P2021-00040WO01 JP 2021-178982 2021-11-01 SHIONOGI & CO., LTD. Novel anti-Nav1.7 monoclonal antibodies 103 8 AA PAT REGION 1..8 note hCE3C peptide source 1..8 mol_type protein organism synthetic construct QPKYEYSL 9 AA PAT REGION 1..9 note N terminal Cys-added-hCE3C peptide source 1..9 mol_type protein organism synthetic construct CQPKYEYSL 119 AA PAT REGION 1..119 note Heavy chain of 15H11 source 1..119 mol_type protein organism synthetic construct EVQLQQSGPELLKPGASVKISCKASGYTFTDYNMHWVKQSHGRSLEWIGRINPKNGVINSNEKFKDKATLTVDKSLSTAYMDLRSLTSEDSAVYFCAPSYYGGNTDAYWGHGTLVTVSA 5 AA PAT REGION 1..5 note CDR1 of 15H11 VH source 1..5 mol_type protein organism synthetic construct DYNMH 17 AA PAT REGION 1..17 note CDR2 of 15H11 VH source 1..17 mol_type protein organism synthetic construct RINPKNGVINSNEKFKD 10 AA PAT REGION 1..10 note CDR3 of 15H11 VH source 1..10 mol_type protein organism synthetic construct SYYGGNTDAY 113 AA PAT REGION 1..113 note Light chain of 15H11 source 1..113 mol_type protein organism synthetic construct DIVLTQSPVSLAVSLGQRATIYCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFSLNIHPMEEDDTAMYFCQQSKEFPWTFGGGTKLEIKRA 15 AA PAT REGION 1..15 note CDR1 of 15H11 VK source 1..15 mol_type protein organism synthetic construct RASESVDNYGISFMN 7 AA PAT REGION 1..7 note CDR2 of 15H11 VK source 1..7 mol_type protein organism synthetic construct AASSQGS 9 AA PAT REGION 1..9 note CDR3 of 15H11 VK source 1..9 mol_type protein organism synthetic construct QQSKEFPWT 327 AA PAT REGION 1..327 note hIgG4Pro source 1..327 mol_type protein organism synthetic construct ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 105 AA PAT REGION 1..105 note hIgK source 1..105 mol_type protein organism synthetic construct VAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 15 AA PAT REGION 1..15 note Nav1.7 CE3C peptide source 1..15 mol_type protein organism synthetic construct CSVNVDKQPKYEYSL 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASESVDNYGISFMNWYQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPVEANDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASESVDNYGISFMNWYQQKPGKAPKLLIYAASSQGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASESVDNYGISFMNWYQQKPGQAPRLLIYAASSQGSGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASESVDNYGISFMNWYQQKPGQAPRLLIYAASSQGSGIPARFSGSGSGTDFTLTISRLEPEDFAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASESVDNYGISFMNWYQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEFPWTFGGGTKVEIKRT 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGRINPKNGVINSNEKFKDRVTMTRDTSISTAYMELSRLRSDDTAVYYCARSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGRINPKNGVINSNEKFKDRVTMTRDTSISTAYMELSRLRSDDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQRLEWMGRINPKNGVINSNEKFKDRVTITRDTSASTAYMELSSLRSEDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGRINPKNGVINSNEKFKDRVTMTTDTSTSTAYMELRSLRSDDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGRINPKNGVINSNEKFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRVTMTRDTSISTAYMELSRLRSDDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEANDTAMYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEANDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPVEANDTAMYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFSLNINPVEANDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPVEANDTANYYCQQSKEFPWTFGGGTKVEIKRT 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTEYNMHWVRQAPGRSLEWMGRINPKNGVILSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGDDDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVILSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGDDDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTEYNMHWVRQAPGRSLEWMGRINPKNGVILSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGDTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGDDDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTEYNMHWVRQAPGRSLEWMGRINPKNGVILSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNDDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVILSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNDDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVILSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGDTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTEYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNDDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNDDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTEYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGDTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTEYNMHWVRQAPGRSLEWMGRINPKNGVILSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTEYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNSDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTEYNMHWVRQAPGRSLEWMGRINPKNGVIQSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNSDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGDTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVILSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVIQSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNSDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTEYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYFGGQSDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNQDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINLNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVIKSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINYNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGNTDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYFGGNSDAYWGQGTLVTVSS 119 AA PAT REGION 1..119 note Heavy chain source 1..119 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNMHWVRQAPGRSLEWMGRINPKNGVINSNEKFKDRFVFSLDTSVSTAYLQISSLKAEDTAVYYCAPSYYGGKTDAYWGQGTLVTVSS 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEANDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRVSDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEANDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASESVDNYGFSFMNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEANDTANYYCQQSKEFPWTFGGGTKVEIKRT 5 AA PAT REGION 1..5 note mutant CDR1 of 15H11 VH source 1..5 mol_type protein organism synthetic construct EYNMH 17 AA PAT REGION 1..17 note mutant CDR2 of 15H11 VH source 1..17 mol_type protein organism synthetic construct RINPKNGVILSNEKFKD 17 AA PAT REGION 1..17 note mutant CDR2 of 15H11 VH source 1..17 mol_type protein organism synthetic construct RINPKNGVIQSNEKFKD 17 AA PAT REGION 1..17 note mutant CDR2 of 15H11 VH source 1..17 mol_type protein organism synthetic construct RINPKNGVINLNEKFKD 17 AA PAT REGION 1..17 note mutant CDR2 of 15H11 VH source 1..17 mol_type protein organism synthetic construct RINPKNGVIKSNEKFKD 17 AA PAT REGION 1..17 note mutant CDR2 of 15H11 V source 1..17 mol_type protein organism synthetic construct RINPKNGVINYNEKFKD 10 AA PAT REGION 1..10 note mutant CDR3 of 15H11 VH source 1..10 mol_type protein organism synthetic construct SYYGGDDDAY 10 AA PAT REGION 1..10 note mutant CDR3 of 15H11 VH source 1..10 mol_type protein organism synthetic construct SYYGGDTDAY 10 AA PAT REGION 1..10 note mutant CDR3 of 15H11 VH source 1..10 mol_type protein organism synthetic construct SYYGGNDDAY 10 AA PAT REGION 1..10 note mutant CDR3 of 15H11 VH source 1..10 mol_type protein organism synthetic construct SYYGGNSDAY 10 AA PAT REGION 1..10 note mutant CDR3 of 15H11 VH source 1..10 mol_type protein organism synthetic construct SYFGGQSDAY 10 AA PAT REGION 1..10 note mutant CDR3 of 15H11 VH source 1..10 mol_type protein organism synthetic construct SYYGGNQDAY 10 AA PAT REGION 1..10 note mutant CDR3 of 15H11 VH source 1..10 mol_type protein organism synthetic construct SYFGGNSDAY 10 AA PAT REGION 1..10 note mutant CDR3 of 15H11 VH source 1..10 mol_type protein organism synthetic construct SYYGGKTDAY 15 AA PAT REGION 1..15 note mutant CDR1 of 15H11 VK source 1..15 mol_type protein organism synthetic construct RASDSVDNYGISFLN 15 AA PAT REGION 1..15 note mutant CDR1 of 15H11 VK source 1..15 mol_type protein organism synthetic construct RVSDSVDNYGISFLN 15 AA PAT REGION 1..15 note mutant CDR1 of 15H11 VK source 1..15 mol_type protein organism synthetic construct RASESVDNYGFSFMN 5 AA PAT REGION 1..5 note CDR1 of 15H11 VH SITE 1 note X can be D or E. source 1..5 mol_type protein organism synthetic construct XYNMH 17 AA PAT REGION 1..17 note CDR2 of 15H11 VH SITE 10 note X can be N, L, Q or K. SITE 11 note X can be S, L or Y. source 1..17 mol_type protein organism synthetic construct RINPKNGVIXXNEKFKD 10 AA PAT REGION 1..10 note CDR3 of 15H11 VH SITE 3 note X can be Y or F. SITE 6 note X can be N, D, Q or K. SITE 7 note X can be T, D, S or Q. source 1..10 mol_type protein organism synthetic construct SYXGGXXDAY 15 AA PAT REGION 1..15 note CDR1 of 15H11 VK SITE 2 note X can be A or V. SITE 4 note X can be E or D. SITE 11 note X can be I or F. SITE 14 note X can be M or L. source 1..15 mol_type protein organism synthetic construct RXSXSVDNYGXSFXN 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEAEDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEAADTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEAQDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEAFDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEALDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEAVDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEAIDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEADDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEARDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEAGDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTINPMEANPTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTISSMQAEDVAMYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTINPMQAEDVAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT source 1..113 mol_type protein organism synthetic construct REGION 1..113 note Light chain DIVMTQSPDSLAVSLGERATINCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTISSMQAEDVAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTISSMQAEDVAMYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTINPMQAEDVAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTISSMQAEDVAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTINPMEAEDTANYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTISSMEAEDVAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPDRFSGSGSGTDFTLTISSMQAEDTAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTISSMQAEDVAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTISSMQAEDVAMYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSLGERATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTISSMQAEDVAVYYCQQSKEFPWTFGGGTKVEIKRT 113 AA PAT REGION 1..113 note Light chain source 1..113 mol_type protein organism synthetic construct DIVLTQSPASLAVSLGQRATINCRASDSVDNYGISFLNWFQQKPGQPPKLLIYAASSQGSGVPARFSGSGSGTDFTLTISSMQAEDVAVYYCQQSKEFPWTFGGGTKVEIKRT 14 AA PAT source 1..14 mol_type protein organism synthetic construct REGION 1..14 note hCE3C peptide SVNVDKQPKYEYSL