CIE24B0181PCT CN 202410016532.8 2024-01-05 VIVIDION THERAPEUTICS, INC. WANG Yuanxian METHOD FOR CATALYTICALLY SYNTHESIZING SINGLE CHIRAL 2-ARYL-SUBSTITUTED NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE BY MEANS OF IMINE REDUCTASE, AND USE THEREOF 10 876 DNA PAT source 1..876 mol_type other DNA organism synthetic construct atgaagccgaccctgaccgtgattggcgcaggtcgtatgggtagcgcactgattaaggcatttctgcagagcggctataccaccaccgtttggaatcgtaccaaagccaaaagcgaaccgctggccaaactgggcgcccatctggccgataccgttcgcgatgccgtgaaacgcagcgatattattgttgtgaatgtgctggattatgataccagtgatcagctgctgcgccaggatgaagtgacccgtgaactgcgtggtaaactgctggtgcagctgaccagcggtagcccggcactggcacgcgaacaggaaacctgggcacgtcagcatggtattgattatctggatggtgcaattatggcaaccccggattttattggccaggcagaatgcgccctgctgtatagcggcagtgccgccctgtttgaaaaacatcgcgccgttctgaatgttctgggcggcgccaccagtcatgttggtgaagatgtgggccatgcaagtgccctggatagcgcactgctgtttcagatgtggggtaccctgtttggcaccctgcaggccctggccattagtcgcgcagaaggcattccgctggaaaaaaccaccgcattcattaagctgaccgaaccggttacccagggtgccgtggcagatgtgctgacccgtgttcagcagaatcgtctgaccgccgatgcacagaccctggcaagtctggaagcacataatgttgcctttcagcatctgctggccctgtgtgaagaacgcaatattcatcgcggcgtggcagatgccatgtatagtgtgattcgcgaagcagtgaaagccggtcatggcaaagatgattttgccattctgacccgctttctgaaataa 291 AA PAT source 1..291 mol_type protein organism synthetic construct MKPTLTVIGAGRMGSALIKAFLQSGYTTTVWNRTKAKSEPLAKLGAHLADTVRDAVKRSDIIVVNVLDYDTSDQLLRQDEVTRELRGKLLVQLTSGSPALAREQETWARQHGIDYLDGAIMATPDFIGQAECALLYSGSAALFEKHRAVLNVLGGATSHVGEDVGHASALDSALLFQMWGTLFGTLQALAISRAEGIPLEKTTAFIKLTEPVTQGAVADVLTRVQQNRLTADAQTLASLEAHNVAFQHLLALCEERNIHRGVADAMYSVIREAVKAGHGKDDFAILTRFLK 855 DNA PAT source 1..855 mol_type other DNA organism synthetic construct atgagtgtgagtgttctgggtctgggcccgatgggtcaggcactgacccgtgccctgctgaatgcaaatcatcgtaccaccgtgtggaatcgtaccgcagcaaaagcagatgatgtggttgcacgcggtgccgtgtgggcagatgatccggcaagtgccattgcagcaggtgatctgaccctggtgaatgtggtggatcagcaggcagttgatgcagtgctgaccgcagcaggtgacgccgtggcaggccgtgtgattattggtctgagcgccggcaccccggatgcagctcgtcgtaccgcatcattcgtgaccggcgccggcggtgcctatctggatggcgctattatgaccccgaccgataccattggtacagccagtgccagtgttctgttcagcggcccgcgtgaactgttcgatgatcatcgtgaagttctgagtgcactgggtacactgacctggctgggcgaagatgttggccgtgccgaagccttcgatgttgcactgctggatctgttctggaccagtgttagcggcttcgttcatgccctgagtattgccaaagccaatggcgttagtgccgttgaactgctgccgcatgcaaatggtattagtgaaattctgccggcaatcttcaccgaaattgcagaacgcgtggaaagcggtcgccatgatgatgcaagcgcaccggtgagcagcgtggccgcttcactgcgcaatctgattagtgccgcccgtagcgcaggcattgatgcaggtgccctggaaaccttccgtgattatgtggatgccgccgtggcagcaggccacggtgatgctgaaattagccgtattaccccgctgggtattggttaa 284 AA PAT source 1..284 mol_type protein organism synthetic construct MSVSVLGLGPMGQALTRALLNANHRTTVWNRTAAKADDVVARGAVWADDPASAIAAGDLTLVNVVDQQAVDAVLTAAGDAVAGRVIIGLSAGTPDAARRTASFVTGAGGAYLDGAIMTPTDTIGTASASVLFSGPRELFDDHREVLSALGTLTWLGEDVGRAEAFDVALLDLFWTSVSGFVHALSIAKANGVSAVELLPHANGISEILPAIFTEIAERVESGRHDDASAPVSSVAASLRNLISAARSAGIDAGALETFRDYVDAAVAAGHGDAEISRITPLGIG 864 DNA PAT source 1..864 mol_type other DNA organism synthetic construct atgcgcatgagtaatgtgattgccgttctgggtctgggtgttatgggcagcgccattgcagccaccctgctgggtgatggcgcagaagtggttgtgtggaatcgcaaagcagaaaaagcacagcgtatgcgtgaactgggtgcccgtgttgccgaacgtgcaaccgccgccgtggatgaagccgatgttattgttgtggttaccgccaccccggtggatctggccgccgacttcgaagccctgggcgaacgcctgaaaggtaaaaccgtgattaatctggcaaccggccgtccgagtgaagtgcagaaactggatcagattgtgcgcggtgccggcgcaaaattcattagcggcaccattcagtgcttcccgccggatattggccgtgaaagcgcagccattctgttcggtggcgatggtaaaatctggggcgaagtggaaccgctgctgcgcaaaattgcaccgcagagcacctatgttagcgcccgcccggatgttccgaatgttctggatgcaggtctgaccggcaccttcgtgttcggtgcaggcgccgccttcctggaaggcctgcgcttcgttgttaatagtggtattagcattgatgaaatccgcgatctgattccgacctatattgcaggtcagacccacttcattgaaggcctgttcgaaagtgttgcagcagcagattatcagccgcgtggcgccgatctggatatatatgcacgtgcaattgaactgttccagcaggcccaggaagatattggccagccgccgcgtattctgaaagccctgcgtgaacgcattctgagtagcattgcagaaggcagtggcggtcgtggttatgcagccctgttcaatcattaa 287 AA PAT source 1..287 mol_type protein organism synthetic construct MRMSNVIAVLGLGVMGSAIAATLLGDGAEVVVWNRKAEKAQRMRELGARVAERATAAVDEADVIVVVTATPVDLAADFEALGERLKGKTVINLATGRPSEVQKLDQIVRGAGAKFISGTIQCFPPDIGRESAAILFGGDGKIWGEVEPLLRKIAPQSTYVSARPDVPNVLDAGLTGTFVFGAGAAFLEGLRFVVNSGISIDEIRDLIPTYIAGQTHFIEGLFESVAAADYQPRGADLDIYARAIELFQQAQEDIGQPPRILKALRERILSSIAEGSGGRGYAALFNH 933 DNA PAT source 1..933 mol_type other DNA organism synthetic construct atgaagagcagcaatcgtagtgaaaatattcgcgtgggtacagaaaataccgttggcaaaagcaaaagcgttaccgtgattggtctgggcccgatgggcaaagcaatggcagccgcatttctggaacatggctataaagtgaccgtgtggaatcgcaccagcaataaggccgatgaactgattaccaaaggtgccgttcgtgcaagcaccgttcatgaagcactggcagcaaatgaactggttattctgagcctgaccgattatgatgccatgtataccattctggaaccggccagtgaaaatctgagtggtaaagttctggtgaatctgagtagtgataccccggataaagcccgtgaagccgcaaaatggctggcaaatcgcggtgccggccatattaccggcggcgtgcaggtgccgccgagtggtattggtaaaccggaaagcagtacctattatagtggtccgaaagaagtgtttgaagcaaataaggaaaccctggaagttctgaccggcaccgattatcgcggcgaagatccgggcctggccgcattatattatcagattcagatggatatgttctggaccgccatgctgagttatctgcatgccaccgccgtggcccaggcaaatggtattaccgccgaacagtttctgccgtatgcagcagaaaccatgagcagcctgccgaaattcattgaattttataccccgcgcattaatgccggcgaatatccgggcgatgttgatcgcctggcaatgggtatggcaagtgtggaacatgttgttcataccacccaggatgcaggtattgatattaccctgccgaccgcagtgctggaagtgtttcgtcgtggcatggaaaatggccatgcaggtaatagttttaccagtctgattgaaattttcaagaagagtgatattcgcccgtaa 310 AA PAT source 1..310 mol_type protein organism synthetic construct MKSSNRSENIRVGTENTVGKSKSVTVIGLGPMGKAMAAAFLEHGYKVTVWNRTSNKADELITKGAVRASTVHEALAANELVILSLTDYDAMYTILEPASENLSGKVLVNLSSDTPDKAREAAKWLANRGAGHITGGVQVPPSGIGKPESSTYYSGPKEVFEANKETLEVLTGTDYRGEDPGLAALYYQIQMDMFWTAMLSYLHATAVAQANGITAEQFLPYAAETMSSLPKFIEFYTPRINAGEYPGDVDRLAMGMASVEHVVHTTQDAGIDITLPTAVLEVFRRGMENGHAGNSFTSLIEIFKKSDIRP 891 DNA PAT source 1..891 mol_type other DNA organism synthetic construct atgaagaccaatcaggataccattaccgtgctgggtctgggtaaaatgggtcagaccctggcacgtctgatgctggaaaaaggtcatcgtgttaccgtttggaatcgtagcagtgataaagccgcagatctggtggcagccggcgcaaccctggcagctacccctgctgaagccattgcagcaggtgacattattctgatgtgtgttcatgattatgcagcagccgatgaaattctgggcgcagcaggtgcaggcgaagcactggaaggccgcctgctgattcagctgaccaccggtagtccggaagaagcccgccgtgcagaaaaatgggtgcatcgtcatggtggtcgttatctggatggcgccattcaggccgcaccgacccagatgggtctgccggataccctgattctggttagtggcgcaaaagatgcctgggaacgcggcgaagaagcactgcgttatctggccggtggtacaacctatctgggtgaaaaaattagcgcagcagccgcaatggatctggcaaccctgagttatgtttatggcgccaccctgggtttctttcatggcgccctgattggcgaagcagaaggctttggcgcagcagaatatggtgaaattgtggcacgcattgccccggcctttggcgattttctgaaatatgaaggcggtgtgattcagaaaggtgactttcgtgtgagtgaaagcccgatgagtattagtgtggaagccaccgaacgcattctgaataccgcacgcgaagcaggcattaataccgaaatgccggaatttttcgcaggtttctttcgtcgtgcagccagcgccggctatggtgacgaagaagttgccgcaattattaagctgctgcgcaaaccggccgcagcctaa 296 AA PAT source 1..296 mol_type protein organism synthetic construct MKTNQDTITVLGLGKMGQTLARLMLEKGHRVTVWNRSSDKAADLVAAGATLAATPAEAIAAGDIILMCVHDYAAADEILGAAGAGEALEGRLLIQLTTGSPEEARRAEKWVHRHGGRYLDGAIQAAPTQMGLPDTLILVSGAKDAWERGEEALRYLAGGTTYLGEKISAAAAMDLATLSYVYGATLGFFHGALIGEAEGFGAAEYGEIVARIAPAFGDFLKYEGGVIQKGDFRVSESPMSISVEATERILNTAREAGINTEMPEFFAGFFRRAASAGYGDEEVAAIIKLLRKPAAA