source 1..32 mol_type protein organism synthetic construct RFTISRDDSKSTLYLQMNSLKTEDTAVYYCVR 11 AA PAT REGION 1..11 note synthetic source 1..11 mol_type protein organism synthetic construct WGQGTLVTVSS 23 AA PAT REGION 1..23 note synthetic source 1..23 mol_type protein organism synthetic construct DIVMTQSPSSVSASVGDRVTITC 15 AA PAT REGION 1..15 note synthetic source 1..15 mol_type protein organism synthetic construct WYQQKPGKAPKLFIY 32 AA PAT REGION 1..32 note synthetic source 1..32 mol_type protein organism synthetic construct GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC 10 AA PAT REGION 1..10 note synthetic source 1..10 mol_type protein organism synthetic construct FGQGTKLEIK 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct QVQLQESGGGLVKPGGSLRLSCAASGFAFTDYYMNWIRQAPGKGLEWVSLIRNKAAGYTIYYADSVKGRFTISRDNAKSSLYLQMNSLRAEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct EIVMTQSPATLSVSPGERATLSCRASQNINIWLSWYQQKPGQAPRLFIYKASNLHTGVPARFSGSGSGTEFTLTISSLQSEDFAVYYCLQSQSYPLTFGQGTKLEIK 19 AA PAT REGION 1..19 note synthetic source 1..19 mol_type protein organism synthetic construct LIRNKAAGYTIYYADSVKG 30 AA PAT REGION 1..30 note synthetic source 1..30 mol_type protein organism synthetic construct QVQLQESGGGLVKPGGSLRLSCAASGFAFT 14 AA PAT REGION 1..14 note synthetic source 1..14 mol_type protein organism synthetic construct WIRQAPGKGLEWVS 32 AA PAT REGION 1..32 note synthetic source 1..32 mol_type protein organism synthetic construct RFTISRDNAKSSLYLQMNSLRAEDTAVYYCVR 23 AA PAT REGION 1..23 note synthetic source 1..23 mol_type protein organism synthetic construct EIVMTQSPATLSVSPGERATLSC 15 AA PAT REGION 1..15 note synthetic source 1..15 mol_type protein organism synthetic construct WYQQKPGQAPRLFIY 32 AA PAT REGION 1..32 note synthetic source 1..32 mol_type protein organism synthetic construct GVPARFSGSGSGTEFTLTISSLQSEDFAVYYC 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct QVQLVESGGGLVKPGGSLRLSCAASGFAFTDYYMNWIRQAPGKGLEWVALIRNKAAGYTIYYSDSVKGRFTISRDNAKSSLYLQMNSLRAEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct DIVMTQSPSSVSASVGDRVTITCRASQNINIWLSWYQQKPGKAPKLFIYKASNLHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQSQSYPLTFGQGTKLEIK 19 AA PAT REGION 1..19 note synthetic source 1..19 mol_type protein organism synthetic construct LIRNKAAGYTIYYSDSVKG 30 AA PAT REGION 1..30 note synthetic source 1..30 mol_type protein organism synthetic construct QVQLVESGGGLVKPGGSLRLSCAASGFAFT 14 AA PAT REGION 1..14 note synthetic source 1..14 mol_type protein organism synthetic construct WIRQAPGKGLEWVA 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFAFTDYYMNWVRQAPGKGLEWVALIRNKAAGYTIYYSAPVKGRFTISRDDSKSTLYLQMNSLKTEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct DIVMTQSPSSVSASVGDRVTITCRASQNINIWLSWYQQKPGKAPKLFIYKASNLHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQSQSYPLTFGQGTKLEIK 30 AA PAT REGION 1..30 note synthetic source 1..30 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFAFT 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFDFTDYYMHWVRQAPGKGLEWVALIRNKAAGYTIYYSAPVKGRFTISRDDSKSTLYLQMNSLKTEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct DYYMH 30 AA PAT REGION 1..30 note synthetic source 1..30 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFDFT 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFDFTDYYMNWVRQAPGKGLEWVALIRNKAAGYTIYYSAPVKGRFTISRDDSKSTLYLQMNSLKTEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFAFTDYYLRWVRQAPGKGLEWVALIRNKAAGYTIYYSAPVKGRFTISRDDSKSTLYLQMNSLKTEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct DYYLR 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFNFTDYYMNWVRQAPGKGLEWVALIRNKAAGYTIYYSAPVKGRFTISRDDSKSTLYLQMNSLKTEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 30 AA PAT REGION 1..30 note synthetic source 1..30 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFNFT 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFAFTDYYLSWVRQAPGKGLEWVALIRNKAAGYTIYYSAPVKGRFTISRDDSKSTLYLQMNSLKTEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 5 AA PAT REGION 1..5 note synthetic source 1..5 mol_type protein organism synthetic construct DYYLS 127 AA PAT REGION 1..127 note synthetic source 1..127 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGYAFTDYYMNWVRQAPGKGLEWVALIRNKAAGYTIYYSAPVKGRFTISRDDSKSTLYLQMNSLKTEDTAVYYCVRDMTIYDGYYVDYALDYWGQGTLVTVSS 30 AA PAT REGION 1..30 note synthetic source 1..30 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGYAFT 000 19 AA PAT REGION 1..19 note synthetic SITE 14 note misc_feature - Xaa can be S or A SITE 15 note misc_feature - Xaa can be A or D SITE 16 note misc_feature - Xaa can be S or P source 1..19 mol_type protein organism synthetic construct LIRNKAAGYTIYYXXXVKG 11 AA PAT REGION 1..11 note synthetic SITE 4 note misc_feature - Xaa can be Q or R source 1..11 mol_type protein organism synthetic construct RASXNINIWLS 9 AA PAT REGION 1..9 note synthetic SITE 1 note misc_feature - Xaa can be Q or L source 1..9 mol_type protein organism synthetic construct XQSQSYPLT 30 AA PAT REGION 1..30 note synthetic SITE 1 note misc_feature - Xaa can be Q or E SITE 5 note misc_feature - Xaa can be Q or V SITE 27 note misc_feature - Xaa can be F or Y SITE 28 note misc_feature - Xaa can be A, D or N SITE 30 note misc_feature - Xaa can be T or G source 1..30 mol_type protein organism synthetic construct XVQLXESGGGLVKPGGSLRLSCAASGXXFX 14 AA PAT REGION 1..14 note synthetic SITE 2 note misc_feature - Xaa can be I or V SITE 14 note misc_feature - Xaa can be S or A source 1..14 mol_type protein organism synthetic construct WXRQAPGKGLEWVX 32 AA PAT REGION 1..32 note synthetic SITE 8 note misc_feature - Xaa can be N or D SITE 9 note misc_feature - Xaa can be A or S SITE 12 note misc_feature - Xaa can be S or T SITE 21 note misc_feature - Xaa can be R or K SITE 22 note misc_feature - Xaa can be A or T source 1..32 mol_type protein organism synthetic construct RFTISRDXXKSXLYLQMNSLXXEDTAVYYCVR 23 AA PAT REGION 1..23 note synthetic SITE 1 note misc_feature - Xaa can be D or E SITE 9 note misc_feature - Xaa can be S or A SITE 10 note misc_feature - Xaa can be S or T SITE 11 note misc_feature - Xaa can be L or V SITE 13 note misc_feature - Xaa can be A or V SITE 15 note misc_feature - Xaa can be V or P SITE 17 note misc_feature - Xaa can be D or E SITE 19 note misc_feature - Xaa can be V or A SITE 21 note misc_feature - Xaa can be I or L SITE 22 note misc_feature - Xaa can be T or S source 1..23 mol_type protein organism synthetic construct XIVMTQSPXXXSXSXGXRXTXXC 15 AA PAT REGION 1..15 note synthetic SITE 8 note misc_feature - Xaa can be Q or K SITE 11 note misc_feature - Xaa can be K or R source 1..15 mol_type protein organism synthetic construct WYQQKPGXAPXLFIY 32 AA PAT REGION 1..32 note synthetic SITE 4 note misc_feature - Xaa can be S or A SITE 14 note misc_feature - Xaa can be D or E SITE 24 note misc_feature - Xaa can be S or P SITE 29 note misc_feature - Xaa can be T or V source 1..32 mol_type protein organism synthetic construct GVPXRFSGSGSGTXFTLTISSLQXEDFAXYYC 327 AA PAT REGION 1..327 note synthetic source 1..327 mol_type protein organism synthetic construct ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 327 AA PAT REGION 1..327 note synthetic source 1..327 mol_type protein organism synthetic construct ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 327 AA PAT REGION 1..327 note synthetic source 1..327 mol_type protein organism synthetic construct ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLQVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHAHYTQKSLSLSLGK 119 AA PAT REGION 1..119 note synthetic source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYSFTSSWIHWVKQAPGQGLEWMGEINPGNVRTNYNENFRNKVTMTVDTSISTAYMELSRLRSDDTAVYYCTVVFYGEPYFPYWGQGTLVTVSS 108 AA PAT REGION 1..108 note synthetic source 1..108 mol_type protein organism synthetic construct QIVLTQSPGTLSLSPGERATMTCTASSSVSSSYFHWYQQKPGQAPRLWIYRTSRLASGVPDRFSGSGSGTDFTLTISRLEPEDAATYYCHQFHRSPLTFGAGTKLEIK 120 AA PAT REGION 1..120 note synthetic source 1..120 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWMNWVRQAPRQGLEWMGMFHPTGDVTRLNQKFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARTTSMIIGGFAYWGQGTLVTVSS 112 AA PAT REGION 1..112 note synthetic source 1..112 mol_type protein organism synthetic construct DIVMTQTPLSLSVTPGQPASISCRSSKSLLHRNAITYFYWYLHKPGQPPQLLIYQMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPLTFGGGTKVEIK 118 AA PAT REGION 1..118 note synthetic source 1..118 mol_type protein organism synthetic construct EVQLVESGGDLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSVISWNSDVIAYSDSVKGRFTISRDNAKNSLYLQMNSLRTEDTALYYCTKGHKWSFFDYWGQGTLVTVSS 107 AA PAT REGION 1..107 note synthetic source 1..107 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSISSYLAWYQQKPGQAPRLLIFNVANRATDIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIK 575 AA PAT REGION 1..575 note synthetic source 1..575 mol_type protein organism synthetic construct MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLLQHTPCYRTAGPELGSRRKKCTLTTG 570 AA PAT REGION 1..570 note synthetic source 1..570 mol_type protein organism synthetic construct MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV