03D197103USP CN 202210496949.X 2022-05-09 Hangzhou Viromab Biotech Co., Ltd. THERAPEUTIC AGENT COMPRISING MULTISPECIFIC ANTIBODY AND USE THEREOF IN TUMOR THERAPY 69 50 AA PAT source 1..50 mol_type protein organism synthetic construct EQKLISEEDLGGGGSGGGGSEQKLISEEDLGGGGSGGGGSEQKLISEEDL 47 AA PAT source 1..47 mol_type protein organism synthetic construct YPYDVPDYAGGGGSGGGGSYPYDVPDYAGGGGSGGGGSYPYDVPDYA 47 AA PAT source 1..47 mol_type protein organism synthetic construct NWSHPQFEKGGGGSGGGGSNWSHPQFEKGGGGSGGGGSNWSHPQFEK 64 AA PAT source 1..64 mol_type protein organism synthetic construct EQKLISEEDLGEQKLISEEDLGEQKLISEEDLGGSYPYDVPDYAGYPYDVPDYAGYPYDVPDYA 43 AA PAT source 1..43 mol_type protein organism synthetic construct EQKLISEEDLGEQKLISEEDLGGSYPYDVPDYAGYPYDVPDYA 55 AA PAT source 1..55 mol_type protein organism synthetic construct FVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACD 28 AA PAT source 1..28 mol_type protein organism synthetic construct IYIWAPLAGTCGVLLLSLVITLYCNHRN 22 AA PAT source 1..22 mol_type protein organism synthetic construct MLLLVTSLLLCELPHPAFLLIP 117 AA PAT source 1..117 mol_type protein organism synthetic construct TGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQI 202 AA PAT source 1..202 mol_type protein organism synthetic construct TGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIASFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRN 145 AA PAT source 1..145 mol_type protein organism synthetic construct EQKLISEEDLGGGGSGGGGSEQKLISEEDLGGGGSGGGGSEQKLISEEDLGGGGSGGGGSASFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRN 142 AA PAT source 1..142 mol_type protein organism synthetic construct YPYDVPDYAGGGGSGGGGSYPYDVPDYAGGGGSGGGGSYPYDVPDYAGGGGSGGGGSASFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRN 142 AA PAT source 1..142 mol_type protein organism synthetic construct NWSHPQFEKGGGGSGGGGSNWSHPQFEKGGGGSGGGGSNWSHPQFEKGGGGSGGGGSASFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRN 149 AA PAT source 1..149 mol_type protein organism synthetic construct EQKLISEEDLGEQKLISEEDLGEQKLISEEDLGGSYPYDVPDYAGYPYDVPDYAGYPYDVPDYAASFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRN 246 AA PAT source 1..246 mol_type protein organism synthetic construct EQKLISEEDLGEQKLISEEDLGGSYPYDVPDYAGYPYDVPDYAGTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIASFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRN 18 AA PAT source 1..18 mol_type protein organism synthetic construct GSTSGSGKPGSGEGSTKG 256 AA PAT source 1..256 mol_type protein organism synthetic construct DIVLTQSPAFLAVSLGQRATISCRASESVDNYGFSFMNWFQQKPGQPPKLLIYAISNRGSGVPARFSGSGSGTDFSLNIHPVEEDDPAMYFCQQTKEVPWTFGGGTKLEIKGSTSGSGKPGSGEGSTKGQVQLQESGGDLVKPGGSLKLSCAASGFTFSHYGMSWVRQTPDKRLEWVATIGSRGTYTHYPDSVKGRFTISRDNDKNALYLQMNSLKSEDTAMYYCARRSEFYYYGNTYYYSAMDYWGQGASVTVSS 15 AA PAT source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 248 AA PAT source 1..248 mol_type protein organism synthetic construct EVKLVESGGDLVKPGGSLKLSCAASGFTFSSYGMSWVRQTPDKRLEWVATISRGGSYTYYPDSVKGRFTISRDNAKNTLYLQMSSLKSEDTAMYYCARRETYDEKGFAYWGQGTTVTVSSGGGGSGGGGSGGGGSDIELTQSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGRDFTLTISSVQAEDLAVYYCQNDNSHPLTFGAGTKLELK 8 AA PAT source 1..8 mol_type protein organism synthetic construct GYTFTNYY 8 AA PAT source 1..8 mol_type protein organism synthetic construct LNPNNGDT 13 AA PAT source 1..13 mol_type protein organism synthetic construct ARTGRYEENAMDY 10 AA PAT source 1..10 mol_type protein organism synthetic construct ESVDSYGKSF 000 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQNNEDPWT 111 AA PAT source 1..111 mol_type protein organism synthetic construct ELVMTQSPASLAVSLGQRATISCRASESVDSYGKSFMHWYQLKPGQPPKLLIYRASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNEDPWTFGGGTKLEIK 120 AA PAT source 1..120 mol_type protein organism synthetic construct EVQLEQSGPELVKPGASVKMSCKASGYTFTNYYMKWVKQSHGKSLEWIGDLNPNNGDTFYNQKFKGKATLTVDKSSNTAYMQLNSLTSEDSAVYYCARTGRYEENAMDYWGQGTSVTVSS 249 AA PAT source 1..249 mol_type protein organism synthetic construct ELVMTQSPASLAVSLGQRATISCRASESVDSYGKSFMHWYQLKPGQPPKLLIYRASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNEDPWTFGGGTKLEIKGSTSGSGKPGSGEGSTKGEVQLEQSGPELVKPGASVKMSCKASGYTFTNYYMKWVKQSHGKSLEWIGDLNPNNGDTFYNQKFKGKATLTVDKSSNTAYMQLNSLTSEDSAVYYCARTGRYEENAMDYWGQGTSVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMKWVKQAPGQRLEWMGDLNPNNGDTFYNQKFKGRVTITVDKSASTAYMELSSLRSEDTAVYYCARTGRYEENAMDYWGQGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMKWVKQAPGQSLEWIGDLNPNNGDTFYNQKFKGRVTITVDKSASTAYMELNSLRSEDTAVYYCARTGRYEENAMDYWGQGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMKWVKQAPGQSLEWIGDLNPNNGDTFYNQKFKGKATLTVDKSASTAYMELNSLRSEDTAVYYCARTGRYEENAMDYWGQGTLVTVSS 111 AA PAT source 1..111 mol_type protein organism synthetic construct DIVLTQSPASLAVSPGQRATITCRASESVDSYGKSFMHWYQQKPGQPPKLLIYRASNLESGVPARFSGSGSRTDFTLTINPVEANDTANYYCQQNNEDPWTFGQGTKLEIK 111 AA PAT source 1..111 mol_type protein organism synthetic construct DLVMTQSPASLAVSPGQRATITCRASESVDSYGKSFMHWYQQKPGQPPKLLIYRASNLESGVPARFSGSGSRTDFTLTINPVEANDTANYYCQQNNEDPWTFGQGTKLEIK 111 AA PAT source 1..111 mol_type protein organism synthetic construct DLVMTQSPASLAVSPGQRATITCRASESVDSYGKSFMHWYQLKPGQPPKLLIYRASNLESGVPARFSGSGSRTDFTLTINPVEANDTANYYCQQNNEDPWTFGQGTKLEIK 8 AA PAT source 1..8 mol_type protein organism synthetic construct GFTFNTYA 10 AA PAT source 1..10 mol_type protein organism synthetic construct IRSKYNNYAT 16 AA PAT source 1..16 mol_type protein organism synthetic construct VRHGNFGNSYVSWFAY 9 AA PAT source 1..9 mol_type protein organism synthetic construct TGAVTTSNY 000 9 AA PAT source 1..9 mol_type protein organism synthetic construct ALWYSNLWV 125 AA PAT source 1..125 mol_type protein organism synthetic construct EVKLLESGGGLVQPKGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSQSILYLQMNNLKTEDTAMYYCVRHGNFGNSYVSWFAYWGQGTLVTVSA 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNKRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNLWVFGGGTKLTVL 125 AA PAT source 1..125 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNSLYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSA 125 AA PAT source 1..125 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNILYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSA 125 AA PAT source 1..125 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNILYLQMNSLKTEDTAMYYCVRHGNFGNSYVSWFAYWGQGTLVTVSA 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPWTPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVL 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPWTPARFSGSLLGGKAALTLSGAQTEDEAEYYCALWYSNLWVFGGGTKLTVL 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPWTPARFSGSLLGGKAALTITGAQTEDEAEYYCALWYSNLWVFGGGTKLTVL 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPWVPARFSGSLLGDKAALTLSGAQTEDEAEYYCALWYSNLWVFGGGTKLTVL 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQEKPGQAPRGLIGGTNKRAPWVPARFSGSLLGDKAALTLSGAQTEDEAEYYCALWYSNLWVFGGGTKLTVL 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRTLIGGTNKRAPWTPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVL 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRTLIGGTNKRAPWVPARFSGSLLGDKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVL 109 AA PAT source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQEKPGQAPRTLIGGTNKRAPWVPARFSGSLLGDKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVL 330 AA PAT source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 220 AA PAT source 1..220 mol_type protein organism synthetic construct PCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 8 AA PAT source 1..8 mol_type protein organism synthetic construct WSHPQFEK 9 AA PAT source 1..9 mol_type protein organism synthetic construct NWSHPQFEK 9 AA PAT source 1..9 mol_type protein organism synthetic construct AWRHPQFGG 10 AA PAT source 1..10 mol_type protein organism synthetic construct GGGGSGGGGS 20 AA PAT source 1..20 mol_type protein organism synthetic construct GSSGGGSGSGSGGGGGGGGS 4 AA PAT source 1..4 mol_type protein organism synthetic construct SGGG 5 AA PAT source 1..5 mol_type protein organism synthetic construct GGGGS 8 AA PAT source 1..8 mol_type protein organism synthetic construct GGGGGSGS 7 AA PAT source 1..7 mol_type protein organism synthetic construct GGGGSGS 20 AA PAT source 1..20 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGS 25 AA PAT source 1..25 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGSGGGGS 28 AA PAT source 1..28 mol_type protein organism synthetic construct GGGGSGGGGSGGGGSGGGGSGGGSGGGS