MTPIMY220472 CN 2020112499603 2020-11-10 Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. BISPECIFIC ANTIBODY FOR CLAUDIN 18A2 AND CD3 AND APPLICATION OF BISPECIFIC ANTIBODY 24 450 AA PAT source 1..450 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYIFTNYWIHWVRQAPGQGLEWMGRIYPGTGNTYYNEKFTGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAREGYGKGNSMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 475 AA PAT source 1..475 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERVTMNCKSSQSLLNAGNQKNYLTWYQQKPGQPPKLLFYWASTRESGVPDRFSGSGSGTDFTLTISSVQAEDVAVYHCQNAYYYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGGGSAQAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVLGGGGSGGGGSGGGGSEVKLVESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDAKNTLYLQMNNLRTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 715 AA PAT source 1..715 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYIFTNYWIHWVRQAPGQGLEWMGRIYPGTGNTYYNEKFTGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAREGYGKGNSMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGAGGGGSGGGGSGGGGSAQAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVLGGGGSGGGGSGGGGSEVKLVESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDAKNTLYLQMNNLRTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 450 AA PAT source 1..450 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYIFTNYWIHWVRQAPGQGLEWMGRIYPGTGNTYYNEKFTGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAREGYGKGNSMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNRYTQKSLSLSPGK 220 AA PAT source 1..220 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERVTMNCKSSQSLLNAGNQKNYLTWYQQKPGQPPKLLFYWASTRESGVPDRFSGSGSGTDFTLTISSVQAEDVAVYHCQNAYYYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 125 AA PAT source 1..125 mol_type protein organism synthetic construct EVKLVESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDAKNTLYLQMNNLRTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVL 250 AA PAT source 1..250 mol_type protein organism synthetic construct AQAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVLGGGGSGGGGSGGGGSEVKLVESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDAKNTLYLQMNNLRTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 455 AA PAT source 1..455 mol_type protein organism synthetic construct EVKLVESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDAKNTLYLQMNNLRTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC 5 AA PAT source 1..5 mol_type protein organism synthetic construct NYWIH 17 AA PAT source 1..17 mol_type protein organism synthetic construct RIYPGTGNTYYNEKFTG 11 AA PAT source 1..11 mol_type protein organism synthetic construct EGYGKGNSMDY 17 AA PAT source 1..17 mol_type protein organism synthetic construct KSSQSLLNAGNQKNYLT 7 AA PAT source 1..7 mol_type protein organism synthetic construct WASTRES 9 AA PAT source 1..9 mol_type protein organism synthetic construct QNAYYYPYT 5 AA PAT source 1..5 mol_type protein organism synthetic construct TYAMN 19 AA PAT source 1..19 mol_type protein organism synthetic construct RIRSKYNNYATYYADSVKD 14 AA PAT source 1..14 mol_type protein organism synthetic construct HGNFGNSYVSWFAY 14 AA PAT source 1..14 mol_type protein organism synthetic construct RSSTGAVTTSNYAN 7 AA PAT source 1..7 mol_type protein organism synthetic construct GTNKRAP 9 AA PAT source 1..9 mol_type protein organism synthetic construct ALWYSNLWV 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYIFTNYWIHWVRQAPGQGLEWMGRIYPGTGNTYYNEKFTGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAREGYGKGNSMDYWGQGTTVTVSS 113 AA PAT source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERVTMNCKSSQSLLNAGNQKNYLTWYQQKPGQPPKLLFYWASTRESGVPDRFSGSGSGTDFTLTISSVQAEDVAVYHCQNAYYYPYTFGGGTKLEIK