US PCT/US2022/044205 2022-09-21 081906-1345059-244210PC US 63/247,014 2021-09-22 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA TUMOR-SPECIFIC BISPECIFIC IMMUNE CELL ENGAGER 102 120 AA PAT source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDSSRWSYDLWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSAYAMHWVRQAPGKGLEWVAVISYEGYNAYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDYSRWAYDYWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSAYAMHWVRQAPGKGLEWVAVISYEGYNAYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDYSRWAYDLWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDSSRWSYDLWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDSSRWSYDLWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVESGGGVVQPGGSLRLSCAASGFAFSSYDMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDSSRWSYDLWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDSSRWGYDLWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVVSYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDSSRWSYDLWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVVSYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDSSRWGYDLWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVESGGGVVQPGGSLRLSCAASGFAFSSYDMHWVRQAPGKGLEWVAVVSYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDSSRWGYDLWGRGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVVSYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDSSRWGYDLWGRGTLVTVSS 111 AA PAT source 1..111 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTIASTLVVFGGGTKLTVL 111 AA PAT source 1..111 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTNYPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTVATTLVVFGGGTKLTVL 111 AA PAT source 1..111 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTIASTPVVFGGGTKLTVL 111 AA PAT source 1..111 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTIASTFVVFGGGTKLTVL 111 AA PAT source 1..111 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYAIASTLVVFGGGTKLTVL 111 AA PAT source 1..111 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTDRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTIASTLVVFGGGTKLTVL 111 AA PAT source 1..111 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTDRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYAIASTLVVFGGGTKLTVL 111 AA PAT source 1..111 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTDRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYAIASTPVVFGGGTKLTVL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFTFSSYAMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VISYDGSNKY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDSSRWSYDL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFTFSAYAMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VISYEGYNAY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDYSRWAYDY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFTFSAYAMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VISYEGYNAY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDYSRWAYDL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFTFSSYAMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VISYDGSNKY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDSSRWSYDL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFTFSSYDMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VISYDGSNKY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDSSRWSYDL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFAFSSYDMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VISYDGSNKY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDSSRWSYDL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFTFSSYAMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VISYDGSNKY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDSSRWGYDL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFTFSSYAMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VVSYDGSNKY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDSSRWSYDL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFTFSSYAMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VVSYDGSNKY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDSSRWGYDL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFAFSSYDMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VVSYDGSNKY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDSSRWGYDL 13 AA PAT source 1..13 mol_type protein organism synthetic construct AASGFTFSSYDMH 10 AA PAT source 1..10 mol_type protein organism synthetic construct VVSYDGSNKY 13 AA PAT source 1..13 mol_type protein organism synthetic construct AKEGDSSRWGYDL 14 AA PAT source 1..14 mol_type protein organism synthetic construct TGTSSDVGGYNYVS 8 AA PAT source 1..8 mol_type protein organism synthetic construct YDVTNRPS 11 AA PAT source 1..11 mol_type protein organism synthetic construct SSYTIASTLVV 14 AA PAT source 1..14 mol_type protein organism synthetic construct TGTSSDVGGYNYVS 8 AA PAT source 1..8 mol_type protein organism synthetic construct YDVTNYPS 11 AA PAT source 1..11 mol_type protein organism synthetic construct SSYTVATTLVV 14 AA PAT source 1..14 mol_type protein organism synthetic construct TGTSSDVGGYNYVS 8 AA PAT source 1..8 mol_type protein organism synthetic construct YDVTNRPS 11 AA PAT source 1..11 mol_type protein organism synthetic construct SSYTIASTPVV 14 AA PAT source 1..14 mol_type protein organism synthetic construct TGTSSDVGGYNYVS 8 AA PAT source 1..8 mol_type protein organism synthetic construct YDVTNRPS 11 AA PAT source 1..11 mol_type protein organism synthetic construct SSYTIASTFVV 14 AA PAT source 1..14 mol_type protein organism synthetic construct TGTSSDVGGYNYVS 8 AA PAT source 1..8 mol_type protein organism synthetic construct YDVTNRPS 11 AA PAT source 1..11 mol_type protein organism synthetic construct SSYAIASTLVV 14 AA PAT source 1..14 mol_type protein organism synthetic construct TGTSSDVGGYNYVS 8 AA PAT source 1..8 mol_type protein organism synthetic construct YDVTDRPS 11 AA PAT source 1..11 mol_type protein organism synthetic construct SSYTIASTLVV 14 AA PAT source 1..14 mol_type protein organism synthetic construct TGTSSDVGGYNYVS 8 AA PAT source 1..8 mol_type protein organism synthetic construct YDVTDRPS 11 AA PAT source 1..11 mol_type protein organism synthetic construct SSYAIASTLVV 14 AA PAT source 1..14 mol_type protein organism synthetic construct TGTSSDVGGYNYVS 8 AA PAT source 1..8 mol_type protein organism synthetic construct YDVTDRPS 11 AA PAT source 1..11 mol_type protein organism synthetic construct SSYAIASTPVV 125 AA PAT source 1..125 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVGRIRSKYNNYATYYADSVKDRFTISRDDSKNSLYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 110 AA PAT source 1..110 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRSSTGAVTTSNYANWVQQKPGKAPKGLIGGTNKRAPGVPSRFSGSLIGDKATLTISSLQPEDFATYYCALWYSNLWVFGQGTKVEIK 12 AA PAT source 1..12 mol_type protein organism synthetic construct ASGFTFNTYAMN 8 AA PAT source 1..8 mol_type protein organism synthetic construct RIRSKYNN 16 AA PAT source 1..16 mol_type protein organism synthetic construct VRHGNFGNSYVSWFAY 13 AA PAT source 1..13 mol_type protein organism synthetic construct SSTGAVTTSNYAN 8 AA PAT source 1..8 mol_type protein organism synthetic construct GGTNKRAP 9 AA PAT source 1..9 mol_type protein organism synthetic construct ALWYSNLWV 344 AA PAT source 1..344 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVGRIRSKYNNYATYYADSVKDRFTISRDDSKNSLYLQMNSLTACDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGGGGSQSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTYRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTVATTLVVFGGGTKLTVLASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 342 AA PAT source 1..342 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSAYAMHWVRQAPGKGLEWVAVISYEGYNAYYADSVKGRFTISRDNSKNTLYLQMNSLTACDTAVYYCAKEGDYSRWAYDYWGRGTLVTVSSGGGGSDIQMTQSPSSLSASVGDRVTITCRSSTGAVTTSNYANWVQQKPGKAPKGLIGGTNKRAPGVPSRFSGSLIGDKATLTISSLQPEDFATYYCALWYSNLWVFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 344 AA PAT source 1..344 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVGRIRSKYNNYATYYADSVKDRFTISRDDSKNSLYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGGGGSQSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVTYRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTVATTLVVFGGGTKLTVLASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 361 AA PAT source 1..361 mol_type protein organism synthetic construct MGWSCIILFLVATATGVHSEVQLVESGGGLVQPGGSLRLSCAASGFTFSAYAMHWVRQAPGKGLEWVAVISYEGYNAYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEGDYSRWAYDYWGRGTLVTVSSGGGGSDIQMTQSPSSLSASVGDRVTITCRSSTGAVTTSNYANWVQQKPGKAPKGLIGGTNKRAPGVPSRFSGSLIGDKATLTISSLQPEDFATYYCALWYSNLWVFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 15 AA PAT source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 10 AA PAT source 1..10 mol_type protein organism synthetic construct GGGGSGGGGS 5 AA PAT source 1..5 mol_type protein organism synthetic construct GGGGS 20 AA PAT source 1..20 mol_type protein organism synthetic construct GSGGGGSGGGGSGGSGGGGS 6 AA PAT source 1..6 mol_type protein organism synthetic construct SGGGGS 4 AA PAT source 1..4 mol_type protein organism synthetic construct GGGS 4 AA PAT source 1..4 mol_type protein organism synthetic construct VPGV 5 AA PAT source 1..5 mol_type protein organism synthetic construct VPGVG 6 AA PAT source 1..6 mol_type protein organism synthetic construct GVPGVG 8 AA PAT source 1..8 mol_type protein organism synthetic construct GVGVPGVG 10 AA PAT source 1..10 mol_type protein organism synthetic construct VPGVGVPGVG 7 AA PAT source 1..7 mol_type protein organism synthetic construct GGSSRSS 18 AA PAT source 1..18 mol_type protein organism synthetic construct GGSSRSSSSGGGGSGGGG 6 AA PAT source 1..6 mol_type protein organism synthetic construct HHHHHH