CN IEC240085PCT CN 202311871776.6 2023-12-29 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Antibody-drug conjugate, pharmaceutical composition thereof, and use thereof 26 116 AA PAT source 1..116 mol_type protein note Ab-02 VH amino acid sequence organism synthetic construct QVQLQESGPGLVQPSGTLSLTCAVSGGSDSSTNWWTWVRQSPGQGLEWIGEISPIGFTSYSPSLRSRVTISVDKSKTQFSLKLSSVTAADTAVYYCARDRLYFAFWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note Ab-01 and Ab-02 VL amino acid sequence organism synthetic construct EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPDRFSGSGSGTEFTLTISSLESEDFAVYYCQQYNNWPITFGQGTRLEIK 6 AA PAT source 1..6 mol_type protein note Ab-01 and Ab-02 CDR-L1 IMGT organism synthetic construct QSVSSN 000 9 AA PAT source 1..9 mol_type protein note Ab-01 and Ab-02 CDR-L3 IMGT/ Chothia/Kabat/AbM organism synthetic construct QQYNNWPIT 11 AA PAT source 1..11 mol_type protein note Ab-01 and Ab-02 CDR-L1 Chothia/Kabat/AbM organism synthetic construct RASQSVSSNLA 7 AA PAT source 1..7 mol_type protein note Ab-01 and Ab-02 CDR-L2 Chothia/Kabat/AbM organism synthetic construct GASTRAT 9 AA PAT source 1..9 mol_type protein note Ab-01 and Ab-02 CDR-H1 IMGT organism synthetic construct GGSDSSTNW 7 AA PAT source 1..7 mol_type protein note Ab-01 and Ab-02 CDR-H2 IMGT organism synthetic construct ISPIGFT 9 AA PAT source 1..9 mol_type protein note Ab-01 and Ab-02 CDR-H3 IMGT organism synthetic construct ARDRLYFAF 8 AA PAT source 1..8 mol_type protein note Ab-01 and Ab-02 CDR-H1 Chothia organism synthetic construct GGSDSSTN 5 AA PAT source 1..5 mol_type protein note Ab-01 and Ab-02 CDR-H2 Chothia organism synthetic construct SPIGF 7 AA PAT source 1..7 mol_type protein note Ab-01 and Ab-02 CDR-H3 Chothia/Kabat/AbM organism synthetic construct DRLYFAF 6 AA PAT source 1..6 mol_type protein note Ab-01 and Ab-02 CDR-H1 Kabat organism synthetic construct STNWWT 16 AA PAT source 1..16 mol_type protein note Ab-01 and Ab-02 CDR-H2 Kabat organism synthetic construct EISPIGFTSYSPSLRS 11 AA PAT source 1..11 mol_type protein note Ab-01 and Ab-02 CDR-H1 AbM organism synthetic construct GGSDSSTNWWT 9 AA PAT source 1..9 mol_type protein note Ab-01 and Ab-02 CDR-H2 AbM organism synthetic construct EISPIGFTS 330 AA PAT source 1..330 mol_type protein note Ab-01 and Ab-02 CH organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein note Ab-01 and Ab-02 CL organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 446 AA PAT source 1..446 mol_type protein note Ab-02 heavy chain amino acid sequence organism synthetic construct QVQLQESGPGLVQPSGTLSLTCAVSGGSDSSTNWWTWVRQSPGQGLEWIGEISPIGFTSYSPSLRSRVTISVDKSKTQFSLKLSSVTAADTAVYYCARDRLYFAFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein note Ab-01 and Ab-02 light chain amino acid sequence organism synthetic construct EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPDRFSGSGSGTEFTLTISSLESEDFAVYYCQQYNNWPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 446 AA PAT source 1..446 mol_type protein note Ab-01 heavy chain amino acid sequence organism synthetic construct QVQLQESGPGLVQPSGTLSLTCAVSGGSDSSTNWWTWVRQSPGQGLEWIGEISPIGFTSYSPSLRSRVTISVDKSKTQFSLNLSSVTAADTAVYYCARDRLYFAFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 116 AA PAT source 1..116 mol_type protein note Ab-01 VH amino acid sequence organism synthetic construct QVQLQESGPGLVQPSGTLSLTCAVSGGSDSSTNWWTWVRQSPGQGLEWIGEISPIGFTSYSPSLRSRVTISVDKSKTQFSLNLSSVTAADTAVYYCARDRLYFAFWGQGTLVTVSS 4 AA PAT source 1..4 mol_type protein note linker fragment organism synthetic construct GGFG 5 AA PAT source 1..5 mol_type protein note linker subunit for connecting LC and HC of an antibody organism synthetic construct GGGGS 20 AA PAT source 1..20 mol_type protein note linker for connecting LC and HC of an antibody organism synthetic construct GGGGSGGGGSGGGGSGGGGS